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18F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer

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18F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer

Auteurs : Eun Jung Kong [Corée du Sud] ; Kyung Ah Chun [Corée du Sud] ; Ihn Ho Cho [Corée du Sud] ; Soo Jung Lee [Corée du Sud]

Source :

Nuclear Medicine and Molecular Imaging [ 1869-3474 ] ; 2010.

RBID : PMC:4042929

Abstract

Background

¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography ((PET) safely predicts axillary status in patients with breast cancer, but is not sufficiently accurate in early breast cancer patients. This study analyzed the value of ¹⁸F-FDG PET/computed tomography (CT) with contrast enhancement in detecting axillary lymph node involvement in T1 breast cancer patients.

Methods

Contrast-enhanced ¹⁸F-FDG PET/CT was performed within 20 days of surgery in 143 breast cancer patients with tumors ≤2 cm in size. The patients underwent either axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB), and histopathology reports were used to provide the definitive diagnosis against which the contrast-enhanced ¹⁸F-FDG PET/CT study results were compared.

Results

The sensitivity, specificity, and negative and positive predictive values of contrast-enhanced ¹⁸F-FDG PET/CT in detecting axillary involvement were 70.0%, 92.2%, 88.8%, and 77.8%, respectively, in the entire series of 143 patients, with eight false-positive and 12 false negative results. The false-negative results were associated with the number of metastatic lymph nodes and the rate of FDG uptake.

Conclusion

Contrast-enhanced ¹⁸F-FDG PET/CT cannot replace histologic staging using SLNB in patients with breast cancer, but ¹⁸F-FDG PET/CT increases the sensitivity for predicting axillary node metastasis, and allows for a selective approach to either ALND or SLNB, even in patients with T1 breast cancer.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042929

DOI: 10.1007/s13139-010-0035-y
PubMed: 24899946
PubMed Central: 4042929

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F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer</title>
<author><name sortKey="Kong, Eun Jung" sort="Kong, Eun Jung" uniqKey="Kong E" first="Eun Jung" last="Kong">Eun Jung Kong</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Nuclear Medicine and Surgery, Yeungnam University Hospital, Namgu Daemyung 5-dong 317-1, 705-717 Daegu, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Nuclear Medicine and Surgery, Yeungnam University Hospital, Namgu Daemyung 5-dong 317-1, 705-717 Daegu</wicri:regionArea>
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<author><name sortKey="Chun, Kyung Ah" sort="Chun, Kyung Ah" uniqKey="Chun K" first="Kyung Ah" last="Chun">Kyung Ah Chun</name>
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F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer</title>
<author><name sortKey="Kong, Eun Jung" sort="Kong, Eun Jung" uniqKey="Kong E" first="Eun Jung" last="Kong">Eun Jung Kong</name>
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<author><name sortKey="Chun, Kyung Ah" sort="Chun, Kyung Ah" uniqKey="Chun K" first="Kyung Ah" last="Chun">Kyung Ah Chun</name>
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<author><name sortKey="Cho, Ihn Ho" sort="Cho, Ihn Ho" uniqKey="Cho I" first="Ihn Ho" last="Cho">Ihn Ho Cho</name>
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<author><name sortKey="Lee, Soo Jung" sort="Lee, Soo Jung" uniqKey="Lee S" first="Soo Jung" last="Lee">Soo Jung Lee</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p><sup>18</sup>
F-fluorodeoxyglucose (<sup>18</sup>
F-FDG) positron emission tomography ((PET) safely predicts axillary status in patients with breast cancer, but is not sufficiently accurate in early breast cancer patients. This study analyzed the value of <sup>18</sup>
F-FDG PET/computed tomography (CT) with contrast enhancement in detecting axillary lymph node involvement in T1 breast cancer patients.</p>
</sec>
<sec><title>Methods</title>
<p>Contrast-enhanced <sup>18</sup>
F-FDG PET/CT was performed within 20 days of surgery in 143 breast cancer patients with tumors ≤2 cm in size. The patients underwent either axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB), and histopathology reports were used to provide the definitive diagnosis against which the contrast-enhanced <sup>18</sup>
F-FDG PET/CT study results were compared.</p>
</sec>
<sec><title>Results</title>
<p>The sensitivity, specificity, and negative and positive predictive values of contrast-enhanced <sup>18</sup>
F-FDG PET/CT in detecting axillary involvement were 70.0%, 92.2%, 88.8%, and 77.8%, respectively, in the entire series of 143 patients, with eight false-positive and 12 false negative results. The false-negative results were associated with the number of metastatic lymph nodes and the rate of FDG uptake.</p>
</sec>
<sec><title>Conclusion</title>
<p>Contrast-enhanced <sup>18</sup>
F-FDG PET/CT cannot replace histologic staging using SLNB in patients with breast cancer, but <sup>18</sup>
F-FDG PET/CT increases the sensitivity for predicting axillary node metastasis, and allows for a selective approach to either ALND or SLNB, even in patients with T1 breast cancer.</p>
</sec>
</div>
</front>
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  <front><journal-meta><journal-id journal-id-type="nlm-ta">Nucl Med Mol Imaging</journal-id>
<journal-id journal-id-type="iso-abbrev">Nucl Med Mol Imaging</journal-id>
<journal-title-group><journal-title>Nuclear Medicine and Molecular Imaging</journal-title>
</journal-title-group>
<issn pub-type="ppub">1869-3474</issn>
<issn pub-type="epub">1869-3482</issn>
<publisher><publisher-name>Springer-Verlag</publisher-name>
<publisher-loc>Berlin/Heidelberg</publisher-loc>
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<article-meta><article-id pub-id-type="pmid">24899946</article-id>
<article-id pub-id-type="pmc">4042929</article-id>
<article-id pub-id-type="publisher-id">35</article-id>
<article-id pub-id-type="doi">10.1007/s13139-010-0035-y</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title><sup>18</sup>
F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kong</surname>
<given-names>Eun Jung</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Chun</surname>
<given-names>Kyung Ah</given-names>
</name>
<address><phone>+82-53-6203135</phone>
<fax>+82-53-6517415</fax>
<email>cka52@yumail.ac.kr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cho</surname>
<given-names>Ihn Ho</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Soo Jung</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1">Department of Nuclear Medicine and Surgery, Yeungnam University Hospital, Namgu Daemyung 5-dong 317-1, 705-717 Daegu, Korea</aff>
</contrib-group>
<pub-date pub-type="epub"><day>15</day>
<month>6</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><month>9</month>
<year>2010</year>
</pub-date>
<volume>44</volume>
<issue>3</issue>
<fpage>170</fpage>
<lpage>176</lpage>
<history><date date-type="received"><day>22</day>
<month>3</month>
<year>2010</year>
</date>
<date date-type="rev-recd"><day>10</day>
<month>5</month>
<year>2010</year>
</date>
<date date-type="accepted"><day>12</day>
<month>5</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>© Korean Society of Nuclear Medicine 2010</copyright-statement>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p><sup>18</sup>
F-fluorodeoxyglucose (<sup>18</sup>
F-FDG) positron emission tomography ((PET) safely predicts axillary status in patients with breast cancer, but is not sufficiently accurate in early breast cancer patients. This study analyzed the value of <sup>18</sup>
F-FDG PET/computed tomography (CT) with contrast enhancement in detecting axillary lymph node involvement in T1 breast cancer patients.</p>
</sec>
<sec><title>Methods</title>
<p>Contrast-enhanced <sup>18</sup>
F-FDG PET/CT was performed within 20 days of surgery in 143 breast cancer patients with tumors ≤2 cm in size. The patients underwent either axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB), and histopathology reports were used to provide the definitive diagnosis against which the contrast-enhanced <sup>18</sup>
F-FDG PET/CT study results were compared.</p>
</sec>
<sec><title>Results</title>
<p>The sensitivity, specificity, and negative and positive predictive values of contrast-enhanced <sup>18</sup>
F-FDG PET/CT in detecting axillary involvement were 70.0%, 92.2%, 88.8%, and 77.8%, respectively, in the entire series of 143 patients, with eight false-positive and 12 false negative results. The false-negative results were associated with the number of metastatic lymph nodes and the rate of FDG uptake.</p>
</sec>
<sec><title>Conclusion</title>
<p>Contrast-enhanced <sup>18</sup>
F-FDG PET/CT cannot replace histologic staging using SLNB in patients with breast cancer, but <sup>18</sup>
F-FDG PET/CT increases the sensitivity for predicting axillary node metastasis, and allows for a selective approach to either ALND or SLNB, even in patients with T1 breast cancer.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Breast cancer</kwd>
<kwd>Axillary lymph node</kwd>
<kwd>FDG</kwd>
<kwd>PET/CT</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© Korean Society of Nuclear Medicine 2010</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>

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18F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer

18F-FDG PET/CT with Contrast Enhancement for Evaluation of Axillary Lymph Node Involvement in T1 Breast Cancer

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