LymphedemaV1, Main, Exploration, bibRecord, 000A86

Successful treatment of cutaneous squamous cell carcinoma with intralesional cryosurgery

Identifieur interne : 000A86 ( Main/Exploration ); précédent : 000A85; suivant : 000A87

Successful treatment of cutaneous squamous cell carcinoma with intralesional cryosurgery

Auteurs : Chaw-Ning Lee ; Shin-Chen Pan ; Julia Yu-Yun Lee ; Tak-Wah Wong [Taïwan]

Source :

Medicine [ 0025-7974 ] ; 2016.

RBID : PMC:5265949

Abstract

AbstractBackground:

Wide excision or Mohs surgery is the standard treatment of skin squamous cell carcinoma (SCC). Superficial SCC or tumor smaller than 1 cm has been treated successfully with open spray cryosurgery. Larger tumor may not be as effective because tissue destruction is usually superficial. Intralesional cryosurgery (IC) may provide a deeper and better cell killing effect in larger tumors. We investigated the safety and efficacy of treating nodular SCC in 4 patients with IC.

Methods:

Four patients with nodular SCC/keratoacanthoma (tumor size, 1–2.5 cm, average 1.48 cm) on the face and extremity were treated with IC. An 18-ga needle was connected to a cryogun and inserted into the center of the tumor after local anesthesia. The tumors were treated with 2 freeze–thaw cycles with a 5- to 10-mm free margin. Additional IC or open spray cryosurgery was applied if residual tumor was noted during monthly follow-up.

Results:

No patient required analgesics or experienced wound infection after the procedures. After IC, all tumors reduced 40% to 75% in size within 1 week. Two patients received 1 additional spray cryosurgery. Complete remission was noted in all tumors (100%) in 2 months. No recurrence was noted during follow-up (average 5.1 years). All patients were satisfied with the results.

Conclusion:

Our observation suggests that IC can be simple and effective alternative treatment for SCC patients whose condition is not suitable for or who refused operation.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265949

DOI: 10.1097/MD.0000000000004991
PubMed: 27684856
PubMed Central: 5265949

Affiliations:

Taïwan

Le document en format XML

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<author><name sortKey="Lee, Chaw Ning" sort="Lee, Chaw Ning" uniqKey="Lee C" first="Chaw-Ning" last="Lee">Chaw-Ning Lee</name>
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<author><name sortKey="Pan, Shin Chen" sort="Pan, Shin Chen" uniqKey="Pan S" first="Shin-Chen" last="Pan">Shin-Chen Pan</name>
<affiliation><nlm:aff id="aff2">Section of Plastic and Reconstructive Surgery, Department of Surgery, National Cheng Kung University Hospital</nlm:aff>
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<author><name sortKey="Lee, Julia Yu Yun" sort="Lee, Julia Yu Yun" uniqKey="Lee J" first="Julia Yu-Yun" last="Lee">Julia Yu-Yun Lee</name>
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<p>Wide excision or Mohs surgery is the standard treatment of skin squamous cell carcinoma (SCC). Superficial SCC or tumor smaller than 1 cm has been treated successfully with open spray cryosurgery. Larger tumor may not be as effective because tissue destruction is usually superficial. Intralesional cryosurgery (IC) may provide a deeper and better cell killing effect in larger tumors. We investigated the safety and efficacy of treating nodular SCC in 4 patients with IC.</p>
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<p>Four patients with nodular SCC/keratoacanthoma (tumor size, 1–2.5 cm, average 1.48 cm) on the face and extremity were treated with IC. An 18-ga needle was connected to a cryogun and inserted into the center of the tumor after local anesthesia. The tumors were treated with 2 freeze–thaw cycles with a 5- to 10-mm free margin. Additional IC or open spray cryosurgery was applied if residual tumor was noted during monthly follow-up.</p>
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<p>No patient required analgesics or experienced wound infection after the procedures. After IC, all tumors reduced 40% to 75% in size within 1 week. Two patients received 1 additional spray cryosurgery. Complete remission was noted in all tumors (100%) in 2 months. No recurrence was noted during follow-up (average 5.1 years). All patients were satisfied with the results.</p>
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Successful treatment of cutaneous squamous cell carcinoma with intralesional cryosurgery

Successful treatment of cutaneous squamous cell carcinoma with intralesional cryosurgery

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Abstract

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