LymphedemaV1, Main, Curation, bibRecord, 002551

Safety of Excisional Inguinal Lymph Node Biopsies Performed for Research Purposes in HIV-1-Infected Women and Men

Identifieur interne : 002551 ( Main/Curation ); précédent : 002550; suivant : 002552

Safety of Excisional Inguinal Lymph Node Biopsies Performed for Research Purposes in HIV-1-Infected Women and Men

Auteurs : Amie L. Meditz ; Elizabeth Connick ; Martin Mccarter

Source :

Surgical Infections [ 1096-2964 ] ; 2014.

RBID : PMC:4135314

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Biopsie (), Biopsie (effets indésirables), Femelle, Humains, Infections à VIH (anatomopathologie), Infections à VIH (virologie), Jeune adulte, Mâle, Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (virologie), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification).
MESH :
- anatomopathologie : Infections à VIH, Noeuds lymphatiques.
- effets indésirables : Biopsie.
- isolement et purification : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- virologie : Infections à VIH, Noeuds lymphatiques.
- Adulte, Adulte d'âge moyen, Biopsie, Femelle, Humains, Jeune adulte, Mâle.

English descriptors

KwdEn :
- Adult, Biopsy (adverse effects), Biopsy (methods), Female, HIV Infections (pathology), HIV Infections (virology), HIV-1 (isolation & purification), Humans, Lymph Nodes (pathology), Lymph Nodes (virology), Male, Middle Aged, Young Adult.
MESH :
- adverse effects : Biopsy.
- isolation & purification : HIV-1.
- methods : Biopsy.
- pathology : HIV Infections, Lymph Nodes.
- virology : HIV Infections, Lymph Nodes.
- Adult, Female, Humans, Male, Middle Aged, Young Adult.

Abstract

Background: Most HIV-1 replication occurs in secondary lymphoid tissues, and evaluating these tissues is crucial to investigations of pathogenesis. Inguinal lymph nodes (LN) are obtained frequently for these studies as they are readily detectable in most individuals and provide abundant numbers of cells. Knowledge of the outcomes of inguinal LN excision for research purposes is important to inform accurately study participants and researchers of the potential risks.

Methods: Data on surgical complications were collected in real time in HIV-1-infected subjects who underwent excisional inguinal LN biopsies for research purposes from February 1997 through June 2011. Data were analyzed retrospectively to determine the frequency of surgical complications using the Fisher exact test and non-parametric testing.

Results: Eighty-seven research subjects underwent a total of 95 LN excisions. Thirty-six percent of subjects were female, 53% were white, 26% were black, 16% Hispanic, and 2% Native American. Median age was 36 y (22–52). The median CD4+ T cell count was 478 cell/mm³ (range, 57–1117) and the median plasma HIV-1 RNA concentration was 4.1 log₁₀copies/mL (range, 1.7–5.9). Minor complications including seroma, transient lymphedema, hematoma, and allergic reaction to surgical tape, occurred in 10% of procedures. Complications that required medical attention occurred in an additional 10% of procedures, and included cellulitis (5%), superficial incisional surgical site infection (3%), and seroma requiring aspiration (1%). Subjects with complications had a lower BMI (25; range, 16–38; n=12) than others (28; range, 19–57; n=40; p=0.05) and tended to have higher platelets, (median, 259×10⁹/L; range, 196–332; vs. 233×10⁹/L; range, 44–633; p=0.07). No other clinical or laboratory characteristics were associated with complications (p≥0.3).

Conclusions: Lymph node excision for research purposes is generally safe in a diverse group of chronically HIV-1-infected women and men, but can result in complications in a minority of subjects. No predictors of complications were identified.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135314

DOI: 10.1089/sur.2013.218
PubMed: 24815090
PubMed Central: 4135314

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PMC:4135314

Le document en format XML

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<term>Female</term>
<term>HIV Infections (pathology)</term>
<term>HIV Infections (virology)</term>
<term>HIV-1 (isolation & purification)</term>
<term>Humans</term>
<term>Lymph Nodes (pathology)</term>
<term>Lymph Nodes (virology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Young Adult</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Biopsie ()</term>
<term>Biopsie (effets indésirables)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à VIH (anatomopathologie)</term>
<term>Infections à VIH (virologie)</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Noeuds lymphatiques (anatomopathologie)</term>
<term>Noeuds lymphatiques (virologie)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification)</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Biopsy</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à VIH</term>
<term>Noeuds lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Biopsie</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biopsy</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>HIV Infections</term>
<term>Lymph Nodes</term>
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<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term>
<term>Noeuds lymphatiques</term>
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<term>Lymph Nodes</term>
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<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Young Adult</term>
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<term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold><italic>Background:</italic>
</bold>
 Most HIV-1 replication occurs in secondary lymphoid tissues, and evaluating these tissues is crucial to investigations of pathogenesis. Inguinal lymph nodes (LN) are obtained frequently for these studies as they are readily detectable in most individuals and provide abundant numbers of cells. Knowledge of the outcomes of inguinal LN excision for research purposes is important to inform accurately study participants and researchers of the potential risks.</p>
<p><bold><italic>Methods:</italic>
</bold>
 Data on surgical complications were collected in real time in HIV-1-infected subjects who underwent excisional inguinal LN biopsies for research purposes from February 1997 through June 2011. Data were analyzed retrospectively to determine the frequency of surgical complications using the Fisher exact test and non-parametric testing.</p>
<p><bold><italic>Results:</italic>
</bold>
 Eighty-seven research subjects underwent a total of 95 LN excisions. Thirty-six percent of subjects were female, 53% were white, 26% were black, 16% Hispanic, and 2% Native American. Median age was 36 y (22–52). The median CD4+ T cell count was 478 cell/mm<sup>3</sup>
 (range, 57–1117) and the median plasma HIV-1 RNA concentration was 4.1 log<sub>10</sub>
copies/mL (range, 1.7–5.9). Minor complications including seroma, transient lymphedema, hematoma, and allergic reaction to surgical tape, occurred in 10% of procedures. Complications that required medical attention occurred in an additional 10% of procedures, and included cellulitis (5%), superficial incisional surgical site infection (3%), and seroma requiring aspiration (1%). Subjects with complications had a lower BMI (25; range, 16–38; n=12) than others (28; range, 19–57; n=40; p=0.05) and tended to have higher platelets, (median, 259×10<sup>9</sup>
/L; range, 196–332; vs. 233×10<sup>9</sup>
/L; range, 44–633; p=0.07). No other clinical or laboratory characteristics were associated with complications (p≥0.3).</p>
<p><bold><italic>Conclusions:</italic>
</bold>
 Lymph node excision for research purposes is generally safe in a diverse group of chronically HIV-1-infected women and men, but can result in complications in a minority of subjects. No predictors of complications were identified.</p>
</div>
</front>
</TEI>
</record>

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Safety of Excisional Inguinal Lymph Node Biopsies Performed for Research Purposes in HIV-1-Infected Women and Men

Safety of Excisional Inguinal Lymph Node Biopsies Performed for Research Purposes in HIV-1-Infected Women and Men

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki