LymphedemaV1, Main, Curation, bibRecord, 007976

Filaria-Induced Monocyte Dysfunction and Its Reversal following Treatment†

Identifieur interne : 007976 ( Main/Curation ); précédent : 007975; suivant : 007977

Filaria-Induced Monocyte Dysfunction and Its Reversal following Treatment†

Auteurs : Roshanak Tolouei Semnani ; Paul B. Keiser ; Yaya I. Coulibaly ; Falaye Keita ; Abdallah A. Diallo ; Diakaridia Traore ; Dapa A. Diallo ; Ogobara K. Doumbo ; Sekou F. Traore ; Joseph Kubofcik ; Amy D. Klion ; Thomas B. Nutman

Source :

Infection and Immunity [ 0019-9567 ] ; 2006.

RBID : PMC:1539612

Descripteurs français

KwdFr :
- Albendazole (usage thérapeutique), Animaux, Antihelminthiques (usage thérapeutique), Antiparasitaires (usage thérapeutique), Association de médicaments, Données de séquences moléculaires, Expression des gènes, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (physiopathologie), Filariose lymphatique (traitement médicamenteux), Humains, Ivermectine (usage thérapeutique), Monocytes (anatomopathologie), Monocytes (métabolisme), Monocytes (parasitologie), Protéines du choc thermique (génétique), Protéines du choc thermique (métabolisme), Résultat thérapeutique, Wuchereria bancrofti (isolement et purification), Wuchereria bancrofti (pathogénicité).
MESH :
- anatomopathologie : Monocytes.
- génétique : Protéines du choc thermique.
- immunologie : Filariose lymphatique.
- isolement et purification : Wuchereria bancrofti.
- métabolisme : Monocytes, Protéines du choc thermique.
- parasitologie : Filariose lymphatique, Monocytes.
- pathogénicité : Wuchereria bancrofti.
- physiopathologie : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Albendazole, Antihelminthiques, Antiparasitaires, Ivermectine.
- Animaux, Association de médicaments, Données de séquences moléculaires, Expression des gènes, Humains, Résultat thérapeutique.

English descriptors

KwdEn :
- Albendazole (therapeutic use), Animals, Anthelmintics (therapeutic use), Antiparasitic Agents (therapeutic use), Drug Therapy, Combination, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (physiopathology), Gene Expression, Heat-Shock Proteins (genetics), Heat-Shock Proteins (metabolism), Humans, Ivermectin (therapeutic use), Molecular Sequence Data, Monocytes (metabolism), Monocytes (parasitology), Monocytes (pathology), Treatment Outcome, Wuchereria bancrofti (isolation & purification), Wuchereria bancrofti (pathogenicity).
MESH :
- chemical , genetics : Heat-Shock Proteins.
- chemical , metabolism : Heat-Shock Proteins.
- chemical , therapeutic use : Albendazole, Anthelmintics, Antiparasitic Agents, Ivermectin.
- drug therapy : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial.
- isolation & purification : Wuchereria bancrofti.
- metabolism : Monocytes.
- parasitology : Elephantiasis, Filarial, Monocytes.
- pathogenicity : Wuchereria bancrofti.
- pathology : Monocytes.
- physiopathology : Elephantiasis, Filarial.
- Animals, Drug Therapy, Combination, Gene Expression, Humans, Molecular Sequence Data, Treatment Outcome.

Abstract

Monocyte dysfunction in filarial infection has been proposed as one mechanism underlying the diminished antigen-specific T-cell response seen in patent lymphatic filariasis. Cytokine/chemokine production and gene expression in monocytes from filaria-infected patients and uninfected healthy donors were assessed unstimulated and in response to stimulation with Staphylococcus aureus Cowan I bacteria plus gamma interferon both before and 8 months following treatment. Monocytes from filaria-infected individuals were studded with intracellular microfilarial antigens. Furthermore, monocytes from these individuals were less capable of producing interleukin-8 (IL-8), Exodus II, MIP-1α, MIP-1β, and IL-1α and preferentially expressed genes involved in apoptosis and adhesion compared with monocytes from uninfected donors. Eight months following treatment with a single dose of ivermectin-albendazole, some of these defects were reversed, with monocyte production of IL-8, IL-1α, MIP-1α, and IL-10 being comparable to that seen in the uninfected controls. In addition, a marked increase in mRNA expression of genes associated with protein metabolism, particularly heat shock proteins, was seen compared with pretreatment expression. These data suggest that the function and gene expression of monocytes in filaria-infected patients are altered but that this dysfunction is partially reversible following antifilarial treatment.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539612

DOI: 10.1128/IAI.01106-05
PubMed: 16861626
PubMed Central: 1539612

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001800
to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :001799
to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003C75
to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003930
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :003930
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003930
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002341
to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :002341
to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002341
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :007B62

Links to Exploration step

PMC:1539612

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Filaria-Induced Monocyte Dysfunction and Its Reversal following Treatment<xref ref-type="fn" rid="fn1">†</xref>
  </title>
<author><name sortKey="Semnani, Roshanak Tolouei" sort="Semnani, Roshanak Tolouei" uniqKey="Semnani R" first="Roshanak Tolouei" last="Semnani">Roshanak Tolouei Semnani</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Keiser, Paul B" sort="Keiser, Paul B" uniqKey="Keiser P" first="Paul B." last="Keiser">Paul B. Keiser</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coulibaly, Yaya I" sort="Coulibaly, Yaya I" uniqKey="Coulibaly Y" first="Yaya I." last="Coulibaly">Yaya I. Coulibaly</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Keita, Falaye" sort="Keita, Falaye" uniqKey="Keita F" first="Falaye" last="Keita">Falaye Keita</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Diallo, Abdallah A" sort="Diallo, Abdallah A" uniqKey="Diallo A" first="Abdallah A." last="Diallo">Abdallah A. Diallo</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Traore, Diakaridia" sort="Traore, Diakaridia" uniqKey="Traore D" first="Diakaridia" last="Traore">Diakaridia Traore</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Diallo, Dapa A" sort="Diallo, Dapa A" uniqKey="Diallo D" first="Dapa A." last="Diallo">Dapa A. Diallo</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Doumbo, Ogobara K" sort="Doumbo, Ogobara K" uniqKey="Doumbo O" first="Ogobara K." last="Doumbo">Ogobara K. Doumbo</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Traore, Sekou F" sort="Traore, Sekou F" uniqKey="Traore S" first="Sekou F." last="Traore">Sekou F. Traore</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kubofcik, Joseph" sort="Kubofcik, Joseph" uniqKey="Kubofcik J" first="Joseph" last="Kubofcik">Joseph Kubofcik</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klion, Amy D" sort="Klion, Amy D" uniqKey="Klion A" first="Amy D." last="Klion">Amy D. Klion</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">16861626</idno>
<idno type="pmc">1539612</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539612</idno>
<idno type="RBID">PMC:1539612</idno>
<idno type="doi">10.1128/IAI.01106-05</idno>
<date when="2006">2006</date>
<idno type="wicri:Area/Pmc/Corpus">001800</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001800</idno>
<idno type="wicri:Area/Pmc/Curation">001799</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001799</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003C75</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003C75</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">003930</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003930</idno>
<idno type="wicri:Area/PubMed/Curation">003930</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003930</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003930</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003930</idno>
<idno type="wicri:Area/Ncbi/Merge">002341</idno>
<idno type="wicri:Area/Ncbi/Curation">002341</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002341</idno>
<idno type="wicri:doubleKey">0019-9567:2006:Semnani R:filaria:induced:monocyte</idno>
<idno type="wicri:Area/Main/Merge">007B62</idno>
<idno type="wicri:Area/Main/Curation">007976</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Filaria-Induced Monocyte Dysfunction and Its Reversal following Treatment<xref ref-type="fn" rid="fn1">†</xref>
  </title>
<author><name sortKey="Semnani, Roshanak Tolouei" sort="Semnani, Roshanak Tolouei" uniqKey="Semnani R" first="Roshanak Tolouei" last="Semnani">Roshanak Tolouei Semnani</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Keiser, Paul B" sort="Keiser, Paul B" uniqKey="Keiser P" first="Paul B." last="Keiser">Paul B. Keiser</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coulibaly, Yaya I" sort="Coulibaly, Yaya I" uniqKey="Coulibaly Y" first="Yaya I." last="Coulibaly">Yaya I. Coulibaly</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Keita, Falaye" sort="Keita, Falaye" uniqKey="Keita F" first="Falaye" last="Keita">Falaye Keita</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Diallo, Abdallah A" sort="Diallo, Abdallah A" uniqKey="Diallo A" first="Abdallah A." last="Diallo">Abdallah A. Diallo</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Traore, Diakaridia" sort="Traore, Diakaridia" uniqKey="Traore D" first="Diakaridia" last="Traore">Diakaridia Traore</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Diallo, Dapa A" sort="Diallo, Dapa A" uniqKey="Diallo D" first="Dapa A." last="Diallo">Dapa A. Diallo</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Doumbo, Ogobara K" sort="Doumbo, Ogobara K" uniqKey="Doumbo O" first="Ogobara K." last="Doumbo">Ogobara K. Doumbo</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Traore, Sekou F" sort="Traore, Sekou F" uniqKey="Traore S" first="Sekou F." last="Traore">Sekou F. Traore</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kubofcik, Joseph" sort="Kubofcik, Joseph" uniqKey="Kubofcik J" first="Joseph" last="Kubofcik">Joseph Kubofcik</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klion, Amy D" sort="Klion, Amy D" uniqKey="Klion A" first="Amy D." last="Klion">Amy D. Klion</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Infection and Immunity</title>
<idno type="ISSN">0019-9567</idno>
<idno type="eISSN">1098-5522</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Albendazole (therapeutic use)</term>
<term>Animals</term>
<term>Anthelmintics (therapeutic use)</term>
<term>Antiparasitic Agents (therapeutic use)</term>
<term>Drug Therapy, Combination</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Elephantiasis, Filarial (parasitology)</term>
<term>Elephantiasis, Filarial (physiopathology)</term>
<term>Gene Expression</term>
<term>Heat-Shock Proteins (genetics)</term>
<term>Heat-Shock Proteins (metabolism)</term>
<term>Humans</term>
<term>Ivermectin (therapeutic use)</term>
<term>Molecular Sequence Data</term>
<term>Monocytes (metabolism)</term>
<term>Monocytes (parasitology)</term>
<term>Monocytes (pathology)</term>
<term>Treatment Outcome</term>
<term>Wuchereria bancrofti (isolation & purification)</term>
<term>Wuchereria bancrofti (pathogenicity)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Albendazole (usage thérapeutique)</term>
<term>Animaux</term>
<term>Antihelminthiques (usage thérapeutique)</term>
<term>Antiparasitaires (usage thérapeutique)</term>
<term>Association de médicaments</term>
<term>Données de séquences moléculaires</term>
<term>Expression des gènes</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filariose lymphatique (parasitologie)</term>
<term>Filariose lymphatique (physiopathologie)</term>
<term>Filariose lymphatique (traitement médicamenteux)</term>
<term>Humains</term>
<term>Ivermectine (usage thérapeutique)</term>
<term>Monocytes (anatomopathologie)</term>
<term>Monocytes (métabolisme)</term>
<term>Monocytes (parasitologie)</term>
<term>Protéines du choc thermique (génétique)</term>
<term>Protéines du choc thermique (métabolisme)</term>
<term>Résultat thérapeutique</term>
<term>Wuchereria bancrofti (isolement et purification)</term>
<term>Wuchereria bancrofti (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Heat-Shock Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Heat-Shock Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Albendazole</term>
<term>Anthelmintics</term>
<term>Antiparasitic Agents</term>
<term>Ivermectin</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Monocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines du choc thermique</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Monocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Monocytes</term>
<term>Protéines du choc thermique</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term>
<term>Monocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Monocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Monocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Albendazole</term>
<term>Antihelminthiques</term>
<term>Antiparasitaires</term>
<term>Ivermectine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Drug Therapy, Combination</term>
<term>Gene Expression</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Association de médicaments</term>
<term>Données de séquences moléculaires</term>
<term>Expression des gènes</term>
<term>Humains</term>
<term>Résultat thérapeutique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Monocyte dysfunction in filarial infection has been proposed as one mechanism underlying the diminished antigen-specific T-cell response seen in patent lymphatic filariasis. Cytokine/chemokine production and gene expression in monocytes from filaria-infected patients and uninfected healthy donors were assessed unstimulated and in response to stimulation with <italic>Staphylococcus aureus</italic>
 Cowan I bacteria plus gamma interferon both before and 8 months following treatment. Monocytes from filaria-infected individuals were studded with intracellular microfilarial antigens. Furthermore, monocytes from these individuals were less capable of producing interleukin-8 (IL-8), Exodus II, MIP-1α, MIP-1β, and IL-1α and preferentially expressed genes involved in apoptosis and adhesion compared with monocytes from uninfected donors. Eight months following treatment with a single dose of ivermectin-albendazole, some of these defects were reversed, with monocyte production of IL-8, IL-1α, MIP-1α, and IL-10 being comparable to that seen in the uninfected controls. In addition, a marked increase in mRNA expression of genes associated with protein metabolism, particularly heat shock proteins, was seen compared with pretreatment expression. These data suggest that the function and gene expression of monocytes in filaria-infected patients are altered but that this dysfunction is partially reversible following antifilarial treatment.</p>
</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007976 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 007976 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:1539612
   |texte=   Filaria-Induced Monocyte Dysfunction and Its Reversal following Treatment†  
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i   -Sk "pubmed:16861626" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Filaria-Induced Monocyte Dysfunction and Its Reversal following Treatment†

Filaria-Induced Monocyte Dysfunction and Its Reversal following Treatment†

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki