Diversity and dialogue in immunity to helminths
Identifieur interne : 000256 ( Istex/Curation ); précédent : 000255; suivant : 000257Diversity and dialogue in immunity to helminths
Auteurs : Judith E. Allen [Royaume-Uni] ; Rick M. Maizels [Royaume-Uni]Source :
- Nature Reviews Immunology [ 1474-1733 ] ; 2011-06.
Abstract
The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity.
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DOI: 10.1038/nri2992
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Allen</name><affiliation wicri:level="1"><mods:affiliation>Institute for Immunology and Infection Research, Ashworth Laboratories, West Mains Road, University of Edinburgh, UK.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Institute for Immunology and Infection Research, Ashworth Laboratories, West Mains Road, University of Edinburgh</wicri:regionArea></affiliation><affiliation><mods:affiliation>Both authors contributed equally to this work.</mods:affiliation><wicri:noCountry code="no comma">Both authors contributed equally to this work.</wicri:noCountry></affiliation></author><author><name sortKey="Maizels, Rick M" sort="Maizels, Rick M" uniqKey="Maizels R" first="Rick M." last="Maizels">Rick M. 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All Rights Reserved.</publisher><date type="published" when="2011-06">2011-06</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="375">375</biblScope><biblScope unit="page" to="388">388</biblScope></imprint><idno type="ISSN">1474-1733</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1474-1733</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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