Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature
Identifieur interne : 006459 ( Main/Exploration ); précédent : 006458; suivant : 006460Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature
Auteurs : M. Manduch [États-Unis] ; A M Oliveira [États-Unis] ; A G Nascimento [États-Unis] ; A L Folpe [États-Unis]Source :
- Journal of Clinical Pathology [ 0021-9746 ] ; 2009-09.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Cellulite sous-cutanée (diagnostic), Diagnostic différentiel, Femelle, Humains, Jambe (anatomopathologie), Lipome (diagnostic), Lymphocèle (diagnostic), Lymphoedème (anatomopathologie), Lymphoedème (étiologie), Mâle, Obésité morbide (), Sarcomes (diagnostic), Sujet âgé, Tumeurs des tissus mous (diagnostic), Études de suivi, Études rétrospectives.
- MESH :
- anatomopathologie : Jambe, Lymphoedème.
- diagnostic : Cellulite sous-cutanée, Lipome, Lymphocèle, Sarcomes, Tumeurs des tissus mous.
- étiologie : Lymphoedème.
- Adulte, Adulte d'âge moyen, Diagnostic différentiel, Femelle, Humains, Mâle, Obésité morbide, Sujet âgé, Études de suivi, Études rétrospectives.
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Anatomic pathology, Bibliographic review, Cellulitis (diagnosis), Diagnosis, Differential, Female, Follow-Up Studies, Humans, Leg (pathology), Lipoma (diagnosis), Lymphedema, Lymphedema (etiology), Lymphedema (pathology), Lymphocele (diagnosis), Male, Middle Aged, Obesity, Morbid (complications), Retrospective Studies, Sarcoma (diagnosis), Soft Tissue Neoplasms (diagnosis).
- MESH :
- complications : Obesity, Morbid.
- diagnosis : Cellulitis, Lipoma, Lymphocele, Sarcoma, Soft Tissue Neoplasms.
- etiology : Lymphedema.
- pathology : Leg, Lymphedema.
- Adult, Aged, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies.
Abstract
Background: Massive localised lymphoedema (MLL) is a rare, relatively recently described pseudosarcoma most often occurring in morbidly obese patients. Aim: To perform a retrospective review of all cases diagnosed as MLL. Methods and Results: Clinical information was obtained. 22 morbidly obese adults (mean patient weight 186 kg) presented with unilateral, large soft tissue lesions of longstanding duration. Most lesions involved the thigh, but also occurred in the posterior calf and lower leg. Clinically, most lesions were regarded as representing benign processes, including pedunculated lipoma, lymphocoele or recurrent cellulites, although soft tissue sarcoma was also suspected in two cases. Grossly, all masses showed markedly thickened skin with a “cobblestone” appearance, and were ill-defined, unencapsulated, lobulate, and very large (mean size 31 cm, range 15–61.5 cm, mean weight 3386 g, range 1133–10800 g). Histologically, all 22 cases showed striking dermal fibrosis, expansion of the fibrous septa between fat lobules with increased numbers of stromal fibroblasts, lymphatic proliferation and lymphangiectasia. Multinucleated fibroblastic cells, marked vascular proliferation, moderate stromal cellularity and fascicular growth raised concern among referring pathologists for atypical lipomatous tumour/well differentiated liposarcoma, angiosarcoma, and a fibroblastic neoplasm such as fibromatosis in 10, 2 and 1 case, respectively. Conclusion: The diagnosis of MLL continues to be challenging, in particular for pathologists. Awareness of this entity, clinical correlation and gross pathological correlation are essential in the separation of this distinctive pseudosarcoma from its various morphological mimics.
Url:
DOI: 10.1136/jcp.2009.066555
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 003C09
- to stream Istex, to step Curation: 003C09
- to stream Istex, to step Checkpoint: 000B99
- to stream PubMed, to step Corpus: 002D53
- to stream PubMed, to step Curation: 002D53
- to stream PubMed, to step Checkpoint: 002D53
- to stream Ncbi, to step Merge: 003603
- to stream Ncbi, to step Curation: 003603
- to stream Ncbi, to step Checkpoint: 003603
- to stream Main, to step Merge: 006537
- to stream PascalFrancis, to step Corpus: 000313
- to stream PascalFrancis, to step Curation: 000645
- to stream PascalFrancis, to step Checkpoint: 000321
- to stream Main, to step Merge: 006891
- to stream Main, to step Curation: 006459
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature</title><author><name sortKey="Manduch, M" sort="Manduch, M" uniqKey="Manduch M" first="M" last="Manduch">M. Manduch</name></author><author><name sortKey="Oliveira, A M" sort="Oliveira, A M" uniqKey="Oliveira A" first="A M" last="Oliveira">A M Oliveira</name></author><author><name sortKey="Nascimento, A G" sort="Nascimento, A G" uniqKey="Nascimento A" first="A G" last="Nascimento">A G Nascimento</name></author><author><name sortKey="Folpe, A L" sort="Folpe, A L" uniqKey="Folpe A" first="A L" last="Folpe">A L Folpe</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7FAC338BF06FE8F4F504E9F8800B080C4D8B799C</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1136/jcp.2009.066555</idno><idno type="url">https://api.istex.fr/document/7FAC338BF06FE8F4F504E9F8800B080C4D8B799C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003C09</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003C09</idno><idno type="wicri:Area/Istex/Curation">003C09</idno><idno type="wicri:Area/Istex/Checkpoint">000B99</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000B99</idno><idno type="wicri:doubleKey">0021-9746:2009:Manduch M:massive:localised:lymphoedema</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:19734477</idno><idno type="wicri:Area/PubMed/Corpus">002D53</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002D53</idno><idno type="wicri:Area/PubMed/Curation">002D53</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002D53</idno><idno type="wicri:Area/PubMed/Checkpoint">002D53</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002D53</idno><idno type="wicri:Area/Ncbi/Merge">003603</idno><idno type="wicri:Area/Ncbi/Curation">003603</idno><idno type="wicri:Area/Ncbi/Checkpoint">003603</idno><idno type="wicri:Area/Main/Merge">006537</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:09-0361685</idno><idno type="wicri:Area/PascalFrancis/Corpus">000313</idno><idno type="wicri:Area/PascalFrancis/Curation">000645</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000321</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000321</idno><idno type="wicri:doubleKey">0021-9746:2009:Manduch M:massive:localised:lymphoedema</idno><idno type="wicri:Area/Main/Merge">006891</idno><idno type="wicri:Area/Main/Curation">006459</idno><idno type="wicri:Area/Main/Exploration">006459</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature</title><author><name sortKey="Manduch, M" sort="Manduch, M" uniqKey="Manduch M" first="M" last="Manduch">M. Manduch</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Oliveira, A M" sort="Oliveira, A M" uniqKey="Oliveira A" first="A M" last="Oliveira">A M Oliveira</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Nascimento, A G" sort="Nascimento, A G" uniqKey="Nascimento A" first="A G" last="Nascimento">A G Nascimento</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Folpe, A L" sort="Folpe, A L" uniqKey="Folpe A" first="A L" last="Folpe">A L Folpe</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Clinical Pathology</title><title level="j" type="abbrev">J Clin Pathol</title><idno type="ISSN">0021-9746</idno><idno type="eISSN">1472-4146</idno><imprint><publisher>BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><date type="published" when="2009-09">2009-09</date><biblScope unit="volume">62</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="808">808</biblScope></imprint><idno type="ISSN">0021-9746</idno></series><idno type="istex">7FAC338BF06FE8F4F504E9F8800B080C4D8B799C</idno><idno type="DOI">10.1136/jcp.2009.066555</idno><idno type="href">jclinpath-62-808.pdf</idno><idno type="ArticleID">cp66555</idno><idno type="PMID">19734477</idno><idno type="local">jclinpath;62/9/808</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0021-9746</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Anatomic pathology</term><term>Bibliographic review</term><term>Cellulitis (diagnosis)</term><term>Diagnosis, Differential</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Leg (pathology)</term><term>Lipoma (diagnosis)</term><term>Lymphedema</term><term>Lymphedema (etiology)</term><term>Lymphedema (pathology)</term><term>Lymphocele (diagnosis)</term><term>Male</term><term>Middle Aged</term><term>Obesity, Morbid (complications)</term><term>Retrospective Studies</term><term>Sarcoma (diagnosis)</term><term>Soft Tissue Neoplasms (diagnosis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Cellulite sous-cutanée (diagnostic)</term><term>Diagnostic différentiel</term><term>Femelle</term><term>Humains</term><term>Jambe (anatomopathologie)</term><term>Lipome (diagnostic)</term><term>Lymphocèle (diagnostic)</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (étiologie)</term><term>Mâle</term><term>Obésité morbide ()</term><term>Sarcomes (diagnostic)</term><term>Sujet âgé</term><term>Tumeurs des tissus mous (diagnostic)</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Jambe</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Obesity, Morbid</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cellulitis</term><term>Lipoma</term><term>Lymphocele</term><term>Sarcoma</term><term>Soft Tissue Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Cellulite sous-cutanée</term><term>Lipome</term><term>Lymphocèle</term><term>Sarcomes</term><term>Tumeurs des tissus mous</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Leg</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Diagnosis, Differential</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Diagnostic différentiel</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Obésité morbide</term><term>Sujet âgé</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anatomopathologie</term><term>Lymphoedème</term><term>Revue bibliographique</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background: Massive localised lymphoedema (MLL) is a rare, relatively recently described pseudosarcoma most often occurring in morbidly obese patients. Aim: To perform a retrospective review of all cases diagnosed as MLL. Methods and Results: Clinical information was obtained. 22 morbidly obese adults (mean patient weight 186 kg) presented with unilateral, large soft tissue lesions of longstanding duration. Most lesions involved the thigh, but also occurred in the posterior calf and lower leg. Clinically, most lesions were regarded as representing benign processes, including pedunculated lipoma, lymphocoele or recurrent cellulites, although soft tissue sarcoma was also suspected in two cases. Grossly, all masses showed markedly thickened skin with a “cobblestone” appearance, and were ill-defined, unencapsulated, lobulate, and very large (mean size 31 cm, range 15–61.5 cm, mean weight 3386 g, range 1133–10800 g). Histologically, all 22 cases showed striking dermal fibrosis, expansion of the fibrous septa between fat lobules with increased numbers of stromal fibroblasts, lymphatic proliferation and lymphangiectasia. Multinucleated fibroblastic cells, marked vascular proliferation, moderate stromal cellularity and fascicular growth raised concern among referring pathologists for atypical lipomatous tumour/well differentiated liposarcoma, angiosarcoma, and a fibroblastic neoplasm such as fibromatosis in 10, 2 and 1 case, respectively. Conclusion: The diagnosis of MLL continues to be challenging, in particular for pathologists. Awareness of this entity, clinical correlation and gross pathological correlation are essential in the separation of this distinctive pseudosarcoma from its various morphological mimics.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Manduch, M" sort="Manduch, M" uniqKey="Manduch M" first="M" last="Manduch">M. Manduch</name></region><name sortKey="Folpe, A L" sort="Folpe, A L" uniqKey="Folpe A" first="A L" last="Folpe">A L Folpe</name><name sortKey="Nascimento, A G" sort="Nascimento, A G" uniqKey="Nascimento A" first="A G" last="Nascimento">A G Nascimento</name><name sortKey="Oliveira, A M" sort="Oliveira, A M" uniqKey="Oliveira A" first="A M" last="Oliveira">A M Oliveira</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006459 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 006459 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:7FAC338BF06FE8F4F504E9F8800B080C4D8B799C
|texte= Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature
}}
| This area was generated with Dilib version V0.6.31. |  |