LymphedemaV1, PubMed, Corpus, bibRecord, 005D95

Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.

Identifieur interne : 005D95 ( PubMed/Corpus ); précédent : 005D94; suivant : 005D96

Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.

Auteurs : J W Mak ; K. Suresh ; P L Lam ; M F Choong ; H P Striebel

Source :

Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) [ 0177-2392 ] ; 1990.

RBID : pubmed:2339241

English descriptors

KwdEn :
- Administration, Oral, Animals, Anthelmintics (therapeutic use), Brugia (drug effects), Cercopithecidae, Elephantiasis, Filarial (drug therapy), Filariasis (drug therapy), Filaricides (administration & dosage), Filaricides (pharmacology), Filaricides (therapeutic use), Thiazoles (administration & dosage), Thiazoles (pharmacology), Thiazoles (therapeutic use).
MESH :
- chemical , administration & dosage : Filaricides, Thiazoles.
- chemical , pharmacology : Filaricides, Thiazoles.
- chemical , therapeutic use : Anthelmintics, Filaricides, Thiazoles.
- drug effects : Brugia.
- drug therapy : Elephantiasis, Filarial, Filariasis.
- Administration, Oral, Animals, Cercopithecidae.

Abstract

CGP 20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of benzothiazole was evaluated for its antifilarial properties and shown to be extremely effective against subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata at oral doses of 20-100 mg/kg. The compound and/or its metabolites had complete micro- and microfilaricidal activities even when given at a single dose of 20 mg/kg. Lower doses had incomplete filaricidal action.

PubMed: 2339241

Links to Exploration step

pubmed:2339241

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.</title>
<author><name sortKey="Mak, J W" sort="Mak, J W" uniqKey="Mak J" first="J W" last="Mak">J W Mak</name>
<affiliation><nlm:affiliation>Institute for Medical Research, Kuala Lumpur, Malaysia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Suresh, K" sort="Suresh, K" uniqKey="Suresh K" first="K" last="Suresh">K. Suresh</name>
</author>
<author><name sortKey="Lam, P L" sort="Lam, P L" uniqKey="Lam P" first="P L" last="Lam">P L Lam</name>
</author>
<author><name sortKey="Choong, M F" sort="Choong, M F" uniqKey="Choong M" first="M F" last="Choong">M F Choong</name>
</author>
<author><name sortKey="Striebel, H P" sort="Striebel, H P" uniqKey="Striebel H" first="H P" last="Striebel">H P Striebel</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1990">1990</date>
<idno type="RBID">pubmed:2339241</idno>
<idno type="pmid">2339241</idno>
<idno type="wicri:Area/PubMed/Corpus">005D95</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005D95</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.</title>
<author><name sortKey="Mak, J W" sort="Mak, J W" uniqKey="Mak J" first="J W" last="Mak">J W Mak</name>
<affiliation><nlm:affiliation>Institute for Medical Research, Kuala Lumpur, Malaysia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Suresh, K" sort="Suresh, K" uniqKey="Suresh K" first="K" last="Suresh">K. Suresh</name>
</author>
<author><name sortKey="Lam, P L" sort="Lam, P L" uniqKey="Lam P" first="P L" last="Lam">P L Lam</name>
</author>
<author><name sortKey="Choong, M F" sort="Choong, M F" uniqKey="Choong M" first="M F" last="Choong">M F Choong</name>
</author>
<author><name sortKey="Striebel, H P" sort="Striebel, H P" uniqKey="Striebel H" first="H P" last="Striebel">H P Striebel</name>
</author>
</analytic>
<series><title level="j">Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)</title>
<idno type="ISSN">0177-2392</idno>
<imprint><date when="1990" type="published">1990</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term>
<term>Animals</term>
<term>Anthelmintics (therapeutic use)</term>
<term>Brugia (drug effects)</term>
<term>Cercopithecidae</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Filariasis (drug therapy)</term>
<term>Filaricides (administration & dosage)</term>
<term>Filaricides (pharmacology)</term>
<term>Filaricides (therapeutic use)</term>
<term>Thiazoles (administration & dosage)</term>
<term>Thiazoles (pharmacology)</term>
<term>Thiazoles (therapeutic use)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Filaricides</term>
<term>Thiazoles</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Filaricides</term>
<term>Thiazoles</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anthelmintics</term>
<term>Filaricides</term>
<term>Thiazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brugia</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Filariasis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term>
<term>Animals</term>
<term>Cercopithecidae</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">CGP 20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of benzothiazole was evaluated for its antifilarial properties and shown to be extremely effective against subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata at oral doses of 20-100 mg/kg. The compound and/or its metabolites had complete micro- and microfilaricidal activities even when given at a single dose of 20 mg/kg. Lower doses had incomplete filaricidal action.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2339241</PMID>
<DateCreated><Year>1990</Year>
<Month>06</Month>
<Day>20</Day>
</DateCreated>
<DateCompleted><Year>1990</Year>
<Month>06</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>08</Month>
<Day>11</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0177-2392</ISSN>
<JournalIssue CitedMedium="Print"><Volume>41</Volume>
<Issue>1</Issue>
<PubDate><Year>1990</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)</Title>
<ISOAbbreviation>Trop. Med. Parasitol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.</ArticleTitle>
<Pagination><MedlinePgn>10-2</MedlinePgn>
</Pagination>
<Abstract><AbstractText>CGP 20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of benzothiazole was evaluated for its antifilarial properties and shown to be extremely effective against subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata at oral doses of 20-100 mg/kg. The compound and/or its metabolites had complete micro- and microfilaricidal activities even when given at a single dose of 20 mg/kg. Lower doses had incomplete filaricidal action.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mak</LastName>
<ForeName>J W</ForeName>
<Initials>JW</Initials>
<AffiliationInfo><Affiliation>Institute for Medical Research, Kuala Lumpur, Malaysia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Suresh</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lam</LastName>
<ForeName>P L</ForeName>
<Initials>PL</Initials>
</Author>
<Author ValidYN="Y"><LastName>Choong</LastName>
<ForeName>M F</ForeName>
<Initials>MF</Initials>
</Author>
<Author ValidYN="Y"><LastName>Striebel</LastName>
<ForeName>H P</ForeName>
<Initials>HP</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Trop Med Parasitol</MedlineTA>
<NlmUniqueID>8503728</NlmUniqueID>
<ISSNLinking>0177-2392</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000871">Anthelmintics</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005369">Filaricides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D013844">Thiazoles</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>81059-04-3</RegistryNumber>
<NameOfSubstance UI="C051745">CGP 20376</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000871" MajorTopicYN="N">Anthelmintics</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002009" MajorTopicYN="N">Brugia</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002520" MajorTopicYN="N">Cercopithecidae</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005369" MajorTopicYN="N">Filaricides</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013844" MajorTopicYN="N">Thiazoles</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1990</Year>
<Month>3</Month>
<Day>1</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>1990</Year>
<Month>3</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>1</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>1990</Year>
<Month>3</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">2339241</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005D95 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 005D95 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    PubMed
   |étape=   Corpus
   |type=    RBID
   |clé=     pubmed:2339241
   |texte=   Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i   -Sk "pubmed:2339241" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.

Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki