Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma.
Identifieur interne : 005F63 ( Main/Curation ); précédent : 005F62; suivant : 005F64Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma.
Auteurs : Wen-Yu Chuang [Taïwan] ; Chi-Ju Yeh ; Yi-Chin Wu ; Yin-Kai Chao ; Yun-Hen Liu ; Chen-Kan Tseng ; Hsien-Kun Chang ; Hui-Ping Liu ; Chuen HsuehSource :
- Histology and histopathology [ 1699-5848 ] ; 2009.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Analyse de survie, Carcinome épidermoïde (anatomopathologie), Carcinome épidermoïde (métabolisme), Facteurs temps, Femelle, Glycoprotéines membranaires (métabolisme), Humains, Immunohistochimie, Marqueurs biologiques tumoraux (métabolisme), Mâle, Métastase lymphatique (anatomopathologie), Sujet âgé, Tumeurs de l'oesophage (anatomopathologie), Tumeurs de l'oesophage (métabolisme), Vaisseaux lymphatiques (anatomopathologie), Études de suivi.
- MESH :
- anatomopathologie : Carcinome épidermoïde, Métastase lymphatique, Tumeurs de l'oesophage, Vaisseaux lymphatiques.
- métabolisme : Carcinome épidermoïde, Glycoprotéines membranaires, Marqueurs biologiques tumoraux, Tumeurs de l'oesophage.
- Adulte d'âge moyen, Analyse de survie, Facteurs temps, Femelle, Humains, Immunohistochimie, Mâle, Sujet âgé, Études de suivi.
English descriptors
- KwdEn :
- Aged, Biomarkers, Tumor (metabolism), Carcinoma, Squamous Cell (metabolism), Carcinoma, Squamous Cell (pathology), Esophageal Neoplasms (metabolism), Esophageal Neoplasms (pathology), Female, Follow-Up Studies, Humans, Immunohistochemistry, Lymphatic Metastasis (pathology), Lymphatic Vessels (pathology), Male, Membrane Glycoproteins (metabolism), Middle Aged, Survival Analysis, Time Factors.
- MESH :
- chemical , metabolism : Biomarkers, Tumor, Membrane Glycoproteins.
- metabolism : Carcinoma, Squamous Cell, Esophageal Neoplasms.
- pathology : Carcinoma, Squamous Cell, Esophageal Neoplasms, Lymphatic Metastasis, Lymphatic Vessels.
- Aged, Female, Follow-Up Studies, Humans, Immunohistochemistry, Male, Middle Aged, Survival Analysis, Time Factors.
Abstract
Podoplanin is a mucin-like glycoprotein expressed in the lymphatic endothelium. It has been suggested to play a role in lymphangiogenesis, since podoplanin deficient mice were found to have dilated malfunctioning lymphatic vessels and lymphedema. High podoplanin expression in tumor cells was found to correlate with lymph node metastasis and poor clinical outcome in patients with oral squamous cell carcinoma (SCC). However, the prognostic significance of podoplanin expression in esophageal SCC remains unexplored. Herein, we studied podoplanin expression in 59 patients who underwent surgical resection of esophageal SCC, with 43 of them preceded by preoperative concurrent chemoradiotherapy (CCRT). We found that high podoplanin expression strongly correlated with clinical nodal metastasis (cN1; p=0.0063), which was associated with short survival (p=0.012). However, there was no direct association between high podoplanin expression and short survival. We also found that lymphatic vessel invasion in the resected esophagus was strongly associated with pathological nodal metastasis (pN1; p=0.00092). Our results suggest that podoplanin could also play a role in tumor aggressiveness in esophageal SCC, as well as in oral SCC.
DOI: 10.14670/HH-24.1021
PubMed: 19554509
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002E20
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :002E20
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002E20
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :003487
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :003487
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003487
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :006034
Links to Exploration step
pubmed:19554509Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma.</title>
<author><name sortKey="Chuang, Wen Yu" sort="Chuang, Wen Yu" uniqKey="Chuang W" first="Wen-Yu" last="Chuang">Wen-Yu Chuang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Pathology, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan</wicri:regionArea>
<wicri:noRegion>Taoyuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yeh, Chi Ju" sort="Yeh, Chi Ju" uniqKey="Yeh C" first="Chi-Ju" last="Yeh">Chi-Ju Yeh</name>
</author>
<author><name sortKey="Wu, Yi Chin" sort="Wu, Yi Chin" uniqKey="Wu Y" first="Yi-Chin" last="Wu">Yi-Chin Wu</name>
</author>
<author><name sortKey="Chao, Yin Kai" sort="Chao, Yin Kai" uniqKey="Chao Y" first="Yin-Kai" last="Chao">Yin-Kai Chao</name>
</author>
<author><name sortKey="Liu, Yun Hen" sort="Liu, Yun Hen" uniqKey="Liu Y" first="Yun-Hen" last="Liu">Yun-Hen Liu</name>
</author>
<author><name sortKey="Tseng, Chen Kan" sort="Tseng, Chen Kan" uniqKey="Tseng C" first="Chen-Kan" last="Tseng">Chen-Kan Tseng</name>
</author>
<author><name sortKey="Chang, Hsien Kun" sort="Chang, Hsien Kun" uniqKey="Chang H" first="Hsien-Kun" last="Chang">Hsien-Kun Chang</name>
</author>
<author><name sortKey="Liu, Hui Ping" sort="Liu, Hui Ping" uniqKey="Liu H" first="Hui-Ping" last="Liu">Hui-Ping Liu</name>
</author>
<author><name sortKey="Hsueh, Chuen" sort="Hsueh, Chuen" uniqKey="Hsueh C" first="Chuen" last="Hsueh">Chuen Hsueh</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2009">2009</date>
<idno type="RBID">pubmed:19554509</idno>
<idno type="pmid">19554509</idno>
<idno type="doi">10.14670/HH-24.1021</idno>
<idno type="wicri:Area/PubMed/Corpus">002E20</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E20</idno>
<idno type="wicri:Area/PubMed/Curation">002E20</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002E20</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002E20</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002E20</idno>
<idno type="wicri:Area/Ncbi/Merge">003487</idno>
<idno type="wicri:Area/Ncbi/Curation">003487</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003487</idno>
<idno type="wicri:Area/Main/Merge">006034</idno>
<idno type="wicri:Area/Main/Curation">005F63</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma.</title>
<author><name sortKey="Chuang, Wen Yu" sort="Chuang, Wen Yu" uniqKey="Chuang W" first="Wen-Yu" last="Chuang">Wen-Yu Chuang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Pathology, Chang Gung Memorial Hospital, Linko, Chang Gung University College of Medicine, Taoyuan</wicri:regionArea>
<wicri:noRegion>Taoyuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yeh, Chi Ju" sort="Yeh, Chi Ju" uniqKey="Yeh C" first="Chi-Ju" last="Yeh">Chi-Ju Yeh</name>
</author>
<author><name sortKey="Wu, Yi Chin" sort="Wu, Yi Chin" uniqKey="Wu Y" first="Yi-Chin" last="Wu">Yi-Chin Wu</name>
</author>
<author><name sortKey="Chao, Yin Kai" sort="Chao, Yin Kai" uniqKey="Chao Y" first="Yin-Kai" last="Chao">Yin-Kai Chao</name>
</author>
<author><name sortKey="Liu, Yun Hen" sort="Liu, Yun Hen" uniqKey="Liu Y" first="Yun-Hen" last="Liu">Yun-Hen Liu</name>
</author>
<author><name sortKey="Tseng, Chen Kan" sort="Tseng, Chen Kan" uniqKey="Tseng C" first="Chen-Kan" last="Tseng">Chen-Kan Tseng</name>
</author>
<author><name sortKey="Chang, Hsien Kun" sort="Chang, Hsien Kun" uniqKey="Chang H" first="Hsien-Kun" last="Chang">Hsien-Kun Chang</name>
</author>
<author><name sortKey="Liu, Hui Ping" sort="Liu, Hui Ping" uniqKey="Liu H" first="Hui-Ping" last="Liu">Hui-Ping Liu</name>
</author>
<author><name sortKey="Hsueh, Chuen" sort="Hsueh, Chuen" uniqKey="Hsueh C" first="Chuen" last="Hsueh">Chuen Hsueh</name>
</author>
</analytic>
<series><title level="j">Histology and histopathology</title>
<idno type="eISSN">1699-5848</idno>
<imprint><date when="2009" type="published">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Biomarkers, Tumor (metabolism)</term>
<term>Carcinoma, Squamous Cell (metabolism)</term>
<term>Carcinoma, Squamous Cell (pathology)</term>
<term>Esophageal Neoplasms (metabolism)</term>
<term>Esophageal Neoplasms (pathology)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Lymphatic Metastasis (pathology)</term>
<term>Lymphatic Vessels (pathology)</term>
<term>Male</term>
<term>Membrane Glycoproteins (metabolism)</term>
<term>Middle Aged</term>
<term>Survival Analysis</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Carcinome épidermoïde (anatomopathologie)</term>
<term>Carcinome épidermoïde (métabolisme)</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Glycoprotéines membranaires (métabolisme)</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Marqueurs biologiques tumoraux (métabolisme)</term>
<term>Mâle</term>
<term>Métastase lymphatique (anatomopathologie)</term>
<term>Sujet âgé</term>
<term>Tumeurs de l'oesophage (anatomopathologie)</term>
<term>Tumeurs de l'oesophage (métabolisme)</term>
<term>Vaisseaux lymphatiques (anatomopathologie)</term>
<term>Études de suivi</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers, Tumor</term>
<term>Membrane Glycoproteins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome épidermoïde</term>
<term>Métastase lymphatique</term>
<term>Tumeurs de l'oesophage</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Carcinoma, Squamous Cell</term>
<term>Esophageal Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Carcinome épidermoïde</term>
<term>Glycoprotéines membranaires</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Tumeurs de l'oesophage</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Squamous Cell</term>
<term>Esophageal Neoplasms</term>
<term>Lymphatic Metastasis</term>
<term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Survival Analysis</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Études de suivi</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Podoplanin is a mucin-like glycoprotein expressed in the lymphatic endothelium. It has been suggested to play a role in lymphangiogenesis, since podoplanin deficient mice were found to have dilated malfunctioning lymphatic vessels and lymphedema. High podoplanin expression in tumor cells was found to correlate with lymph node metastasis and poor clinical outcome in patients with oral squamous cell carcinoma (SCC). However, the prognostic significance of podoplanin expression in esophageal SCC remains unexplored. Herein, we studied podoplanin expression in 59 patients who underwent surgical resection of esophageal SCC, with 43 of them preceded by preoperative concurrent chemoradiotherapy (CCRT). We found that high podoplanin expression strongly correlated with clinical nodal metastasis (cN1; p=0.0063), which was associated with short survival (p=0.012). However, there was no direct association between high podoplanin expression and short survival. We also found that lymphatic vessel invasion in the resected esophagus was strongly associated with pathological nodal metastasis (pN1; p=0.00092). Our results suggest that podoplanin could also play a role in tumor aggressiveness in esophageal SCC, as well as in oral SCC.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005F63 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 005F63 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Curation |type= RBID |clé= pubmed:19554509 |texte= Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:19554509" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |