The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs
Identifieur interne : 00C189 ( Main/Exploration ); précédent : 00C188; suivant : 00C190The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs
Auteurs : T. S. Chang [République populaire de Chine] ; J. L. Gan [République populaire de Chine] ; K. D. Fu [République populaire de Chine] ; W. Y. Huang [République populaire de Chine]Source :
- Lymphology [ 0024-7766 ] ; 1996.
Descripteurs français
- KwdFr :
- Administration par voie orale, Adulte, Anticoagulants (usage thérapeutique), Association thérapeutique, Bandages, Coumarines (usage thérapeutique), Femelle, Humains, Hyperthermie provoquée, Jambe, Lymphoedème (), Maladie chronique, Micro-ondes, Mâle, Méthode en double aveugle, Résultat thérapeutique, Études de suivi.
- MESH :
- usage thérapeutique : Anticoagulants, Coumarines.
- Pascal (Inist)
- Administration par voie orale, Adulte, Association thérapeutique, Bandages, Femelle, Humains, Hyperthermie provoquée, Jambe, Lymphoedème, Coumarine, Chauffage, Hyperfréquence, Chimiothérapie, Maladie chronique, Micro-ondes, Mâle, Méthode en double aveugle, Résultat thérapeutique, Traitement, Association, Homme, Anticoagulant, Études de suivi.
- Wicri :
- topic : Chauffage, Association, Homme.
English descriptors
- KwdEn :
- Administration, Oral, Adult, Anticoagulant, Anticoagulants (therapeutic use), Association, Bandages, Chemotherapy, Chronic Disease, Combined Modality Therapy, Coumarin, Coumarins (therapeutic use), Double-Blind Method, Female, Follow-Up Studies, Heating, Human, Humans, Hyperthermia, Induced, Leg, Lymphedema, Lymphedema (therapy), Male, Microwave, Microwaves, Treatment, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Anticoagulants, Coumarins.
- therapy : Lymphedema.
- Administration, Oral, Adult, Bandages, Chronic Disease, Combined Modality Therapy, Double-Blind Method, Female, Follow-Up Studies, Humans, Hyperthermia, Induced, Leg, Male, Microwaves, Treatment Outcome.
Abstract
Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10-4) and improvement in circumferences and tonometry (p=10-5 and 10-7). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10-7). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10-9) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10-9).
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The use of 5,6 benzo-[α]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs</title>
<author><name sortKey="Chang, T S" sort="Chang, T S" uniqKey="Chang T" first="T. S." last="Chang">T. S. Chang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1>
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<author><name sortKey="Fu, K D" sort="Fu, K D" uniqKey="Fu K" first="K. D." last="Fu">K. D. Fu</name>
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<author><name sortKey="Huang, W Y" sort="Huang, W Y" uniqKey="Huang W" first="W. Y." last="Huang">W. Y. Huang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University</s1>
<s2>Shanghai</s2>
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<sZ>2 aut.</sZ>
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<series><title level="j" type="main">Lymphology</title>
<title level="j" type="abbreviated">Lymphology</title>
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<imprint><date when="1996">1996</date>
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<seriesStmt><title level="j" type="main">Lymphology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term>
<term>Adult</term>
<term>Anticoagulant</term>
<term>Anticoagulants (therapeutic use)</term>
<term>Association</term>
<term>Bandages</term>
<term>Chemotherapy</term>
<term>Chronic Disease</term>
<term>Combined Modality Therapy</term>
<term>Coumarin</term>
<term>Coumarins (therapeutic use)</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Heating</term>
<term>Human</term>
<term>Humans</term>
<term>Hyperthermia, Induced</term>
<term>Leg</term>
<term>Lymphedema</term>
<term>Lymphedema (therapy)</term>
<term>Male</term>
<term>Microwave</term>
<term>Microwaves</term>
<term>Treatment</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale</term>
<term>Adulte</term>
<term>Anticoagulants (usage thérapeutique)</term>
<term>Association thérapeutique</term>
<term>Bandages</term>
<term>Coumarines (usage thérapeutique)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hyperthermie provoquée</term>
<term>Jambe</term>
<term>Lymphoedème ()</term>
<term>Maladie chronique</term>
<term>Micro-ondes</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Résultat thérapeutique</term>
<term>Études de suivi</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anticoagulants</term>
<term>Coumarins</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticoagulants</term>
<term>Coumarines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term>
<term>Adult</term>
<term>Bandages</term>
<term>Chronic Disease</term>
<term>Combined Modality Therapy</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Hyperthermia, Induced</term>
<term>Leg</term>
<term>Male</term>
<term>Microwaves</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Administration par voie orale</term>
<term>Adulte</term>
<term>Association thérapeutique</term>
<term>Bandages</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hyperthermie provoquée</term>
<term>Jambe</term>
<term>Lymphoedème</term>
<term>Coumarine</term>
<term>Chauffage</term>
<term>Hyperfréquence</term>
<term>Chimiothérapie</term>
<term>Maladie chronique</term>
<term>Micro-ondes</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Résultat thérapeutique</term>
<term>Traitement</term>
<term>Association</term>
<term>Homme</term>
<term>Anticoagulant</term>
<term>Études de suivi</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chauffage</term>
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<front><div type="abstract" xml:lang="en">Sixty patients with leg lymph edema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymph edema. Using a double-blind format, one group received 5,6 benzo-[α]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months ; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p=10<sup>-4</sup>
) and improvement in circumferences and tonometry (p=10<sup>-5</sup>
and 10<sup>-7</sup>
). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p=0.03 to 10<sup>-7</sup>
). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p=0.03 to 10<sup>-9</sup>
) in signs and symptoms of lymph edema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p=0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p=0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p=0.8 to 10<sup>-9</sup>
).</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Chang, T S" sort="Chang, T S" uniqKey="Chang T" first="T. S." last="Chang">T. S. Chang</name>
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<name sortKey="Fu, K D" sort="Fu, K D" uniqKey="Fu K" first="K. D." last="Fu">K. D. Fu</name>
<name sortKey="Gan, J L" sort="Gan, J L" uniqKey="Gan J" first="J. L." last="Gan">J. L. Gan</name>
<name sortKey="Huang, W Y" sort="Huang, W Y" uniqKey="Huang W" first="W. Y." last="Huang">W. Y. Huang</name>
</country>
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