Point-of-care quantification of blood-borne filarial parasites with a mobile phone microscope.
Identifieur interne : 001984 ( Main/Exploration ); précédent : 001983; suivant : 001985Point-of-care quantification of blood-borne filarial parasites with a mobile phone microscope.
Auteurs : Michael V. D'Ambrosio [États-Unis] ; Matthew Bakalar [États-Unis] ; Sasisekhar Bennuru [États-Unis] ; Clay Reber [États-Unis] ; Arunan Skandarajah [États-Unis] ; Lina Nilsson [États-Unis] ; Neil Switz [États-Unis] ; Joseph Kamgno [Cameroun] ; Sébastien Pion [France] ; Michel Boussinesq [France] ; Thomas B. Nutman [États-Unis] ; Daniel A. Fletcher [États-Unis]Source :
- Science translational medicine [ 1946-6242 ] ; 2015.
Descripteurs français
- KwdFr :
- Afrique centrale, Algorithmes, Animaux, Automatisation, Cameroun, Déplacement, Faux négatifs, Filariose lymphatique (diagnostic), Loa (isolement et purification), Onchocercose (diagnostic), Reproductibilité des résultats, Sensibilité et spécificité, Systèmes automatisés lit malade, Traitement d'image par ordinateur, Téléphones portables, Vidéomicroscopie ().
- MESH :
- diagnostic : Filariose lymphatique, Onchocercose.
- isolement et purification : Loa.
- Afrique centrale, Algorithmes, Animaux, Automatisation, Cameroun, Déplacement, Faux négatifs, Reproductibilité des résultats, Sensibilité et spécificité, Systèmes automatisés lit malade, Traitement d'image par ordinateur, Téléphones portables, Vidéomicroscopie.
- Wicri :
- geographic : Cameroun.
English descriptors
- KwdEn :
- Africa, Central, Algorithms, Animals, Automation, Cameroon, Cell Phones, Elephantiasis, Filarial (diagnosis), False Negative Reactions, Image Processing, Computer-Assisted, Loa (isolation & purification), Microscopy, Video (methods), Motion, Onchocerciasis (diagnosis), Point-of-Care Systems, Reproducibility of Results, Sensitivity and Specificity.
- MESH :
- geographic : Africa, Central, Cameroon.
- diagnosis : Elephantiasis, Filarial, Onchocerciasis.
- isolation & purification : Loa.
- methods : Microscopy, Video.
- Algorithms, Animals, Automation, Cell Phones, False Negative Reactions, Image Processing, Computer-Assisted, Motion, Point-of-Care Systems, Reproducibility of Results, Sensitivity and Specificity.
Abstract
Parasitic helminths cause debilitating diseases that affect millions of people in primarily low-resource settings. Efforts to eliminate onchocerciasis and lymphatic filariasis in Central Africa through mass drug administration have been suspended because of ivermectin-associated serious adverse events, including death, in patients infected with the filarial parasite Loa loa. To safely administer ivermectin for onchocerciasis or lymphatic filariasis in regions co-endemic with L. loa, a strategy termed "test and (not) treat" has been proposed whereby those with high levels of L. loa microfilariae (>30,000/ml) that put them at risk for life-threatening serious adverse events are identified and excluded from mass drug administration. To enable this, we developed a mobile phone-based video microscope that automatically quantifies L. loa microfilariae in whole blood loaded directly into a small glass capillary from a fingerprick without the need for conventional sample preparation or staining. This point-of-care device automatically captures and analyzes videos of microfilarial motion in whole blood using motorized sample scanning and onboard motion detection, minimizing input from health care workers and providing a quantification of microfilariae per milliliter of whole blood in under 2 min. To validate performance and usability of the mobile phone microscope, we tested 33 potentially Loa-infected patients in Cameroon and confirmed that automated counts correlated with manual thick smear counts (94% specificity; 100% sensitivity). Use of this technology to exclude patients from ivermectin-based treatment at the point of care in Loa-endemic regions would allow resumption/expansion of mass drug administration programs for onchocerciasis and lymphatic filariasis in Central Africa.
DOI: 10.1126/scitranslmed.aaa3480
PubMed: 25947164
Affiliations:
- Cameroun, France, États-Unis
- Californie, Languedoc-Roussillon, Maryland, Occitanie (région administrative)
- Montpellier
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Parasitic helminths cause debilitating diseases that affect millions of people in primarily low-resource settings. Efforts to eliminate onchocerciasis and lymphatic filariasis in Central Africa through mass drug administration have been suspended because of ivermectin-associated serious adverse events, including death, in patients infected with the filarial parasite Loa loa. To safely administer ivermectin for onchocerciasis or lymphatic filariasis in regions co-endemic with L. loa, a strategy termed "test and (not) treat" has been proposed whereby those with high levels of L. loa microfilariae (>30,000/ml) that put them at risk for life-threatening serious adverse events are identified and excluded from mass drug administration. To enable this, we developed a mobile phone-based video microscope that automatically quantifies L. loa microfilariae in whole blood loaded directly into a small glass capillary from a fingerprick without the need for conventional sample preparation or staining. This point-of-care device automatically captures and analyzes videos of microfilarial motion in whole blood using motorized sample scanning and onboard motion detection, minimizing input from health care workers and providing a quantification of microfilariae per milliliter of whole blood in under 2 min. To validate performance and usability of the mobile phone microscope, we tested 33 potentially Loa-infected patients in Cameroon and confirmed that automated counts correlated with manual thick smear counts (94% specificity; 100% sensitivity). Use of this technology to exclude patients from ivermectin-based treatment at the point of care in Loa-endemic regions would allow resumption/expansion of mass drug administration programs for onchocerciasis and lymphatic filariasis in Central Africa.</div>
</front>
</TEI>
<affiliations><list><country><li>Cameroun</li>
<li>France</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Languedoc-Roussillon</li>
<li>Maryland</li>
<li>Occitanie (région administrative)</li>
</region>
<settlement><li>Montpellier</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="D Ambrosio, Michael V" sort="D Ambrosio, Michael V" uniqKey="D Ambrosio M" first="Michael V" last="D'Ambrosio">Michael V. D'Ambrosio</name>
</region>
<name sortKey="Bakalar, Matthew" sort="Bakalar, Matthew" uniqKey="Bakalar M" first="Matthew" last="Bakalar">Matthew Bakalar</name>
<name sortKey="Bennuru, Sasisekhar" sort="Bennuru, Sasisekhar" uniqKey="Bennuru S" first="Sasisekhar" last="Bennuru">Sasisekhar Bennuru</name>
<name sortKey="Fletcher, Daniel A" sort="Fletcher, Daniel A" uniqKey="Fletcher D" first="Daniel A" last="Fletcher">Daniel A. Fletcher</name>
<name sortKey="Nilsson, Lina" sort="Nilsson, Lina" uniqKey="Nilsson L" first="Lina" last="Nilsson">Lina Nilsson</name>
<name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B" last="Nutman">Thomas B. Nutman</name>
<name sortKey="Reber, Clay" sort="Reber, Clay" uniqKey="Reber C" first="Clay" last="Reber">Clay Reber</name>
<name sortKey="Skandarajah, Arunan" sort="Skandarajah, Arunan" uniqKey="Skandarajah A" first="Arunan" last="Skandarajah">Arunan Skandarajah</name>
<name sortKey="Switz, Neil" sort="Switz, Neil" uniqKey="Switz N" first="Neil" last="Switz">Neil Switz</name>
</country>
<country name="Cameroun"><noRegion><name sortKey="Kamgno, Joseph" sort="Kamgno, Joseph" uniqKey="Kamgno J" first="Joseph" last="Kamgno">Joseph Kamgno</name>
</noRegion>
</country>
<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Pion, Sebastien" sort="Pion, Sebastien" uniqKey="Pion S" first="Sébastien" last="Pion">Sébastien Pion</name>
</region>
<name sortKey="Boussinesq, Michel" sort="Boussinesq, Michel" uniqKey="Boussinesq M" first="Michel" last="Boussinesq">Michel Boussinesq</name>
</country>
</tree>
</affiliations>
</record>
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