Safety of excisional inguinal lymph node biopsies performed for research purposes in HIV-1-infected women and men.
Identifieur interne : 001526 ( PubMed/Corpus ); précédent : 001525; suivant : 001527Safety of excisional inguinal lymph node biopsies performed for research purposes in HIV-1-infected women and men.
Auteurs : Amie L. Meditz ; Elizabeth Connick ; Martin MccarterSource :
- Surgical infections [ 1557-8674 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Biopsy.
- isolation & purification : HIV-1.
- methods : Biopsy.
- pathology : HIV Infections, Lymph Nodes.
- virology : HIV Infections, Lymph Nodes.
- Adult, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
Most HIV-1 replication occurs in secondary lymphoid tissues, and evaluating these tissues is crucial to investigations of pathogenesis. Inguinal lymph nodes (LN) are obtained frequently for these studies as they are readily detectable in most individuals and provide abundant numbers of cells. Knowledge of the outcomes of inguinal LN excision for research purposes is important to inform accurately study participants and researchers of the potential risks.
DOI: 10.1089/sur.2013.218
PubMed: 24815090
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Safety of excisional inguinal lymph node biopsies performed for research purposes in HIV-1-infected women and men.</title><author><name sortKey="Meditz, Amie L" sort="Meditz, Amie L" uniqKey="Meditz A" first="Amie L" last="Meditz">Amie L. Meditz</name><affiliation><nlm:affiliation>1 Division of Infectious Diseases, Department of Medicine, University of Colorado-Denver , Aurora, Colorado.</nlm:affiliation></affiliation></author><author><name sortKey="Connick, Elizabeth" sort="Connick, Elizabeth" uniqKey="Connick E" first="Elizabeth" last="Connick">Elizabeth Connick</name></author><author><name sortKey="Mccarter, Martin" sort="Mccarter, Martin" uniqKey="Mccarter M" first="Martin" last="Mccarter">Martin Mccarter</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24815090</idno><idno type="pmid">24815090</idno><idno type="doi">10.1089/sur.2013.218</idno><idno type="wicri:Area/PubMed/Corpus">001526</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001526</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Safety of excisional inguinal lymph node biopsies performed for research purposes in HIV-1-infected women and men.</title><author><name sortKey="Meditz, Amie L" sort="Meditz, Amie L" uniqKey="Meditz A" first="Amie L" last="Meditz">Amie L. Meditz</name><affiliation><nlm:affiliation>1 Division of Infectious Diseases, Department of Medicine, University of Colorado-Denver , Aurora, Colorado.</nlm:affiliation></affiliation></author><author><name sortKey="Connick, Elizabeth" sort="Connick, Elizabeth" uniqKey="Connick E" first="Elizabeth" last="Connick">Elizabeth Connick</name></author><author><name sortKey="Mccarter, Martin" sort="Mccarter, Martin" uniqKey="Mccarter M" first="Martin" last="Mccarter">Martin Mccarter</name></author></analytic><series><title level="j">Surgical infections</title><idno type="eISSN">1557-8674</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Biopsy (adverse effects)</term><term>Biopsy (methods)</term><term>Female</term><term>HIV Infections (pathology)</term><term>HIV Infections (virology)</term><term>HIV-1 (isolation & purification)</term><term>Humans</term><term>Lymph Nodes (pathology)</term><term>Lymph Nodes (virology)</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Biopsy</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biopsy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>HIV Infections</term><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term><term>Lymph Nodes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Most HIV-1 replication occurs in secondary lymphoid tissues, and evaluating these tissues is crucial to investigations of pathogenesis. Inguinal lymph nodes (LN) are obtained frequently for these studies as they are readily detectable in most individuals and provide abundant numbers of cells. Knowledge of the outcomes of inguinal LN excision for research purposes is important to inform accurately study participants and researchers of the potential risks.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24815090</PMID><DateCreated><Year>2014</Year><Month>08</Month><Day>16</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>07</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-8674</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>4</Issue><PubDate><Year>2014</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Surgical infections</Title><ISOAbbreviation>Surg Infect (Larchmt)</ISOAbbreviation></Journal><ArticleTitle>Safety of excisional inguinal lymph node biopsies performed for research purposes in HIV-1-infected women and men.</ArticleTitle><Pagination><MedlinePgn>399-403</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/sur.2013.218</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Most HIV-1 replication occurs in secondary lymphoid tissues, and evaluating these tissues is crucial to investigations of pathogenesis. Inguinal lymph nodes (LN) are obtained frequently for these studies as they are readily detectable in most individuals and provide abundant numbers of cells. Knowledge of the outcomes of inguinal LN excision for research purposes is important to inform accurately study participants and researchers of the potential risks.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Data on surgical complications were collected in real time in HIV-1-infected subjects who underwent excisional inguinal LN biopsies for research purposes from February 1997 through June 2011. Data were analyzed retrospectively to determine the frequency of surgical complications using the Fisher exact test and non-parametric testing.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Eighty-seven research subjects underwent a total of 95 LN excisions. Thirty-six percent of subjects were female, 53% were white, 26% were black, 16% Hispanic, and 2% Native American. Median age was 36 y (22-52). The median CD4+ T cell count was 478 cell/mm(3) (range, 57-1117) and the median plasma HIV-1 RNA concentration was 4.1 log10copies/mL (range, 1.7-5.9). Minor complications including seroma, transient lymphedema, hematoma, and allergic reaction to surgical tape, occurred in 10% of procedures. Complications that required medical attention occurred in an additional 10% of procedures, and included cellulitis (5%), superficial incisional surgical site infection (3%), and seroma requiring aspiration (1%). Subjects with complications had a lower BMI (25; range, 16-38; n=12) than others (28; range, 19-57; n=40; p=0.05) and tended to have higher platelets, (median, 259×10(9)/L; range, 196-332; vs. 233×10(9)/L; range, 44-633; p=0.07). No other clinical or laboratory characteristics were associated with complications (p≥0.3).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Lymph node excision for research purposes is generally safe in a diverse group of chronically HIV-1-infected women and men, but can result in complications in a minority of subjects. No predictors of complications were identified.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Meditz</LastName><ForeName>Amie L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>1 Division of Infectious Diseases, Department of Medicine, University of Colorado-Denver , Aurora, Colorado.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Connick</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>McCarter</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P30-AI-054907</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01-AI-55356</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R29AI-42499</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UO1AI-41536</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21HD-051450</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Surg Infect (Larchmt)</MedlineTA><NlmUniqueID>9815642</NlmUniqueID><ISSNLinking>1096-2964</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Ann Surg Oncol. 2013 Jun;20(6):2049-55</RefSource><PMID 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