Molecular mechanisms of lymphangiogenesis.
Identifieur interne : 001A85 ( Ncbi/Curation ); précédent : 001A84; suivant : 001A86Molecular mechanisms of lymphangiogenesis.
Auteurs : Meiko Takahashi [Japon] ; Takanobu Yoshimoto ; Hajime KuboSource :
- International journal of hematology [ 0925-5710 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D, Vascular Endothelial Growth Factor Receptor-3.
- physiology : Lymphangiogenesis.
- physiopathology : Lymphedema.
- Animals, Humans.
Abstract
Although the process of vascular development has been well documented, little is understood about lymphatic vasculature formation, despite its importance in normal and pathologic conditions. The dysfunction or abnormal growth of lymphatic vessels is associated with lymphedema and cancer metastasis. The recent discovery of lymphangiogenic growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D and of their receptor, VEGFR-3, on lymphatic endothelial cells has started to provide an understanding of the molecular mechanisms of lymphangiogenesis. In addition, other genes that participate in the specification of lymphatic endothelial cells and the modulation of lymphatic vascular development have been identified. The capacity to induce or inhibit lymphangiogenesis by the manipulation of such molecules offers new opportunities to understand the function of the lymphatic system and to develop novel treatments for lymphatic disorders. This review describes the main players in lymphangiogenesis that have been identified so far and the attempts to shed some light on the mysteries surrounding this process.
PubMed: 15293565
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003F39
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :003F39
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003F39
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001A85
Links to Exploration step
pubmed:15293565Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular mechanisms of lymphangiogenesis.</title><author><name sortKey="Takahashi, Meiko" sort="Takahashi, Meiko" uniqKey="Takahashi M" first="Meiko" last="Takahashi">Meiko Takahashi</name><affiliation wicri:level="4"><nlm:affiliation>Molecular & Cancer Research Unit, HMRO, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Molecular & Cancer Research Unit, HMRO, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea><orgName type="university">Université de Kyoto</orgName><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName></affiliation></author><author><name sortKey="Yoshimoto, Takanobu" sort="Yoshimoto, Takanobu" uniqKey="Yoshimoto T" first="Takanobu" last="Yoshimoto">Takanobu Yoshimoto</name></author><author><name sortKey="Kubo, Hajime" sort="Kubo, Hajime" uniqKey="Kubo H" first="Hajime" last="Kubo">Hajime Kubo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15293565</idno><idno type="pmid">15293565</idno><idno type="wicri:Area/PubMed/Corpus">003F39</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003F39</idno><idno type="wicri:Area/PubMed/Curation">003F39</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003F39</idno><idno type="wicri:Area/PubMed/Checkpoint">003F39</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003F39</idno><idno type="wicri:Area/Ncbi/Merge">001A85</idno><idno type="wicri:Area/Ncbi/Curation">001A85</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Molecular mechanisms of lymphangiogenesis.</title><author><name sortKey="Takahashi, Meiko" sort="Takahashi, Meiko" uniqKey="Takahashi M" first="Meiko" last="Takahashi">Meiko Takahashi</name><affiliation wicri:level="4"><nlm:affiliation>Molecular & Cancer Research Unit, HMRO, Graduate School of Medicine, Kyoto University, Kyoto, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Molecular & Cancer Research Unit, HMRO, Graduate School of Medicine, Kyoto University, Kyoto</wicri:regionArea><orgName type="university">Université de Kyoto</orgName><placeName><settlement type="city">Kyoto</settlement><region type="prefecture">Région du Kansai</region></placeName></affiliation></author><author><name sortKey="Yoshimoto, Takanobu" sort="Yoshimoto, Takanobu" uniqKey="Yoshimoto T" first="Takanobu" last="Yoshimoto">Takanobu Yoshimoto</name></author><author><name sortKey="Kubo, Hajime" sort="Kubo, Hajime" uniqKey="Kubo H" first="Hajime" last="Kubo">Hajime Kubo</name></author></analytic><series><title level="j">International journal of hematology</title><idno type="ISSN">0925-5710</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Humans</term><term>Lymphangiogenesis (physiology)</term><term>Lymphedema (physiopathology)</term><term>Vascular Endothelial Growth Factor C (physiology)</term><term>Vascular Endothelial Growth Factor D (physiology)</term><term>Vascular Endothelial Growth Factor Receptor-3 (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Facteur de croissance endothéliale vasculaire de type C (physiologie)</term><term>Facteur de croissance endothéliale vasculaire de type D (physiologie)</term><term>Humains</term><term>Lymphangiogenèse (physiologie)</term><term>Lymphoedème (physiopathologie)</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term><term>Vascular Endothelial Growth Factor D</term><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Facteur de croissance endothéliale vasculaire de type D</term><term>Lymphangiogenèse</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphangiogenesis</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although the process of vascular development has been well documented, little is understood about lymphatic vasculature formation, despite its importance in normal and pathologic conditions. The dysfunction or abnormal growth of lymphatic vessels is associated with lymphedema and cancer metastasis. The recent discovery of lymphangiogenic growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D and of their receptor, VEGFR-3, on lymphatic endothelial cells has started to provide an understanding of the molecular mechanisms of lymphangiogenesis. In addition, other genes that participate in the specification of lymphatic endothelial cells and the modulation of lymphatic vascular development have been identified. The capacity to induce or inhibit lymphangiogenesis by the manipulation of such molecules offers new opportunities to understand the function of the lymphatic system and to develop novel treatments for lymphatic disorders. This review describes the main players in lymphangiogenesis that have been identified so far and the attempts to shed some light on the mysteries surrounding this process.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A85 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001A85 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:15293565
|texte= Molecular mechanisms of lymphangiogenesis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:15293565" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |