Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells
Identifieur interne : 002F96 ( Main/Curation ); précédent : 002F95; suivant : 002F97Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells
Auteurs : Cristina T. Kesler [États-Unis] ; Angera Kuo [États-Unis] ; Hon-Kit Wong [États-Unis] ; David J. Masuck [États-Unis] ; Jennifer L. Shah [États-Unis] ; Kevin Kozak [États-Unis] ; Kathryn D. Held [États-Unis] ; Timothy P. Padera [États-Unis]Source :
- Angiogenesis [ 0969-6970 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Agents protecteurs (pharmacologie), Altération de l'ADN, Apoptose (), Cellules endothéliales (), Cellules endothéliales (métabolisme), Cycle cellulaire (), Facteur de croissance endothéliale vasculaire de type C (pharmacologie), Humains, Lymphangiogenèse (), Radiotolérance (), Survie cellulaire ().
- MESH :
English descriptors
- KwdEn :
- Adult, Apoptosis (drug effects), Cell Cycle (drug effects), Cell Survival (drug effects), DNA Damage, Endothelial Cells (drug effects), Endothelial Cells (metabolism), Humans, Lymphangiogenesis (drug effects), Protective Agents (pharmacology), Radiation Tolerance (drug effects), Vascular Endothelial Growth Factor C (pharmacology).
- MESH :
- chemical , pharmacology : Protective Agents, Vascular Endothelial Growth Factor C.
- drug effects : Apoptosis, Cell Cycle, Cell Survival, Endothelial Cells, Lymphangiogenesis, Radiation Tolerance.
- metabolism : Endothelial Cells.
- Adult, DNA Damage, Humans.
Abstract
Radiation therapy after lymph node dissection increases the risk of developing painful and incurable lymphedema in breast cancer patients. Lymphedema occurs when lymphatic vessels become unable to maintain proper fluid balance. The sensitivity of lymphatic endothelial cells (LECs) to ionizing radiation has not been reported to date. Here, the radiosensitivity of LECs
Url:
DOI: 10.1007/s10456-013-9400-7
PubMed: 24201897
PubMed Central: 3981926
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PMC:3981926Le document en format XML
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<series><title level="j">Angiogenesis</title>
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<term>Apoptosis (drug effects)</term>
<term>Cell Cycle (drug effects)</term>
<term>Cell Survival (drug effects)</term>
<term>DNA Damage</term>
<term>Endothelial Cells (drug effects)</term>
<term>Endothelial Cells (metabolism)</term>
<term>Humans</term>
<term>Lymphangiogenesis (drug effects)</term>
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<term>Agents protecteurs (pharmacologie)</term>
<term>Altération de l'ADN</term>
<term>Apoptose ()</term>
<term>Cellules endothéliales ()</term>
<term>Cellules endothéliales (métabolisme)</term>
<term>Cycle cellulaire ()</term>
<term>Facteur de croissance endothéliale vasculaire de type C (pharmacologie)</term>
<term>Humains</term>
<term>Lymphangiogenèse ()</term>
<term>Radiotolérance ()</term>
<term>Survie cellulaire ()</term>
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<term>Vascular Endothelial Growth Factor C</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term>
<term>Cell Cycle</term>
<term>Cell Survival</term>
<term>Endothelial Cells</term>
<term>Lymphangiogenesis</term>
<term>Radiation Tolerance</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelial Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules endothéliales</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents protecteurs</term>
<term>Facteur de croissance endothéliale vasculaire de type C</term>
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<term>DNA Damage</term>
<term>Humans</term>
</keywords>
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<term>Altération de l'ADN</term>
<term>Apoptose</term>
<term>Cellules endothéliales</term>
<term>Cycle cellulaire</term>
<term>Humains</term>
<term>Lymphangiogenèse</term>
<term>Radiotolérance</term>
<term>Survie cellulaire</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Radiation therapy after lymph node dissection increases the risk of developing painful and incurable lymphedema in breast cancer patients. Lymphedema occurs when lymphatic vessels become unable to maintain proper fluid balance. The sensitivity of lymphatic endothelial cells (LECs) to ionizing radiation has not been reported to date. Here, the radiosensitivity of LECs <italic>in vitro</italic>
has been determined using clonogenic survival assays. The ability of various growth factors to alter LEC radiosensitivity was also examined. Vascular endothelial growth factor (VEGF)-C enhanced radiosensitivity when LECs were treated prior to radiation. VEGF-C-treated LECs exhibited higher levels of entry into the cell cycle at the time of radiation, with a greater number of cells in the S and G2/M phases. These LECs showed higher levels of H2A.X—an indicator of DNA damage—after radiation. VEGF-C did not increase cell death as a result of radiation. Instead, it increased the relative number of quiescent LECs. These data suggest that abundant VEGF-C or lymphangiogenesis may predispose patients to radiation-induced lymphedema by impairing lymphatic vessel repair through induction of LEC quiescence.</p>
</div>
</front>
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