LymphedemaV1, Main, Curation, bibRecord, 008D05

Molecular mechanisms of lymphangiogenesis

Identifieur interne : 008D05 ( Main/Curation ); précédent : 008D04; suivant : 008D06

Molecular mechanisms of lymphangiogenesis

Auteurs : Meiko Takahashi [Japon] ; Takanobu Yoshimoto [Japon] ; Hajime Kubo [Japon]

Source :

International journal of hematology [ 0925-5710 ] ; 2004.

RBID : Pascal:04-0463672

Descripteurs français

KwdFr :
- Animaux, Facteur de croissance endothéliale vasculaire de type C (physiologie), Facteur de croissance endothéliale vasculaire de type D (physiologie), Humains, Lymphangiogenèse (physiologie), Lymphoedème (physiopathologie), Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie).
MESH :
- physiologie : Facteur de croissance endothéliale vasculaire de type C, Facteur de croissance endothéliale vasculaire de type D, Lymphangiogenèse, Récepteur-3 au facteur croissance endothéliale vasculaire.
- physiopathologie : Lymphoedème.
Pascal (Inist)
- Animaux, Humains, Lymphoedème, Facteur croissance endothélium vasculaire, Hématologie, Adénopathie maligne, Lymphangiogenèse, Récepteur VEGFR3.

English descriptors

KwdEn :
- Animals, Hematology, Humans, Lymphangiogenesis, Lymphangiogenesis (physiology), Lymphedema, Lymphedema (physiopathology), Malignant lymphadenopathy, Vascular Endothelial Growth Factor C (physiology), Vascular Endothelial Growth Factor D (physiology), Vascular Endothelial Growth Factor Receptor-3 (physiology), Vascular endothelial growth factor receptor 3, Vascular endothelium growth factor.
MESH :
- chemical , physiology : Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D, Vascular Endothelial Growth Factor Receptor-3.
- physiology : Lymphangiogenesis.
- physiopathology : Lymphedema.
- Animals, Humans.

Abstract

Although the process of vascular development has been well documented, little is understood about lymphatic vasculature formation, despite its importance in normal and pathologic conditions. The dysfunction or abnormal growth of lymphatic vessels is associated with lymphedema and cancer metastasis. The recent discovery of lymphangiogenic growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D and of their receptor, VEGFR-3, on lymphatic endothelial cells has started to provide an understanding of the molecular mechanisms of lymphangiogenesis. In addition, other genes that participate in the specification of lymphatic endothelial cells and the modulation of lymphatic vascular development have been identified. The capacity to induce or inhibit lymphangiogenesis by the manipulation of such molecules offers new opportunities to understand the function of the lymphatic system and to develop novel treatments for lymphatic disorders. This review describes the main players in lymphangiogenesis that have been identified so far and the attempts to shed some light on the mysteries surrounding this process.

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Le document en format XML

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<affiliation wicri:level="4"><nlm:affiliation>Molecular & Cancer Research Unit, HMRO, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Molecular & Cancer Research Unit, HMRO, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea>
<orgName type="university">Université de Kyoto</orgName>
<placeName><settlement type="city">Kyoto</settlement>
<region type="prefecture">Région du Kansai</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yoshimoto, Takanobu" sort="Yoshimoto, Takanobu" uniqKey="Yoshimoto T" first="Takanobu" last="Yoshimoto">Takanobu Yoshimoto</name>
</author>
<author><name sortKey="Kubo, Hajime" sort="Kubo, Hajime" uniqKey="Kubo H" first="Hajime" last="Kubo">Hajime Kubo</name>
</author>
</analytic>
<series><title level="j">International journal of hematology</title>
<idno type="ISSN">0925-5710</idno>
<imprint><date when="2004" type="published">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Lymphangiogenesis (physiology)</term>
<term>Lymphedema (physiopathology)</term>
<term>Vascular Endothelial Growth Factor C (physiology)</term>
<term>Vascular Endothelial Growth Factor D (physiology)</term>
<term>Vascular Endothelial Growth Factor Receptor-3 (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Facteur de croissance endothéliale vasculaire de type C (physiologie)</term>
<term>Facteur de croissance endothéliale vasculaire de type D (physiologie)</term>
<term>Humains</term>
<term>Lymphangiogenèse (physiologie)</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term>
<term>Vascular Endothelial Growth Factor D</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term>
<term>Facteur de croissance endothéliale vasculaire de type D</term>
<term>Lymphangiogenèse</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphangiogenesis</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Although the process of vascular development has been well documented, little is understood about lymphatic vasculature formation, despite its importance in normal and pathologic conditions. The dysfunction or abnormal growth of lymphatic vessels is associated with lymphedema and cancer metastasis. The recent discovery of lymphangiogenic growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D and of their receptor, VEGFR-3, on lymphatic endothelial cells has started to provide an understanding of the molecular mechanisms of lymphangiogenesis. In addition, other genes that participate in the specification of lymphatic endothelial cells and the modulation of lymphatic vascular development have been identified. The capacity to induce or inhibit lymphangiogenesis by the manipulation of such molecules offers new opportunities to understand the function of the lymphatic system and to develop novel treatments for lymphatic disorders. This review describes the main players in lymphangiogenesis that have been identified so far and the attempts to shed some light on the mysteries surrounding this process.</div>
</front>
</TEI>
</PubMed>
</double>
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Molecular mechanisms of lymphangiogenesis

Molecular mechanisms of lymphangiogenesis

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