Photoacoustic Sentinel Lymph Node Imaging with Self-Assembled Copper Neodecanoate Nanoparticles
Identifieur interne : 004018 ( Main/Exploration ); précédent : 004017; suivant : 004019Photoacoustic Sentinel Lymph Node Imaging with Self-Assembled Copper Neodecanoate Nanoparticles
Auteurs : Dipanjan Pan ; Xin Cai ; Ceren Yalaz ; Angana Senpan ; Karthik Omanakuttan ; Samuel A. Wickline ; Lihong V. Wang ; Gregory M. LanzaSource :
- ACS Nano [ 1936-0851 ] ; 2012.
Abstract
Photoacoustic tomography (PAT) is emerging as a novel, hybrid, and non ionizing imaging modality, because of its satisfactory spatial resolution and high soft tissue contrast. PAT combines the advantages of both optical and ultrasonic imaging methods. It opens up the possibilities for non-invasive staging of breast cancer and may replace sentinel lymph node (SLN) biopsy in clinic in the near future. In this work, we demonstrate for the first time that Copper can be used as a contrast metal for near infrared detection of SLN using PAT. A unique strategy is adopted to encapsulate multiple copies of Cu as organically soluble small molecule complexes within a phospholipids-entrapped nanoparticle. The nanoparticles assumed a size of 80–90nm, which is the optimum hydrodynamic diameter for its distribution throughout the lymphatic systems. These particles provided at least six times higher signal sensitivity in comparison to blood, which is a natural absorber of light. We also demonstrated that high SLN detection sensitivity with PAT can be achieved in rodent model. This work clearly demonstrates for the first time, the potential use of copper as an optical contrast agent.
Url:
DOI: 10.1021/nn203895n
PubMed: 22229462
PubMed Central: 3289744
Affiliations:
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Wickline</name></author><author><name sortKey="Wang, Lihong V" sort="Wang, Lihong V" uniqKey="Wang L" first="Lihong V." last="Wang">Lihong V. Wang</name></author><author><name sortKey="Lanza, Gregory M" sort="Lanza, Gregory M" uniqKey="Lanza G" first="Gregory M." last="Lanza">Gregory M. 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Wickline</name></author><author><name sortKey="Wang, Lihong V" sort="Wang, Lihong V" uniqKey="Wang L" first="Lihong V." last="Wang">Lihong V. Wang</name></author><author><name sortKey="Lanza, Gregory M" sort="Lanza, Gregory M" uniqKey="Lanza G" first="Gregory M." last="Lanza">Gregory M. Lanza</name></author></analytic><series><title level="j">ACS Nano</title><idno type="ISSN">1936-0851</idno><idno type="eISSN">1936-086X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Photoacoustic tomography (PAT) is emerging as a novel, hybrid, and non ionizing imaging modality, because of its satisfactory spatial resolution and high soft tissue contrast. PAT combines the advantages of both optical and ultrasonic imaging methods. It opens up the possibilities for non-invasive staging of breast cancer and may replace sentinel lymph node (SLN) biopsy in clinic in the near future. In this work, we demonstrate for the first time that Copper can be used as a contrast metal for near infrared detection of SLN using PAT. A unique strategy is adopted to encapsulate multiple copies of Cu as organically soluble small molecule complexes within a phospholipids-entrapped nanoparticle. The nanoparticles assumed a size of 80–90nm, which is the optimum hydrodynamic diameter for its distribution throughout the lymphatic systems. These particles provided at least six times higher signal sensitivity in comparison to blood, which is a natural absorber of light. We also demonstrated that high SLN detection sensitivity with PAT can be achieved in rodent model. This work clearly demonstrates for the first time, the potential use of copper as an optical contrast agent.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cai, Xin" sort="Cai, Xin" uniqKey="Cai X" first="Xin" last="Cai">Xin Cai</name><name sortKey="Lanza, Gregory M" sort="Lanza, Gregory M" uniqKey="Lanza G" first="Gregory M." last="Lanza">Gregory M. Lanza</name><name sortKey="Omanakuttan, Karthik" sort="Omanakuttan, Karthik" uniqKey="Omanakuttan K" first="Karthik" last="Omanakuttan">Karthik Omanakuttan</name><name sortKey="Pan, Dipanjan" sort="Pan, Dipanjan" uniqKey="Pan D" first="Dipanjan" last="Pan">Dipanjan Pan</name><name sortKey="Senpan, Angana" sort="Senpan, Angana" uniqKey="Senpan A" first="Angana" last="Senpan">Angana Senpan</name><name sortKey="Wang, Lihong V" sort="Wang, Lihong V" uniqKey="Wang L" first="Lihong V." last="Wang">Lihong V. Wang</name><name sortKey="Wickline, Samuel A" sort="Wickline, Samuel A" uniqKey="Wickline S" first="Samuel A." last="Wickline">Samuel A. Wickline</name><name sortKey="Yalaz, Ceren" sort="Yalaz, Ceren" uniqKey="Yalaz C" first="Ceren" last="Yalaz">Ceren Yalaz</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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