Intra-arterial mitoxantrone and paclitaxel in a patient with Stewart-Treves syndrome: selection of chemotherapy by an ex vivo ATP-based chemosensitivity assay.
Identifieur interne : 00A236 ( Main/Exploration ); précédent : 00A235; suivant : 00A237Intra-arterial mitoxantrone and paclitaxel in a patient with Stewart-Treves syndrome: selection of chemotherapy by an ex vivo ATP-based chemosensitivity assay.
Auteurs : M. Breidenbach [Allemagne] ; D. Rein ; T. Schmidt ; W. Heindel ; H. Kolhagen ; P. Mallmann ; C M KurbacherSource :
- Anti-cancer drugs [ 0959-4973 ] ; 2000.
Descripteurs français
- KwdFr :
- Adénosine triphosphate (métabolisme), Carcinome canalaire du sein (anatomopathologie), Carcinome canalaire du sein (radiothérapie), Femelle, Humains, Lymphangiosarcome (métabolisme), Lymphangiosarcome (traitement médicamenteux), Lymphangiosarcome (étiologie), Lymphoedème (traitement médicamenteux), Lymphoedème (étiologie), Mitoxantrone (administration et posologie), Paclitaxel (administration et posologie), Perfusions artérielles, Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Sujet âgé, Syndrome, Tests de criblage d'agents antitumoraux, Tumeurs des tissus mous (métabolisme), Tumeurs des tissus mous (traitement médicamenteux), Tumeurs des tissus mous (étiologie), Tumeurs du sein (anatomopathologie), Tumeurs du sein (radiothérapie), Tumeurs radio-induites (métabolisme), Tumeurs radio-induites (traitement médicamenteux), Tumeurs radio-induites (étiologie).
- MESH :
- administration et posologie : Mitoxantrone, Paclitaxel.
- anatomopathologie : Carcinome canalaire du sein, Tumeurs du sein.
- métabolisme : Adénosine triphosphate, Lymphangiosarcome, Tumeurs des tissus mous, Tumeurs radio-induites.
- radiothérapie : Carcinome canalaire du sein, Tumeurs du sein.
- traitement médicamenteux : Lymphangiosarcome, Lymphoedème, Tumeurs des tissus mous, Tumeurs radio-induites.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- étiologie : Lymphangiosarcome, Lymphoedème, Tumeurs des tissus mous, Tumeurs radio-induites.
- Femelle, Humains, Perfusions artérielles, Sujet âgé, Syndrome, Tests de criblage d'agents antitumoraux.
English descriptors
- KwdEn :
- Adenosine Triphosphate (metabolism), Aged, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Breast Neoplasms (pathology), Breast Neoplasms (radiotherapy), Carcinoma, Ductal, Breast (pathology), Carcinoma, Ductal, Breast (radiotherapy), Drug Screening Assays, Antitumor, Female, Humans, Infusions, Intra-Arterial, Lymphangiosarcoma (drug therapy), Lymphangiosarcoma (etiology), Lymphangiosarcoma (metabolism), Lymphedema (drug therapy), Lymphedema (etiology), Mitoxantrone (administration & dosage), Neoplasms, Radiation-Induced (drug therapy), Neoplasms, Radiation-Induced (etiology), Neoplasms, Radiation-Induced (metabolism), Paclitaxel (administration & dosage), Soft Tissue Neoplasms (drug therapy), Soft Tissue Neoplasms (etiology), Soft Tissue Neoplasms (metabolism), Syndrome.
- MESH :
- chemical , administration & dosage : Mitoxantrone, Paclitaxel.
- chemical , metabolism : Adenosine Triphosphate.
- drug therapy : Lymphangiosarcoma, Lymphedema, Neoplasms, Radiation-Induced, Soft Tissue Neoplasms.
- etiology : Lymphangiosarcoma, Lymphedema, Neoplasms, Radiation-Induced, Soft Tissue Neoplasms.
- metabolism : Lymphangiosarcoma, Neoplasms, Radiation-Induced, Soft Tissue Neoplasms.
- pathology : Breast Neoplasms, Carcinoma, Ductal, Breast.
- radiotherapy : Breast Neoplasms, Carcinoma, Ductal, Breast.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Aged, Drug Screening Assays, Antitumor, Female, Humans, Infusions, Intra-Arterial, Syndrome.
Abstract
We report on a 72-year-old patient developing Stewart-Treves syndrome (STS) of the right arm 9 years after curative irradiation for ipsilateral stage III breast cancer. Facing the poor track record of both irradiation and chemotherapy in this highly malignant lymphangiosarcoma, amputation was recommended but refused by the patient. Therefore, limb conserving-therapy using three courses of intra-arterial mitoxantrone (MX) and paclitaxel (PTX) was attempted. This novel chemotherapy protocol was selected by pretherapeutic ex vivo ATP-based chemosensitivity testing of autologous tumor tissue. The patient experienced complete response, which was subsequent histologically confirmed by compartment resection. When developing recurrent STS outside of the perfused area 6 months after primary therapy, the patient was retested and reinduced with three other courses of intraarterial MX/PTX which again produced durable complete remission. This case demonstrates the benefit of indivdualized therapy in this prognostically desperate disease allowing both limb conservation and maintained quality of life.
PubMed: 10898542
Affiliations:
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Le document en format XML
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<series><title level="j">Anti-cancer drugs</title>
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<term>Aged</term>
<term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term>
<term>Breast Neoplasms (pathology)</term>
<term>Breast Neoplasms (radiotherapy)</term>
<term>Carcinoma, Ductal, Breast (pathology)</term>
<term>Carcinoma, Ductal, Breast (radiotherapy)</term>
<term>Drug Screening Assays, Antitumor</term>
<term>Female</term>
<term>Humans</term>
<term>Infusions, Intra-Arterial</term>
<term>Lymphangiosarcoma (drug therapy)</term>
<term>Lymphangiosarcoma (etiology)</term>
<term>Lymphangiosarcoma (metabolism)</term>
<term>Lymphedema (drug therapy)</term>
<term>Lymphedema (etiology)</term>
<term>Mitoxantrone (administration & dosage)</term>
<term>Neoplasms, Radiation-Induced (drug therapy)</term>
<term>Neoplasms, Radiation-Induced (etiology)</term>
<term>Neoplasms, Radiation-Induced (metabolism)</term>
<term>Paclitaxel (administration & dosage)</term>
<term>Soft Tissue Neoplasms (drug therapy)</term>
<term>Soft Tissue Neoplasms (etiology)</term>
<term>Soft Tissue Neoplasms (metabolism)</term>
<term>Syndrome</term>
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<term>Carcinome canalaire du sein (anatomopathologie)</term>
<term>Carcinome canalaire du sein (radiothérapie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphangiosarcome (métabolisme)</term>
<term>Lymphangiosarcome (traitement médicamenteux)</term>
<term>Lymphangiosarcome (étiologie)</term>
<term>Lymphoedème (traitement médicamenteux)</term>
<term>Lymphoedème (étiologie)</term>
<term>Mitoxantrone (administration et posologie)</term>
<term>Paclitaxel (administration et posologie)</term>
<term>Perfusions artérielles</term>
<term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term>
<term>Sujet âgé</term>
<term>Syndrome</term>
<term>Tests de criblage d'agents antitumoraux</term>
<term>Tumeurs des tissus mous (métabolisme)</term>
<term>Tumeurs des tissus mous (traitement médicamenteux)</term>
<term>Tumeurs des tissus mous (étiologie)</term>
<term>Tumeurs du sein (anatomopathologie)</term>
<term>Tumeurs du sein (radiothérapie)</term>
<term>Tumeurs radio-induites (métabolisme)</term>
<term>Tumeurs radio-induites (traitement médicamenteux)</term>
<term>Tumeurs radio-induites (étiologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Mitoxantrone</term>
<term>Paclitaxel</term>
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<term>Paclitaxel</term>
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<term>Tumeurs du sein</term>
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<term>Lymphedema</term>
<term>Neoplasms, Radiation-Induced</term>
<term>Soft Tissue Neoplasms</term>
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<term>Lymphedema</term>
<term>Neoplasms, Radiation-Induced</term>
<term>Soft Tissue Neoplasms</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphangiosarcoma</term>
<term>Neoplasms, Radiation-Induced</term>
<term>Soft Tissue Neoplasms</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adénosine triphosphate</term>
<term>Lymphangiosarcome</term>
<term>Tumeurs des tissus mous</term>
<term>Tumeurs radio-induites</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
<term>Carcinoma, Ductal, Breast</term>
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<term>Carcinoma, Ductal, Breast</term>
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<term>Lymphoedème</term>
<term>Tumeurs des tissus mous</term>
<term>Tumeurs radio-induites</term>
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<term>Syndrome</term>
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<front><div type="abstract" xml:lang="en">We report on a 72-year-old patient developing Stewart-Treves syndrome (STS) of the right arm 9 years after curative irradiation for ipsilateral stage III breast cancer. Facing the poor track record of both irradiation and chemotherapy in this highly malignant lymphangiosarcoma, amputation was recommended but refused by the patient. Therefore, limb conserving-therapy using three courses of intra-arterial mitoxantrone (MX) and paclitaxel (PTX) was attempted. This novel chemotherapy protocol was selected by pretherapeutic ex vivo ATP-based chemosensitivity testing of autologous tumor tissue. The patient experienced complete response, which was subsequent histologically confirmed by compartment resection. When developing recurrent STS outside of the perfused area 6 months after primary therapy, the patient was retested and reinduced with three other courses of intraarterial MX/PTX which again produced durable complete remission. This case demonstrates the benefit of indivdualized therapy in this prognostically desperate disease allowing both limb conservation and maintained quality of life.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
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<tree><noCountry><name sortKey="Heindel, W" sort="Heindel, W" uniqKey="Heindel W" first="W" last="Heindel">W. Heindel</name>
<name sortKey="Kolhagen, H" sort="Kolhagen, H" uniqKey="Kolhagen H" first="H" last="Kolhagen">H. Kolhagen</name>
<name sortKey="Kurbacher, C M" sort="Kurbacher, C M" uniqKey="Kurbacher C" first="C M" last="Kurbacher">C M Kurbacher</name>
<name sortKey="Mallmann, P" sort="Mallmann, P" uniqKey="Mallmann P" first="P" last="Mallmann">P. Mallmann</name>
<name sortKey="Rein, D" sort="Rein, D" uniqKey="Rein D" first="D" last="Rein">D. Rein</name>
<name sortKey="Schmidt, T" sort="Schmidt, T" uniqKey="Schmidt T" first="T" last="Schmidt">T. Schmidt</name>
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<country name="Allemagne"><noRegion><name sortKey="Breidenbach, M" sort="Breidenbach, M" uniqKey="Breidenbach M" first="M" last="Breidenbach">M. Breidenbach</name>
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