Intra-arterial mitoxantrone and paclitaxel in a patient with Stewart-Treves syndrome: selection of chemotherapy by an ex vivo ATP-based chemosensitivity assay.
Identifieur interne : 004A40 ( PubMed/Corpus ); précédent : 004A39; suivant : 004A41Intra-arterial mitoxantrone and paclitaxel in a patient with Stewart-Treves syndrome: selection of chemotherapy by an ex vivo ATP-based chemosensitivity assay.
Auteurs : M. Breidenbach ; D. Rein ; T. Schmidt ; W. Heindel ; H. Kolhagen ; P. Mallmann ; C M KurbacherSource :
- Anti-cancer drugs [ 0959-4973 ] ; 2000.
English descriptors
- KwdEn :
- Adenosine Triphosphate (metabolism), Aged, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Breast Neoplasms (pathology), Breast Neoplasms (radiotherapy), Carcinoma, Ductal, Breast (pathology), Carcinoma, Ductal, Breast (radiotherapy), Drug Screening Assays, Antitumor, Female, Humans, Infusions, Intra-Arterial, Lymphangiosarcoma (drug therapy), Lymphangiosarcoma (etiology), Lymphangiosarcoma (metabolism), Lymphedema (drug therapy), Lymphedema (etiology), Mitoxantrone (administration & dosage), Neoplasms, Radiation-Induced (drug therapy), Neoplasms, Radiation-Induced (etiology), Neoplasms, Radiation-Induced (metabolism), Paclitaxel (administration & dosage), Soft Tissue Neoplasms (drug therapy), Soft Tissue Neoplasms (etiology), Soft Tissue Neoplasms (metabolism), Syndrome.
- MESH :
- chemical , administration & dosage : Mitoxantrone, Paclitaxel.
- chemical , metabolism : Adenosine Triphosphate.
- drug therapy : Lymphangiosarcoma, Lymphedema, Neoplasms, Radiation-Induced, Soft Tissue Neoplasms.
- etiology : Lymphangiosarcoma, Lymphedema, Neoplasms, Radiation-Induced, Soft Tissue Neoplasms.
- metabolism : Lymphangiosarcoma, Neoplasms, Radiation-Induced, Soft Tissue Neoplasms.
- pathology : Breast Neoplasms, Carcinoma, Ductal, Breast.
- radiotherapy : Breast Neoplasms, Carcinoma, Ductal, Breast.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Aged, Drug Screening Assays, Antitumor, Female, Humans, Infusions, Intra-Arterial, Syndrome.
Abstract
We report on a 72-year-old patient developing Stewart-Treves syndrome (STS) of the right arm 9 years after curative irradiation for ipsilateral stage III breast cancer. Facing the poor track record of both irradiation and chemotherapy in this highly malignant lymphangiosarcoma, amputation was recommended but refused by the patient. Therefore, limb conserving-therapy using three courses of intra-arterial mitoxantrone (MX) and paclitaxel (PTX) was attempted. This novel chemotherapy protocol was selected by pretherapeutic ex vivo ATP-based chemosensitivity testing of autologous tumor tissue. The patient experienced complete response, which was subsequent histologically confirmed by compartment resection. When developing recurrent STS outside of the perfused area 6 months after primary therapy, the patient was retested and reinduced with three other courses of intraarterial MX/PTX which again produced durable complete remission. This case demonstrates the benefit of indivdualized therapy in this prognostically desperate disease allowing both limb conservation and maintained quality of life.
PubMed: 10898542
Links to Exploration step
pubmed:10898542Le document en format XML
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<author><name sortKey="Breidenbach, M" sort="Breidenbach, M" uniqKey="Breidenbach M" first="M" last="Breidenbach">M. Breidenbach</name>
<affiliation><nlm:affiliation>Department of Gynecology and Obstetrics, University of Cologne, Germany. Martina.Breidenbach@medizin.uni-koeln.de</nlm:affiliation>
</affiliation>
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<author><name sortKey="Rein, D" sort="Rein, D" uniqKey="Rein D" first="D" last="Rein">D. Rein</name>
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<author><name sortKey="Schmidt, T" sort="Schmidt, T" uniqKey="Schmidt T" first="T" last="Schmidt">T. Schmidt</name>
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<author><name sortKey="Heindel, W" sort="Heindel, W" uniqKey="Heindel W" first="W" last="Heindel">W. Heindel</name>
</author>
<author><name sortKey="Kolhagen, H" sort="Kolhagen, H" uniqKey="Kolhagen H" first="H" last="Kolhagen">H. Kolhagen</name>
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<author><name sortKey="Mallmann, P" sort="Mallmann, P" uniqKey="Mallmann P" first="P" last="Mallmann">P. Mallmann</name>
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<author><name sortKey="Kurbacher, C M" sort="Kurbacher, C M" uniqKey="Kurbacher C" first="C M" last="Kurbacher">C M Kurbacher</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Intra-arterial mitoxantrone and paclitaxel in a patient with Stewart-Treves syndrome: selection of chemotherapy by an ex vivo ATP-based chemosensitivity assay.</title>
<author><name sortKey="Breidenbach, M" sort="Breidenbach, M" uniqKey="Breidenbach M" first="M" last="Breidenbach">M. Breidenbach</name>
<affiliation><nlm:affiliation>Department of Gynecology and Obstetrics, University of Cologne, Germany. Martina.Breidenbach@medizin.uni-koeln.de</nlm:affiliation>
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<author><name sortKey="Rein, D" sort="Rein, D" uniqKey="Rein D" first="D" last="Rein">D. Rein</name>
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<author><name sortKey="Schmidt, T" sort="Schmidt, T" uniqKey="Schmidt T" first="T" last="Schmidt">T. Schmidt</name>
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<author><name sortKey="Heindel, W" sort="Heindel, W" uniqKey="Heindel W" first="W" last="Heindel">W. Heindel</name>
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<author><name sortKey="Kolhagen, H" sort="Kolhagen, H" uniqKey="Kolhagen H" first="H" last="Kolhagen">H. Kolhagen</name>
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<author><name sortKey="Mallmann, P" sort="Mallmann, P" uniqKey="Mallmann P" first="P" last="Mallmann">P. Mallmann</name>
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<series><title level="j">Anti-cancer drugs</title>
<idno type="ISSN">0959-4973</idno>
<imprint><date when="2000" type="published">2000</date>
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<term>Aged</term>
<term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term>
<term>Breast Neoplasms (pathology)</term>
<term>Breast Neoplasms (radiotherapy)</term>
<term>Carcinoma, Ductal, Breast (pathology)</term>
<term>Carcinoma, Ductal, Breast (radiotherapy)</term>
<term>Drug Screening Assays, Antitumor</term>
<term>Female</term>
<term>Humans</term>
<term>Infusions, Intra-Arterial</term>
<term>Lymphangiosarcoma (drug therapy)</term>
<term>Lymphangiosarcoma (etiology)</term>
<term>Lymphangiosarcoma (metabolism)</term>
<term>Lymphedema (drug therapy)</term>
<term>Lymphedema (etiology)</term>
<term>Mitoxantrone (administration & dosage)</term>
<term>Neoplasms, Radiation-Induced (drug therapy)</term>
<term>Neoplasms, Radiation-Induced (etiology)</term>
<term>Neoplasms, Radiation-Induced (metabolism)</term>
<term>Paclitaxel (administration & dosage)</term>
<term>Soft Tissue Neoplasms (drug therapy)</term>
<term>Soft Tissue Neoplasms (etiology)</term>
<term>Soft Tissue Neoplasms (metabolism)</term>
<term>Syndrome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Mitoxantrone</term>
<term>Paclitaxel</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine Triphosphate</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphangiosarcoma</term>
<term>Lymphedema</term>
<term>Neoplasms, Radiation-Induced</term>
<term>Soft Tissue Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphangiosarcoma</term>
<term>Lymphedema</term>
<term>Neoplasms, Radiation-Induced</term>
<term>Soft Tissue Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphangiosarcoma</term>
<term>Neoplasms, Radiation-Induced</term>
<term>Soft Tissue Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
<term>Carcinoma, Ductal, Breast</term>
</keywords>
<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term>
<term>Carcinoma, Ductal, Breast</term>
</keywords>
<keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Drug Screening Assays, Antitumor</term>
<term>Female</term>
<term>Humans</term>
<term>Infusions, Intra-Arterial</term>
<term>Syndrome</term>
</keywords>
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<front><div type="abstract" xml:lang="en">We report on a 72-year-old patient developing Stewart-Treves syndrome (STS) of the right arm 9 years after curative irradiation for ipsilateral stage III breast cancer. Facing the poor track record of both irradiation and chemotherapy in this highly malignant lymphangiosarcoma, amputation was recommended but refused by the patient. Therefore, limb conserving-therapy using three courses of intra-arterial mitoxantrone (MX) and paclitaxel (PTX) was attempted. This novel chemotherapy protocol was selected by pretherapeutic ex vivo ATP-based chemosensitivity testing of autologous tumor tissue. The patient experienced complete response, which was subsequent histologically confirmed by compartment resection. When developing recurrent STS outside of the perfused area 6 months after primary therapy, the patient was retested and reinduced with three other courses of intraarterial MX/PTX which again produced durable complete remission. This case demonstrates the benefit of indivdualized therapy in this prognostically desperate disease allowing both limb conservation and maintained quality of life.</div>
</front>
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<DateCreated><Year>2000</Year>
<Month>10</Month>
<Day>11</Day>
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<DateCompleted><Year>2000</Year>
<Month>10</Month>
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<DateRevised><Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
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<JournalIssue CitedMedium="Print"><Volume>11</Volume>
<Issue>4</Issue>
<PubDate><Year>2000</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Anti-cancer drugs</Title>
<ISOAbbreviation>Anticancer Drugs</ISOAbbreviation>
</Journal>
<ArticleTitle>Intra-arterial mitoxantrone and paclitaxel in a patient with Stewart-Treves syndrome: selection of chemotherapy by an ex vivo ATP-based chemosensitivity assay.</ArticleTitle>
<Pagination><MedlinePgn>269-73</MedlinePgn>
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<Abstract><AbstractText>We report on a 72-year-old patient developing Stewart-Treves syndrome (STS) of the right arm 9 years after curative irradiation for ipsilateral stage III breast cancer. Facing the poor track record of both irradiation and chemotherapy in this highly malignant lymphangiosarcoma, amputation was recommended but refused by the patient. Therefore, limb conserving-therapy using three courses of intra-arterial mitoxantrone (MX) and paclitaxel (PTX) was attempted. This novel chemotherapy protocol was selected by pretherapeutic ex vivo ATP-based chemosensitivity testing of autologous tumor tissue. The patient experienced complete response, which was subsequent histologically confirmed by compartment resection. When developing recurrent STS outside of the perfused area 6 months after primary therapy, the patient was retested and reinduced with three other courses of intraarterial MX/PTX which again produced durable complete remission. This case demonstrates the benefit of indivdualized therapy in this prognostically desperate disease allowing both limb conservation and maintained quality of life.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Breidenbach</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Gynecology and Obstetrics, University of Cologne, Germany. Martina.Breidenbach@medizin.uni-koeln.de</Affiliation>
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<Author ValidYN="Y"><LastName>Rein</LastName>
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<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schmidt</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
</Author>
<Author ValidYN="Y"><LastName>Heindel</LastName>
<ForeName>W</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kolhagen</LastName>
<ForeName>H</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mallmann</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
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<Author ValidYN="Y"><LastName>Kurbacher</LastName>
<ForeName>C M</ForeName>
<Initials>CM</Initials>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType>
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<ChemicalList><Chemical><RegistryNumber>8L70Q75FXE</RegistryNumber>
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<MeshHeading><DescriptorName UI="D007261" MajorTopicYN="N">Infusions, Intra-Arterial</DescriptorName>
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<MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName>
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<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D017239" MajorTopicYN="N">Paclitaxel</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D012983" MajorTopicYN="N">Soft Tissue Neoplasms</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D013577" MajorTopicYN="N">Syndrome</DescriptorName>
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