LymphedemaV1, Main, Curation, bibRecord, 004058

PTPN14 is required for the density-dependent control of YAP1

Identifieur interne : 004058 ( Main/Curation ); précédent : 004057; suivant : 004059

PTPN14 is required for the density-dependent control of YAP1

Auteurs : Wenqi Wang [États-Unis] ; Jun Huang [République populaire de Chine] ; Xin Wang [États-Unis] ; Jingsong Yuan [États-Unis] ; Xu Li [États-Unis] ; Lin Feng [États-Unis] ; Jae-Il Park [États-Unis] ; Junjie Chen [États-Unis]

Source :

Genes & Development [ 0890-9369 ] ; 2012.

RBID : PMC:3435498

Abstract

Wang et al. identify the protein tyrosine phosphatase PTPN14 as a novel regulator of the Hippo pathway and the oncoprotein YAP1 and as a potential tumor suppressor. They show that PTPN14 associates with and negatively regulates the oncoprotein YAP1 during contact inhibition and that PTPN14 stability is controlled at low cell density by way of the CRL2^LRR1 E3 ligase complex.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435498

DOI: 10.1101/gad.192955.112
PubMed: 22948661
PubMed Central: 3435498

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PMC:3435498

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Wang et al. identify the protein tyrosine phosphatase PTPN14 as a novel regulator of the Hippo pathway and the oncoprotein YAP1 and as a potential tumor suppressor. They show that PTPN14 associates with and negatively regulates the oncoprotein YAP1 during contact inhibition and that PTPN14 stability is controlled at low cell density by way of the CRL2<sup>LRR1</sup>
 E3 ligase complex.</p>
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PTPN14 is required for the density-dependent control of YAP1

PTPN14 is required for the density-dependent control of YAP1

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Abstract

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