Animal Models for the Molecular and Mechanistic Study of Lymphatic Biology and Disease
Identifieur interne : 006C62 ( Istex/Curation ); précédent : 006C61; suivant : 006C63Animal Models for the Molecular and Mechanistic Study of Lymphatic Biology and Disease
Auteurs : William S. Shin [États-Unis] ; Stanley G. Rockson [États-Unis]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2008-05.
Abstract
The development of animal model systems for the study of the lymphatic system has resulted in an explosion of information regarding the mechanisms governing lymphatic development and the diseases associated with lymphatic dysfunction. Animal studies have led to a new molecular model of embryonic lymphatic vascular development, and have provided insight into the pathophysiology of both inherited and acquired lymphatic insufficiency. It has become apparent, however, that the importance of the lymphatic system to human disease extends, beyond its role in lymphedema, to many other diverse pathologic processes, including, very notably, inflammation and tumor lymphangiogenesis. Here, we have undertaken a systematic review of the models as they relate to molecular and functional characterization of the development, maturation, genetics, heritable and acquired diseases, and neoplastic implications of the lymphatic system. The translation of these advances into therapies for human diseases associated with lymphatic dysfunction will require the continued study of the lymphatic system through robust animal disease models that simulate their human counterparts.
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DOI: 10.1196/annals.1413.005
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Rockson</name><affiliation wicri:level="1"><mods:affiliation>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E78D82447855E6869FE3C8BC08538C865593AA6D</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1196/annals.1413.005</idno><idno type="url">https://api.istex.fr/document/E78D82447855E6869FE3C8BC08538C865593AA6D/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">006C62</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">006C62</idno><idno type="wicri:Area/Istex/Curation">006C62</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main"><hi rend="italic">Animal Models for the Molecular and Mechanistic Study of Lymphatic Biology and Disease</hi></title><author><name sortKey="Shin, William S" sort="Shin, William S" uniqKey="Shin W" first="William S." last="Shin">William S. Shin</name><affiliation wicri:level="1"><mods:affiliation>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea></affiliation></author><author><name sortKey="Rockson, Stanley G" sort="Rockson, Stanley G" uniqKey="Rockson S" first="Stanley G." last="Rockson">Stanley G. Rockson</name><affiliation wicri:level="1"><mods:affiliation>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of the New York Academy of Sciences</title><title level="j" type="alt">ANNALS OF NEW YORK ACADEMY SCIENCES</title><idno type="ISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><imprint><biblScope unit="vol">1131</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="50">50</biblScope><biblScope unit="page" to="74">74</biblScope><biblScope unit="page-count">25</biblScope><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2008-05">2008-05</date></imprint><idno type="ISSN">0077-8923</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0077-8923</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The development of animal model systems for the study of the lymphatic system has resulted in an explosion of information regarding the mechanisms governing lymphatic development and the diseases associated with lymphatic dysfunction. Animal studies have led to a new molecular model of embryonic lymphatic vascular development, and have provided insight into the pathophysiology of both inherited and acquired lymphatic insufficiency. It has become apparent, however, that the importance of the lymphatic system to human disease extends, beyond its role in lymphedema, to many other diverse pathologic processes, including, very notably, inflammation and tumor lymphangiogenesis. Here, we have undertaken a systematic review of the models as they relate to molecular and functional characterization of the development, maturation, genetics, heritable and acquired diseases, and neoplastic implications of the lymphatic system. The translation of these advances into therapies for human diseases associated with lymphatic dysfunction will require the continued study of the lymphatic system through robust animal disease models that simulate their human counterparts.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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