Role of paclitaxel and platinum-based adjuvant chemotherapy in high-risk penile cancer
Identifieur interne : 003F07 ( Main/Curation ); précédent : 003F06; suivant : 003F08Role of paclitaxel and platinum-based adjuvant chemotherapy in high-risk penile cancer
Auteurs : Vanita Noronha [Inde] ; Vijay Patil [Inde] ; Vikas Ostwal [Inde] ; Hemant Tongaonkar [Inde] ; Ganesh Bakshi [Inde] ; Kumar Prabhash [Inde]Source :
- Urology Annals [ 0974-7796 ] ; 2012.
Abstract
To study the efficacy and safety of paclitaxel and platinum doublet chemotherapy in penile cancer patients with high-risk features of local failure.
Retrospective analysis was done of patients with 19 carcinoma of the penis who were offered adjuvant chemotherapy with paclitaxel and platinum combination. The data regarding the surgical details, high-risk features for which chemotherapy was offered, chemotherapy toxicity details (in accordance with CTCAE vs 3), failure pattern, and survival data were noted. SPSS version 16 was used for statistical analysis. Descriptive and Kaplan–Meier survival analysis was performed.
Median age of patients was 48 years. Fifteen patients received paclitaxel in combination with cisplatin and four received paclitaxel with carboplatin in view of their low serum creatinine clearance. The treatment was completed by 12 patients (63.2%). Of 79 planned cycles, 50 were taken. The treatment was well tolerated with grade 3-4 gastrointestinal toxicity was seen in 1 patient, grade 3 neurological toxicity in one and grade 5 neutropenia in one patient. Treatment related death occured in one patient. The median follow-up was 15.33 months and 6 loco-regional relapsed had taken place. The estimated median DFS was 16.2 months and the estimated median OS was not reached. The estimated DFS for treatment completed patients was 23.13 months as against 2.16 months for patients not completing treatment.
The platinum and taxane doublet chemotherapy was found to be safe and effective.
Url:
DOI: 10.4103/0974-7796.102659
PubMed: 23248520
PubMed Central: 3519105
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :004661
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :004660
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002729
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :005437
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :005437
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :005437
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003F21
Links to Exploration step
PMC:3519105Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of paclitaxel and platinum-based adjuvant chemotherapy in high-risk penile cancer</title>
<author><name sortKey="Noronha, Vanita" sort="Noronha, Vanita" uniqKey="Noronha V" first="Vanita" last="Noronha">Vanita Noronha</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Patil, Vijay" sort="Patil, Vijay" uniqKey="Patil V" first="Vijay" last="Patil">Vijay Patil</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ostwal, Vikas" sort="Ostwal, Vikas" uniqKey="Ostwal V" first="Vikas" last="Ostwal">Vikas Ostwal</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tongaonkar, Hemant" sort="Tongaonkar, Hemant" uniqKey="Tongaonkar H" first="Hemant" last="Tongaonkar">Hemant Tongaonkar</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bakshi, Ganesh" sort="Bakshi, Ganesh" uniqKey="Bakshi G" first="Ganesh" last="Bakshi">Ganesh Bakshi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Prabhash, Kumar" sort="Prabhash, Kumar" uniqKey="Prabhash K" first="Kumar" last="Prabhash">Kumar Prabhash</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23248520</idno>
<idno type="pmc">3519105</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519105</idno>
<idno type="RBID">PMC:3519105</idno>
<idno type="doi">10.4103/0974-7796.102659</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">004661</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004661</idno>
<idno type="wicri:Area/Pmc/Curation">004660</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004660</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002729</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002729</idno>
<idno type="wicri:Area/Ncbi/Merge">005437</idno>
<idno type="wicri:Area/Ncbi/Curation">005437</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">005437</idno>
<idno type="wicri:doubleKey">0974-7796:2012:Noronha V:role:of:paclitaxel</idno>
<idno type="wicri:Area/Main/Merge">003F21</idno>
<idno type="wicri:Area/Main/Curation">003F07</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of paclitaxel and platinum-based adjuvant chemotherapy in high-risk penile cancer</title>
<author><name sortKey="Noronha, Vanita" sort="Noronha, Vanita" uniqKey="Noronha V" first="Vanita" last="Noronha">Vanita Noronha</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Patil, Vijay" sort="Patil, Vijay" uniqKey="Patil V" first="Vijay" last="Patil">Vijay Patil</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ostwal, Vikas" sort="Ostwal, Vikas" uniqKey="Ostwal V" first="Vikas" last="Ostwal">Vikas Ostwal</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tongaonkar, Hemant" sort="Tongaonkar, Hemant" uniqKey="Tongaonkar H" first="Hemant" last="Tongaonkar">Hemant Tongaonkar</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bakshi, Ganesh" sort="Bakshi, Ganesh" uniqKey="Bakshi G" first="Ganesh" last="Bakshi">Ganesh Bakshi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Prabhash, Kumar" sort="Prabhash, Kumar" uniqKey="Prabhash K" first="Kumar" last="Prabhash">Kumar Prabhash</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Medical Oncology, Tata Memorial Hospital, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Urology Annals</title>
<idno type="ISSN">0974-7796</idno>
<idno type="eISSN">0974-7834</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="st1"><title>Aim:</title>
<p>To study the efficacy and safety of paclitaxel and platinum doublet chemotherapy in penile cancer patients with high-risk features of local failure.</p>
</sec>
<sec id="st2"><title>Materials and Methods:</title>
<p>Retrospective analysis was done of patients with 19 carcinoma of the penis who were offered adjuvant chemotherapy with paclitaxel and platinum combination. The data regarding the surgical details, high-risk features for which chemotherapy was offered, chemotherapy toxicity details (in accordance with CTCAE vs 3), failure pattern, and survival data were noted. SPSS version 16 was used for statistical analysis. Descriptive and Kaplan–Meier survival analysis was performed.</p>
</sec>
<sec id="st3"><title>Results:</title>
<p>Median age of patients was 48 years. Fifteen patients received paclitaxel in combination with cisplatin and four received paclitaxel with carboplatin in view of their low serum creatinine clearance. The treatment was completed by 12 patients (63.2%). Of 79 planned cycles, 50 were taken. The treatment was well tolerated with grade 3-4 gastrointestinal toxicity was seen in 1 patient, grade 3 neurological toxicity in one and grade 5 neutropenia in one patient. Treatment related death occured in one patient. The median follow-up was 15.33 months and 6 loco-regional relapsed had taken place. The estimated median DFS was 16.2 months and the estimated median OS was not reached. The estimated DFS for treatment completed patients was 23.13 months as against 2.16 months for patients not completing treatment.</p>
</sec>
<sec id="st4"><title>Conclusion:</title>
<p>The platinum and taxane doublet chemotherapy was found to be safe and effective.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Barnholtz Sloan, Js" uniqKey="Barnholtz Sloan J">JS Barnholtz-Sloan</name>
</author>
<author><name sortKey="Maldonado, Jl" uniqKey="Maldonado J">JL Maldonado</name>
</author>
<author><name sortKey="Pow Sang, J" uniqKey="Pow Sang J">J Pow-sang</name>
</author>
<author><name sortKey="Giuliano, Ar" uniqKey="Giuliano A">AR Giuliano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Misra, S" uniqKey="Misra S">S Misra</name>
</author>
<author><name sortKey="Chaturvedi, A" uniqKey="Chaturvedi A">A Chaturvedi</name>
</author>
<author><name sortKey="Misra, Nc" uniqKey="Misra N">NC Misra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ficarra, V" uniqKey="Ficarra V">V Ficarra</name>
</author>
<author><name sortKey="Akduman, B" uniqKey="Akduman B">B Akduman</name>
</author>
<author><name sortKey="Bouchot, O" uniqKey="Bouchot O">O Bouchot</name>
</author>
<author><name sortKey="Palou, J" uniqKey="Palou J">J Palou</name>
</author>
<author><name sortKey="Tobias Machado, M" uniqKey="Tobias Machado M">M Tobias-Machado</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Novara, G" uniqKey="Novara G">G Novara</name>
</author>
<author><name sortKey="Galfano, A" uniqKey="Galfano A">A Galfano</name>
</author>
<author><name sortKey="De Marco, V" uniqKey="De Marco V">V De Marco</name>
</author>
<author><name sortKey="Artibani, W" uniqKey="Artibani W">W Artibani</name>
</author>
<author><name sortKey="Ficarra, V" uniqKey="Ficarra V">V Ficarra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ravi, R" uniqKey="Ravi R">R Ravi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pizzocaro, G" uniqKey="Pizzocaro G">G Pizzocaro</name>
</author>
<author><name sortKey="Algaba, F" uniqKey="Algaba F">F Algaba</name>
</author>
<author><name sortKey="Horenblas, S" uniqKey="Horenblas S">S Horenblas</name>
</author>
<author><name sortKey="Solsona, E" uniqKey="Solsona E">E Solsona</name>
</author>
<author><name sortKey="Tana, S" uniqKey="Tana S">S Tana</name>
</author>
<author><name sortKey="Van Der Poel, H" uniqKey="Van Der Poel H">H Van Der Poel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hakenberg, Ow" uniqKey="Hakenberg O">OW Hakenberg</name>
</author>
<author><name sortKey="Nippgen, Jb" uniqKey="Nippgen J">JB Nippgen</name>
</author>
<author><name sortKey="Froehner, M" uniqKey="Froehner M">M Froehner</name>
</author>
<author><name sortKey="Zastrow, S" uniqKey="Zastrow S">S Zastrow</name>
</author>
<author><name sortKey="Wirth, Mp" uniqKey="Wirth M">MP Wirth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pizzocaro, G" uniqKey="Pizzocaro G">G Pizzocaro</name>
</author>
<author><name sortKey="Piva, L" uniqKey="Piva L">L Piva</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Protzel, C" uniqKey="Protzel C">C Protzel</name>
</author>
<author><name sortKey="Ruppin, S" uniqKey="Ruppin S">S Ruppin</name>
</author>
<author><name sortKey="Milerski, S" uniqKey="Milerski S">S Milerski</name>
</author>
<author><name sortKey="Klebingat, K" uniqKey="Klebingat K">K Klebingat</name>
</author>
<author><name sortKey="Hakenberg, Ow" uniqKey="Hakenberg O">OW Hakenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Di Lorenzo, G" uniqKey="Di Lorenzo G">G Di Lorenzo</name>
</author>
<author><name sortKey="Carteni, G" uniqKey="Carteni G">G Cartenì</name>
</author>
<author><name sortKey="Autorino, R" uniqKey="Autorino R">R Autorino</name>
</author>
<author><name sortKey="Gonnella, A" uniqKey="Gonnella A">A Gonnella</name>
</author>
<author><name sortKey="Perdona, S" uniqKey="Perdona S">S Perdonà</name>
</author>
<author><name sortKey="Ferro, M" uniqKey="Ferro M">M Ferro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Posner, M" uniqKey="Posner M">M Posner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lont, Ap" uniqKey="Lont A">AP Lont</name>
</author>
<author><name sortKey="Kroon, Bk" uniqKey="Kroon B">BK Kroon</name>
</author>
<author><name sortKey="Gallee, Mp" uniqKey="Gallee M">MP Gallee</name>
</author>
<author><name sortKey="Van Tinteren, H" uniqKey="Van Tinteren H">H van Tinteren</name>
</author>
<author><name sortKey="Moonen, Lm" uniqKey="Moonen L">LM Moonen</name>
</author>
<author><name sortKey="Horenblas, S" uniqKey="Horenblas S">S Horenblas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pandey, D" uniqKey="Pandey D">D Pandey</name>
</author>
<author><name sortKey="Mahajan, V" uniqKey="Mahajan V">V Mahajan</name>
</author>
<author><name sortKey="Kannan, Rr" uniqKey="Kannan R">RR Kannan</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003F07 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 003F07 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Curation |type= RBID |clé= PMC:3519105 |texte= Role of paclitaxel and platinum-based adjuvant chemotherapy in high-risk penile cancer }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:23248520" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |