Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.
Identifieur interne : 00DA64 ( Main/Curation ); précédent : 00DA63; suivant : 00DA65Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.
Auteurs : J W Mak [Malaisie] ; K. Suresh ; P L Lam ; M F Choong ; H P StriebelSource :
- Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) [ 0177-2392 ] ; 1990.
Descripteurs français
- KwdFr :
- Administration par voie orale, Animaux, Antihelminthiques (usage thérapeutique), Brugia (), Cercopithecidae, Filaricides (administration et posologie), Filaricides (pharmacologie), Filaricides (usage thérapeutique), Filariose lymphatique (traitement médicamenteux), Filarioses (traitement médicamenteux), Thiazoles (administration et posologie), Thiazoles (pharmacologie), Thiazoles (usage thérapeutique).
- MESH :
- administration et posologie : Filaricides, Thiazoles.
- pharmacologie : Filaricides, Thiazoles.
- traitement médicamenteux : Filariose lymphatique, Filarioses.
- usage thérapeutique : Antihelminthiques, Filaricides, Thiazoles.
- Administration par voie orale, Animaux, Brugia, Cercopithecidae.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Anthelmintics (therapeutic use), Brugia (drug effects), Cercopithecidae, Elephantiasis, Filarial (drug therapy), Filariasis (drug therapy), Filaricides (administration & dosage), Filaricides (pharmacology), Filaricides (therapeutic use), Thiazoles (administration & dosage), Thiazoles (pharmacology), Thiazoles (therapeutic use).
- MESH :
- chemical , administration & dosage : Filaricides, Thiazoles.
- chemical , pharmacology : Filaricides, Thiazoles.
- chemical , therapeutic use : Anthelmintics, Filaricides, Thiazoles.
- drug effects : Brugia.
- drug therapy : Elephantiasis, Filarial, Filariasis.
- Administration, Oral, Animals, Cercopithecidae.
Abstract
CGP 20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of benzothiazole was evaluated for its antifilarial properties and shown to be extremely effective against subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata at oral doses of 20-100 mg/kg. The compound and/or its metabolites had complete micro- and microfilaricidal activities even when given at a single dose of 20 mg/kg. Lower doses had incomplete filaricidal action.
PubMed: 2339241
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pubmed:2339241Le document en format XML
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<term>Thiazoles (administration et posologie)</term>
<term>Thiazoles (pharmacologie)</term>
<term>Thiazoles (usage thérapeutique)</term>
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<front><div type="abstract" xml:lang="en">CGP 20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of benzothiazole was evaluated for its antifilarial properties and shown to be extremely effective against subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata at oral doses of 20-100 mg/kg. The compound and/or its metabolites had complete micro- and microfilaricidal activities even when given at a single dose of 20 mg/kg. Lower doses had incomplete filaricidal action.</div>
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