Management options for vulvar carcinoma in a low resource setting
Identifieur interne : 004666 ( Pmc/Curation ); précédent : 004665; suivant : 004667Management options for vulvar carcinoma in a low resource setting
Auteurs : Ahizechukwu C. Eke [Nigeria] ; Lilian I. Alabi-Isama [Royaume-Uni] ; Josephat C. Akabuike [Nigeria]Source :
- World Journal of Surgical Oncology [ 1477-7819 ] ; 2010.
Abstract
Vulvar carcinoma is a rare tumor of the female genital tract. In Nigeria, very few studies have looked at the management options for vulvar carcinoma. The objective of this study was therefore, to describe the management options available and the challenges in treating this malignancy in Nigeria.
A descriptive study of all vulvar cancer cases managed at the Nnamdi Azikiwe University Teaching Hospital, Nnewi over a 12 year period (1998-2009). The theatre, ward register, histo-pathologic records and case notes of all women who had surgery for vulvar carcinomas were retrieved and socio-demographic characteristics, clinical presentation, type of surgery, histologic type and complications of treatment were retrieved and analyzed.
There were 867 gynecological malignancies and vulval carcinoma accounted for 11 cases, giving a prevalence of 1.27%. The ages ranged from 54 to 79 years with a mean of 61.2 years. Parity was 2-14, with a mean of 6.7± 2.33. Most of the patients were of low socio-economic class. All the 11 patients had surgery as 1st line treatment. Radical vulvectomy was done for 6 cases since they presented in the advanced stage. The complications of surgery included hemorrhage (18.2%), chronic lymphedema, wound infection and anesthetic complications. There were no hospital mortalities. Late presentation, with stage III (45.4%) was the commonest stage at presentation while the majority of the vulvar carcinomas (72.7%) were of epithelial origin. Squamous cell carcinoma predominated (63.6%).
Carcinoma of the vulva is a rare gynecological malignancy in Nigeria. Surgery and radiotherapy remains the mainstay of this disease in Nigeria and can be highly successful if patients present early.
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DOI: 10.1186/1477-7819-8-94
PubMed: 21040577
PubMed Central: 2987879
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Alabi-Isama</name><affiliation wicri:level="1"><nlm:aff id="I2">Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Imperial College, Hammersmith Campus, Du cane Road, London W120NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Imperial College, Hammersmith Campus, Du cane Road, London W120NN</wicri:regionArea></affiliation></author><author><name sortKey="Akabuike, Josephat C" sort="Akabuike, Josephat C" uniqKey="Akabuike J" first="Josephat C" last="Akabuike">Josephat C. Akabuike</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21040577</idno><idno type="pmc">2987879</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987879</idno><idno type="RBID">PMC:2987879</idno><idno type="doi">10.1186/1477-7819-8-94</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">004667</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004667</idno><idno type="wicri:Area/Pmc/Curation">004666</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004666</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Management options for vulvar carcinoma in a low resource setting</title><author><name sortKey="Eke, Ahizechukwu C" sort="Eke, Ahizechukwu C" uniqKey="Eke A" first="Ahizechukwu C" last="Eke">Ahizechukwu C. Eke</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State</wicri:regionArea></affiliation></author><author><name sortKey="Alabi Isama, Lilian I" sort="Alabi Isama, Lilian I" uniqKey="Alabi Isama L" first="Lilian I" last="Alabi-Isama">Lilian I. Alabi-Isama</name><affiliation wicri:level="1"><nlm:aff id="I2">Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Imperial College, Hammersmith Campus, Du cane Road, London W120NN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Imperial College, Hammersmith Campus, Du cane Road, London W120NN</wicri:regionArea></affiliation></author><author><name sortKey="Akabuike, Josephat C" sort="Akabuike, Josephat C" uniqKey="Akabuike J" first="Josephat C" last="Akabuike">Josephat C. Akabuike</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State</wicri:regionArea></affiliation></author></analytic><series><title level="j">World Journal of Surgical Oncology</title><idno type="eISSN">1477-7819</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Vulvar carcinoma is a rare tumor of the female genital tract. In Nigeria, very few studies have looked at the management options for vulvar carcinoma. The objective of this study was therefore, to describe the management options available and the challenges in treating this malignancy in Nigeria.</p></sec><sec><title>Methods</title><p>A descriptive study of all vulvar cancer cases managed at the Nnamdi Azikiwe University Teaching Hospital, Nnewi over a 12 year period (1998-2009). The theatre, ward register, histo-pathologic records and case notes of all women who had surgery for vulvar carcinomas were retrieved and socio-demographic characteristics, clinical presentation, type of surgery, histologic type and complications of treatment were retrieved and analyzed.</p></sec><sec><title>Results</title><p>There were 867 gynecological malignancies and vulval carcinoma accounted for 11 cases, giving a prevalence of 1.27%. The ages ranged from 54 to 79 years with a mean of 61.2 years. Parity was 2-14, with a mean of 6.7± 2.33. Most of the patients were of low socio-economic class. All the 11 patients had surgery as 1<sup>st </sup>line treatment. Radical vulvectomy was done for 6 cases since they presented in the advanced stage. The complications of surgery included hemorrhage (18.2%), chronic lymphedema, wound infection and anesthetic complications. There were no hospital mortalities. Late presentation, with stage III (45.4%) was the commonest stage at presentation while the majority of the vulvar carcinomas (72.7%) were of epithelial origin. Squamous cell carcinoma predominated (63.6%).</p></sec><sec><title>Conclusion</title><p>Carcinoma of the vulva is a rare gynecological malignancy in Nigeria. Surgery and radiotherapy remains the mainstay of this disease in Nigeria and can be highly successful if patients present early.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mohammed, A" uniqKey="Mohammed A">A Mohammed</name></author><author><name sortKey="Ahmed, Sa" uniqKey="Ahmed S">SA Ahmed</name></author><author><name sortKey="Oluwole, Op" uniqKey="Oluwole O">OP Oluwole</name></author><author><name sortKey="Avidine, S" uniqKey="Avidine S">S Avidine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siddiqui, N" uniqKey="Siddiqui N">N Siddiqui</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="De Cherney, Ah" uniqKey="De Cherney A">AH De-Cherney</name></author><author><name sortKey="Goodwin, Tm" uniqKey="Goodwin T">TM Goodwin</name></author><author><name sortKey="Nathan, L" uniqKey="Nathan L">L Nathan</name></author><author><name sortKey="Laufer, N" uniqKey="Laufer N">N Laufer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luesley, D" uniqKey="Luesley D">D Luesley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Briggs, Nd" uniqKey="Briggs N">ND Briggs</name></author><author><name sortKey="Katchy, Kc" uniqKey="Katchy K">KC Katchy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nkyekyer, K" uniqKey="Nkyekyer K">K Nkyekyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kasule, J" uniqKey="Kasule J">J Kasule</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hay, Dm" uniqKey="Hay D">DM Hay</name></author><author><name sortKey="Cole, Fm" uniqKey="Cole F">FM Cole</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perecolli, S" uniqKey="Perecolli S">S Perecolli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ansink, A" uniqKey="Ansink A">A Ansink</name></author><author><name sortKey="Van Der Velden, J" uniqKey="Van Der Velden J">J Van der velden</name></author><author><name sortKey="Collingwood, M" uniqKey="Collingwood M">M Collingwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hacker, Nf" uniqKey="Hacker N">NF Hacker</name></author><author><name sortKey="Leuchter, Rs" uniqKey="Leuchter R">RS Leuchter</name></author><author><name sortKey="Bereck, Js" uniqKey="Bereck J">JS Bereck</name></author><author><name sortKey="Castaldo, Tw" uniqKey="Castaldo T">TW Castaldo</name></author><author><name sortKey="Lagasse, Ld" uniqKey="Lagasse L">LD Lagasse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grimshaw, Rn" uniqKey="Grimshaw R">RN Grimshaw</name></author><author><name sortKey="Murdoch, Jb" uniqKey="Murdoch J">JB Murdoch</name></author><author><name sortKey="Monaghan, Jm" uniqKey="Monaghan J">JM Monaghan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hacker, Nf" uniqKey="Hacker N">NF Hacker</name></author><author><name sortKey="Van Der Velden, J" uniqKey="Van Der Velden J">J Van der velden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dennerstein, G" uniqKey="Dennerstein G">G Dennerstein</name></author><author><name sortKey="Scurry, J" uniqKey="Scurry J">J Scurry</name></author><author><name sortKey="Brenan, J" uniqKey="Brenan J">J Brenan</name></author><author><name sortKey="Allen, D" uniqKey="Allen D">D Allen</name></author><author><name sortKey="Marin, M G" uniqKey="Marin M">M-G Marin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Surg Oncol</journal-id><journal-title-group><journal-title>World Journal of Surgical Oncology</journal-title></journal-title-group><issn pub-type="epub">1477-7819</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21040577</article-id><article-id pub-id-type="pmc">2987879</article-id><article-id pub-id-type="publisher-id">1477-7819-8-94</article-id><article-id pub-id-type="doi">10.1186/1477-7819-8-94</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Management options for vulvar carcinoma in a low resource setting</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Eke</surname><given-names>Ahizechukwu C</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>ahizeeke2nd@yahoo.ca</email></contrib><contrib contrib-type="author" id="A2"><name><surname>Alabi-Isama</surname><given-names>Lilian I</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>lilianisama@yahoo.com</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Akabuike</surname><given-names>Josephat C</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>josephatakabuike@yahoo.com</email></contrib></contrib-group><aff id="I1"><label>1</label>Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria</aff><aff id="I2"><label>2</label>Division of Surgery, Oncology, Reproductive Biology and Anesthetics, Imperial College, Hammersmith Campus, Du cane Road, London W120NN, UK</aff><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>1</day><month>11</month><year>2010</year></pub-date><volume>8</volume><fpage>94</fpage><lpage>94</lpage><history><date date-type="received"><day>12</day><month>7</month><year>2010</year></date><date date-type="accepted"><day>1</day><month>11</month><year>2010</year></date></history><permissions><copyright-statement>Copyright ©2010 Eke et al; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2010</copyright-year><copyright-holder>Eke et al; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.wjso.com/content/8/1/94"></self-uri><abstract><sec><title>Background</title><p>Vulvar carcinoma is a rare tumor of the female genital tract. In Nigeria, very few studies have looked at the management options for vulvar carcinoma. The objective of this study was therefore, to describe the management options available and the challenges in treating this malignancy in Nigeria.</p></sec><sec><title>Methods</title><p>A descriptive study of all vulvar cancer cases managed at the Nnamdi Azikiwe University Teaching Hospital, Nnewi over a 12 year period (1998-2009). The theatre, ward register, histo-pathologic records and case notes of all women who had surgery for vulvar carcinomas were retrieved and socio-demographic characteristics, clinical presentation, type of surgery, histologic type and complications of treatment were retrieved and analyzed.</p></sec><sec><title>Results</title><p>There were 867 gynecological malignancies and vulval carcinoma accounted for 11 cases, giving a prevalence of 1.27%. The ages ranged from 54 to 79 years with a mean of 61.2 years. Parity was 2-14, with a mean of 6.7± 2.33. Most of the patients were of low socio-economic class. All the 11 patients had surgery as 1<sup>st </sup>line treatment. Radical vulvectomy was done for 6 cases since they presented in the advanced stage. The complications of surgery included hemorrhage (18.2%), chronic lymphedema, wound infection and anesthetic complications. There were no hospital mortalities. Late presentation, with stage III (45.4%) was the commonest stage at presentation while the majority of the vulvar carcinomas (72.7%) were of epithelial origin. Squamous cell carcinoma predominated (63.6%).</p></sec><sec><title>Conclusion</title><p>Carcinoma of the vulva is a rare gynecological malignancy in Nigeria. Surgery and radiotherapy remains the mainstay of this disease in Nigeria and can be highly successful if patients present early.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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