The immunodeficient scid mouse as a model for human lymphatic filariasis.
Identifieur interne : 005B87 ( PubMed/Corpus ); précédent : 005B86; suivant : 005B88The immunodeficient scid mouse as a model for human lymphatic filariasis.
Auteurs : F K Nelson ; D L Greiner ; L D Shultz ; T V RajanSource :
- The Journal of experimental medicine [ 0022-1007 ] ; 1991.
English descriptors
- KwdEn :
- Animals, Brugia, Disease Models, Animal, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (pathology), Humans, Immunoglobulins (genetics), Immunologic Deficiency Syndromes (complications), Immunologic Deficiency Syndromes (genetics), Immunologic Deficiency Syndromes (pathology), Inflammation, Lymphocyte Subsets (immunology), Mice, Mice, Mutant Strains, Receptors, Antigen, T-Cell (genetics), Spleen (immunology).
- MESH :
- chemical , genetics : Immunoglobulins, Receptors, Antigen, T-Cell.
- complications : Immunologic Deficiency Syndromes.
- genetics : Immunologic Deficiency Syndromes.
- immunology : Elephantiasis, Filarial, Lymphocyte Subsets, Spleen.
- pathology : Elephantiasis, Filarial, Immunologic Deficiency Syndromes.
- Animals, Brugia, Disease Models, Animal, Humans, Inflammation, Mice, Mice, Mutant Strains.
Abstract
The C.B.-17-scid/scid mouse (hereafter referred to as the scid mouse) is homozygous for a recessive mutation at a locus that influences the assembly of intact immunoglobulin and T cell receptor genes. Therefore, scid mice cannot generate functional B or T lymphocytes, are profoundly immunodeficient, and have been reported to be receptive to reconstitution with human immune cells. In the present study, we injected scid mice with infective larvae of the human filarial parasite Brugia malayi. Within 6-10 wk after subcutaneous injection of infective L3 larvae, both male and female worms were observed in various stages of development in 90% of the mice. In animals tested 8 weeks or more after infection, microfilariae were detected in the blood or peritoneal cavity of 52% of the mice examined. Adult worms were observed in the lymphatics of the infected scid mice, where their presence was associated with lymphangitis and lymphangiectasia. These results suggest that the scid mouse model of lymphatic filariasis may be important in investigation of the interaction of the murine, and possibly the human, immune system with the lymphatic filarial parasite.
PubMed: 1997651
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The immunodeficient scid mouse as a model for human lymphatic filariasis.</title><author><name sortKey="Nelson, F K" sort="Nelson, F K" uniqKey="Nelson F" first="F K" last="Nelson">F K Nelson</name><affiliation><nlm:affiliation>Department of Pathology, University of Connecticut Health Center, Farmington 06030.</nlm:affiliation></affiliation></author><author><name sortKey="Greiner, D L" sort="Greiner, D L" uniqKey="Greiner D" first="D L" last="Greiner">D L Greiner</name></author><author><name sortKey="Shultz, L D" sort="Shultz, L D" uniqKey="Shultz L" first="L D" last="Shultz">L D Shultz</name></author><author><name sortKey="Rajan, T V" sort="Rajan, T V" uniqKey="Rajan T" first="T V" last="Rajan">T V Rajan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1997651</idno><idno type="pmid">1997651</idno><idno type="wicri:Area/PubMed/Corpus">005B87</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005B87</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The immunodeficient scid mouse as a model for human lymphatic filariasis.</title><author><name sortKey="Nelson, F K" sort="Nelson, F K" uniqKey="Nelson F" first="F K" last="Nelson">F K Nelson</name><affiliation><nlm:affiliation>Department of Pathology, University of Connecticut Health Center, Farmington 06030.</nlm:affiliation></affiliation></author><author><name sortKey="Greiner, D L" sort="Greiner, D L" uniqKey="Greiner D" first="D L" last="Greiner">D L Greiner</name></author><author><name sortKey="Shultz, L D" sort="Shultz, L D" uniqKey="Shultz L" first="L D" last="Shultz">L D Shultz</name></author><author><name sortKey="Rajan, T V" sort="Rajan, T V" uniqKey="Rajan T" first="T V" last="Rajan">T V Rajan</name></author></analytic><series><title level="j">The Journal of experimental medicine</title><idno type="ISSN">0022-1007</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brugia</term><term>Disease Models, Animal</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (pathology)</term><term>Humans</term><term>Immunoglobulins (genetics)</term><term>Immunologic Deficiency Syndromes (complications)</term><term>Immunologic Deficiency Syndromes (genetics)</term><term>Immunologic Deficiency Syndromes (pathology)</term><term>Inflammation</term><term>Lymphocyte Subsets (immunology)</term><term>Mice</term><term>Mice, Mutant Strains</term><term>Receptors, Antigen, T-Cell (genetics)</term><term>Spleen (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Immunoglobulins</term><term>Receptors, Antigen, T-Cell</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Immunologic Deficiency Syndromes</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Immunologic Deficiency Syndromes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphocyte Subsets</term><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Immunologic Deficiency Syndromes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brugia</term><term>Disease Models, Animal</term><term>Humans</term><term>Inflammation</term><term>Mice</term><term>Mice, Mutant Strains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The C.B.-17-scid/scid mouse (hereafter referred to as the scid mouse) is homozygous for a recessive mutation at a locus that influences the assembly of intact immunoglobulin and T cell receptor genes. Therefore, scid mice cannot generate functional B or T lymphocytes, are profoundly immunodeficient, and have been reported to be receptive to reconstitution with human immune cells. In the present study, we injected scid mice with infective larvae of the human filarial parasite Brugia malayi. Within 6-10 wk after subcutaneous injection of infective L3 larvae, both male and female worms were observed in various stages of development in 90% of the mice. In animals tested 8 weeks or more after infection, microfilariae were detected in the blood or peritoneal cavity of 52% of the mice examined. Adult worms were observed in the lymphatics of the infected scid mice, where their presence was associated with lymphangitis and lymphangiectasia. These results suggest that the scid mouse model of lymphatic filariasis may be important in investigation of the interaction of the murine, and possibly the human, immune system with the lymphatic filarial parasite.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1997651</PMID><DateCreated><Year>1991</Year><Month>04</Month><Day>02</Day></DateCreated><DateCompleted><Year>1991</Year><Month>04</Month><Day>02</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-1007</ISSN><JournalIssue CitedMedium="Print"><Volume>173</Volume><Issue>3</Issue><PubDate><Year>1991</Year><Month>Mar</Month><Day>01</Day></PubDate></JournalIssue><Title>The Journal of experimental medicine</Title><ISOAbbreviation>J. Exp. Med.</ISOAbbreviation></Journal><ArticleTitle>The immunodeficient scid mouse as a model for human lymphatic filariasis.</ArticleTitle><Pagination><MedlinePgn>659-63</MedlinePgn></Pagination><Abstract><AbstractText>The C.B.-17-scid/scid mouse (hereafter referred to as the scid mouse) is homozygous for a recessive mutation at a locus that influences the assembly of intact immunoglobulin and T cell receptor genes. Therefore, scid mice cannot generate functional B or T lymphocytes, are profoundly immunodeficient, and have been reported to be receptive to reconstitution with human immune cells. In the present study, we injected scid mice with infective larvae of the human filarial parasite Brugia malayi. Within 6-10 wk after subcutaneous injection of infective L3 larvae, both male and female worms were observed in various stages of development in 90% of the mice. In animals tested 8 weeks or more after infection, microfilariae were detected in the blood or peritoneal cavity of 52% of the mice examined. Adult worms were observed in the lymphatics of the infected scid mice, where their presence was associated with lymphangitis and lymphangiectasia. These results suggest that the scid mouse model of lymphatic filariasis may be important in investigation of the interaction of the murine, and possibly the human, immune system with the lymphatic filarial parasite.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nelson</LastName><ForeName>F K</ForeName><Initials>FK</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Connecticut Health Center, Farmington 06030.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greiner</LastName><ForeName>D L</ForeName><Initials>DL</Initials></Author><Author ValidYN="Y"><LastName>Shultz</LastName><ForeName>L D</ForeName><Initials>LD</Initials></Author><Author ValidYN="Y"><LastName>Rajan</LastName><ForeName>T V</ForeName><Initials>TV</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>AI-30046</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI-30389</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA-20408</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Exp Med</MedlineTA><NlmUniqueID>2985109R</NlmUniqueID><ISSNLinking>0022-1007</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007136">Immunoglobulins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011948">Receptors, Antigen, T-Cell</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Parasitol. 1970 Oct;56(5):969-73</RefSource><PMID Version="1">5504534</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1983 Feb 10;301(5900):527-30</RefSource><PMID Version="1">6823332</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Parasitol. 1983 Jun;69(3):478-85</RefSource><PMID Version="1">6605421</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 1984 Nov;6(6):545-59</RefSource><PMID Version="1">6522098</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Trop Med Hyg. 1985 May;34(3):476-83</RefSource><PMID Version="1">3890576</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 1990 Oct 1;172(4):1055-63</RefSource><PMID Version="1">2212942</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 1988 Mar 1;167(3):1016-33</RefSource><PMID Version="1">3280724</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 1988 Sep 23;241(4873):1632-9</RefSource><PMID Version="1">2971269</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 1989 Jun;134(6):1373-6</RefSource><PMID Version="1">2757121</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Top Microbiol Immunol. 1989;152:235-42</RefSource><PMID Version="1">2509143</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 1987 Aug 1;166(2):461-75</RefSource><PMID Version="1">3496416</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002009" MajorTopicYN="Y">Brugia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007136" MajorTopicYN="N">Immunoglobulins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007153" MajorTopicYN="N">Immunologic Deficiency Syndromes</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016131" MajorTopicYN="N">Lymphocyte Subsets</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008817" MajorTopicYN="N">Mice, Mutant Strains</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011948" MajorTopicYN="N">Receptors, Antigen, T-Cell</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013154" MajorTopicYN="N">Spleen</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC2118823</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>3</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>3</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>3</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1997651</ArticleId><ArticleId IdType="pmc">PMC2118823</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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