LymphedemaV1, Main, Exploration, bibRecord, 00B915

Circulating connective tissue metabolites in patients with bancroftian filariasis

Identifieur interne : 00B915 ( Main/Exploration ); précédent : 00B914; suivant : 00B916

Circulating connective tissue metabolites in patients with bancroftian filariasis

Auteurs : Suzanne Fleming-Hübertz [Danemark] ; Paul E. Simonsen [Danemark] ; Lars Thorbj Rn Jensen [Danemark]

Source :

Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1997-07.

RBID : ISTEX:7C088EC3CC3E0A7CD04CAF07656CC9668F930F80

English descriptors

KwdEn :
- ICTP, PICP, PIIINP, circulating antigens, collagen, elephantiasis, filariasis, hyaluronan, pathogenesis.

Abstract

Sera from adults from an area of Tanzania with high endemicity for Wuchereria bancrofti infection were examined for 4 serological markers of extracellular matrix activity, namely the amino-terminal propeptide of type III procollagen (PIIINP), the carboxy-terminal propeptide of type I procollagen (PICP), the carboxyterminal telopeptide of type I collagen (ICTP), and hyaluronan. Sera from individuals with nonfilarial elephantiasis and from healthy Danes were included as controls. No association was observed between the mean serum concentration of PIIINP or PICP and the clinical, microfilarial or circulating filarial antigen status of the individuals. The mean concentration of ICTP was significantly higher (P < 0 · 01) in sera from individuals with filarial and non-filarial elephantiasis than in sera from individuals living in filariasis endemic areas but without elephantiasis or in the Danish control sera. Among individuals from the filariasis endemic area, the mean serum concentration of hyaluronan was significantly higher (P < 0 · 01) in microfilaraemic than in amicrofilaraemic individuals, and significantly higher (P < 0 · 01) in individuals who had circulating filarial antigens than in those who did not, but there was no relation to the clinical status. The significance of the findings are discussed in relation to the pathological processes taking place in bancroftian filariasis.

Url:

DOI: 10.1016/S0035-9203(97)90277-7

Affiliations:

Danemark

Le document en format XML

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<front><div type="abstract">Sera from adults from an area of Tanzania with high endemicity for Wuchereria bancrofti infection were examined for 4 serological markers of extracellular matrix activity, namely the amino-terminal propeptide of type III procollagen (PIIINP), the carboxy-terminal propeptide of type I procollagen (PICP), the carboxyterminal telopeptide of type I collagen (ICTP), and hyaluronan. Sera from individuals with nonfilarial elephantiasis and from healthy Danes were included as controls. No association was observed between the mean serum concentration of PIIINP or PICP and the clinical, microfilarial or circulating filarial antigen status of the individuals. The mean concentration of ICTP was significantly higher (P < 0 · 01) in sera from individuals with filarial and non-filarial elephantiasis than in sera from individuals living in filariasis endemic areas but without elephantiasis or in the Danish control sera. Among individuals from the filariasis endemic area, the mean serum concentration of hyaluronan was significantly higher (P < 0 · 01) in microfilaraemic than in amicrofilaraemic individuals, and significantly higher (P < 0 · 01) in individuals who had circulating filarial antigens than in those who did not, but there was no relation to the clinical status. The significance of the findings are discussed in relation to the pathological processes taking place in bancroftian filariasis.</div>
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Circulating connective tissue metabolites in patients with bancroftian filariasis

Circulating connective tissue metabolites in patients with bancroftian filariasis

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur le lymphœdème
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