Interleukin-10- and Transforming Growth Factor β-Independent Regulation of CD8+ T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis
Identifieur interne : 002D60 ( Pmc/Curation ); précédent : 002D59; suivant : 002D61Interleukin-10- and Transforming Growth Factor β-Independent Regulation of CD8+ T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis
Auteurs : Rajamanickam Anuradha [Inde] ; Parakkal Jovvian George [Inde] ; Paul Kumaran [Inde] ; Thomas B. Nutman [États-Unis] ; Subash Babu [Inde, États-Unis]Source :
- Clinical and Vaccine Immunology : CVI [ 1556-6811 ] ; 2014.
Abstract
Lymphatic filariasis is known to be associated with diminished CD4+ Th1 and elevated CD4+ Th2 responses to parasite-specific antigens. The roles of cytokine-expressing CD8+ T cells in immune responses to filarial infections are not well defined. To study the roles of CD8+ T cells expressing type 1, type 2, and type 17 cytokines in filarial infections, we examined the frequencies of these cells in clinically asymptomatic, patently infected (INF) individuals, directly
Url:
DOI: 10.1128/CVI.00598-14
PubMed: 25253667
PubMed Central: 4248783
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T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis</title>
<author><name sortKey="Anuradha, Rajamanickam" sort="Anuradha, Rajamanickam" uniqKey="Anuradha R" first="Rajamanickam" last="Anuradha">Rajamanickam Anuradha</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Interleukin-10- and Transforming Growth Factor β-Independent Regulation of CD8<sup>+</sup>
T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis</title>
<author><name sortKey="Anuradha, Rajamanickam" sort="Anuradha, Rajamanickam" uniqKey="Anuradha R" first="Rajamanickam" last="Anuradha">Rajamanickam Anuradha</name>
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<country xml:lang="fr">Inde</country>
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</affiliation>
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<author><name sortKey="George, Parakkal Jovvian" sort="George, Parakkal Jovvian" uniqKey="George P" first="Parakkal Jovvian" last="George">Parakkal Jovvian George</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">National Institutes of Health-International Center for Excellence in Research, Chennai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>National Institutes of Health-International Center for Excellence in Research, Chennai</wicri:regionArea>
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<author><name sortKey="Kumaran, Paul" sort="Kumaran, Paul" uniqKey="Kumaran P" first="Paul" last="Kumaran">Paul Kumaran</name>
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<country xml:lang="fr">Inde</country>
<wicri:regionArea>National Institute for Research in Tuberculosis, Chennai</wicri:regionArea>
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<author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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<author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">National Institutes of Health-International Center for Excellence in Research, Chennai, India</nlm:aff>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>National Institutes of Health-International Center for Excellence in Research, Chennai</wicri:regionArea>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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<series><title level="j">Clinical and Vaccine Immunology : CVI</title>
<idno type="ISSN">1556-6811</idno>
<idno type="eISSN">1556-679X</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><p>Lymphatic filariasis is known to be associated with diminished CD4<sup>+</sup>
Th1 and elevated CD4<sup>+</sup>
Th2 responses to parasite-specific antigens. The roles of cytokine-expressing CD8<sup>+</sup>
T cells in immune responses to filarial infections are not well defined. To study the roles of CD8<sup>+</sup>
T cells expressing type 1, type 2, and type 17 cytokines in filarial infections, we examined the frequencies of these cells in clinically asymptomatic, patently infected (INF) individuals, directly <italic>ex vivo</italic>
and in response to parasite or nonparasite antigens; these frequencies were compared with the results for individuals with filarial lymphedema (i.e., clinical pathology [CP]) and those without active infection or pathology (i.e., endemic normal [EN]). INF individuals exhibited significant decreases in the frequencies of CD8<sup>+</sup>
T cells expressing tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ), and interleukin-22 (IL-22) at baseline and/or in response to filarial antigens, compared with CP and EN individuals. In contrast, the same individuals exhibited significant increases in the frequencies of CD8<sup>+</sup>
T cells expressing IL-4, IL-5, IL-9, IL-13, and IL-21, compared with CP and/or EN individuals. Curative treatment resulted in significantly increased frequencies of CD8<sup>+</sup>
T cells expressing IL-2 and significantly decreased frequencies of CD8<sup>+</sup>
T cells expressing type 2 cytokines. Finally, the regulation of these responses appears to be independent of IL-10 and transforming growth factor β (TGF-β), since blockade of IL-10 or TGF-β signaling did not significantly alter the frequencies of type 1 or type 2 cytokine-expressing CD8<sup>+</sup>
T cells. Our findings suggest that alterations in the frequencies of cytokine-expressing CD8<sup>+</sup>
T cells are characteristic features of lymphatic filarial infections.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Vaccine Immunol</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin. Vaccine Immunol</journal-id>
<journal-id journal-id-type="hwp">cdli</journal-id>
<journal-id journal-id-type="pmc">cvi</journal-id>
<journal-id journal-id-type="publisher-id">CVI</journal-id>
<journal-title-group><journal-title>Clinical and Vaccine Immunology : CVI</journal-title>
</journal-title-group>
<issn pub-type="ppub">1556-6811</issn>
<issn pub-type="epub">1556-679X</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
<publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25253667</article-id>
<article-id pub-id-type="pmc">4248783</article-id>
<article-id pub-id-type="publisher-id">00598-14</article-id>
<article-id pub-id-type="doi">10.1128/CVI.00598-14</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Clinical Immunology</subject>
</subj-group>
</article-categories>
<title-group><article-title>Interleukin-10- and Transforming Growth Factor β-Independent Regulation of CD8<sup>+</sup>
T Cells Expressing Type 1 and Type 2 Cytokines in Human Lymphatic Filariasis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Anuradha</surname>
<given-names>Rajamanickam</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>George</surname>
<given-names>Parakkal Jovvian</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kumaran</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>b</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nutman</surname>
<given-names>Thomas B.</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>c</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Babu</surname>
<given-names>Subash</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>c</sup>
</xref>
</contrib>
<aff id="aff1"><label>a</label>
National Institutes of Health-International Center for Excellence in Research, Chennai, India</aff>
<aff id="aff2"><label>b</label>
National Institute for Research in Tuberculosis, Chennai, India</aff>
<aff id="aff3"><label>c</label>
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA</aff>
</contrib-group>
<contrib-group><contrib contrib-type="editor"><name><surname>Wilkins</surname>
<given-names>P. P.</given-names>
</name>
<role>Editor</role>
</contrib>
</contrib-group>
<author-notes><corresp id="cor1">Address correspondence to Subash Babu, <email>sbabu@mail.nih.gov</email>
.</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>12</month>
<year>2014</year>
</pub-date>
<volume>21</volume>
<issue>12</issue>
<fpage>1620</fpage>
<lpage>1627</lpage>
<history><date date-type="received"><day>8</day>
<month>9</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>19</day>
<month>9</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2014, American Society for Microbiology. All Rights Reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
<copyright-holder>American Society for Microbiology</copyright-holder>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zcd01214001620.pdf"></self-uri>
<abstract><p>Lymphatic filariasis is known to be associated with diminished CD4<sup>+</sup>
Th1 and elevated CD4<sup>+</sup>
Th2 responses to parasite-specific antigens. The roles of cytokine-expressing CD8<sup>+</sup>
T cells in immune responses to filarial infections are not well defined. To study the roles of CD8<sup>+</sup>
T cells expressing type 1, type 2, and type 17 cytokines in filarial infections, we examined the frequencies of these cells in clinically asymptomatic, patently infected (INF) individuals, directly <italic>ex vivo</italic>
and in response to parasite or nonparasite antigens; these frequencies were compared with the results for individuals with filarial lymphedema (i.e., clinical pathology [CP]) and those without active infection or pathology (i.e., endemic normal [EN]). INF individuals exhibited significant decreases in the frequencies of CD8<sup>+</sup>
T cells expressing tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ), and interleukin-22 (IL-22) at baseline and/or in response to filarial antigens, compared with CP and EN individuals. In contrast, the same individuals exhibited significant increases in the frequencies of CD8<sup>+</sup>
T cells expressing IL-4, IL-5, IL-9, IL-13, and IL-21, compared with CP and/or EN individuals. Curative treatment resulted in significantly increased frequencies of CD8<sup>+</sup>
T cells expressing IL-2 and significantly decreased frequencies of CD8<sup>+</sup>
T cells expressing type 2 cytokines. Finally, the regulation of these responses appears to be independent of IL-10 and transforming growth factor β (TGF-β), since blockade of IL-10 or TGF-β signaling did not significantly alter the frequencies of type 1 or type 2 cytokine-expressing CD8<sup>+</sup>
T cells. Our findings suggest that alterations in the frequencies of cytokine-expressing CD8<sup>+</sup>
T cells are characteristic features of lymphatic filarial infections.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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