Interleukin-10- and Transforming Growth Factor β-Independent Regulation of CD8+ T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis
Identifieur interne : 002978 ( Main/Curation ); précédent : 002977; suivant : 002979Interleukin-10- and Transforming Growth Factor β-Independent Regulation of CD8+ T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis
Auteurs : Rajamanickam Anuradha [Inde] ; Parakkal Jovvian George [Inde] ; Paul Kumaran [Inde] ; Thomas B. Nutman [États-Unis] ; Subash Babu [Inde, États-Unis]Source :
- Clinical and Vaccine Immunology : CVI [ 1556-6811 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Cytokines (métabolisme), Facteur de croissance transformant bêta (physiologie), Filariose lymphatique (immunologie), Humains, Interleukine-10 (physiologie), Lymphocytes T CD4+ (immunologie), Lymphocytes T CD8+ (immunologie), Lymphocytes auxiliaires Th1 (immunologie), Lymphocytes auxiliaires Th2 (immunologie), Sujet âgé.
- MESH :
- immunologie : Filariose lymphatique, Lymphocytes T CD4+, Lymphocytes T CD8+, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2.
- métabolisme : Cytokines.
- physiologie : Facteur de croissance transformant bêta, Interleukine-10.
- Adulte, Adulte d'âge moyen, Humains, Sujet âgé.
English descriptors
- KwdEn :
- Adult, Aged, CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), Cytokines (metabolism), Elephantiasis, Filarial (immunology), Humans, Interleukin-10 (physiology), Middle Aged, Th1 Cells (immunology), Th2 Cells (immunology), Transforming Growth Factor beta (physiology).
- MESH :
- chemical , metabolism : Cytokines.
- immunology : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Elephantiasis, Filarial, Th1 Cells, Th2 Cells.
- chemical , physiology : Interleukin-10, Transforming Growth Factor beta.
- Adult, Aged, Humans, Middle Aged.
Abstract
Lymphatic filariasis is known to be associated with diminished CD4+ Th1 and elevated CD4+ Th2 responses to parasite-specific antigens. The roles of cytokine-expressing CD8+ T cells in immune responses to filarial infections are not well defined. To study the roles of CD8+ T cells expressing type 1, type 2, and type 17 cytokines in filarial infections, we examined the frequencies of these cells in clinically asymptomatic, patently infected (INF) individuals, directly
Url:
DOI: 10.1128/CVI.00598-14
PubMed: 25253667
PubMed Central: 4248783
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PMC:4248783Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Interleukin-10- and Transforming Growth Factor β-Independent Regulation of CD8<sup>+</sup>
T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis</title>
<author><name sortKey="Anuradha, Rajamanickam" sort="Anuradha, Rajamanickam" uniqKey="Anuradha R" first="Rajamanickam" last="Anuradha">Rajamanickam Anuradha</name>
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<author><name sortKey="George, Parakkal Jovvian" sort="George, Parakkal Jovvian" uniqKey="George P" first="Parakkal Jovvian" last="George">Parakkal Jovvian George</name>
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<author><name sortKey="Kumaran, Paul" sort="Kumaran, Paul" uniqKey="Kumaran P" first="Paul" last="Kumaran">Paul Kumaran</name>
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<wicri:regionArea>National Institute for Research in Tuberculosis, Chennai</wicri:regionArea>
<wicri:noRegion>Chennai</wicri:noRegion>
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<author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
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<author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">National Institutes of Health-International Center for Excellence in Research, Chennai, India</nlm:aff>
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<series><title level="j">Clinical and Vaccine Immunology : CVI</title>
<idno type="ISSN">1556-6811</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>CD4-Positive T-Lymphocytes (immunology)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>Cytokines (metabolism)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Humans</term>
<term>Interleukin-10 (physiology)</term>
<term>Middle Aged</term>
<term>Th1 Cells (immunology)</term>
<term>Th2 Cells (immunology)</term>
<term>Transforming Growth Factor beta (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Cytokines (métabolisme)</term>
<term>Facteur de croissance transformant bêta (physiologie)</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Humains</term>
<term>Interleukine-10 (physiologie)</term>
<term>Lymphocytes T CD4+ (immunologie)</term>
<term>Lymphocytes T CD8+ (immunologie)</term>
<term>Lymphocytes auxiliaires Th1 (immunologie)</term>
<term>Lymphocytes auxiliaires Th2 (immunologie)</term>
<term>Sujet âgé</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term>
<term>Lymphocytes T CD4+</term>
<term>Lymphocytes T CD8+</term>
<term>Lymphocytes auxiliaires Th1</term>
<term>Lymphocytes auxiliaires Th2</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>CD8-Positive T-Lymphocytes</term>
<term>Elephantiasis, Filarial</term>
<term>Th1 Cells</term>
<term>Th2 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Facteur de croissance transformant bêta</term>
<term>Interleukine-10</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Interleukin-10</term>
<term>Transforming Growth Factor beta</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Humans</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Humains</term>
<term>Sujet âgé</term>
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<front><div type="abstract" xml:lang="en"><p>Lymphatic filariasis is known to be associated with diminished CD4<sup>+</sup>
Th1 and elevated CD4<sup>+</sup>
Th2 responses to parasite-specific antigens. The roles of cytokine-expressing CD8<sup>+</sup>
T cells in immune responses to filarial infections are not well defined. To study the roles of CD8<sup>+</sup>
T cells expressing type 1, type 2, and type 17 cytokines in filarial infections, we examined the frequencies of these cells in clinically asymptomatic, patently infected (INF) individuals, directly <italic>ex vivo</italic>
and in response to parasite or nonparasite antigens; these frequencies were compared with the results for individuals with filarial lymphedema (i.e., clinical pathology [CP]) and those without active infection or pathology (i.e., endemic normal [EN]). INF individuals exhibited significant decreases in the frequencies of CD8<sup>+</sup>
T cells expressing tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ), and interleukin-22 (IL-22) at baseline and/or in response to filarial antigens, compared with CP and EN individuals. In contrast, the same individuals exhibited significant increases in the frequencies of CD8<sup>+</sup>
T cells expressing IL-4, IL-5, IL-9, IL-13, and IL-21, compared with CP and/or EN individuals. Curative treatment resulted in significantly increased frequencies of CD8<sup>+</sup>
T cells expressing IL-2 and significantly decreased frequencies of CD8<sup>+</sup>
T cells expressing type 2 cytokines. Finally, the regulation of these responses appears to be independent of IL-10 and transforming growth factor β (TGF-β), since blockade of IL-10 or TGF-β signaling did not significantly alter the frequencies of type 1 or type 2 cytokine-expressing CD8<sup>+</sup>
T cells. Our findings suggest that alterations in the frequencies of cytokine-expressing CD8<sup>+</sup>
T cells are characteristic features of lymphatic filarial infections.</p>
</div>
</front>
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