Animal Models for the Molecular and Mechanistic Study of Lymphatic Biology and Disease
Identifieur interne : 006C62 ( Istex/Corpus ); précédent : 006C61; suivant : 006C63Animal Models for the Molecular and Mechanistic Study of Lymphatic Biology and Disease
Auteurs : William S. Shin ; Stanley G. RocksonSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2008-05.
Abstract
The development of animal model systems for the study of the lymphatic system has resulted in an explosion of information regarding the mechanisms governing lymphatic development and the diseases associated with lymphatic dysfunction. Animal studies have led to a new molecular model of embryonic lymphatic vascular development, and have provided insight into the pathophysiology of both inherited and acquired lymphatic insufficiency. It has become apparent, however, that the importance of the lymphatic system to human disease extends, beyond its role in lymphedema, to many other diverse pathologic processes, including, very notably, inflammation and tumor lymphangiogenesis. Here, we have undertaken a systematic review of the models as they relate to molecular and functional characterization of the development, maturation, genetics, heritable and acquired diseases, and neoplastic implications of the lymphatic system. The translation of these advances into therapies for human diseases associated with lymphatic dysfunction will require the continued study of the lymphatic system through robust animal disease models that simulate their human counterparts.
Url:
DOI: 10.1196/annals.1413.005
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ISTEX:E78D82447855E6869FE3C8BC08538C865593AA6DLe document en format XML
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USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Stanley G.</forename><surname>Rockson</surname></persName><affiliation>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA<address><country key="US"></country></address></affiliation></author><idno type="istex">E78D82447855E6869FE3C8BC08538C865593AA6D</idno><idno type="DOI">10.1196/annals.1413.005</idno><idno type="unit">NYAS1131005</idno><idno type="toTypesetVersion">file:NYAS.NYAS1131005.pdf</idno></analytic><monogr><title level="j" type="main">Annals of the New York Academy of Sciences</title><title level="j" type="alt">ANNALS OF NEW YORK ACADEMY SCIENCES</title><idno type="pISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><idno type="book-DOI">10.1111/(ISSN)1749-6632</idno><idno type="book-part-DOI">10.1196/nyas.2008.1131.issue-1</idno><idno type="product">NYAS</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">1131</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="50">50</biblScope><biblScope unit="page" to="74">74</biblScope><biblScope unit="page-count">25</biblScope><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2008-05"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p>The development of animal model systems for the study of the lymphatic system has resulted in an explosion of information regarding the mechanisms governing lymphatic development and the diseases associated with lymphatic dysfunction. Animal studies have led to a new molecular model of embryonic lymphatic vascular development, and have provided insight into the pathophysiology of both inherited and acquired lymphatic insufficiency. It has become apparent, however, that the importance of the lymphatic system to human disease extends, beyond its role in lymphedema, to many other diverse pathologic processes, including, very notably, inflammation and tumor lymphangiogenesis. Here, we have undertaken a systematic review of the models as they relate to molecular and functional characterization of the development, maturation, genetics, heritable and acquired diseases, and neoplastic implications of the lymphatic system. The translation of these advances into therapies for human diseases associated with lymphatic dysfunction will require the continued study of the lymphatic system through robust animal disease models that simulate their human counterparts.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">animal model systems</term><term xml:id="k2">diseases</term><term xml:id="k3">lymphangiomas</term><term xml:id="k4">vascular malformations</term><term xml:id="k5">VEGF‐C</term></keywords><classCode scheme="tocHeading1">Part I. Tools for Lymphatic Investigation</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/E78D82447855E6869FE3C8BC08538C865593AA6D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Inc</publisherName><publisherLoc>Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1749-6632</doi><issn type="print">0077-8923</issn><issn type="electronic">1749-6632</issn><idGroup><id type="product" value="NYAS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ANNALS OF NEW YORK ACADEMY SCIENCES">Annals of the New York Academy of Sciences</title></titleGroup></publicationMeta><publicationMeta level="part" position="05001"><doi origin="wiley">10.1196/nyas.2008.1131.issue-1</doi><titleGroup><title type="main">The Lymphatic Continuum Revisited</title></titleGroup><numberingGroup><numbering type="journalVolume" number="1131">1131</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2008-05">May 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="6" status="forIssue"><doi origin="wiley">10.1196/annals.1413.005</doi><idGroup><id type="unit" value="NYAS1131005"></id></idGroup><countGroup><count type="pageTotal" number="25"></count></countGroup><titleGroup><title type="tocHeading1">Part I. Tools for Lymphatic Investigation</title></titleGroup><copyright>© 2008 New York Academy of Sciences</copyright><eventGroup><event type="firstOnline" date="2008-05-28"></event><event type="publishedOnlineFinalForm" date="2008-05-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.5 mode:FullText source:FullText result:FullText" date="2010-04-07"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="50">50</numbering><numbering type="pageLast" number="74">74</numbering></numberingGroup><correspondenceTo>Address for correspondence: Stanley G. Rockson, M.D., Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305. Voice: +1‐650‐725‐7571; fax: +1‐650‐725‐1599. <email>srockson@cvmed.stanford.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NYAS.NYAS1131005.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="0"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="252"></count><count type="linksCrossRef" number="310"></count></countGroup><titleGroup><title type="main"><i>Animal Models for the Molecular and Mechanistic Study of Lymphatic Biology and Disease</i></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>William S.</givenNames><familyName>Shin</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Stanley G.</givenNames><familyName>Rockson</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">animal model systems</keyword><keyword xml:id="k2">diseases</keyword><keyword xml:id="k3">lymphangiomas</keyword><keyword xml:id="k4">vascular malformations</keyword><keyword xml:id="k5">VEGF‐C</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>The development of animal model systems for the study of the lymphatic system has resulted in an explosion of information regarding the mechanisms governing lymphatic development and the diseases associated with lymphatic dysfunction. 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The translation of these advances into therapies for human diseases associated with lymphatic dysfunction will require the continued study of the lymphatic system through robust animal disease models that simulate their human counterparts.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Animal Models for the Molecular and Mechanistic Study of Lymphatic Biology and Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Animal Models for the Molecular and Mechanistic Study of Lymphatic Biology and Disease</title></titleInfo><name type="personal"><namePart type="given">William S.</namePart><namePart type="family">Shin</namePart><affiliation>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stanley G.</namePart><namePart type="family">Rockson</namePart><affiliation>Stanford Center for Lymphatic and Venous Disorders, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Inc</publisher><place><placeTerm type="text">Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2008-05</dateIssued><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">252</extent></physicalDescription><abstract lang="en">The development of animal model systems for the study of the lymphatic system has resulted in an explosion of information regarding the mechanisms governing lymphatic development and the diseases associated with lymphatic dysfunction. Animal studies have led to a new molecular model of embryonic lymphatic vascular development, and have provided insight into the pathophysiology of both inherited and acquired lymphatic insufficiency. It has become apparent, however, that the importance of the lymphatic system to human disease extends, beyond its role in lymphedema, to many other diverse pathologic processes, including, very notably, inflammation and tumor lymphangiogenesis. Here, we have undertaken a systematic review of the models as they relate to molecular and functional characterization of the development, maturation, genetics, heritable and acquired diseases, and neoplastic implications of the lymphatic system. The translation of these advances into therapies for human diseases associated with lymphatic dysfunction will require the continued study of the lymphatic system through robust animal disease models that simulate their human counterparts.</abstract><subject lang="en"><genre>keywords</genre><topic>animal model systems</topic><topic>diseases</topic><topic>lymphangiomas</topic><topic>vascular malformations</topic><topic>VEGF‐C</topic></subject><relatedItem type="host"><titleInfo><title>Annals of the New York Academy of Sciences</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0077-8923</identifier><identifier type="eISSN">1749-6632</identifier><identifier type="DOI">10.1111/(ISSN)1749-6632</identifier><identifier type="PublisherID">NYAS</identifier><part><date>2008</date><detail type="title"><title>The Lymphatic Continuum Revisited</title></detail><detail type="volume"><caption>vol.</caption><number>1131</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>50</start><end>74</end><total>25</total></extent></part></relatedItem><identifier type="istex">E78D82447855E6869FE3C8BC08538C865593AA6D</identifier><identifier type="DOI">10.1196/annals.1413.005</identifier><identifier type="ArticleID">NYAS1131005</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 New York Academy of Sciences</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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