Successful treatment of cutaneous squamous cell carcinoma with intralesional cryosurgery
Identifieur interne : 002348 ( Pmc/Corpus ); précédent : 002347; suivant : 002349Successful treatment of cutaneous squamous cell carcinoma with intralesional cryosurgery
Auteurs : Chaw-Ning Lee ; Shin-Chen Pan ; Julia Yu-Yun Lee ; Tak-Wah WongSource :
- Medicine [ 0025-7974 ] ; 2016.
Abstract
Wide excision or Mohs surgery is the standard treatment of skin squamous cell carcinoma (SCC). Superficial SCC or tumor smaller than 1 cm has been treated successfully with open spray cryosurgery. Larger tumor may not be as effective because tissue destruction is usually superficial. Intralesional cryosurgery (IC) may provide a deeper and better cell killing effect in larger tumors. We investigated the safety and efficacy of treating nodular SCC in 4 patients with IC.
Four patients with nodular SCC/keratoacanthoma (tumor size, 1–2.5 cm, average 1.48 cm) on the face and extremity were treated with IC. An 18-ga needle was connected to a cryogun and inserted into the center of the tumor after local anesthesia. The tumors were treated with 2 freeze–thaw cycles with a 5- to 10-mm free margin. Additional IC or open spray cryosurgery was applied if residual tumor was noted during monthly follow-up.
No patient required analgesics or experienced wound infection after the procedures. After IC, all tumors reduced 40% to 75% in size within 1 week. Two patients received 1 additional spray cryosurgery. Complete remission was noted in all tumors (100%) in 2 months. No recurrence was noted during follow-up (average 5.1 years). All patients were satisfied with the results.
Our observation suggests that IC can be simple and effective alternative treatment for SCC patients whose condition is not suitable for or who refused operation.
Url:
DOI: 10.1097/MD.0000000000004991
PubMed: 27684856
PubMed Central: 5265949
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Successful treatment of cutaneous squamous cell carcinoma with intralesional cryosurgery</title><author><name sortKey="Lee, Chaw Ning" sort="Lee, Chaw Ning" uniqKey="Lee C" first="Chaw-Ning" last="Lee">Chaw-Ning Lee</name><affiliation><nlm:aff id="aff1">Department of Dermatology</nlm:aff></affiliation></author><author><name sortKey="Pan, Shin Chen" sort="Pan, Shin Chen" uniqKey="Pan S" first="Shin-Chen" last="Pan">Shin-Chen Pan</name><affiliation><nlm:aff id="aff2">Section of Plastic and Reconstructive Surgery, Department of Surgery, National Cheng Kung University Hospital</nlm:aff></affiliation></author><author><name sortKey="Lee, Julia Yu Yun" sort="Lee, Julia Yu Yun" uniqKey="Lee J" first="Julia Yu-Yun" last="Lee">Julia Yu-Yun Lee</name><affiliation><nlm:aff id="aff1">Department of Dermatology</nlm:aff></affiliation></author><author><name sortKey="Wong, Tak Wah" sort="Wong, Tak Wah" uniqKey="Wong T" first="Tak-Wah" last="Wong">Tak-Wah Wong</name><affiliation><nlm:aff id="aff1">Department of Dermatology</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27684856</idno><idno type="pmc">5265949</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265949</idno><idno type="RBID">PMC:5265949</idno><idno type="doi">10.1097/MD.0000000000004991</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002348</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002348</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Successful treatment of cutaneous squamous cell carcinoma with intralesional cryosurgery</title><author><name sortKey="Lee, Chaw Ning" sort="Lee, Chaw Ning" uniqKey="Lee C" first="Chaw-Ning" last="Lee">Chaw-Ning Lee</name><affiliation><nlm:aff id="aff1">Department of Dermatology</nlm:aff></affiliation></author><author><name sortKey="Pan, Shin Chen" sort="Pan, Shin Chen" uniqKey="Pan S" first="Shin-Chen" last="Pan">Shin-Chen Pan</name><affiliation><nlm:aff id="aff2">Section of Plastic and Reconstructive Surgery, Department of Surgery, National Cheng Kung University Hospital</nlm:aff></affiliation></author><author><name sortKey="Lee, Julia Yu Yun" sort="Lee, Julia Yu Yun" uniqKey="Lee J" first="Julia Yu-Yun" last="Lee">Julia Yu-Yun Lee</name><affiliation><nlm:aff id="aff1">Department of Dermatology</nlm:aff></affiliation></author><author><name sortKey="Wong, Tak Wah" sort="Wong, Tak Wah" uniqKey="Wong T" first="Tak-Wah" last="Wong">Tak-Wah Wong</name><affiliation><nlm:aff id="aff1">Department of Dermatology</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.</nlm:aff></affiliation></author></analytic><series><title level="j">Medicine</title><idno type="ISSN">0025-7974</idno><idno type="eISSN">1536-5964</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec sec-type="background"><title>Background:</title><p>Wide excision or Mohs surgery is the standard treatment of skin squamous cell carcinoma (SCC). Superficial SCC or tumor smaller than 1 cm has been treated successfully with open spray cryosurgery. Larger tumor may not be as effective because tissue destruction is usually superficial. Intralesional cryosurgery (IC) may provide a deeper and better cell killing effect in larger tumors. We investigated the safety and efficacy of treating nodular SCC in 4 patients with IC.</p></sec><sec sec-type="methods"><title>Methods:</title><p>Four patients with nodular SCC/keratoacanthoma (tumor size, 1–2.5 cm, average 1.48 cm) on the face and extremity were treated with IC. An 18-ga needle was connected to a cryogun and inserted into the center of the tumor after local anesthesia. The tumors were treated with 2 freeze–thaw cycles with a 5- to 10-mm free margin. Additional IC or open spray cryosurgery was applied if residual tumor was noted during monthly follow-up.</p></sec><sec sec-type="results"><title>Results:</title><p>No patient required analgesics or experienced wound infection after the procedures. After IC, all tumors reduced 40% to 75% in size within 1 week. Two patients received 1 additional spray cryosurgery. Complete remission was noted in all tumors (100%) in 2 months. No recurrence was noted during follow-up (average 5.1 years). All patients were satisfied with the results.</p></sec><sec sec-type="conclusion"><title>Conclusion:</title><p>Our observation suggests that IC can be simple and effective alternative treatment for SCC patients whose condition is not suitable for or who refused operation.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Takai, T" uniqKey="Takai T">T Takai</name></author><author><name sortKey="Misago, N" uniqKey="Misago N">N Misago</name></author><author><name sortKey="Murata, Y" uniqKey="Murata Y">Y Murata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brodland, Dg" uniqKey="Brodland D">DG Brodland</name></author><author><name sortKey="Zitelli, Ja" uniqKey="Zitelli J">JA Zitelli</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Emanuel, Gk" uniqKey="Emanuel G">GK Emanuel</name></author><author><name sortKey="Julianne, Hk" uniqKey="Julianne H">HK Julianne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ridky, Tw" uniqKey="Ridky T">TW Ridky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neville, Ja" uniqKey="Neville J">JA Neville</name></author><author><name sortKey="Welch, E" uniqKey="Welch E">E Welch</name></author><author><name sortKey="Leffell, Dj" uniqKey="Leffell D">DJ Leffell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weshahy, Ah" uniqKey="Weshahy A">AH Weshahy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weshahy, Ah" uniqKey="Weshahy A">AH Weshahy</name></author><author><name sortKey="Abdel Hay, Rm" uniqKey="Abdel Hay R">RM Abdel Hay</name></author><author><name sortKey="Metwally, D" uniqKey="Metwally D">D Metwally</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lansbury, L" uniqKey="Lansbury L">L Lansbury</name></author><author><name sortKey="Bath Hextall, F" uniqKey="Bath Hextall F">F Bath-Hextall</name></author><author><name sortKey="Perkins, W" uniqKey="Perkins W">W Perkins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bahner, Jd" uniqKey="Bahner J">JD Bahner</name></author><author><name sortKey="Bordeaux, Js" uniqKey="Bordeaux J">JS Bordeaux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuflik, Eg" uniqKey="Kuflik E">EG Kuflik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Har Shai, Y" uniqKey="Har Shai Y">Y Har-Shai</name></author><author><name sortKey="Amar, M" uniqKey="Amar M">M Amar</name></author><author><name sortKey="Sabo, E" uniqKey="Sabo E">E Sabo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chopinaud, M" uniqKey="Chopinaud M">M Chopinaud</name></author><author><name sortKey="Pham, Ad" uniqKey="Pham A">AD Pham</name></author><author><name sortKey="Labbe, D" uniqKey="Labbe D">D Labbe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Har Shai, Y" uniqKey="Har Shai Y">Y Har-Shai</name></author><author><name sortKey="Dujovny, E" uniqKey="Dujovny E">E Dujovny</name></author><author><name sortKey="Rohde, E" uniqKey="Rohde E">E Rohde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samstein, Rm" uniqKey="Samstein R">RM Samstein</name></author><author><name sortKey="Ho, Al" uniqKey="Ho A">AL Ho</name></author><author><name sortKey="Lee, Ny" uniqKey="Lee N">NY Lee</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Medicine (Baltimore)</journal-id><journal-id journal-id-type="iso-abbrev">Medicine (Baltimore)</journal-id><journal-id journal-id-type="publisher-id">MEDI</journal-id><journal-title-group><journal-title>Medicine</journal-title></journal-title-group><issn pub-type="ppub">0025-7974</issn><issn pub-type="epub">1536-5964</issn><publisher><publisher-name>Wolters Kluwer Health</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27684856</article-id><article-id pub-id-type="pmc">5265949</article-id><article-id pub-id-type="doi">10.1097/MD.0000000000004991</article-id><article-id pub-id-type="art-access-id">04991</article-id><article-categories><subj-group subj-group-type="heading"><subject>4000</subject></subj-group><subj-group><subject>Research Article</subject><subject>Clinical Case Report</subject></subj-group></article-categories><title-group><article-title>Successful treatment of cutaneous squamous cell carcinoma with intralesional cryosurgery</article-title><subtitle>Case report</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Chaw-Ning</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pan</surname><given-names>Shin-Chen</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Julia Yu-Yun</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>Tak-Wah</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff3"><sup>c</sup></xref><xref><sup>∗</sup></xref></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Li.</surname><given-names>Jianfeng</given-names></name></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Dermatology</aff><aff id="aff2"><label>b</label>Section of Plastic and Reconstructive Surgery, Department of Surgery, National Cheng Kung University Hospital</aff><aff id="aff3"><label>c</label>Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.</aff><author-notes id="cor1"><corresp><label>∗</label>Correspondence: Tak-Wah Wong, Department of Dermatology, National Cheng Kung University Medical College and Hospital, National Cheng Kung University, 138 Sheng Li Road, Tainan 704, Taiwan (e-mail: <email>Dr.kentwwong@gmail.com; twwong@mail.ncku.edu.tw</email>).</corresp></author-notes><pub-date pub-type="collection"><month>9</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>9</month><year>2016</year></pub-date><volume>95</volume><issue>39</issue><elocation-id>e4991</elocation-id><history><date date-type="received"><day>2</day><month>7</month><year>2016</year></date><date date-type="rev-recd"><day>30</day><month>8</month><year>2016</year></date><date date-type="accepted"><day>7</day><month>9</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved.</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nd/4.0"><license-p>This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nd/4.0">http://creativecommons.org/licenses/by-nd/4.0</ext-link></license-p></license></permissions><self-uri xlink:type="simple" xlink:href="medi-95-e4991.pdf"></self-uri><abstract><title>Abstract</title><sec sec-type="background"><title>Background:</title><p>Wide excision or Mohs surgery is the standard treatment of skin squamous cell carcinoma (SCC). Superficial SCC or tumor smaller than 1 cm has been treated successfully with open spray cryosurgery. Larger tumor may not be as effective because tissue destruction is usually superficial. Intralesional cryosurgery (IC) may provide a deeper and better cell killing effect in larger tumors. We investigated the safety and efficacy of treating nodular SCC in 4 patients with IC.</p></sec><sec sec-type="methods"><title>Methods:</title><p>Four patients with nodular SCC/keratoacanthoma (tumor size, 1–2.5 cm, average 1.48 cm) on the face and extremity were treated with IC. An 18-ga needle was connected to a cryogun and inserted into the center of the tumor after local anesthesia. The tumors were treated with 2 freeze–thaw cycles with a 5- to 10-mm free margin. Additional IC or open spray cryosurgery was applied if residual tumor was noted during monthly follow-up.</p></sec><sec sec-type="results"><title>Results:</title><p>No patient required analgesics or experienced wound infection after the procedures. After IC, all tumors reduced 40% to 75% in size within 1 week. Two patients received 1 additional spray cryosurgery. Complete remission was noted in all tumors (100%) in 2 months. No recurrence was noted during follow-up (average 5.1 years). All patients were satisfied with the results.</p></sec><sec sec-type="conclusion"><title>Conclusion:</title><p>Our observation suggests that IC can be simple and effective alternative treatment for SCC patients whose condition is not suitable for or who refused operation.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>case report</kwd><kwd>intralesional cryosurgery</kwd><kwd>keratoacanthoma</kwd><kwd>squamous cell carcinoma</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec><label>1</label><title>Introduction</title><p>Cutaneous squamous cell carcinoma (SCC) is the second most common nonmelanoma skin cancers.<sup>[<xref rid="R1" ref-type="bibr">1</xref>]</sup> Keratoacanthoma (KA) is a variant of SCC with a tendency to self-regression. However, some KA may progress with tumor metastasis as the conventional SCC. The National Comprehensive Cancer Network guideline for the treatment of local, low-risk SCC is complete surgical excision with at least 4 to 6 mm safety margins, or Mohs micrographic surgery if feasible.<sup>[<xref rid="R2" ref-type="bibr">2</xref>,<xref rid="R3" ref-type="bibr">3</xref>]</sup> Alternative treatments may be required for patients who are not suitable for or refuse surgery. Cryosurgery has been used for different benign, premalignant, and malignant skin lesions by different application methods such as cotton-tipped applicator, cryoprobe, superficial spray, and intralesional.<sup>[<xref rid="R4" ref-type="bibr">4</xref>]</sup></p><p>Superficial, in situ, or SCC less and equal to 1 cm has been successfully treated with cryosurgery with results comparable to traditional surgical excision.<sup>[<xref rid="R5" ref-type="bibr">5</xref>,<xref rid="R6" ref-type="bibr">6</xref>]</sup> Intralesional cryosurgery (IC) has been applied to treat keloids in 1990s.<sup>[<xref rid="R7" ref-type="bibr">7</xref>]</sup> Weshahy et al<sup>[<xref rid="R8" ref-type="bibr">8</xref>]</sup> reported the success of treating basal cell carcinoma with IC. Taking the advantage of possible more effective cell killing from deep freezing of the tumor tissue by inserting a cooling needle inside SCC, we treated 4 elderly patients with nodular SCC/KA with IC.</p></sec><sec><label>2</label><title>Patients and methods</title><sec><label>2.1</label><title>Case series</title><p>Four elderly Taiwanese men (Table <xref ref-type="table" rid="T1">1</xref>) with nodular SCC or KA larger than 1 cm were treated with IC in the outpatient clinic of the Department of Dermatology, National Cheng Kung University Hospital after the diagnosis was confirmed histopathologically. Ethical approval and informed consent were not required for this case report as it did not relate to the patient's privacy and IC is not a new treatment. No regional lymphadenopathy or distant metastasis was noted during physical examination. After local anesthesia, an 18-ga needle was connected to a liquid nitrogen gun (Cry-AC; Brymill Cryogenic Systems, Basingstoke, United Kingdom) and inserted into the center along the long axis of the tumor (Fig. <xref ref-type="fig" rid="F1">1</xref>A). The tumor was treated with 2 freeze–thaw cycles. Freezing time was around 30 to 60 seconds. The end point was ice formation of the whole tumor with at least 5-mm free margins (Fig. <xref ref-type="fig" rid="F1">1</xref>B). For tumors larger than 1.5 cm, 2 needles were inserted perpendicular at 1/3 and 2/3 of the long (<italic>y</italic>) axis of the tumor to achieve adequate free margins. Regional lymph node and the tumor were examined at monthly follow-up. Additional IC or spray cryosurgery was performed if there was residual tumor during follow-up.</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Demographic data and outcomes of 4 patients treated with IC.</p></caption><graphic xlink:href="medi-95-e4991-g001"></graphic></table-wrap><fig id="F1" position="float"><label>Figure 1</label><caption><p>An 18-ga needle was connected to a cryogun and inserted into the center of squamous cell carcinoma (SCC) after local anesthesia. (A) Two wooden tongue blades were placed under the needle to keep frostbites from adjacent normal skin. (B) A 1.2 × 1.4 cm<sup>2</sup> well differentiated SCC on the left cheek of a 94-year-old gentleman (case 4). The tumor was treated with 2 freeze–thaw cycles with 5- to 10-mm free margins. (C) A 1.2 × 1 cm<sup>2</sup> well differentiated SCC with features of keratoacanthoma (KA) appeared on the right shin of an 81-year-old male farmer (case 1). (D) No visible tumor and scar 5 months after treatment. The patient was free of tumor at 9.5 years follow-up. (E) A 68-year-old man (case 2) with a 2 × 2 × 0.5 cm<sup>3</sup> well differentiated SCC, KA type, on his left dorsal hand for 2 months. (F) No tumor was observed 14 weeks and no recurrence at 5.7 years follow-up after intralesional cryosurgery. The skin healed well with hypopigmentation which was recovered 8 months later.</p></caption><graphic xlink:href="medi-95-e4991-g002"></graphic></fig></sec><sec><label>2.2</label><title>Illustrative cases</title><p>Case 1 was an 81-year-old male farmer. He received surgical removal of an SCC on his left hand 6 months ago. Another asymptomatic nodule (1.2 × 1 cm<sup>2</sup>) grew on his right shin (it became smaller after biopsied, Fig. <xref ref-type="fig" rid="F1">1</xref>C). Skin biopsy revealed well differentiated SCC with features of KA. He refused surgical intervention and was treated with IC after failed 1 intralesional methotrexate 0.12-mL (50 mg/2 mL, Hospira Australia Pty Ltd., Melbourne, Victoria, Australia) injection. Within 1 week, the tumor reduced around 40%. Spray cryosurgery (3 freeze–thaw cycles with 10-second freezing) was performed 3 weeks after IC because the tumor was too small for IC. No visible tumor was observed by week 6, and no recurrence was noted during follow-up at 9.5 years (Fig. <xref ref-type="fig" rid="F1">1</xref>D). He died of colon cancer with lung metastasis.</p><p>Case 2 was a 68-year-old man who presented with an itchy 2 × 2 × 0.5 cm<sup>3</sup> protruded nodule with central hyperkeratosis over his left dorsal hand for 2 months. Skin biopsy revealed well differentiated SCC, KA type (Fig. <xref ref-type="fig" rid="F1">1</xref>E). The tumor shrank by 75% 2 weeks after IC. A spray cryosurgery (25 seconds × 2 cycles) was applied at 4 weeks after IC to reinforce the effect. No tumor was observed by week 7. There was no recurrence, and the scar was invisible at 5.7-year follow-up.</p><p>Case 3 was a 77-year-old man presented with a 1.1 × 0.9 cm<sup>2</sup> tumor on his left political fossa. The tumor was growing after he was treated with 5 spray cryosurgeries every 2 weeks under the impression of verruca at a local clinic. Skin biopsy confirmed the diagnosis of SCC, KA type. The tumor was treated with IC and became undetectable clinically at week 8. No clinical recurrence of tumor was noted at 3.8-year follow-up.</p><p>Case 4 was a 94-year-old bedridden man. His medical history was significant for dementia, hypertension, prostate cancer complicated with neurogenic bladder and hip fracture with partial hip replacement. He presented with a 1-month history of fast growing tumor on his left cheek. On examination, a 1.2 × 1.4 cm<sup>2</sup> nodule was noted on his left cheek, which was proved to be well differentiated SCC histologically. His general condition precluded surgery or chemotherapy. He lived in rural area, and it was not easy for him to come for daily radiotherapy. He was finally treated with IC (Fig. <xref ref-type="fig" rid="F1">1</xref>B). The tumor subsided by week 6 after 1 IC. No additional cryosurgery was needed. He was free of tumor at 1.4-year follow-up.</p></sec></sec><sec><label>3</label><title>Discussion</title><p>We described 4 cases of SCC, 3 of them were KA types, in elderly patients who were successfully treated with IC without complications. Takai et al<sup>[<xref rid="R1" ref-type="bibr">1</xref>]</sup> showed a regression rate of 98.1% in KA, 33.3% in that of KA-like SCC/KA with malignant transformation.<sup>[<xref rid="R1" ref-type="bibr">1</xref>]</sup> With the potential progression as in conventional SCC, we believe that active treatment of SCC, KA type is more advisable than watchful waiting.</p><p>There are several large studies showing high cure rates of cryosurgery for nonmelanocytic skin cancers.<sup>[<xref rid="R9" ref-type="bibr">9</xref>,<xref rid="R10" ref-type="bibr">10</xref>]</sup> In the report by Kuflik,<sup>[<xref rid="R11" ref-type="bibr">11</xref>]</sup> most patients were treated by curettage before open spray technique, which achieved a 99% cure rate in 522 cases. The 5-year cure rate in SCC smaller than 2 cm (n = 134) was 100%. In dermatology, IC was first introduced by Weshahy<sup>[<xref rid="R7" ref-type="bibr">7</xref>]</sup> to treat keloid or hypertrophic scar. A newly developed intralesional cryoneedle, which consists of an elongated double-lumen uninsulated needle (CryoShape; Etgar Group International Ltd., Raanana, Israel) was invented.<sup>[<xref rid="R12" ref-type="bibr">12</xref>,<xref rid="R13" ref-type="bibr">13</xref>]</sup> The cryoneedle is not available in our country. We simply connected an 18-ga needle to a liquid nitrogen gun as a cryoneedle. This is simple and feasible in most clinics. IC shows more therapeutic effect than spraying in nodular lesions because the lethal zone is located in deep tissue and causes more tumor damage. In comparison to spray cryosurgery, IC induces almost no hypopigmentation of the skin because a deep-seated cryoprobe is less damaging to the epidermal melanocytes. Our results agree with previous report,<sup>[<xref rid="R14" ref-type="bibr">14</xref>]</sup> and only 1 patient (25%) developed temporally hypopigmentation on the skin even 3 patients received additional spray cryosurgery (Fig. <xref ref-type="fig" rid="F1">1</xref>F).</p><p>Our study is limited by its small case number. Nevertheless, IC appears safe, simple, and suitable for elevated nodular tumor. All tumors reduced in sizes after 1 IC treatment in our patients. The residual tumor was cleared by additional spray cryosurgery. IC may provide long-term remission as complete clinical remission was noted in all 4 cases during the 1.4 to 9.5 years of follow-up (average 5.1 years). Moreover, the cosmetic outcome was also highly satisfactory. Nevertheless, it should be noted that IC may not be suitable for patients with conditions or tumor locations where cryosurgery is contraindicated, such as medial canthus or eyelash region to avoid damage of canaliculus or ocular tissue, acral part in patients with poor circulation or poor healing, or location where nerves are fairly superficial with potential of nerve injury. In addition, IC is superior to radiotherapy for its simplicity and free of complications such as radiodermatitis, lymphedema, and secondary cancers.<sup>[<xref rid="R15" ref-type="bibr">15</xref>]</sup></p><p>In conclusion, IC can be an effective alternative treatment for elevated, nodular SCC in elder patients, especially those who refuse or whose condition is not suitable for operation. 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