A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma
Identifieur interne : 006265 ( Istex/Corpus ); précédent : 006264; suivant : 006266A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma
Auteurs : Thelma D. BatesSource :
- Clinical Radiology [ 0009-9260 ] ; 1975.
Abstract
The results are presented of a five-year prospective trial of 411 patients with breast carcinoma treated by mastectomy and post-operative radiotherapy. Twice or thrice weekly dose-fractionation techniques were used, i.e. 12 fractions in 28 days and six fractions in 18 days. The results show that, in terms of survival and control of local disease, the two techniques are very similar. The early and late radiation effects on the normal tissues up to five years are similar and acceptable.Dose levels thought to be biologically equivalent on the basis of experience at St Thomas's Hospital were selected. It is stressed that there is a narrower margin of normal tissue tolerance when six fractions over 18 days are used, that it is essential to treat all fields on each treatment occasion and that the total maximum tissue dose of 3600 R is not exceeded. Attention is drawn to the fact that the dose for six fractions, derived from the NSD formula which would be predicted to be equivalent to the 12-fraction dose is, in fact, over 10% higher than the dose used here and likely to produce unacceptable late radiation changes.
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DOI: 10.1016/S0009-9260(75)80064-X
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ISTEX:D21F06971C7ED49514442E815B7167C655C2BE44Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma</title><author><name sortKey="Bates, Thelma D" sort="Bates, Thelma D" uniqKey="Bates T" first="Thelma D." last="Bates">Thelma D. Bates</name><affiliation><mods:affiliation>From the Department of Radiotherapy, St Thomas's Hospital, London, S.E.1, UK</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D21F06971C7ED49514442E815B7167C655C2BE44</idno><date when="1975" year="1975">1975</date><idno type="doi">10.1016/S0009-9260(75)80064-X</idno><idno type="url">https://api.istex.fr/document/D21F06971C7ED49514442E815B7167C655C2BE44/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">006265</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">006265</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma</title><author><name sortKey="Bates, Thelma D" sort="Bates, Thelma D" uniqKey="Bates T" first="Thelma D." last="Bates">Thelma D. Bates</name><affiliation><mods:affiliation>From the Department of Radiotherapy, St Thomas's Hospital, London, S.E.1, UK</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Radiology</title><title level="j" type="abbrev">YCRAD</title><idno type="ISSN">0009-9260</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1975">1975</date><biblScope unit="volume">26</biblScope><biblScope unit="supplement">C</biblScope><biblScope unit="page" from="297">297</biblScope><biblScope unit="page" to="304">304</biblScope></imprint><idno type="ISSN">0009-9260</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0009-9260</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The results are presented of a five-year prospective trial of 411 patients with breast carcinoma treated by mastectomy and post-operative radiotherapy. Twice or thrice weekly dose-fractionation techniques were used, i.e. 12 fractions in 28 days and six fractions in 18 days. The results show that, in terms of survival and control of local disease, the two techniques are very similar. The early and late radiation effects on the normal tissues up to five years are similar and acceptable.Dose levels thought to be biologically equivalent on the basis of experience at St Thomas's Hospital were selected. It is stressed that there is a narrower margin of normal tissue tolerance when six fractions over 18 days are used, that it is essential to treat all fields on each treatment occasion and that the total maximum tissue dose of 3600 R is not exceeded. Attention is drawn to the fact that the dose for six fractions, derived from the NSD formula which would be predicted to be equivalent to the 12-fraction dose is, in fact, over 10% higher than the dose used here and likely to produce unacceptable late radiation changes.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>radiotherapy</json:string><json:string>radiology</json:string><json:string>breast carcinoma</json:string><json:string>british journal</json:string><json:string>metastasis</json:string><json:string>tumour</json:string><json:string>wiernik</json:string><json:string>carcinoma</json:string><json:string>late radiation effects</json:string><json:string>distant metastases</json:string><json:string>normal tissues</json:string><json:string>fraction group</json:string><json:string>radiation therapy</json:string><json:string>fraction technique</json:string><json:string>fractions number</json:string><json:string>chest wall</json:string><json:string>recurrence</json:string><json:string>tissue dose</json:string><json:string>late skin changes</json:string><json:string>local disease</json:string><json:string>average score</json:string><json:string>early skin reaction</json:string><json:string>local recurrence</json:string><json:string>radiotherapy department</json:string><json:string>prospective trial</json:string><json:string>fractionation</json:string><json:string>apparent nodal involvement</json:string><json:string>groups number</json:string><json:string>oesophageal reaction</json:string><json:string>fractionation groups</json:string><json:string>local recurrence patients</json:string><json:string>clinical radiology</json:string><json:string>radiation effects</json:string><json:string>radiotherapy technique</json:string><json:string>moist desquamation</json:string><json:string>mild erythema</json:string><json:string>mastectomy scar</json:string><json:string>direct field</json:string><json:string>skin changes</json:string><json:string>malignant tumours</json:string><json:string>radiological changes</json:string><json:string>patients lymphoedema</json:string><json:string>results show</json:string><json:string>total dose</json:string><json:string>british institute</json:string><json:string>tissue tolerance</json:string><json:string>american journal</json:string><json:string>weekly techniques</json:string><json:string>weekly treatments</json:string></teeft></keywords><author><json:item><name>Thelma D. Bates</name><affiliations><json:string>From the Department of Radiotherapy, St Thomas's Hospital, London, S.E.1, UK</json:string></affiliations></json:item></author><articleId><json:string>7580064X</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>The results are presented of a five-year prospective trial of 411 patients with breast carcinoma treated by mastectomy and post-operative radiotherapy. Twice or thrice weekly dose-fractionation techniques were used, i.e. 12 fractions in 28 days and six fractions in 18 days. The results show that, in terms of survival and control of local disease, the two techniques are very similar. The early and late radiation effects on the normal tissues up to five years are similar and acceptable.Dose levels thought to be biologically equivalent on the basis of experience at St Thomas's Hospital were selected. It is stressed that there is a narrower margin of normal tissue tolerance when six fractions over 18 days are used, that it is essential to treat all fields on each treatment occasion and that the total maximum tissue dose of 3600 R is not exceeded. Attention is drawn to the fact that the dose for six fractions, derived from the NSD formula which would be predicted to be equivalent to the 12-fraction dose is, in fact, over 10% higher than the dose used here and likely to produce unacceptable late radiation changes.</abstract><qualityIndicators><score>6.229</score><pdfVersion>1.3</pdfVersion><pdfPageSize>540 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1125</abstractCharCount><pdfWordCount>3973</pdfWordCount><pdfCharCount>20506</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>188</abstractWordCount></qualityIndicators><title>A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma</title><pii><json:string>S0009-9260(75)80064-X</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Clinical Radiology</title><language><json:string>unknown</json:string></language><publicationDate>1975</publicationDate><issn><json:string>0009-9260</json:string></issn><pii><json:string>S0009-9260(75)X8001-2</json:string></pii><volume>26</volume><pages><first>297</first><last>304</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>radiology, nuclear medicine & medical imaging</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>nuclear medicine & medical imaging</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>1975</publicationDate><copyrightDate>1975</copyrightDate><doi><json:string>10.1016/S0009-9260(75)80064-X</json:string></doi><id>D21F06971C7ED49514442E815B7167C655C2BE44</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/D21F06971C7ED49514442E815B7167C655C2BE44/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/D21F06971C7ED49514442E815B7167C655C2BE44/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/D21F06971C7ED49514442E815B7167C655C2BE44/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1975</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma</title><author xml:id="author-0000"><persName><forename type="first">Thelma D.</forename><surname>Bates</surname></persName><affiliation>From the Department of Radiotherapy, St Thomas's Hospital, London, S.E.1, UK</affiliation></author><idno type="istex">D21F06971C7ED49514442E815B7167C655C2BE44</idno><idno type="DOI">10.1016/S0009-9260(75)80064-X</idno><idno type="PII">S0009-9260(75)80064-X</idno><idno type="ArticleID">7580064X</idno></analytic><monogr><title level="j">Clinical Radiology</title><title level="j" type="abbrev">YCRAD</title><idno type="pISSN">0009-9260</idno><idno type="PII">S0009-9260(75)X8001-2</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1975"></date><biblScope unit="volume">26</biblScope><biblScope unit="supplement">C</biblScope><biblScope unit="page" from="297">297</biblScope><biblScope unit="page" to="304">304</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1975</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The results are presented of a five-year prospective trial of 411 patients with breast carcinoma treated by mastectomy and post-operative radiotherapy. Twice or thrice weekly dose-fractionation techniques were used, i.e. 12 fractions in 28 days and six fractions in 18 days. The results show that, in terms of survival and control of local disease, the two techniques are very similar. The early and late radiation effects on the normal tissues up to five years are similar and acceptable.Dose levels thought to be biologically equivalent on the basis of experience at St Thomas's Hospital were selected. It is stressed that there is a narrower margin of normal tissue tolerance when six fractions over 18 days are used, that it is essential to treat all fields on each treatment occasion and that the total maximum tissue dose of 3600 R is not exceeded. Attention is drawn to the fact that the dose for six fractions, derived from the NSD formula which would be predicted to be equivalent to the 12-fraction dose is, in fact, over 10% higher than the dose used here and likely to produce unacceptable late radiation changes.</p></abstract></profileDesc><revisionDesc><change when="1975">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/D21F06971C7ED49514442E815B7167C655C2BE44/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>YCRAD</jid><aid>7580064X</aid><ce:pii>S0009-9260(75)80064-X</ce:pii><ce:doi>10.1016/S0009-9260(75)80064-X</ce:doi><ce:copyright type="unknown" year="1975"></ce:copyright></item-info><head><ce:title>A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma</ce:title><ce:author-group><ce:author><ce:given-name>Thelma D.</ce:given-name><ce:surname>Bates</ce:surname></ce:author><ce:affiliation id="aff1"><ce:textfn>From the Department of Radiotherapy, St Thomas's Hospital, London, S.E.1, UK</ce:textfn></ce:affiliation></ce:author-group><ce:abstract id="ab1" class="author" xml:lang="en"><ce:abstract-sec><ce:simple-para>The results are presented of a five-year prospective trial of 411 patients with breast carcinoma treated by mastectomy and post-operative radiotherapy. Twice or thrice weekly dose-fractionation techniques were used, i.e. 12 fractions in 28 days and six fractions in 18 days. The results show that, in terms of survival and control of local disease, the two techniques are very similar. The early and late radiation effects on the normal tissues up to five years are similar and acceptable.</ce:simple-para><ce:simple-para>Dose levels thought to be biologically equivalent on the basis of experience at St Thomas's Hospital were selected. It is stressed that there is a narrower margin of normal tissue tolerance when six fractions over 18 days are used, that it is essential to treat all fields on each treatment occasion and that the total maximum tissue dose of 3600 R is not exceeded. Attention is drawn to the fact that the dose for six fractions, derived from the NSD formula which would be predicted to be equivalent to the 12-fraction dose is, in fact, over 10% higher than the dose used here and likely to produce unacceptable late radiation changes.</ce:simple-para></ce:abstract-sec></ce:abstract></head><tail><ce:bibliography><ce:section-title>References</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>Baclesse, 1964</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Baclesse</ce:surname><ce:given-name>F.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Hyperfraction</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>American Journal of Roentgenology</sb:maintitle></sb:title><sb:volume-nr>91</sb:volume-nr></sb:series><sb:date>1964</sb:date></sb:issue><sb:pages><sb:first-page>32</sb:first-page><sb:last-page>36</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib2"><ce:label>Bates, et al, 1969</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bates</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Fleming</ce:surname><ce:given-name>J.A.C.</ce:given-name></sb:author><sb:author><ce:surname>Wiernik</ce:surname><ce:given-name>G.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Carcinoma of the breast. 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progress report on the British Institute of Radiology fractionation trial of 3F/week or 5F/week treatment of larynx and pharynx</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>British Journal of Radiology</sb:maintitle></sb:title><sb:volume-nr>45</sb:volume-nr></sb:series><sb:date>1972</sb:date></sb:issue><sb:pages><sb:first-page>754</sb:first-page><sb:last-page>756</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma</title></titleInfo><name type="personal"><namePart type="given">Thelma D.</namePart><namePart type="family">Bates</namePart><affiliation>From the Department of Radiotherapy, St Thomas's Hospital, London, S.E.1, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1975</dateIssued><copyrightDate encoding="w3cdtf">1975</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The results are presented of a five-year prospective trial of 411 patients with breast carcinoma treated by mastectomy and post-operative radiotherapy. Twice or thrice weekly dose-fractionation techniques were used, i.e. 12 fractions in 28 days and six fractions in 18 days. The results show that, in terms of survival and control of local disease, the two techniques are very similar. The early and late radiation effects on the normal tissues up to five years are similar and acceptable.Dose levels thought to be biologically equivalent on the basis of experience at St Thomas's Hospital were selected. It is stressed that there is a narrower margin of normal tissue tolerance when six fractions over 18 days are used, that it is essential to treat all fields on each treatment occasion and that the total maximum tissue dose of 3600 R is not exceeded. Attention is drawn to the fact that the dose for six fractions, derived from the NSD formula which would be predicted to be equivalent to the 12-fraction dose is, in fact, over 10% higher than the dose used here and likely to produce unacceptable late radiation changes.</abstract><relatedItem type="host"><titleInfo><title>Clinical Radiology</title></titleInfo><titleInfo type="abbreviated"><title>YCRAD</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">1975</dateIssued></originInfo><identifier type="ISSN">0009-9260</identifier><identifier type="PII">S0009-9260(75)X8001-2</identifier><part><date>1975</date><detail type="volume"><number>26</number><caption>vol.</caption></detail><detail type="supplement"><number>C</number><caption>Suppl.</caption></detail><extent unit="issue pages"><start>1</start><end>560</end></extent><extent unit="pages"><start>297</start><end>304</end></extent></part></relatedItem><identifier type="istex">D21F06971C7ED49514442E815B7167C655C2BE44</identifier><identifier type="DOI">10.1016/S0009-9260(75)80064-X</identifier><identifier type="PII">S0009-9260(75)80064-X</identifier><identifier type="ArticleID">7580064X</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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