A comparison of two tests for filarial antigenemia in areas in Sri Lanka and Indonesia with low-level persistence of lymphatic filariasis following mass drug administration
Identifieur interne : 002225 ( Main/Curation ); précédent : 002224; suivant : 002226A comparison of two tests for filarial antigenemia in areas in Sri Lanka and Indonesia with low-level persistence of lymphatic filariasis following mass drug administration
Auteurs : Thishan C. Yahathugoda [Sri Lanka] ; Taniawati Supali [Indonésie] ; Ramakrishna U. Rao [États-Unis] ; Yenny Djuardi [Indonésie] ; Difa Stefani [Indonésie] ; Femmy Pical [Indonésie] ; Peter U. Fischer [États-Unis] ; Melanie M. Lloyd [États-Unis] ; Prasad H. Premaratne [Sri Lanka] ; Mirani V. Weerasooriya [Sri Lanka] ; Gary J. Weil [États-Unis]Source :
- Parasites & Vectors [ 1756-3305 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe (sang), Antihelminthiques (administration et posologie), Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique (parasitologie), Filariose lymphatique (sang), Filariose lymphatique (traitement médicamenteux), Humains, Indonésie, Jeune adulte, Mâle, Parasitologie (), Sri Lanka, Sujet âgé, Sujet âgé de 80 ans ou plus, Wuchereria bancrofti (), Wuchereria bancrofti (immunologie), Wuchereria bancrofti (isolement et purification).
- MESH :
- administration et posologie : Antihelminthiques.
- immunologie : Wuchereria bancrofti.
- isolement et purification : Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- sang : Antigènes d'helminthe, Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Indonésie, Jeune adulte, Mâle, Parasitologie, Sri Lanka, Sujet âgé, Sujet âgé de 80 ans ou plus, Wuchereria bancrofti.
- Wicri :
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Anthelmintics (administration & dosage), Antigens, Helminth (blood), Child, Child, Preschool, Elephantiasis, Filarial (blood), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (parasitology), Female, Humans, Indonesia, Male, Middle Aged, Parasitology (methods), Sri Lanka, Wuchereria bancrofti (drug effects), Wuchereria bancrofti (immunology), Wuchereria bancrofti (isolation & purification), Young Adult.
- MESH :
- chemical , administration & dosage : Anthelmintics.
- chemical , blood : Antigens, Helminth.
- geographic : Indonesia, Sri Lanka.
- blood : Elephantiasis, Filarial.
- drug effects : Wuchereria bancrofti.
- drug therapy : Elephantiasis, Filarial.
- immunology : Wuchereria bancrofti.
- isolation & purification : Wuchereria bancrofti.
- methods : Parasitology.
- parasitology : Elephantiasis, Filarial.
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
Filarial antigen tests are key tools for mapping the distribution of bancroftian filariasis and for detecting areas with persistent infections following mass drug administration (MDA). A recent study showed that the new Alere Filariasis Test Strip (FTS) has better analytical sensitivity than the BinaxNOW Filariasis card test (Card Test) for detecting circulating filarial antigen, and the FTS detected more positive results than the Card Test in a field study performed in a highly endemic area in Liberia.
The present study compared the performance of the FTS and the Card Test in community surveys that were conducted in southern Sri Lanka and in Indonesia (Central Java) in areas with low-level persistence of LF following multiple rounds of MDA with diethylcarbamazine plus albendazole. The studies were performed in densely populated semi-urban areas where
Antigenemia rates by FTS were 138 % higher in the Sri Lanka study (43/852 vs. 18/852) and 21 % higher in the Indonesia study (50/778 vs. 41/778) than antigenemia rates by Card Test. Antigenemia rates were significantly higher in males than in females and higher in adults than in children in both study sites. Although overall antigenemia rates and test scores were significantly higher by FTS than by Card Test in both study areas, rates in young children were similar with both tests in both areas.
These results extend the previously reported superior sensitivity of the FTS to areas with low residual infection rates following MDA, and this could affect mapping and post-MDA survey results in adults. However, our findings suggest that results of transmission assessment surveys (TAS) performed in school-aged children are likely to be similar with both tests.
Url:
DOI: 10.1186/s13071-015-0979-y
PubMed: 26168919
PubMed Central: 4501213
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PMC:4501213Le document en format XML
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<author><name sortKey="Lloyd, Melanie M" sort="Lloyd, Melanie M" uniqKey="Lloyd M" first="Melanie M." last="Lloyd">Melanie M. Lloyd</name>
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<country>États-Unis</country>
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<author><name sortKey="Weerasooriya, Mirani V" sort="Weerasooriya, Mirani V" uniqKey="Weerasooriya M" first="Mirani V." last="Weerasooriya">Mirani V. Weerasooriya</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Anthelmintics (administration & dosage)</term>
<term>Antigens, Helminth (blood)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Elephantiasis, Filarial (blood)</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Elephantiasis, Filarial (parasitology)</term>
<term>Female</term>
<term>Humans</term>
<term>Indonesia</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parasitology (methods)</term>
<term>Sri Lanka</term>
<term>Wuchereria bancrofti (drug effects)</term>
<term>Wuchereria bancrofti (immunology)</term>
<term>Wuchereria bancrofti (isolation & purification)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Antigènes d'helminthe (sang)</term>
<term>Antihelminthiques (administration et posologie)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Filariose lymphatique (parasitologie)</term>
<term>Filariose lymphatique (sang)</term>
<term>Filariose lymphatique (traitement médicamenteux)</term>
<term>Humains</term>
<term>Indonésie</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Parasitologie ()</term>
<term>Sri Lanka</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Wuchereria bancrofti ()</term>
<term>Wuchereria bancrofti (immunologie)</term>
<term>Wuchereria bancrofti (isolement et purification)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anthelmintics</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Helminth</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Indonesia</term>
<term>Sri Lanka</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antihelminthiques</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Parasitology</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes d'helminthe</term>
<term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indonésie</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Parasitologie</term>
<term>Sri Lanka</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Indonésie</term>
<term>Sri Lanka</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Filarial antigen tests are key tools for mapping the distribution of bancroftian filariasis and for detecting areas with persistent infections following mass drug administration (MDA). A recent study showed that the new Alere Filariasis Test Strip (FTS) has better analytical sensitivity than the BinaxNOW Filariasis card test (Card Test) for detecting circulating filarial antigen, and the FTS detected more positive results than the Card Test in a field study performed in a highly endemic area in Liberia.</p>
</sec>
<sec><title>Methods</title>
<p>The present study compared the performance of the FTS and the Card Test in community surveys that were conducted in southern Sri Lanka and in Indonesia (Central Java) in areas with low-level persistence of LF following multiple rounds of MDA with diethylcarbamazine plus albendazole. The studies were performed in densely populated semi-urban areas where <italic>Wuchereria bancrofti</italic>
is transmitted by <italic>Culex quinquefasciatus</italic>
.</p>
</sec>
<sec><title>Results</title>
<p>Antigenemia rates by FTS were 138 % higher in the Sri Lanka study (43/852 vs. 18/852) and 21 % higher in the Indonesia study (50/778 vs. 41/778) than antigenemia rates by Card Test. Antigenemia rates were significantly higher in males than in females and higher in adults than in children in both study sites. Although overall antigenemia rates and test scores were significantly higher by FTS than by Card Test in both study areas, rates in young children were similar with both tests in both areas.</p>
</sec>
<sec><title>Conclusions</title>
<p>These results extend the previously reported superior sensitivity of the FTS to areas with low residual infection rates following MDA, and this could affect mapping and post-MDA survey results in adults. However, our findings suggest that results of transmission assessment surveys (TAS) performed in school-aged children are likely to be similar with both tests.</p>
</sec>
</div>
</front>
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<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
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