Circulating connective tissue metabolites in patients with bancroftian filariasis
Identifieur interne : 003F26 ( Istex/Corpus ); précédent : 003F25; suivant : 003F27Circulating connective tissue metabolites in patients with bancroftian filariasis
Auteurs : Suzanne Fleming-Hübertz ; Paul E. Simonsen ; Lars Thorbj Rn JensenSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1997.
Abstract
Sera from adults from an area of Tanzania with high endemicity for Wuchereria bancrofti infection were examined for 4 serological markers of extracellular matrix activity, namely the amino-terminal propeptide of type III procollagen (PIIINP), the carboxy-terminal propeptide of type I procollagen (PICP), the carboxyterminal telopeptide of type I collagen (ICTP), and hyaluronan. Sera from individuals with nonfilarial elephantiasis and from healthy Danes were included as controls. No association was observed between the mean serum concentration of PIIINP or PICP and the clinical, microfilarial or circulating filarial antigen status of the individuals. The mean concentration of ICTP was significantly higher (P < 0 · 01) in sera from individuals with filarial and non-filarial elephantiasis than in sera from individuals living in filariasis endemic areas but without elephantiasis or in the Danish control sera. Among individuals from the filariasis endemic area, the mean serum concentration of hyaluronan was significantly higher (P < 0 · 01) in microfilaraemic than in amicrofilaraemic individuals, and significantly higher (P < 0 · 01) in individuals who had circulating filarial antigens than in those who did not, but there was no relation to the clinical status. The significance of the findings are discussed in relation to the pathological processes taking place in bancroftian filariasis.
Url:
DOI: 10.1016/S0035-9203(97)90277-7
Links to Exploration step
ISTEX:860B2F4A4D3D364659CC35A90832EC01A68CD2B7Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Circulating connective tissue metabolites in patients with bancroftian filariasis</title><author><name sortKey="Fleming Hubertz, Suzanne" sort="Fleming Hubertz, Suzanne" uniqKey="Fleming Hubertz S" first="Suzanne" last="Fleming-Hübertz">Suzanne Fleming-Hübertz</name><affiliation><mods:affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Simonsen, Paul E" sort="Simonsen, Paul E" uniqKey="Simonsen P" first="Paul E." last="Simonsen">Paul E. Simonsen</name><affiliation><mods:affiliation>Address for correspondence: Dr Paul E. Simonsen, Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark; phone +45 39626168, fax +45 39626121.</mods:affiliation></affiliation><affiliation><mods:affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: pes@bilharziasis.dk</mods:affiliation></affiliation></author><author><name sortKey="Jensen, Lars Thorbj Rn" sort="Jensen, Lars Thorbj Rn" uniqKey="Jensen L" first="Lars Thorbj Rn" last="Jensen">Lars Thorbj Rn Jensen</name><affiliation><mods:affiliation>Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, DK-2600 Glostrup, Denmark</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:860B2F4A4D3D364659CC35A90832EC01A68CD2B7</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1016/S0035-9203(97)90277-7</idno><idno type="url">https://api.istex.fr/document/860B2F4A4D3D364659CC35A90832EC01A68CD2B7/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003F26</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003F26</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Circulating connective tissue metabolites in patients with bancroftian filariasis</title><author><name sortKey="Fleming Hubertz, Suzanne" sort="Fleming Hubertz, Suzanne" uniqKey="Fleming Hubertz S" first="Suzanne" last="Fleming-Hübertz">Suzanne Fleming-Hübertz</name><affiliation><mods:affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Simonsen, Paul E" sort="Simonsen, Paul E" uniqKey="Simonsen P" first="Paul E." last="Simonsen">Paul E. Simonsen</name><affiliation><mods:affiliation>Address for correspondence: Dr Paul E. Simonsen, Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark; phone +45 39626168, fax +45 39626121.</mods:affiliation></affiliation><affiliation><mods:affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: pes@bilharziasis.dk</mods:affiliation></affiliation></author><author><name sortKey="Jensen, Lars Thorbj Rn" sort="Jensen, Lars Thorbj Rn" uniqKey="Jensen L" first="Lars Thorbj Rn" last="Jensen">Lars Thorbj Rn Jensen</name><affiliation><mods:affiliation>Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, DK-2600 Glostrup, Denmark</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">TRSTMH</title><idno type="ISSN">0035-9203</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">91</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="442">442</biblScope><biblScope unit="page" to="445">445</biblScope></imprint><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0035-9203</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sera from adults from an area of Tanzania with high endemicity for Wuchereria bancrofti infection were examined for 4 serological markers of extracellular matrix activity, namely the amino-terminal propeptide of type III procollagen (PIIINP), the carboxy-terminal propeptide of type I procollagen (PICP), the carboxyterminal telopeptide of type I collagen (ICTP), and hyaluronan. Sera from individuals with nonfilarial elephantiasis and from healthy Danes were included as controls. No association was observed between the mean serum concentration of PIIINP or PICP and the clinical, microfilarial or circulating filarial antigen status of the individuals. The mean concentration of ICTP was significantly higher (P < 0 · 01) in sera from individuals with filarial and non-filarial elephantiasis than in sera from individuals living in filariasis endemic areas but without elephantiasis or in the Danish control sera. Among individuals from the filariasis endemic area, the mean serum concentration of hyaluronan was significantly higher (P < 0 · 01) in microfilaraemic than in amicrofilaraemic individuals, and significantly higher (P < 0 · 01) in individuals who had circulating filarial antigens than in those who did not, but there was no relation to the clinical status. The significance of the findings are discussed in relation to the pathological processes taking place in bancroftian filariasis.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>filariasis</json:string><json:string>hyaluronan</json:string><json:string>elephantiasis</json:string><json:string>ictp</json:string><json:string>picp</json:string><json:string>piiinp</json:string><json:string>filarial</json:string><json:string>bancroftian</json:string><json:string>endemic</json:string><json:string>risteli</json:string><json:string>bancroftian filariasis</json:string><json:string>microfilaraemic</json:string><json:string>tanzania</json:string><json:string>procollagen</json:string><json:string>amicrofilaraemic</json:string><json:string>hydrocele</json:string><json:string>lymphatic</json:string><json:string>antigen status</json:string><json:string>serum concentration</json:string><json:string>danish controls</json:string><json:string>connective tissue metabolism</json:string><json:string>amicrofilaraemic individuals</json:string><json:string>northeastern tanzania</json:string><json:string>endemic area</json:string><json:string>elephantiasis patients</json:string><json:string>pathological processes</json:string><json:string>tropical medicine</json:string><json:string>simultaneous analysis</json:string><json:string>significant relationship</json:string><json:string>control individuals</json:string><json:string>patient groups</json:string><json:string>collagen</json:string><json:string>degradation</json:string><json:string>serum levels</json:string><json:string>danish control group</json:string><json:string>elephantiasis group</json:string><json:string>connectivetissue metabolites</json:string><json:string>study individuals</json:string><json:string>adult filarial worms</json:string><json:string>clinical manifestations</json:string><json:string>study groups</json:string><json:string>collagen turnover</json:string><json:string>microfilaraemic individuals</json:string><json:string>filarial antigen status</json:string><json:string>such infections</json:string><json:string>active filarial infection</json:string><json:string>serum concentrations</json:string><json:string>infectious diseases</json:string><json:string>endemic communities</json:string><json:string>jaegersborg alle</json:string></teeft></keywords><author><json:item><name>Suzanne Fleming-Hübertz</name><affiliations><json:string>Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark</json:string></affiliations></json:item><json:item><name>Paul E. Simonsen</name><affiliations><json:string>Address for correspondence: Dr Paul E. Simonsen, Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark; phone +45 39626168, fax +45 39626121.</json:string><json:string>Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark</json:string><json:string>E-mail: pes@bilharziasis.dk</json:string></affiliations></json:item><json:item><name>Lars Thorbjørn Jensen</name><affiliations><json:string>Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, DK-2600 Glostrup, Denmark</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Clinical studies and pathology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>filariasis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>elephantiasis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Wuchereria bancrofti</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>circulating antigens</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PIIINP</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PICP</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ICTP</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hyaluronan</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>collagen</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pathogenesis</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Sera from adults from an area of Tanzania with high endemicity for Wuchereria bancrofti infection were examined for 4 serological markers of extracellular matrix activity, namely the amino-terminal propeptide of type III procollagen (PIIINP), the carboxy-terminal propeptide of type I procollagen (PICP), the carboxyterminal telopeptide of type I collagen (ICTP), and hyaluronan. Sera from individuals with nonfilarial elephantiasis and from healthy Danes were included as controls. No association was observed between the mean serum concentration of PIIINP or PICP and the clinical, microfilarial or circulating filarial antigen status of the individuals. The mean concentration of ICTP was significantly higher (P > 0 · 01) in sera from individuals with filarial and non-filarial elephantiasis than in sera from individuals living in filariasis endemic areas but without elephantiasis or in the Danish control sera. Among individuals from the filariasis endemic area, the mean serum concentration of hyaluronan was significantly higher (P > 0 · 01) in microfilaraemic than in amicrofilaraemic individuals, and significantly higher (P > 0 · 01) in individuals who had circulating filarial antigens than in those who did not, but there was no relation to the clinical status. The significance of the findings are discussed in relation to the pathological processes taking place in bancroftian filariasis.</abstract><qualityIndicators><score>5.38</score><pdfVersion>1.3</pdfVersion><pdfPageSize>576 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>11</keywordCount><abstractCharCount>1404</abstractCharCount><pdfWordCount>2896</pdfWordCount><pdfCharCount>20275</pdfCharCount><pdfPageCount>4</pdfPageCount><abstractWordCount>207</abstractWordCount></qualityIndicators><title>Circulating connective tissue metabolites in patients with bancroftian filariasis</title><pii><json:string>S0035-9203(97)90277-7</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>The Biology of Hyaluronan</title><language><json:string>unknown</json:string></language><pages><first>233</first><last>247</last></pages></serie><host><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><language><json:string>unknown</json:string></language><publicationDate>1997</publicationDate><issn><json:string>0035-9203</json:string></issn><pii><json:string>S0035-9203(00)X0058-2</json:string></pii><volume>91</volume><issue>4</issue><pages><first>442</first><last>445</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>social science</json:string><json:string>public, environmental & occupational health</json:string><json:string>science</json:string><json:string>tropical medicine</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>tropical medicine</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>1997</publicationDate><copyrightDate>1997</copyrightDate><doi><json:string>10.1016/S0035-9203(97)90277-7</json:string></doi><id>860B2F4A4D3D364659CC35A90832EC01A68CD2B7</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/860B2F4A4D3D364659CC35A90832EC01A68CD2B7/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/860B2F4A4D3D364659CC35A90832EC01A68CD2B7/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/860B2F4A4D3D364659CC35A90832EC01A68CD2B7/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Circulating connective tissue metabolites in patients with bancroftian filariasis</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1997</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Circulating connective tissue metabolites in patients with bancroftian filariasis</title><author xml:id="author-0000"><persName><forename type="first">Suzanne</forename><surname>Fleming-Hübertz</surname></persName><affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Paul E.</forename><surname>Simonsen</surname></persName><email>pes@bilharziasis.dk</email><affiliation>Address for correspondence: Dr Paul E. Simonsen, Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark; phone +45 39626168, fax +45 39626121.</affiliation><affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Lars Thorbjørn</forename><surname>Jensen</surname></persName><affiliation>Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, DK-2600 Glostrup, Denmark</affiliation></author><idno type="istex">860B2F4A4D3D364659CC35A90832EC01A68CD2B7</idno><idno type="DOI">10.1016/S0035-9203(97)90277-7</idno><idno type="PII">S0035-9203(97)90277-7</idno></analytic><monogr><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">TRSTMH</title><idno type="pISSN">0035-9203</idno><idno type="PII">S0035-9203(00)X0058-2</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997"></date><biblScope unit="volume">91</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="442">442</biblScope><biblScope unit="page" to="445">445</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1997</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Sera from adults from an area of Tanzania with high endemicity for Wuchereria bancrofti infection were examined for 4 serological markers of extracellular matrix activity, namely the amino-terminal propeptide of type III procollagen (PIIINP), the carboxy-terminal propeptide of type I procollagen (PICP), the carboxyterminal telopeptide of type I collagen (ICTP), and hyaluronan. Sera from individuals with nonfilarial elephantiasis and from healthy Danes were included as controls. No association was observed between the mean serum concentration of PIIINP or PICP and the clinical, microfilarial or circulating filarial antigen status of the individuals. The mean concentration of ICTP was significantly higher (P < 0 · 01) in sera from individuals with filarial and non-filarial elephantiasis than in sera from individuals living in filariasis endemic areas but without elephantiasis or in the Danish control sera. Among individuals from the filariasis endemic area, the mean serum concentration of hyaluronan was significantly higher (P < 0 · 01) in microfilaraemic than in amicrofilaraemic individuals, and significantly higher (P < 0 · 01) in individuals who had circulating filarial antigens than in those who did not, but there was no relation to the clinical status. The significance of the findings are discussed in relation to the pathological processes taking place in bancroftian filariasis.</p></abstract><textClass><keywords scheme="keyword"><list><head>article-category</head><item><term>Clinical studies and pathology</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>filariasis</term></item><item><term>elephantiasis</term></item><item><term>Wuchereria bancrofti</term></item><item><term>circulating antigens</term></item><item><term>PIIINP</term></item><item><term>PICP</term></item><item><term>ICTP</term></item><item><term>hyaluronan</term></item><item><term>collagen</term></item><item><term>pathogenesis</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1997-02-06">Modified</change><change when="1997">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/860B2F4A4D3D364659CC35A90832EC01A68CD2B7/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>TRSTMH</jid><aid>97902777</aid><ce:pii>S0035-9203(97)90277-7</ce:pii><ce:doi>10.1016/S0035-9203(97)90277-7</ce:doi><ce:copyright type="unknown" year="1997"></ce:copyright><ce:doctopics><ce:doctopic><ce:text>Clinical studies and pathology</ce:text></ce:doctopic></ce:doctopics></item-info><head><ce:title>Circulating connective tissue metabolites in patients with bancroftian filariasis</ce:title><ce:author-group><ce:author><ce:given-name>Suzanne</ce:given-name><ce:surname>Fleming-Hübertz</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Paul E.</ce:given-name><ce:surname>Simonsen</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref><ce:e-address>pes@bilharziasis.dk</ce:e-address></ce:author><ce:author><ce:given-name>Lars Thorbjørn</ce:given-name><ce:surname>Jensen</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>1</ce:label><ce:textfn>Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>2</ce:label><ce:textfn>Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, DK-2600 Glostrup, Denmark</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address for correspondence: Dr Paul E. Simonsen, Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark; phone +45 39626168, fax +45 39626121.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="17" month="12" year="1996"></ce:date-received><ce:date-revised day="6" month="2" year="1997"></ce:date-revised><ce:date-accepted day="6" month="2" year="1997"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Sera from adults from an area of Tanzania with high endemicity for <ce:italic>Wuchereria bancrofti</ce:italic> infection were examined for 4 serological markers of extracellular matrix activity, namely the amino-terminal propeptide of type III procollagen (PIIINP), the carboxy-terminal propeptide of type I procollagen (PICP), the carboxyterminal telopeptide of type I collagen (ICTP), and hyaluronan. Sera from individuals with nonfilarial elephantiasis and from healthy Danes were included as controls. No association was observed between the mean serum concentration of PIIINP or PICP and the clinical, microfilarial or circulating filarial antigen status of the individuals. The mean concentration of ICTP was significantly higher (<ce:italic>P</ce:italic> < 0 · 01) in sera from individuals with filarial and non-filarial elephantiasis than in sera from individuals living in filariasis endemic areas but without elephantiasis or in the Danish control sera. Among individuals from the filariasis endemic area, the mean serum concentration of hyaluronan was significantly higher (<ce:italic>P</ce:italic> < 0 · 01) in microfilaraemic than in amicrofilaraemic individuals, and significantly higher (<ce:italic>P</ce:italic> < 0 · 01) in individuals who had circulating filarial antigens than in those who did not, but there was no relation to the clinical status. The significance of the findings are discussed in relation to the pathological processes taking place in bancroftian filariasis.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>filariasis</ce:text></ce:keyword><ce:keyword><ce:text>elephantiasis</ce:text></ce:keyword><ce:keyword><ce:text><ce:italic>Wuchereria bancrofti</ce:italic></ce:text></ce:keyword><ce:keyword><ce:text>circulating antigens</ce:text></ce:keyword><ce:keyword><ce:text>PIIINP</ce:text></ce:keyword><ce:keyword><ce:text>PICP</ce:text></ce:keyword><ce:keyword><ce:text>ICTP</ce:text></ce:keyword><ce:keyword><ce:text>hyaluronan</ce:text></ce:keyword><ce:keyword><ce:text>collagen</ce:text></ce:keyword><ce:keyword><ce:text>pathogenesis</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Circulating connective tissue metabolites in patients with bancroftian filariasis</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Circulating connective tissue metabolites in patients with bancroftian filariasis</title></titleInfo><name type="personal"><namePart type="given">Suzanne</namePart><namePart type="family">Fleming-Hübertz</namePart><affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul E.</namePart><namePart type="family">Simonsen</namePart><affiliation>Address for correspondence: Dr Paul E. Simonsen, Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark; phone +45 39626168, fax +45 39626121.</affiliation><affiliation>Danish Bilharziasis Laboratory, Jaegersborg Alle 1 D, DK-2920 Charlottenlund, Denmark</affiliation><affiliation>E-mail: pes@bilharziasis.dk</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lars Thorbjørn</namePart><namePart type="family">Jensen</namePart><affiliation>Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, DK-2600 Glostrup, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued><dateModified encoding="w3cdtf">1997-02-06</dateModified><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Sera from adults from an area of Tanzania with high endemicity for Wuchereria bancrofti infection were examined for 4 serological markers of extracellular matrix activity, namely the amino-terminal propeptide of type III procollagen (PIIINP), the carboxy-terminal propeptide of type I procollagen (PICP), the carboxyterminal telopeptide of type I collagen (ICTP), and hyaluronan. Sera from individuals with nonfilarial elephantiasis and from healthy Danes were included as controls. No association was observed between the mean serum concentration of PIIINP or PICP and the clinical, microfilarial or circulating filarial antigen status of the individuals. The mean concentration of ICTP was significantly higher (P < 0 · 01) in sera from individuals with filarial and non-filarial elephantiasis than in sera from individuals living in filariasis endemic areas but without elephantiasis or in the Danish control sera. Among individuals from the filariasis endemic area, the mean serum concentration of hyaluronan was significantly higher (P < 0 · 01) in microfilaraemic than in amicrofilaraemic individuals, and significantly higher (P < 0 · 01) in individuals who had circulating filarial antigens than in those who did not, but there was no relation to the clinical status. The significance of the findings are discussed in relation to the pathological processes taking place in bancroftian filariasis.</abstract><subject><genre>article-category</genre><topic>Clinical studies and pathology</topic></subject><subject><genre>Keywords</genre><topic>filariasis</topic><topic>elephantiasis</topic><topic>Wuchereria bancrofti</topic><topic>circulating antigens</topic><topic>PIIINP</topic><topic>PICP</topic><topic>ICTP</topic><topic>hyaluronan</topic><topic>collagen</topic><topic>pathogenesis</topic></subject><relatedItem type="host"><titleInfo><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title></titleInfo><titleInfo type="abbreviated"><title>TRSTMH</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199707</dateIssued></originInfo><identifier type="ISSN">0035-9203</identifier><identifier type="PII">S0035-9203(00)X0058-2</identifier><part><date>199707</date><detail type="volume"><number>91</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue pages"><start>369</start><end>496</end></extent><extent unit="pages"><start>442</start><end>445</end></extent></part></relatedItem><identifier type="istex">860B2F4A4D3D364659CC35A90832EC01A68CD2B7</identifier><identifier type="DOI">10.1016/S0035-9203(97)90277-7</identifier><identifier type="PII">S0035-9203(97)90277-7</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003F26 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 003F26 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:860B2F4A4D3D364659CC35A90832EC01A68CD2B7
|texte= Circulating connective tissue metabolites in patients with bancroftian filariasis
}}
| This area was generated with Dilib version V0.6.31. |  |