PTPN14 is required for the density-dependent control of YAP1
Identifieur interne : 002E10 ( Pmc/Curation ); précédent : 002E09; suivant : 002E11PTPN14 is required for the density-dependent control of YAP1
Auteurs : Wenqi Wang [États-Unis] ; Jun Huang [République populaire de Chine] ; Xin Wang [États-Unis] ; Jingsong Yuan [États-Unis] ; Xu Li [États-Unis] ; Lin Feng [États-Unis] ; Jae-Il Park [États-Unis] ; Junjie Chen [États-Unis]Source :
- Genes & Development [ 0890-9369 ] ; 2012.
Abstract
Wang et al. identify the protein tyrosine phosphatase PTPN14 as a novel regulator of the Hippo pathway and the oncoprotein YAP1 and as a potential tumor suppressor. They show that PTPN14 associates with and negatively regulates the oncoprotein YAP1 during contact inhibition and that PTPN14 stability is controlled at low cell density by way of the CRL2LRR1 E3 ligase complex.
Url:
DOI: 10.1101/gad.192955.112
PubMed: 22948661
PubMed Central: 3435498
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Institute, Zhejiang University, Hangzhou, Zhejiang 310058</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xin" sort="Wang, Xin" uniqKey="Wang X" first="Xin" last="Wang">Xin Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea></affiliation></author><author><name sortKey="Yuan, Jingsong" sort="Yuan, Jingsong" uniqKey="Yuan J" first="Jingsong" last="Yuan">Jingsong Yuan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea></affiliation></author><author><name sortKey="Li, Xu" sort="Li, Xu" uniqKey="Li X" first="Xu" last="Li">Xu Li</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea></affiliation></author><author><name sortKey="Feng, Lin" sort="Feng, Lin" uniqKey="Feng L" first="Lin" last="Feng">Lin Feng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;</nlm:aff><country 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Center, Houston, Texas 77030, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22948661</idno><idno type="pmc">3435498</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435498</idno><idno type="RBID">PMC:3435498</idno><idno type="doi">10.1101/gad.192955.112</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002E11</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E11</idno><idno type="wicri:Area/Pmc/Curation">002E10</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002E10</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">PTPN14 is required for the density-dependent control of YAP1</title><author><name sortKey="Wang, Wenqi" sort="Wang, Wenqi" uniqKey="Wang W" first="Wenqi" last="Wang">Wenqi Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Jun" sort="Huang, Jun" uniqKey="Huang J" first="Jun" last="Huang">Jun Huang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xin" sort="Wang, Xin" uniqKey="Wang X" first="Xin" last="Wang">Xin Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea></affiliation></author><author><name sortKey="Yuan, Jingsong" sort="Yuan, Jingsong" uniqKey="Yuan J" first="Jingsong" last="Yuan">Jingsong Yuan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea></affiliation></author><author><name sortKey="Li, Xu" sort="Li, Xu" uniqKey="Li X" first="Xu" last="Li">Xu Li</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea></affiliation></author><author><name sortKey="Feng, Lin" sort="Feng, Lin" uniqKey="Feng L" first="Lin" last="Feng">Lin Feng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea></affiliation></author><author><name sortKey="Park, Jae Il" sort="Park, Jae Il" uniqKey="Park J" first="Jae-Il" last="Park">Jae-Il Park</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Junjie" sort="Chen, Junjie" uniqKey="Chen J" first="Junjie" last="Chen">Junjie Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea></affiliation></author></analytic><series><title level="j">Genes & Development</title><idno type="ISSN">0890-9369</idno><idno type="eISSN">1549-5477</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Wang et al. identify the protein tyrosine phosphatase PTPN14 as a novel regulator of the Hippo pathway and the oncoprotein YAP1 and as a potential tumor suppressor. They show that PTPN14 associates with and negatively regulates the oncoprotein YAP1 during contact inhibition and that PTPN14 stability is controlled at low cell density by way of the CRL2<sup>LRR1</sup> E3 ligase complex.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Genes Dev</journal-id><journal-id journal-id-type="iso-abbrev">Genes Dev</journal-id><journal-id journal-id-type="publisher-id">GAD</journal-id><journal-title-group><journal-title>Genes & Development</journal-title></journal-title-group><issn pub-type="ppub">0890-9369</issn><issn pub-type="epub">1549-5477</issn><publisher><publisher-name>Cold Spring Harbor Laboratory Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22948661</article-id><article-id pub-id-type="pmc">3435498</article-id><article-id pub-id-type="medline">8711660</article-id><article-id pub-id-type="doi">10.1101/gad.192955.112</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Paper</subject></subj-group></article-categories><title-group><article-title>PTPN14 is required for the density-dependent control of YAP1</article-title><alt-title alt-title-type="left-running">Wang et al.</alt-title><alt-title alt-title-type="right-running">Cell density-dependent control of YAP1 by PTPN14</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Wenqi</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Jun</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Xin</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yuan</surname><given-names>Jingsong</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Xu</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Feng</surname><given-names>Lin</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Jae-Il</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Junjie</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1">3</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;</aff><aff id="aff2"><label>2</label>Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China</aff><author-notes><corresp id="cor1"><label>3</label>Corresponding author E-mail <email xlink:type="simple">jchen8@mdanderson.org</email></corresp></author-notes><pub-date pub-type="ppub"><day>1</day><month>9</month><year>2012</year></pub-date><volume>26</volume><issue>17</issue><fpage>1959</fpage><lpage>1971</lpage><history><date date-type="received"><day>27</day><month>3</month><year>2012</year></date><date date-type="accepted"><day>17</day><month>7</month><year>2012</year></date></history><permissions><copyright-statement>Copyright © 2012 by Cold Spring Harbor Laboratory Press</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="1959.pdf"></self-uri><abstract abstract-type="precis"><p>Wang et al. identify the protein tyrosine phosphatase PTPN14 as a novel regulator of the Hippo pathway and the oncoprotein YAP1 and as a potential tumor suppressor. They show that PTPN14 associates with and negatively regulates the oncoprotein YAP1 during contact inhibition and that PTPN14 stability is controlled at low cell density by way of the CRL2<sup>LRR1</sup> E3 ligase complex.</p></abstract><abstract><p>Through an shRNA-mediated loss-of-function screen, we identified PTPN14 as a potential tumor suppressor. PTPN14 interacts with yes-associated protein 1 (YAP1), a member of the hippo signaling pathway. We showed that PTPN14 promotes the nucleus-to-cytoplasm translocation of YAP1 during contact inhibition and thus inhibits YAP1 transactivation activity. Interestingly, PTPN14 protein stability was positively controlled by cell density. We identified the CRL2<sup>LRR1</sup> (cullin2 RING ubiquitin ligase complex/leucine-rich repeat protein 1) complex as the E3 ligase that targets PTPN14 for degradation at low cell density. Collectively, these data suggest that PTPN14 acts to suppress cell proliferation by promoting cell density-dependent cytoplasmic translocation of YAP1.</p></abstract><kwd-group><kwd>tumor suppressor</kwd><kwd>PTPN14</kwd><kwd>YAP1</kwd><kwd>hippo pathway</kwd><kwd>cell density</kwd><kwd>CRL2<sup>LRR1</sup></kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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