A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma
Identifieur interne : 010525 ( Main/Exploration ); précédent : 010524; suivant : 010526A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma
Auteurs : Thelma D. Bates [Royaume-Uni]Source :
- Clinical Radiology [ 0009-9260 ] ; 1975.
Descripteurs français
- KwdFr :
- Bras, Dosimétrie en radiothérapie, Facteurs temps, Femelle, Fibrose pulmonaire (étiologie), Fractures de côte (étiologie), Humains, Lymphoedème (étiologie), Mastectomie, Métastase tumorale, Peau (effets des radiations), Radiothérapie (effets indésirables), Relation dose-effet des radiations, Récidive tumorale locale, Soins postopératoires, Tumeurs du sein (), Tumeurs du sein (mortalité), Tumeurs du sein (radiothérapie), Études prospectives.
- MESH :
- effets des radiations : Peau.
- effets indésirables : Radiothérapie.
- mortalité : Tumeurs du sein.
- radiothérapie : Tumeurs du sein.
- étiologie : Fibrose pulmonaire, Fractures de côte, Lymphoedème.
- Bras, Dosimétrie en radiothérapie, Facteurs temps, Femelle, Humains, Mastectomie, Métastase tumorale, Relation dose-effet des radiations, Récidive tumorale locale, Soins postopératoires, Tumeurs du sein, Études prospectives.
English descriptors
- KwdEn :
- Arm, Breast Neoplasms (mortality), Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Dose-Response Relationship, Radiation, Female, Humans, Lymphedema (etiology), Mastectomy, Neoplasm Metastasis, Neoplasm Recurrence, Local, Postoperative Care, Prospective Studies, Pulmonary Fibrosis (etiology), Radiotherapy (adverse effects), Radiotherapy Dosage, Rib Fractures (etiology), Skin (radiation effects), Time Factors.
- MESH :
- adverse effects : Radiotherapy.
- etiology : Lymphedema, Pulmonary Fibrosis, Rib Fractures.
- mortality : Breast Neoplasms.
- radiation effects : Skin.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- Arm, Dose-Response Relationship, Radiation, Female, Humans, Mastectomy, Neoplasm Metastasis, Neoplasm Recurrence, Local, Postoperative Care, Prospective Studies, Radiotherapy Dosage, Time Factors.
Abstract
The results are presented of a five-year prospective trial of 411 patients with breast carcinoma treated by mastectomy and post-operative radiotherapy. Twice or thrice weekly dose-fractionation techniques were used, i.e. 12 fractions in 28 days and six fractions in 18 days. The results show that, in terms of survival and control of local disease, the two techniques are very similar. The early and late radiation effects on the normal tissues up to five years are similar and acceptable.Dose levels thought to be biologically equivalent on the basis of experience at St Thomas's Hospital were selected. It is stressed that there is a narrower margin of normal tissue tolerance when six fractions over 18 days are used, that it is essential to treat all fields on each treatment occasion and that the total maximum tissue dose of 3600 R is not exceeded. Attention is drawn to the fact that the dose for six fractions, derived from the NSD formula which would be predicted to be equivalent to the 12-fraction dose is, in fact, over 10% higher than the dose used here and likely to produce unacceptable late radiation changes.
Url:
DOI: 10.1016/S0009-9260(75)80064-X
Affiliations:
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Twice or thrice weekly dose-fractionation techniques were used, i.e. 12 fractions in 28 days and six fractions in 18 days. The results show that, in terms of survival and control of local disease, the two techniques are very similar. The early and late radiation effects on the normal tissues up to five years are similar and acceptable.Dose levels thought to be biologically equivalent on the basis of experience at St Thomas's Hospital were selected. It is stressed that there is a narrower margin of normal tissue tolerance when six fractions over 18 days are used, that it is essential to treat all fields on each treatment occasion and that the total maximum tissue dose of 3600 R is not exceeded. Attention is drawn to the fact that the dose for six fractions, derived from the NSD formula which would be predicted to be equivalent to the 12-fraction dose is, in fact, over 10% higher than the dose used here and likely to produce unacceptable late radiation changes.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Bates, Thelma D" sort="Bates, Thelma D" uniqKey="Bates T" first="Thelma D." last="Bates">Thelma D. Bates</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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