Photoacoustic Sentinel Lymph Node Imaging with Self-Assembled Copper Neodecanoate Nanoparticles
Identifieur interne : 004955 ( Ncbi/Merge ); précédent : 004954; suivant : 004956Photoacoustic Sentinel Lymph Node Imaging with Self-Assembled Copper Neodecanoate Nanoparticles
Auteurs : Dipanjan Pan ; Xin Cai ; Ceren Yalaz ; Angana Senpan ; Karthik Omanakuttan ; Samuel A. Wickline ; Lihong V. Wang ; Gregory M. LanzaSource :
- ACS Nano [ 1936-0851 ] ; 2012.
Abstract
Photoacoustic tomography (PAT) is emerging as a novel, hybrid, and non ionizing imaging modality, because of its satisfactory spatial resolution and high soft tissue contrast. PAT combines the advantages of both optical and ultrasonic imaging methods. It opens up the possibilities for non-invasive staging of breast cancer and may replace sentinel lymph node (SLN) biopsy in clinic in the near future. In this work, we demonstrate for the first time that Copper can be used as a contrast metal for near infrared detection of SLN using PAT. A unique strategy is adopted to encapsulate multiple copies of Cu as organically soluble small molecule complexes within a phospholipids-entrapped nanoparticle. The nanoparticles assumed a size of 80–90nm, which is the optimum hydrodynamic diameter for its distribution throughout the lymphatic systems. These particles provided at least six times higher signal sensitivity in comparison to blood, which is a natural absorber of light. We also demonstrated that high SLN detection sensitivity with PAT can be achieved in rodent model. This work clearly demonstrates for the first time, the potential use of copper as an optical contrast agent.
Url:
DOI: 10.1021/nn203895n
PubMed: 22229462
PubMed Central: 3289744
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<front><div type="abstract" xml:lang="en"><p id="P1">Photoacoustic tomography (PAT) is emerging as a novel, hybrid, and non ionizing imaging modality, because of its satisfactory spatial resolution and high soft tissue contrast. PAT combines the advantages of both optical and ultrasonic imaging methods. It opens up the possibilities for non-invasive staging of breast cancer and may replace sentinel lymph node (SLN) biopsy in clinic in the near future. In this work, we demonstrate for the first time that Copper can be used as a contrast metal for near infrared detection of SLN using PAT. A unique strategy is adopted to encapsulate multiple copies of Cu as organically soluble small molecule complexes within a phospholipids-entrapped nanoparticle. The nanoparticles assumed a size of 80–90nm, which is the optimum hydrodynamic diameter for its distribution throughout the lymphatic systems. These particles provided at least six times higher signal sensitivity in comparison to blood, which is a natural absorber of light. We also demonstrated that high SLN detection sensitivity with PAT can be achieved in rodent model. This work clearly demonstrates for the first time, the potential use of copper as an optical contrast agent.</p>
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<pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101313589</journal-id>
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<title-group><article-title>Photoacoustic Sentinel Lymph Node Imaging with Self-Assembled Copper Neodecanoate Nanoparticles</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Pan</surname>
<given-names>Dipanjan</given-names>
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<xref rid="FN1" ref-type="author-notes">*</xref>
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<contrib contrib-type="author"><name><surname>Cai</surname>
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<contrib contrib-type="author"><name><surname>Yalaz</surname>
<given-names>Ceren</given-names>
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<contrib contrib-type="author"><name><surname>Senpan</surname>
<given-names>Angana</given-names>
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<contrib contrib-type="author"><name><surname>Omanakuttan</surname>
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<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Lihong V.</given-names>
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<xref rid="FN1" ref-type="author-notes">*</xref>
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<contrib contrib-type="author"><name><surname>Lanza</surname>
<given-names>Gregory M.</given-names>
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<aff id="A1">C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108 AND Department of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, Saint Louis, MO 63110</aff>
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<author-notes><corresp id="FN1">AUTHOR ADDRESS <email>dipanjan@wustl.edu</email>
(Nanoparticle) AND <email>lhwang@biomed.wustl.edu</email>
(Photoacoustics)</corresp>
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<pub-date pub-type="nihms-submitted"><day>12</day>
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<pub-date pub-type="pmc-release"><day>28</day>
<month>2</month>
<year>2013</year>
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<volume>6</volume>
<issue>2</issue>
<fpage>1260</fpage>
<lpage>1267</lpage>
<abstract><p id="P1">Photoacoustic tomography (PAT) is emerging as a novel, hybrid, and non ionizing imaging modality, because of its satisfactory spatial resolution and high soft tissue contrast. PAT combines the advantages of both optical and ultrasonic imaging methods. It opens up the possibilities for non-invasive staging of breast cancer and may replace sentinel lymph node (SLN) biopsy in clinic in the near future. In this work, we demonstrate for the first time that Copper can be used as a contrast metal for near infrared detection of SLN using PAT. A unique strategy is adopted to encapsulate multiple copies of Cu as organically soluble small molecule complexes within a phospholipids-entrapped nanoparticle. The nanoparticles assumed a size of 80–90nm, which is the optimum hydrodynamic diameter for its distribution throughout the lymphatic systems. These particles provided at least six times higher signal sensitivity in comparison to blood, which is a natural absorber of light. We also demonstrated that high SLN detection sensitivity with PAT can be achieved in rodent model. This work clearly demonstrates for the first time, the potential use of copper as an optical contrast agent.</p>
</abstract>
<kwd-group><kwd>Copper</kwd>
<kwd>Nanoparticle</kwd>
<kwd>Optical Imaging</kwd>
<kwd>Contrast Agent</kwd>
<kwd>Photoacoustic Imaging</kwd>
<kwd>Sentinel Lymph Node</kwd>
<kwd>Breast Cancer Staging</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>R01 CA154737-01A1 || CA</award-id>
</award-group>
</funding-group>
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<name sortKey="Omanakuttan, Karthik" sort="Omanakuttan, Karthik" uniqKey="Omanakuttan K" first="Karthik" last="Omanakuttan">Karthik Omanakuttan</name>
<name sortKey="Pan, Dipanjan" sort="Pan, Dipanjan" uniqKey="Pan D" first="Dipanjan" last="Pan">Dipanjan Pan</name>
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<name sortKey="Wang, Lihong V" sort="Wang, Lihong V" uniqKey="Wang L" first="Lihong V." last="Wang">Lihong V. Wang</name>
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