LymphedemaV1, Main, Exploration, bibRecord, 005A83

18F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer

Identifieur interne : 005A83 ( Main/Exploration ); précédent : 005A82; suivant : 005A84

18F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer

Auteurs : Eun Jung Kong [Corée du Sud] ; Kyung Ah Chun [Corée du Sud] ; Ihn Ho Cho [Corée du Sud] ; Soo Jung Lee [Corée du Sud]

Source :

Nuclear Medicine and Molecular Imaging [ 1869-3474 ] ; 2010.

RBID : PMC:4042929

Abstract

Background

¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography ((PET) safely predicts axillary status in patients with breast cancer, but is not sufficiently accurate in early breast cancer patients. This study analyzed the value of ¹⁸F-FDG PET/computed tomography (CT) with contrast enhancement in detecting axillary lymph node involvement in T1 breast cancer patients.

Methods

Contrast-enhanced ¹⁸F-FDG PET/CT was performed within 20 days of surgery in 143 breast cancer patients with tumors ≤2 cm in size. The patients underwent either axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB), and histopathology reports were used to provide the definitive diagnosis against which the contrast-enhanced ¹⁸F-FDG PET/CT study results were compared.

Results

The sensitivity, specificity, and negative and positive predictive values of contrast-enhanced ¹⁸F-FDG PET/CT in detecting axillary involvement were 70.0%, 92.2%, 88.8%, and 77.8%, respectively, in the entire series of 143 patients, with eight false-positive and 12 false negative results. The false-negative results were associated with the number of metastatic lymph nodes and the rate of FDG uptake.

Conclusion

Contrast-enhanced ¹⁸F-FDG PET/CT cannot replace histologic staging using SLNB in patients with breast cancer, but ¹⁸F-FDG PET/CT increases the sensitivity for predicting axillary node metastasis, and allows for a selective approach to either ALND or SLNB, even in patients with T1 breast cancer.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042929

DOI: 10.1007/s13139-010-0035-y
PubMed: 24899946
PubMed Central: 4042929

Affiliations:

Corée du Sud

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F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer</title>
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F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p><sup>18</sup>
F-fluorodeoxyglucose (<sup>18</sup>
F-FDG) positron emission tomography ((PET) safely predicts axillary status in patients with breast cancer, but is not sufficiently accurate in early breast cancer patients. This study analyzed the value of <sup>18</sup>
F-FDG PET/computed tomography (CT) with contrast enhancement in detecting axillary lymph node involvement in T1 breast cancer patients.</p>
</sec>
<sec><title>Methods</title>
<p>Contrast-enhanced <sup>18</sup>
F-FDG PET/CT was performed within 20 days of surgery in 143 breast cancer patients with tumors ≤2 cm in size. The patients underwent either axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB), and histopathology reports were used to provide the definitive diagnosis against which the contrast-enhanced <sup>18</sup>
F-FDG PET/CT study results were compared.</p>
</sec>
<sec><title>Results</title>
<p>The sensitivity, specificity, and negative and positive predictive values of contrast-enhanced <sup>18</sup>
F-FDG PET/CT in detecting axillary involvement were 70.0%, 92.2%, 88.8%, and 77.8%, respectively, in the entire series of 143 patients, with eight false-positive and 12 false negative results. The false-negative results were associated with the number of metastatic lymph nodes and the rate of FDG uptake.</p>
</sec>
<sec><title>Conclusion</title>
<p>Contrast-enhanced <sup>18</sup>
F-FDG PET/CT cannot replace histologic staging using SLNB in patients with breast cancer, but <sup>18</sup>
F-FDG PET/CT increases the sensitivity for predicting axillary node metastasis, and allows for a selective approach to either ALND or SLNB, even in patients with T1 breast cancer.</p>
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18F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer

18F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer

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Abstract

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