Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
Identifieur interne : 002B48 ( Main/Merge ); précédent : 002B47; suivant : 002B49Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
Auteurs : Thittamaranahalli Muguregowda Honnegowda [Inde] ; Pramod Kumar [Inde] ; Padmanabha Udupa [Inde] ; Pragna Rao [Inde] ; Siddhartha Bhandary [Inde] ; Krishna Kumar Mahato [Inde] ; Anurag Sharan [Inde] ; Shreemathi S. Mayya [Inde]Source :
- Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India [ 0970-0358 ] ; 2014.
Abstract
Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue.
A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (
Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (
Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.
Url:
DOI: 10.4103/0970-0358.138952
PubMed: 25190917
PubMed Central: 4147456
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers</title>
<author><name sortKey="Honnegowda, Thittamaranahalli Muguregowda" sort="Honnegowda, Thittamaranahalli Muguregowda" uniqKey="Honnegowda T" first="Thittamaranahalli Muguregowda" last="Honnegowda">Thittamaranahalli Muguregowda Honnegowda</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Plastic Surgery and Burns, Kasturba Medical College, Manipal, Karnataka, India</nlm:aff>
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<author><name sortKey="Kumar, Pramod" sort="Kumar, Pramod" uniqKey="Kumar P" first="Pramod" last="Kumar">Pramod Kumar</name>
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<author><name sortKey="Rao, Pragna" sort="Rao, Pragna" uniqKey="Rao P" first="Pragna" last="Rao">Pragna Rao</name>
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<author><name sortKey="Sharan, Anurag" sort="Sharan, Anurag" uniqKey="Sharan A" first="Anurag" last="Sharan">Anurag Sharan</name>
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<author><name sortKey="Mayya, Shreemathi S" sort="Mayya, Shreemathi S" uniqKey="Mayya S" first="Shreemathi S." last="Mayya">Shreemathi S. Mayya</name>
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<series><title level="j">Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India</title>
<idno type="ISSN">0970-0358</idno>
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<front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title>
<p>Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue.</p>
</sec>
<sec id="st2"><title>Materials and Method:</title>
<p>A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (<italic>n</italic>
= 17) and conventional dressing group (<italic>n</italic>
= 17).</p>
</sec>
<sec id="st3"><title>Results:</title>
<p>Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (<italic>P</italic>
= 0.026), total protein (<italic>P</italic>
= 0.004), GPx level (<italic>P</italic>
= 0.030) and GST level (<italic>P</italic>
= 0.045).</p>
</sec>
<sec id="st4"><title>Conclusion:</title>
<p>Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.</p>
</sec>
</div>
</front>
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