Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature.
Identifieur interne : 002D53 ( PubMed/Curation ); précédent : 002D52; suivant : 002D54Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature.
Auteurs : M. Manduch [États-Unis] ; A M Oliveira ; A G Nascimento ; A L FolpeSource :
- Journal of clinical pathology [ 1472-4146 ] ; 2009.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Cellulite sous-cutanée (diagnostic), Diagnostic différentiel, Femelle, Humains, Jambe (anatomopathologie), Lipome (diagnostic), Lymphocèle (diagnostic), Lymphoedème (anatomopathologie), Lymphoedème (étiologie), Mâle, Obésité morbide (), Sarcomes (diagnostic), Sujet âgé, Tumeurs des tissus mous (diagnostic), Études de suivi, Études rétrospectives.
- MESH :
- anatomopathologie : Jambe, Lymphoedème.
- diagnostic : Cellulite sous-cutanée, Lipome, Lymphocèle, Sarcomes, Tumeurs des tissus mous.
- étiologie : Lymphoedème.
- Adulte, Adulte d'âge moyen, Diagnostic différentiel, Femelle, Humains, Mâle, Obésité morbide, Sujet âgé, Études de suivi, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Cellulitis (diagnosis), Diagnosis, Differential, Female, Follow-Up Studies, Humans, Leg (pathology), Lipoma (diagnosis), Lymphedema (etiology), Lymphedema (pathology), Lymphocele (diagnosis), Male, Middle Aged, Obesity, Morbid (complications), Retrospective Studies, Sarcoma (diagnosis), Soft Tissue Neoplasms (diagnosis).
- MESH :
- complications : Obesity, Morbid.
- diagnosis : Cellulitis, Lipoma, Lymphocele, Sarcoma, Soft Tissue Neoplasms.
- etiology : Lymphedema.
- pathology : Leg, Lymphedema.
- Adult, Aged, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies.
Abstract
Massive localised lymphoedema (MLL) is a rare, relatively recently described pseudosarcoma most often occurring in morbidly obese patients.
DOI: 10.1136/jcp.2009.066555
PubMed: 19734477
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pubmed:19734477Le document en format XML
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<author><name sortKey="Oliveira, A M" sort="Oliveira, A M" uniqKey="Oliveira A" first="A M" last="Oliveira">A M Oliveira</name>
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<author><name sortKey="Nascimento, A G" sort="Nascimento, A G" uniqKey="Nascimento A" first="A G" last="Nascimento">A G Nascimento</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cellulitis (diagnosis)</term>
<term>Diagnosis, Differential</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Leg (pathology)</term>
<term>Lipoma (diagnosis)</term>
<term>Lymphedema (etiology)</term>
<term>Lymphedema (pathology)</term>
<term>Lymphocele (diagnosis)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Obesity, Morbid (complications)</term>
<term>Retrospective Studies</term>
<term>Sarcoma (diagnosis)</term>
<term>Soft Tissue Neoplasms (diagnosis)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Cellulite sous-cutanée (diagnostic)</term>
<term>Diagnostic différentiel</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jambe (anatomopathologie)</term>
<term>Lipome (diagnostic)</term>
<term>Lymphocèle (diagnostic)</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Lymphoedème (étiologie)</term>
<term>Mâle</term>
<term>Obésité morbide ()</term>
<term>Sarcomes (diagnostic)</term>
<term>Sujet âgé</term>
<term>Tumeurs des tissus mous (diagnostic)</term>
<term>Études de suivi</term>
<term>Études rétrospectives</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Jambe</term>
<term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Obesity, Morbid</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cellulitis</term>
<term>Lipoma</term>
<term>Lymphocele</term>
<term>Sarcoma</term>
<term>Soft Tissue Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Cellulite sous-cutanée</term>
<term>Lipome</term>
<term>Lymphocèle</term>
<term>Sarcomes</term>
<term>Tumeurs des tissus mous</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Leg</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Diagnosis, Differential</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Diagnostic différentiel</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Obésité morbide</term>
<term>Sujet âgé</term>
<term>Études de suivi</term>
<term>Études rétrospectives</term>
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<front><div type="abstract" xml:lang="en">Massive localised lymphoedema (MLL) is a rare, relatively recently described pseudosarcoma most often occurring in morbidly obese patients.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19734477</PMID>
<DateCreated><Year>2009</Year>
<Month>09</Month>
<Day>07</Day>
</DateCreated>
<DateCompleted><Year>2009</Year>
<Month>12</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2009</Year>
<Month>09</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1472-4146</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>62</Volume>
<Issue>9</Issue>
<PubDate><Year>2009</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Journal of clinical pathology</Title>
<ISOAbbreviation>J. Clin. Pathol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature.</ArticleTitle>
<Pagination><MedlinePgn>808-11</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/jcp.2009.066555</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Massive localised lymphoedema (MLL) is a rare, relatively recently described pseudosarcoma most often occurring in morbidly obese patients.</AbstractText>
<AbstractText Label="AIM" NlmCategory="OBJECTIVE">To perform a retrospective review of all cases diagnosed as MLL.</AbstractText>
<AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Clinical information was obtained. 22 morbidly obese adults (mean patient weight 186 kg) presented with unilateral, large soft tissue lesions of longstanding duration. Most lesions involved the thigh, but also occurred in the posterior calf and lower leg. Clinically, most lesions were regarded as representing benign processes, including pedunculated lipoma, lymphocoele or recurrent cellulites, although soft tissue sarcoma was also suspected in two cases. Grossly, all masses showed markedly thickened skin with a "cobblestone" appearance, and were ill-defined, unencapsulated, lobulate, and very large (mean size 31 cm, range 15-61.5 cm, mean weight 3386 g, range 1133-10,800 g). Histologically, all 22 cases showed striking dermal fibrosis, expansion of the fibrous septa between fat lobules with increased numbers of stromal fibroblasts, lymphatic proliferation and lymphangiectasia. Multinucleated fibroblastic cells, marked vascular proliferation, moderate stromal cellularity and fascicular growth raised concern among referring pathologists for atypical lipomatous tumour/well differentiated liposarcoma, angiosarcoma, and a fibroblastic neoplasm such as fibromatosis in 10, 2 and 1 case, respectively.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The diagnosis of MLL continues to be challenging, in particular for pathologists. Awareness of this entity, clinical correlation and gross pathological correlation are essential in the separation of this distinctive pseudosarcoma from its various morphological mimics.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Manduch</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Oliveira</LastName>
<ForeName>A M</ForeName>
<Initials>AM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Nascimento</LastName>
<ForeName>A G</ForeName>
<Initials>AG</Initials>
</Author>
<Author ValidYN="Y"><LastName>Folpe</LastName>
<ForeName>A L</ForeName>
<Initials>AL</Initials>
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<Language>eng</Language>
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<MedlineJournalInfo><Country>England</Country>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D002481" MajorTopicYN="N">Cellulitis</DescriptorName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D007866" MajorTopicYN="N">Leg</DescriptorName>
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<MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
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<MeshHeading><DescriptorName UI="D008210" MajorTopicYN="N">Lymphocele</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D009767" MajorTopicYN="N">Obesity, Morbid</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
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<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
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<MeshHeading><DescriptorName UI="D012509" MajorTopicYN="N">Sarcoma</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012983" MajorTopicYN="N">Soft Tissue Neoplasms</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
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<NumberOfReferences>23</NumberOfReferences>
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