Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
Identifieur interne : 002B44 ( Main/Exploration ); précédent : 002B43; suivant : 002B45Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
Auteurs : Thittamaranahalli Muguregowda Honnegowda [Inde] ; Pramod Kumar [Inde] ; Padmanabha Udupa [Inde] ; Pragna Rao [Inde] ; Siddhartha Bhandary [Inde] ; Krishna Kumar Mahato [Inde] ; Anurag Sharan [Inde] ; Shreemathi S. Mayya [Inde]Source :
- Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India [ 0970-0358 ] ; 2014.
Abstract
Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue.
A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (
Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (
Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.
Url:
DOI: 10.4103/0970-0358.138952
PubMed: 25190917
PubMed Central: 4147456
Affiliations:
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wicri:level="1"><nlm:aff id="aff1">Department of Plastic Surgery and Burns, Kasturba Medical College, Manipal, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Plastic Surgery and Burns, Kasturba Medical College, Manipal, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Kumar, Pramod" sort="Kumar, Pramod" uniqKey="Kumar P" first="Pramod" last="Kumar">Pramod Kumar</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Plastic Surgery and Burns, Kasturba Medical College, Manipal, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Plastic Surgery and Burns, Kasturba Medical College, Manipal, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Udupa, Padmanabha" sort="Udupa, Padmanabha" uniqKey="Udupa P" first="Padmanabha" last="Udupa">Padmanabha Udupa</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry, Kasturba Medical College, Manipal, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Kasturba Medical College, Manipal, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Rao, Pragna" sort="Rao, Pragna" uniqKey="Rao P" first="Pragna" last="Rao">Pragna Rao</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry, Kasturba Medical College, Manipal, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Kasturba Medical College, Manipal, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Bhandary, Siddhartha" sort="Bhandary, Siddhartha" uniqKey="Bhandary S" first="Siddhartha" last="Bhandary">Siddhartha Bhandary</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Surgery, Kasturba Medical College, Manipal, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Surgery, Kasturba Medical College, Manipal, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Mahato, Krishna Kumar" sort="Mahato, Krishna Kumar" uniqKey="Mahato K" first="Krishna Kumar" last="Mahato">Krishna Kumar Mahato</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Biophysics, Kasturba Medical College, Manipal, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biophysics, Kasturba Medical College, Manipal, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Sharan, Anurag" sort="Sharan, Anurag" uniqKey="Sharan A" first="Anurag" last="Sharan">Anurag Sharan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Plastic Surgery and Burns, Kasturba Medical College, Manipal, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Plastic Surgery and Burns, Kasturba Medical College, Manipal, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Mayya, Shreemathi S" sort="Mayya, Shreemathi S" uniqKey="Mayya S" first="Shreemathi S." last="Mayya">Shreemathi S. Mayya</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Biostatistics, Kasturba Medical College, Manipal, Karnataka, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biostatistics, Kasturba Medical College, Manipal, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author></analytic><series><title level="j">Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India</title><idno type="ISSN">0970-0358</idno><idno type="eISSN">1998-376X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue.</p></sec><sec id="st2"><title>Materials and Method:</title><p>A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (<italic>n</italic> = 17) and conventional dressing group (<italic>n</italic> = 17).</p></sec><sec id="st3"><title>Results:</title><p>Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (<italic>P</italic> = 0.026), total protein (<italic>P</italic> = 0.004), GPx level (<italic>P</italic> = 0.030) and GST level (<italic>P</italic> = 0.045).</p></sec><sec id="st4"><title>Conclusion:</title><p>Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Goldberg, Sr" 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sort="Bhandary, Siddhartha" uniqKey="Bhandary S" first="Siddhartha" last="Bhandary">Siddhartha Bhandary</name><name sortKey="Kumar, Pramod" sort="Kumar, Pramod" uniqKey="Kumar P" first="Pramod" last="Kumar">Pramod Kumar</name><name sortKey="Mahato, Krishna Kumar" sort="Mahato, Krishna Kumar" uniqKey="Mahato K" first="Krishna Kumar" last="Mahato">Krishna Kumar Mahato</name><name sortKey="Mayya, Shreemathi S" sort="Mayya, Shreemathi S" uniqKey="Mayya S" first="Shreemathi S." last="Mayya">Shreemathi S. Mayya</name><name sortKey="Rao, Pragna" sort="Rao, Pragna" uniqKey="Rao P" first="Pragna" last="Rao">Pragna Rao</name><name sortKey="Sharan, Anurag" sort="Sharan, Anurag" uniqKey="Sharan A" first="Anurag" last="Sharan">Anurag Sharan</name><name sortKey="Udupa, Padmanabha" sort="Udupa, Padmanabha" uniqKey="Udupa P" first="Padmanabha" last="Udupa">Padmanabha Udupa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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