Management options for vulvar carcinoma in a low resource setting
Identifieur interne : 005768 ( Main/Exploration ); précédent : 005767; suivant : 005769Management options for vulvar carcinoma in a low resource setting
Auteurs : Ahizechukwu C. Eke [Nigeria] ; Lilian I. Alabi-Isama [Royaume-Uni] ; Josephat C. Akabuike [Nigeria]Source :
- World Journal of Surgical Oncology [ 1477-7819 ] ; 2010.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Carcinomes (), Carcinomes (diagnostic), Carcinomes (épidémiologie), Femelle, Humains, Nigeria (épidémiologie), Procédures de chirurgie gynécologique (), Prévalence, Résultat thérapeutique, Stade de la tumeur, Sujet âgé, Tumeurs de la vulve (), Tumeurs de la vulve (diagnostic), Tumeurs de la vulve (épidémiologie), Vulve (), Études de suivi, Études rétrospectives.
- MESH :
- diagnostic : Carcinomes, Tumeurs de la vulve.
- épidémiologie : Carcinomes, Nigeria, Tumeurs de la vulve.
- Adulte d'âge moyen, Carcinomes, Femelle, Humains, Procédures de chirurgie gynécologique, Prévalence, Résultat thérapeutique, Stade de la tumeur, Sujet âgé, Tumeurs de la vulve, Vulve, Études de suivi, Études rétrospectives.
- Wicri :
- geographic : Nigeria.
English descriptors
- KwdEn :
- Aged, Carcinoma (diagnosis), Carcinoma (epidemiology), Carcinoma (therapy), Female, Follow-Up Studies, Gynecologic Surgical Procedures (methods), Humans, Middle Aged, Neoplasm Staging, Nigeria (epidemiology), Prevalence, Retrospective Studies, Treatment Outcome, Vulva (surgery), Vulvar Neoplasms (diagnosis), Vulvar Neoplasms (epidemiology), Vulvar Neoplasms (therapy).
- MESH :
- geographic , epidemiology : Nigeria.
- diagnosis : Carcinoma, Vulvar Neoplasms.
- epidemiology : Carcinoma, Vulvar Neoplasms.
- methods : Gynecologic Surgical Procedures.
- surgery : Vulva.
- therapy : Carcinoma, Vulvar Neoplasms.
- Aged, Female, Follow-Up Studies, Humans, Middle Aged, Neoplasm Staging, Prevalence, Retrospective Studies, Treatment Outcome.
Abstract
Vulvar carcinoma is a rare tumor of the female genital tract. In Nigeria, very few studies have looked at the management options for vulvar carcinoma. The objective of this study was therefore, to describe the management options available and the challenges in treating this malignancy in Nigeria.
A descriptive study of all vulvar cancer cases managed at the Nnamdi Azikiwe University Teaching Hospital, Nnewi over a 12 year period (1998-2009). The theatre, ward register, histo-pathologic records and case notes of all women who had surgery for vulvar carcinomas were retrieved and socio-demographic characteristics, clinical presentation, type of surgery, histologic type and complications of treatment were retrieved and analyzed.
There were 867 gynecological malignancies and vulval carcinoma accounted for 11 cases, giving a prevalence of 1.27%. The ages ranged from 54 to 79 years with a mean of 61.2 years. Parity was 2-14, with a mean of 6.7± 2.33. Most of the patients were of low socio-economic class. All the 11 patients had surgery as 1st line treatment. Radical vulvectomy was done for 6 cases since they presented in the advanced stage. The complications of surgery included hemorrhage (18.2%), chronic lymphedema, wound infection and anesthetic complications. There were no hospital mortalities. Late presentation, with stage III (45.4%) was the commonest stage at presentation while the majority of the vulvar carcinomas (72.7%) were of epithelial origin. Squamous cell carcinoma predominated (63.6%).
Carcinoma of the vulva is a rare gynecological malignancy in Nigeria. Surgery and radiotherapy remains the mainstay of this disease in Nigeria and can be highly successful if patients present early.
Url:
DOI: 10.1186/1477-7819-8-94
PubMed: 21040577
PubMed Central: 2987879
Affiliations:
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Eke</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State</wicri:regionArea><wicri:noRegion>Anambra State</wicri:noRegion></affiliation></author><author><name sortKey="Alabi Isama, Lilian I" sort="Alabi Isama, Lilian I" uniqKey="Alabi Isama L" first="Lilian I" last="Alabi-Isama">Lilian I. Alabi-Isama</name><affiliation wicri:level="1"><nlm:aff id="I2">Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Imperial College, Hammersmith Campus, Du cane Road, London W120NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Imperial College, Hammersmith Campus, Du cane Road, London W120NN</wicri:regionArea><wicri:noRegion>London W120NN</wicri:noRegion></affiliation></author><author><name sortKey="Akabuike, Josephat C" sort="Akabuike, Josephat C" uniqKey="Akabuike J" first="Josephat C" last="Akabuike">Josephat C. Akabuike</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State</wicri:regionArea><wicri:noRegion>Anambra State</wicri:noRegion></affiliation></author></analytic><series><title level="j">World Journal of Surgical Oncology</title><idno type="eISSN">1477-7819</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Carcinoma (diagnosis)</term><term>Carcinoma (epidemiology)</term><term>Carcinoma (therapy)</term><term>Female</term><term>Follow-Up Studies</term><term>Gynecologic Surgical Procedures (methods)</term><term>Humans</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Nigeria (epidemiology)</term><term>Prevalence</term><term>Retrospective Studies</term><term>Treatment Outcome</term><term>Vulva (surgery)</term><term>Vulvar Neoplasms (diagnosis)</term><term>Vulvar Neoplasms (epidemiology)</term><term>Vulvar Neoplasms (therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Carcinomes ()</term><term>Carcinomes (diagnostic)</term><term>Carcinomes (épidémiologie)</term><term>Femelle</term><term>Humains</term><term>Nigeria (épidémiologie)</term><term>Procédures de chirurgie gynécologique ()</term><term>Prévalence</term><term>Résultat thérapeutique</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Tumeurs de la vulve ()</term><term>Tumeurs de la vulve (diagnostic)</term><term>Tumeurs de la vulve (épidémiologie)</term><term>Vulve ()</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Nigeria</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Carcinoma</term><term>Vulvar Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Carcinomes</term><term>Tumeurs de la vulve</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Carcinoma</term><term>Vulvar Neoplasms</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Gynecologic Surgical Procedures</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Vulva</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Carcinoma</term><term>Vulvar Neoplasms</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Carcinomes</term><term>Nigeria</term><term>Tumeurs de la vulve</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Prevalence</term><term>Retrospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Carcinomes</term><term>Femelle</term><term>Humains</term><term>Procédures de chirurgie gynécologique</term><term>Prévalence</term><term>Résultat thérapeutique</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Tumeurs de la vulve</term><term>Vulve</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Nigeria</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Vulvar carcinoma is a rare tumor of the female genital tract. In Nigeria, very few studies have looked at the management options for vulvar carcinoma. The objective of this study was therefore, to describe the management options available and the challenges in treating this malignancy in Nigeria.</p></sec><sec><title>Methods</title><p>A descriptive study of all vulvar cancer cases managed at the Nnamdi Azikiwe University Teaching Hospital, Nnewi over a 12 year period (1998-2009). The theatre, ward register, histo-pathologic records and case notes of all women who had surgery for vulvar carcinomas were retrieved and socio-demographic characteristics, clinical presentation, type of surgery, histologic type and complications of treatment were retrieved and analyzed.</p></sec><sec><title>Results</title><p>There were 867 gynecological malignancies and vulval carcinoma accounted for 11 cases, giving a prevalence of 1.27%. The ages ranged from 54 to 79 years with a mean of 61.2 years. Parity was 2-14, with a mean of 6.7± 2.33. Most of the patients were of low socio-economic class. All the 11 patients had surgery as 1<sup>st </sup>line treatment. Radical vulvectomy was done for 6 cases since they presented in the advanced stage. The complications of surgery included hemorrhage (18.2%), chronic lymphedema, wound infection and anesthetic complications. There were no hospital mortalities. Late presentation, with stage III (45.4%) was the commonest stage at presentation while the majority of the vulvar carcinomas (72.7%) were of epithelial origin. Squamous cell carcinoma predominated (63.6%).</p></sec><sec><title>Conclusion</title><p>Carcinoma of the vulva is a rare gynecological malignancy in Nigeria. Surgery and radiotherapy remains the mainstay of this disease in Nigeria and can be highly successful if patients present early.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mohammed, A" uniqKey="Mohammed A">A Mohammed</name></author><author><name sortKey="Ahmed, Sa" uniqKey="Ahmed S">SA Ahmed</name></author><author><name sortKey="Oluwole, Op" uniqKey="Oluwole O">OP Oluwole</name></author><author><name sortKey="Avidine, S" uniqKey="Avidine S">S Avidine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siddiqui, N" uniqKey="Siddiqui N">N Siddiqui</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="De Cherney, Ah" uniqKey="De Cherney A">AH De-Cherney</name></author><author><name sortKey="Goodwin, Tm" uniqKey="Goodwin T">TM Goodwin</name></author><author><name sortKey="Nathan, L" uniqKey="Nathan L">L Nathan</name></author><author><name sortKey="Laufer, N" uniqKey="Laufer N">N Laufer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luesley, D" uniqKey="Luesley D">D Luesley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Briggs, Nd" uniqKey="Briggs N">ND Briggs</name></author><author><name sortKey="Katchy, Kc" uniqKey="Katchy K">KC Katchy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nkyekyer, K" uniqKey="Nkyekyer K">K Nkyekyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kasule, J" uniqKey="Kasule J">J Kasule</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hay, Dm" uniqKey="Hay D">DM Hay</name></author><author><name sortKey="Cole, Fm" uniqKey="Cole F">FM Cole</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perecolli, S" uniqKey="Perecolli S">S Perecolli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ansink, A" uniqKey="Ansink A">A Ansink</name></author><author><name sortKey="Van Der Velden, J" uniqKey="Van Der Velden J">J Van der velden</name></author><author><name sortKey="Collingwood, M" uniqKey="Collingwood M">M Collingwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hacker, Nf" uniqKey="Hacker N">NF Hacker</name></author><author><name sortKey="Leuchter, Rs" uniqKey="Leuchter R">RS Leuchter</name></author><author><name sortKey="Bereck, Js" uniqKey="Bereck J">JS Bereck</name></author><author><name sortKey="Castaldo, Tw" uniqKey="Castaldo T">TW Castaldo</name></author><author><name sortKey="Lagasse, Ld" uniqKey="Lagasse L">LD Lagasse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grimshaw, Rn" uniqKey="Grimshaw R">RN Grimshaw</name></author><author><name sortKey="Murdoch, Jb" uniqKey="Murdoch J">JB Murdoch</name></author><author><name sortKey="Monaghan, Jm" uniqKey="Monaghan J">JM Monaghan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hacker, Nf" uniqKey="Hacker N">NF Hacker</name></author><author><name sortKey="Van Der Velden, J" uniqKey="Van Der Velden J">J Van der velden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dennerstein, G" uniqKey="Dennerstein G">G Dennerstein</name></author><author><name sortKey="Scurry, J" uniqKey="Scurry J">J Scurry</name></author><author><name sortKey="Brenan, J" uniqKey="Brenan J">J Brenan</name></author><author><name sortKey="Allen, D" uniqKey="Allen D">D Allen</name></author><author><name sortKey="Marin, M G" uniqKey="Marin M">M-G Marin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Nigeria</li><li>Royaume-Uni</li></country></list><tree><country name="Nigeria"><noRegion><name sortKey="Eke, Ahizechukwu C" sort="Eke, Ahizechukwu C" uniqKey="Eke A" first="Ahizechukwu C" last="Eke">Ahizechukwu C. Eke</name></noRegion><name sortKey="Akabuike, Josephat C" sort="Akabuike, Josephat C" uniqKey="Akabuike J" first="Josephat C" last="Akabuike">Josephat C. Akabuike</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Alabi Isama, Lilian I" sort="Alabi Isama, Lilian I" uniqKey="Alabi Isama L" first="Lilian I" last="Alabi-Isama">Lilian I. Alabi-Isama</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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