A double-blind, cross-over trial of O-(β-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs
Identifieur interne : 00E480 ( Main/Curation ); précédent : 00E479; suivant : 00E481A double-blind, cross-over trial of O-(β-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs
Auteurs : N. B. Piller [Australie] ; R. Gwyn Morgan [Australie] ; J. R. Casley-Smith [Australie]Source :
- British Journal of Plastic Surgery [ 0007-1226 ] ; 1988.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Attribution aléatoire, Bras, Complications postopératoires (traitement médicamenteux), Essais cliniques comme sujet, Femelle, Humains, Jambe, Lymphoedème (physiopathologie), Lymphoedème (traitement médicamenteux), Mastectomie, Mâle, Méthode en double aveugle, O-(bêta-Hydroxyéthyl)rutosides (administration et posologie), O-(bêta-Hydroxyéthyl)rutosides (analogues et dérivés), O-(bêta-Hydroxyéthyl)rutosides (usage thérapeutique), Rutoside (analogues et dérivés), Température cutanée ().
- MESH :
- administration et posologie : O-(bêta-Hydroxyéthyl)rutosides.
- analogues et dérivés : O-(bêta-Hydroxyéthyl)rutosides, Rutoside.
- physiopathologie : Lymphoedème.
- traitement médicamenteux : Complications postopératoires, Lymphoedème.
- usage thérapeutique : O-(bêta-Hydroxyéthyl)rutosides.
- Adulte d'âge moyen, Attribution aléatoire, Bras, Essais cliniques comme sujet, Femelle, Humains, Jambe, Mastectomie, Mâle, Méthode en double aveugle, Température cutanée.
English descriptors
- KwdEn :
- Arm, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Hydroxyethylrutoside (administration & dosage), Hydroxyethylrutoside (analogs & derivatives), Hydroxyethylrutoside (therapeutic use), Leg, Lymphedema (drug therapy), Lymphedema (physiopathology), Male, Mastectomy, Middle Aged, Postoperative Complications (drug therapy), Random Allocation, Rutin (analogs & derivatives), Skin Temperature (drug effects).
- MESH :
- chemical , administration & dosage : Hydroxyethylrutoside.
- chemical , analogs & derivatives : Hydroxyethylrutoside, Rutin.
- chemical , therapeutic use : Hydroxyethylrutoside.
- drug effects : Skin Temperature.
- drug therapy : Lymphedema, Postoperative Complications.
- physiopathology : Lymphedema.
- Arm, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Leg, Male, Mastectomy, Middle Aged, Random Allocation.
Abstract
Abstract: A randomised, double-blind, cross-over trial was performed on 26 patients with post-mastectomy lymphoedema of the arm, and 14 with lymphoedema of the leg. For 6 months, patients took O-(β-hydroxyethyl)-rutosides (oxerutin; “Paroven®”, “Venoruton®”, Zyma) in doses of 3 g/day, or the placebos; then they took the reverse. Measurements (volume, circumferences, tonometry and skin temperature) were made monthly. The active drug reduced the volumes of the limbs (p<0.05 to 0.01) and their circumferences (p<0.05 to 0.001). It increased the softness of the limbs, as shown by the increases in the tonometry values (p<0.01 to 0.001). There was a lowering of the elevated skin temperatures (p<0.05 to 0.001). Patients reported increased comfort and freedom of movement, a lessening of their bursting pains, heaviness and tension (p<0.05 to 0.01), and an increased mobility of their limbs (p<0.0001). Most patients (70%) preferred the active drug (p<0.0001). An increase in general well-being was reported by 97% of patients when taking the active drug compared with 4% for the placebo (p<0.0001).
Url:
DOI: 10.1016/0007-1226(88)90139-7
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<front><div type="abstract" xml:lang="en">Abstract: A randomised, double-blind, cross-over trial was performed on 26 patients with post-mastectomy lymphoedema of the arm, and 14 with lymphoedema of the leg. For 6 months, patients took O-(β-hydroxyethyl)-rutosides (oxerutin; “Paroven®”, “Venoruton®”, Zyma) in doses of 3 g/day, or the placebos; then they took the reverse. Measurements (volume, circumferences, tonometry and skin temperature) were made monthly. The active drug reduced the volumes of the limbs (p<0.05 to 0.01) and their circumferences (p<0.05 to 0.001). It increased the softness of the limbs, as shown by the increases in the tonometry values (p<0.01 to 0.001). There was a lowering of the elevated skin temperatures (p<0.05 to 0.001). Patients reported increased comfort and freedom of movement, a lessening of their bursting pains, heaviness and tension (p<0.05 to 0.01), and an increased mobility of their limbs (p<0.0001). Most patients (70%) preferred the active drug (p<0.0001). An increase in general well-being was reported by 97% of patients when taking the active drug compared with 4% for the placebo (p<0.0001).</div>
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<term>Hydroxyethylrutoside (administration & dosage)</term>
<term>Hydroxyethylrutoside (analogs & derivatives)</term>
<term>Hydroxyethylrutoside (therapeutic use)</term>
<term>Leg</term>
<term>Lymphedema (drug therapy)</term>
<term>Lymphedema (physiopathology)</term>
<term>Male</term>
<term>Mastectomy</term>
<term>Middle Aged</term>
<term>Postoperative Complications (drug therapy)</term>
<term>Random Allocation</term>
<term>Rutin (analogs & derivatives)</term>
<term>Skin Temperature (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Attribution aléatoire</term>
<term>Bras</term>
<term>Complications postopératoires (traitement médicamenteux)</term>
<term>Essais cliniques comme sujet</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jambe</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Lymphoedème (traitement médicamenteux)</term>
<term>Mastectomie</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>O-(bêta-Hydroxyéthyl)rutosides (administration et posologie)</term>
<term>O-(bêta-Hydroxyéthyl)rutosides (analogues et dérivés)</term>
<term>O-(bêta-Hydroxyéthyl)rutosides (usage thérapeutique)</term>
<term>Rutoside (analogues et dérivés)</term>
<term>Température cutanée ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydroxyethylrutoside</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Hydroxyethylrutoside</term>
<term>Rutin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxyethylrutoside</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>O-(bêta-Hydroxyéthyl)rutosides</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>O-(bêta-Hydroxyéthyl)rutosides</term>
<term>Rutoside</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Skin Temperature</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term>
<term>Postoperative Complications</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Complications postopératoires</term>
<term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>O-(bêta-Hydroxyéthyl)rutosides</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Arm</term>
<term>Clinical Trials as Topic</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Leg</term>
<term>Male</term>
<term>Mastectomy</term>
<term>Middle Aged</term>
<term>Random Allocation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Attribution aléatoire</term>
<term>Bras</term>
<term>Essais cliniques comme sujet</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jambe</term>
<term>Mastectomie</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Température cutanée</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A randomised, double-blind, cross-over trial was performed on 26 patients with postmastectomy lymphoedema of the arm, and 14 with lymphoedema of the leg. For 6 months, patients took 0-(beta-hydroxyethyl)-rutosides (oxerutin; "Paroven", "Venoruton", Zyma) in doses of 3 g/day, or the placebos; then they took the reverse. Measurements (volume, circumferences, tonometry and skin temperature) were made monthly. The active drug reduced the volumes of the limbs (p less than 0.05 to 0.01) and their circumferences (p less than 0.05 to 0.001). It increased the softness of the limbs, as shown by the increases in the tonometry values (p less than 0.01 to 0.001). There was a lowering of the elevated skin temperatures (p less than 0.05 to 0.001). Patients reported increased comfort and freedom of movement, a lessening of their bursting pains, heaviness and tension (p less than 0.05 to 0.01), and an increased mobility of their limbs (p less than 0.0001). Most patients (70%) preferred the active drug (p less than 0.0001). An increase in general well-being was reported by 97% of patients when taking the active drug compared with 4% for placebo (p less than 0.0001).</div>
</front>
</TEI>
</PubMed>
</double>
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