Proinflammatory Cytokine Gene Expression by Murine Macrophages in Response to Brugia malayi Wolbachia Surface Protein
Identifieur interne : 007140 ( Main/Exploration ); précédent : 007139; suivant : 007141Proinflammatory Cytokine Gene Expression by Murine Macrophages in Response to Brugia malayi Wolbachia Surface Protein
Auteurs : Chantima Porksakorn [Thaïlande] ; Surang Nuchprayoon [Thaïlande] ; Kiwon Park [États-Unis] ; Alan L. Scott [États-Unis]Source :
- Mediators of Inflammation [ 0962-9351 ] ; 2007.
Abstract
Url:
DOI: 10.1155/2007/84318
PubMed: 17641731
PubMed Central: 1906711
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Proinflammatory Cytokine Gene Expression by Murine Macrophages in Response to <italic>Brugia malayi Wolbachia</italic> Surface Protein</title><author><name sortKey="Porksakorn, Chantima" sort="Porksakorn, Chantima" uniqKey="Porksakorn C" first="Chantima" last="Porksakorn">Chantima Porksakorn</name><affiliation wicri:level="1"><nlm:aff id="a1">Lymphatic Filariasis Research Unit, Department of Parasitology, and Chulalongkorn Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Lymphatic Filariasis Research Unit, Department of Parasitology, and Chulalongkorn Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330</wicri:regionArea><wicri:noRegion>Bangkok 10330</wicri:noRegion></affiliation></author><author><name sortKey="Nuchprayoon, Surang" sort="Nuchprayoon, Surang" uniqKey="Nuchprayoon S" first="Surang" last="Nuchprayoon">Surang Nuchprayoon</name><affiliation wicri:level="1"><nlm:aff id="a1">Lymphatic Filariasis Research Unit, Department of Parasitology, and Chulalongkorn Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Lymphatic Filariasis Research Unit, Department of Parasitology, and Chulalongkorn Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330</wicri:regionArea><wicri:noRegion>Bangkok 10330</wicri:noRegion></affiliation></author><author><name sortKey="Park, Kiwon" sort="Park, Kiwon" uniqKey="Park K" first="Kiwon" last="Park">Kiwon Park</name><affiliation wicri:level="1"><nlm:aff id="a2">Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205</wicri:regionArea><wicri:noRegion>MD 21205</wicri:noRegion></affiliation></author><author><name sortKey="Scott, Alan L" sort="Scott, Alan L" uniqKey="Scott A" first="Alan L." last="Scott">Alan L. Scott</name><affiliation wicri:level="1"><nlm:aff id="a2">Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205</wicri:regionArea><wicri:noRegion>MD 21205</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17641731</idno><idno type="pmc">1906711</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906711</idno><idno type="RBID">PMC:1906711</idno><idno type="doi">10.1155/2007/84318</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">004191</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004191</idno><idno type="wicri:Area/Pmc/Curation">004190</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004190</idno><idno type="wicri:Area/Pmc/Checkpoint">003A98</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003A98</idno><idno type="wicri:Area/Ncbi/Merge">002810</idno><idno type="wicri:Area/Ncbi/Curation">002810</idno><idno type="wicri:Area/Ncbi/Checkpoint">002810</idno><idno type="wicri:doubleKey">0962-9351:2007:Porksakorn C:proinflammatory:cytokine:gene</idno><idno type="wicri:Area/Main/Merge">007268</idno><idno type="wicri:Area/Main/Curation">007140</idno><idno type="wicri:Area/Main/Exploration">007140</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Proinflammatory Cytokine Gene Expression by Murine Macrophages in Response to <italic>Brugia malayi Wolbachia</italic> Surface Protein</title><author><name sortKey="Porksakorn, Chantima" sort="Porksakorn, Chantima" uniqKey="Porksakorn C" first="Chantima" last="Porksakorn">Chantima Porksakorn</name><affiliation wicri:level="1"><nlm:aff id="a1">Lymphatic Filariasis Research Unit, Department of Parasitology, and Chulalongkorn Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Lymphatic Filariasis Research Unit, Department of Parasitology, and Chulalongkorn Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330</wicri:regionArea><wicri:noRegion>Bangkok 10330</wicri:noRegion></affiliation></author><author><name sortKey="Nuchprayoon, Surang" sort="Nuchprayoon, Surang" uniqKey="Nuchprayoon S" first="Surang" last="Nuchprayoon">Surang Nuchprayoon</name><affiliation wicri:level="1"><nlm:aff id="a1">Lymphatic Filariasis Research Unit, Department of Parasitology, and Chulalongkorn Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Lymphatic Filariasis Research Unit, Department of Parasitology, and Chulalongkorn Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330</wicri:regionArea><wicri:noRegion>Bangkok 10330</wicri:noRegion></affiliation></author><author><name sortKey="Park, Kiwon" sort="Park, Kiwon" uniqKey="Park K" first="Kiwon" last="Park">Kiwon Park</name><affiliation wicri:level="1"><nlm:aff id="a2">Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205</wicri:regionArea><wicri:noRegion>MD 21205</wicri:noRegion></affiliation></author><author><name sortKey="Scott, Alan L" sort="Scott, Alan L" uniqKey="Scott A" first="Alan L." last="Scott">Alan L. Scott</name><affiliation wicri:level="1"><nlm:aff id="a2">Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205</wicri:regionArea><wicri:noRegion>MD 21205</wicri:noRegion></affiliation></author></analytic><series><title level="j">Mediators of Inflammation</title><idno type="ISSN">0962-9351</idno><idno type="eISSN">1466-1861</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Wolbachia</italic>, an endosymbiotic bacterium found in most species of filarial parasites, is thought to play a significant role in inducing innate inflammatory responses in lymphatic filariasis patients. However, the <italic>Wolbachia</italic>-derived molecules that are recognized by the innate immune system have not yet been identified. In this study, we exposed the murine macrophage cell line RAW 264.7 to a recombinant form of the major <italic>Wolbachia</italic> surface protein (rWSP) to determine if WSP is capable of innately inducing cytokine transcription. Interleukin (IL)-1<italic>β</italic>, IL-6, and tumor necrosis factor (TNF) mRNAs were all upregulated by the rWSP stimulation in a dose-dependant manner. TNF transcription peaked at 3 hours, whereas IL-1<italic>β</italic> and IL-6 transcription peaked at 6 hours post-rWSP exposure. The levels of innate cytokine expression induced by a high-dose (9.0 <italic>μ</italic>g/mL) rWSP in the RAW 264.7 cells were comparable to the levels induced by 0.1 <italic>μ</italic>g/mL <italic>E. coli</italic>-derived lipopolysaccharides. Pretreatment of the rWSP with
proteinase-K drastically reduced IL-1<italic>β</italic>, IL-6, and TNF transcription. However, the proinflammatory response was not inhibited by polymyxin B treatment. These results strongly suggest that the major <italic>Wolbachia</italic> surface protein molecule WSP is an important inducer of innate immune responses during filarial infections.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name></author><author><name sortKey="Bradley, M" uniqKey="Bradley M">M Bradley</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author><author><name sortKey="Kyelem, D" uniqKey="Kyelem D">D Kyelem</name></author><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Triteeraprapab, S" uniqKey="Triteeraprapab S">S Triteeraprapab</name></author><author><name sortKey="Songtrus, J" uniqKey="Songtrus J">J Songtrus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Triteeraprapab, S" 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sortKey="Nuchprayoon, Surang" sort="Nuchprayoon, Surang" uniqKey="Nuchprayoon S" first="Surang" last="Nuchprayoon">Surang Nuchprayoon</name></country><country name="États-Unis"><noRegion><name sortKey="Park, Kiwon" sort="Park, Kiwon" uniqKey="Park K" first="Kiwon" last="Park">Kiwon Park</name></noRegion><name sortKey="Scott, Alan L" sort="Scott, Alan L" uniqKey="Scott A" first="Alan L." last="Scott">Alan L. 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