Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence12
Identifieur interne : 005862 ( Main/Curation ); précédent : 005861; suivant : 005863Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence12
Auteurs : John C. Rasmussen [États-Unis] ; I-Chih Tan [États-Unis] ; Milton V. Marshall [États-Unis] ; Kristen E. Adams [États-Unis] ; Sunkuk Kwon [États-Unis] ; Caroline E. Fife [États-Unis] ; Erik A. Maus [États-Unis] ; Latisha A. Smith [États-Unis] ; Kyle R. Covington [États-Unis] ; Eva M. Sevick-Muraca [États-Unis]Source :
- Translational Oncology [ 1936-5233 ] ; 2010.
Abstract
Url:
PubMed: 21151475
PubMed Central: 3000461
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<author><name sortKey="Fife, Caroline E" sort="Fife, Caroline E" uniqKey="Fife C" first="Caroline E" last="Fife">Caroline E. Fife</name>
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<wicri:noRegion>TX</wicri:noRegion>
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<author><name sortKey="Smith, Latisha A" sort="Smith, Latisha A" uniqKey="Smith L" first="Latisha A" last="Smith">Latisha A. Smith</name>
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<front><div type="abstract" xml:lang="en"><p><italic>BACKGROUND:</italic>
Although the importance of lymphatic function is well recognized, the lack of real-time imaging modalities limits our understanding of its role in many diseases. In a phase 0 exploratory study, we used dynamic, near-infrared (NIR) fluorescence imaging to assess the extremes of lymphatic architecture and transport in healthy human subjects and in subjects clinically diagnosed with unilateral lymphedema (LE), a disease that can be prevalent in cancer survivors. <italic>METHODS AND RESULTS:</italic>
Active lymphatic propulsion was imaged after intradermal injections of 25 <italic>µ</italic>
g of indocyanine green (total maximum dose ≤400 <italic>µ</italic>
g) bilaterally in the arms or legs of control and subjects. Images show well-defined lymphatic structures with propulsive dye transport in limbs of healthy subjects. In LE subjects, we observed extravascular dye accumulation, networks of fluorescent lymphatic capillaries, and/or tortuous lymphatic vessels in all symptomatic and some asymptomatic limbs. Statistical models indicate that disease status and/or limb significantly affect parameters of apparent lymph propagation velocity and contractile frequency. <italic>CONCLUSIONS:</italic>
These clinical research studies demonstrate the potential of NIR fluorescence imaging as a diagnostic measure of functional lymphatics and as a new tool in translational research studies to decipher the role of the lymphatic system in cancer and other diseases.</p>
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