The immunodeficient scid mouse as a model for human lymphatic filariasis
Identifieur interne : 00D492 ( Main/Exploration ); précédent : 00D491; suivant : 00D493The immunodeficient scid mouse as a model for human lymphatic filariasis
Auteurs :Source :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 1991.
Descripteurs français
- KwdFr :
- Animaux, Brugia, Déficits immunitaires (), Déficits immunitaires (anatomopathologie), Déficits immunitaires (génétique), Filariose lymphatique (anatomopathologie), Filariose lymphatique (immunologie), Humains, Immunoglobulines (génétique), Inflammation, Modèles animaux de maladie humaine, Rate (immunologie), Récepteurs aux antigènes des cellules T (génétique), Souches mutantes de souris, Souris, Sous-populations de lymphocytes (immunologie).
- MESH :
- anatomopathologie : Déficits immunitaires, Filariose lymphatique.
- génétique : Déficits immunitaires, Immunoglobulines, Récepteurs aux antigènes des cellules T.
- immunologie : Filariose lymphatique, Rate, Sous-populations de lymphocytes.
- Animaux, Brugia, Déficits immunitaires, Humains, Inflammation, Modèles animaux de maladie humaine, Souches mutantes de souris, Souris.
English descriptors
- KwdEn :
- Animals, Brugia, Disease Models, Animal, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (pathology), Humans, Immunoglobulins (genetics), Immunologic Deficiency Syndromes (complications), Immunologic Deficiency Syndromes (genetics), Immunologic Deficiency Syndromes (pathology), Inflammation, Lymphocyte Subsets (immunology), Mice, Mice, Mutant Strains, Receptors, Antigen, T-Cell (genetics), Spleen (immunology).
- MESH :
- chemical , genetics : Immunoglobulins, Receptors, Antigen, T-Cell.
- complications : Immunologic Deficiency Syndromes.
- genetics : Immunologic Deficiency Syndromes.
- immunology : Elephantiasis, Filarial, Lymphocyte Subsets, Spleen.
- pathology : Elephantiasis, Filarial, Immunologic Deficiency Syndromes.
- Animals, Brugia, Disease Models, Animal, Humans, Inflammation, Mice, Mice, Mutant Strains.
Abstract
The C.B.-17-scid/scid mouse (hereafter referred to as the scid mouse) is homozygous for a recessive mutation at a locus that influences the assembly of intact immunoglobulin and T cell receptor genes. Therefore, scid mice cannot generate functional B or T lymphocytes, are profoundly immunodeficient, and have been reported to be receptive to reconstitution with human immune cells. In the present study, we injected scid mice with infective larvae of the human filarial parasite Brugia malayi. Within 6-10 wk after subcutaneous injection of infective L3 larvae, both male and female worms were observed in various stages of development in 90% of the mice. In animals tested 8 weeks or more after infection, microfilariae were detected in the blood or peritoneal cavity of 52% of the mice examined. Adult worms were observed in the lymphatics of the infected scid mice, where their presence was associated with lymphangitis and lymphangiectasia. These results suggest that the scid mouse model of lymphatic filariasis may be important in investigation of the interaction of the murine, and possibly the human, immune system with the lymphatic filarial parasite.
Url:
PubMed: 1997651
PubMed Central: 2118823
Affiliations:
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qualifier="génétique" xml:lang="fr"><term>Déficits immunitaires</term><term>Immunoglobulines</term><term>Récepteurs aux antigènes des cellules T</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Rate</term><term>Sous-populations de lymphocytes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphocyte Subsets</term><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Immunologic Deficiency Syndromes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brugia</term><term>Disease Models, Animal</term><term>Humans</term><term>Inflammation</term><term>Mice</term><term>Mice, Mutant Strains</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Brugia</term><term>Déficits 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Therefore, scid mice cannot generate functional B or T lymphocytes, are profoundly immunodeficient, and have been reported to be receptive to reconstitution with human immune cells. In the present study, we injected scid mice with infective larvae of the human filarial parasite Brugia malayi. Within 6-10 wk after subcutaneous injection of infective L3 larvae, both male and female worms were observed in various stages of development in 90% of the mice. In animals tested 8 weeks or more after infection, microfilariae were detected in the blood or peritoneal cavity of 52% of the mice examined. Adult worms were observed in the lymphatics of the infected scid mice, where their presence was associated with lymphangitis and lymphangiectasia. These results suggest that the scid mouse model of lymphatic filariasis may be important in investigation of the interaction of the murine, and possibly the human, immune system with the lymphatic filarial parasite.</p></div></front></TEI><affiliations><list></list><tree></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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