Filaria-Induced Monocyte Dysfunction and Its Reversal following Treatment†
Identifieur interne : 007B62 ( Main/Merge ); précédent : 007B61; suivant : 007B63Filaria-Induced Monocyte Dysfunction and Its Reversal following Treatment†
Auteurs : Roshanak Tolouei Semnani ; Paul B. Keiser ; Yaya I. Coulibaly ; Falaye Keita ; Abdallah A. Diallo ; Diakaridia Traore ; Dapa A. Diallo ; Ogobara K. Doumbo ; Sekou F. Traore ; Joseph Kubofcik ; Amy D. Klion ; Thomas B. NutmanSource :
- Infection and Immunity [ 0019-9567 ] ; 2006.
Descripteurs français
- KwdFr :
- Albendazole (usage thérapeutique), Animaux, Antihelminthiques (usage thérapeutique), Antiparasitaires (usage thérapeutique), Association de médicaments, Données de séquences moléculaires, Expression des gènes, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (physiopathologie), Filariose lymphatique (traitement médicamenteux), Humains, Ivermectine (usage thérapeutique), Monocytes (anatomopathologie), Monocytes (métabolisme), Monocytes (parasitologie), Protéines du choc thermique (génétique), Protéines du choc thermique (métabolisme), Résultat thérapeutique, Wuchereria bancrofti (isolement et purification), Wuchereria bancrofti (pathogénicité).
- MESH :
- anatomopathologie : Monocytes.
- génétique : Protéines du choc thermique.
- immunologie : Filariose lymphatique.
- isolement et purification : Wuchereria bancrofti.
- métabolisme : Monocytes, Protéines du choc thermique.
- parasitologie : Filariose lymphatique, Monocytes.
- pathogénicité : Wuchereria bancrofti.
- physiopathologie : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Albendazole, Antihelminthiques, Antiparasitaires, Ivermectine.
- Animaux, Association de médicaments, Données de séquences moléculaires, Expression des gènes, Humains, Résultat thérapeutique.
English descriptors
- KwdEn :
- Albendazole (therapeutic use), Animals, Anthelmintics (therapeutic use), Antiparasitic Agents (therapeutic use), Drug Therapy, Combination, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (physiopathology), Gene Expression, Heat-Shock Proteins (genetics), Heat-Shock Proteins (metabolism), Humans, Ivermectin (therapeutic use), Molecular Sequence Data, Monocytes (metabolism), Monocytes (parasitology), Monocytes (pathology), Treatment Outcome, Wuchereria bancrofti (isolation & purification), Wuchereria bancrofti (pathogenicity).
- MESH :
- chemical , genetics : Heat-Shock Proteins.
- chemical , metabolism : Heat-Shock Proteins.
- chemical , therapeutic use : Albendazole, Anthelmintics, Antiparasitic Agents, Ivermectin.
- drug therapy : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial.
- isolation & purification : Wuchereria bancrofti.
- metabolism : Monocytes.
- parasitology : Elephantiasis, Filarial, Monocytes.
- pathogenicity : Wuchereria bancrofti.
- pathology : Monocytes.
- physiopathology : Elephantiasis, Filarial.
- Animals, Drug Therapy, Combination, Gene Expression, Humans, Molecular Sequence Data, Treatment Outcome.
Abstract
Monocyte dysfunction in filarial infection has been proposed as one mechanism underlying the diminished antigen-specific T-cell response seen in patent lymphatic filariasis. Cytokine/chemokine production and gene expression in monocytes from filaria-infected patients and uninfected healthy donors were assessed unstimulated and in response to stimulation with
Url:
DOI: 10.1128/IAI.01106-05
PubMed: 16861626
PubMed Central: 1539612
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PMC:1539612Le document en format XML
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<term>Antiparasitic Agents (therapeutic use)</term>
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<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Elephantiasis, Filarial (parasitology)</term>
<term>Elephantiasis, Filarial (physiopathology)</term>
<term>Gene Expression</term>
<term>Heat-Shock Proteins (genetics)</term>
<term>Heat-Shock Proteins (metabolism)</term>
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<term>Ivermectin (therapeutic use)</term>
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<term>Monocytes (metabolism)</term>
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<term>Données de séquences moléculaires</term>
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<front><div type="abstract" xml:lang="en"><p>Monocyte dysfunction in filarial infection has been proposed as one mechanism underlying the diminished antigen-specific T-cell response seen in patent lymphatic filariasis. Cytokine/chemokine production and gene expression in monocytes from filaria-infected patients and uninfected healthy donors were assessed unstimulated and in response to stimulation with <italic>Staphylococcus aureus</italic>
Cowan I bacteria plus gamma interferon both before and 8 months following treatment. Monocytes from filaria-infected individuals were studded with intracellular microfilarial antigens. Furthermore, monocytes from these individuals were less capable of producing interleukin-8 (IL-8), Exodus II, MIP-1α, MIP-1β, and IL-1α and preferentially expressed genes involved in apoptosis and adhesion compared with monocytes from uninfected donors. Eight months following treatment with a single dose of ivermectin-albendazole, some of these defects were reversed, with monocyte production of IL-8, IL-1α, MIP-1α, and IL-10 being comparable to that seen in the uninfected controls. In addition, a marked increase in mRNA expression of genes associated with protein metabolism, particularly heat shock proteins, was seen compared with pretreatment expression. These data suggest that the function and gene expression of monocytes in filaria-infected patients are altered but that this dysfunction is partially reversible following antifilarial treatment.</p>
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