Spindle cell angiosarcoma following irradiation therapy for cervical carcinoma
Identifieur interne : 007744 ( Istex/Corpus ); précédent : 007743; suivant : 007745Spindle cell angiosarcoma following irradiation therapy for cervical carcinoma
Auteurs : Takahiro Kiyohara ; Masanobu Kumakiri ; Hitoshi Kobayashi ; Kei Itoh ; Li-Min Lao ; Akira Ohkawara ; Hideki NakamuraSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2002-02.
Abstract
Background: Angiosarcomas arise in the scalp and face in the elderly, in association with chronic lymphedema (Stewart–Treves syndrome), and in irradiated areas. Rarely in these settings, angiosarcomas exhibit pure spindle cell phenotype.
Url:
DOI: 10.1034/j.1600-0560.2002.290206.x
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ISTEX:FE23CDAEE0CE994E13A8F280FE46A15FAEDD542ELe document en format XML
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Medicine, Sapporo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Itoh, Kei" sort="Itoh, Kei" uniqKey="Itoh K" first="Kei" last="Itoh">Kei Itoh</name><affiliation><mods:affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Lao, Li In" sort="Lao, Li In" uniqKey="Lao L" first="Li-Min" last="Lao">Li-Min Lao</name><affiliation><mods:affiliation>Department of Dermatology, Fukui Medical University, Fukui, Japan,</mods:affiliation></affiliation></author><author><name sortKey="Ohkawara, Akira" sort="Ohkawara, Akira" uniqKey="Ohkawara A" first="Akira" last="Ohkawara">Akira Ohkawara</name><affiliation><mods:affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Nakamura, Hideki" sort="Nakamura, Hideki" uniqKey="Nakamura H" first="Hideki" last="Nakamura">Hideki 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Japan</mods:affiliation></affiliation></author><author><name sortKey="Lao, Li In" sort="Lao, Li In" uniqKey="Lao L" first="Li-Min" last="Lao">Li-Min Lao</name><affiliation><mods:affiliation>Department of Dermatology, Fukui Medical University, Fukui, Japan,</mods:affiliation></affiliation></author><author><name sortKey="Ohkawara, Akira" sort="Ohkawara, Akira" uniqKey="Ohkawara A" first="Akira" last="Ohkawara">Akira Ohkawara</name><affiliation><mods:affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Nakamura, Hideki" sort="Nakamura, Hideki" uniqKey="Nakamura H" first="Hideki" last="Nakamura">Hideki Nakamura</name><affiliation><mods:affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" 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type="first">Masanobu</forename><surname>Kumakiri</surname></persName><affiliation>Department of Dermatology, Fukui Medical University, Fukui, Japan,<address><country key="JP"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Hitoshi</forename><surname>Kobayashi</surname></persName><affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan<address><country key="JP"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Kei</forename><surname>Itoh</surname></persName><affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan<address><country key="JP"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Li‐Min</forename><surname>Lao</surname></persName><affiliation>Department of Dermatology, Fukui Medical University, Fukui, Japan,<address><country key="JP"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Akira</forename><surname>Ohkawara</surname></persName><affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan<address><country key="JP"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Hideki</forename><surname>Nakamura</surname></persName><affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan<address><country key="JP"></country></address></affiliation></author><idno type="istex">FE23CDAEE0CE994E13A8F280FE46A15FAEDD542E</idno><idno type="DOI">10.1034/j.1600-0560.2002.290206.x</idno><idno type="supplier">cup1o009</idno><idno type="unit">CUP290206</idno><idno type="toTypesetVersion">file:CUP.CUP290206.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="pISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><idno type="book-DOI">10.1111/(ISSN)1600-0560</idno><idno type="book-part-DOI">10.1111/cup.2002.29.issue-2</idno><idno type="product">CUP</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">29</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="96">96</biblScope><biblScope unit="page" to="100">100</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Science, Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2002-02"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">Background: </hi> Angiosarcomas arise in the scalp and face in the elderly, in association with chronic lymphedema (Stewart–Treves syndrome), and in irradiated areas. Rarely in these settings, angiosarcomas exhibit pure spindle cell phenotype.</p><p><hi rend="bold">Methods: </hi> Herein, the clinicopathologic features of a 72‐year‐old‐woman with spindle cell angiosarcoma are described.</p><p><hi rend="bold">Results: </hi> A 72‐year‐old woman presented with numerous nodules and diffuse induration from the lower abdomen to the right buttock, corresponding to the area exposed to <hi rend="superscript">60</hi>Co‐irradiation during treatment for cervical carcinoma 10 years earlier. Histopathological examination revealed inflitrative, atypical, spindle cells that labeled with antibodies to CD31, CD34, and factor VIII‐related antigen. Ultrastructurally, these malignant spindle cells contained Weibel–Palade bodies. No features suggesting radiation dermatitis (sclerosis or bizarre, large fibroblasts) were identified, but lymphangiectases and widely spaced collagen bundles(lymphedema) were prominent in the skin surrounding the angiosarcoma. Computed tomographic scan of the abdomen highlighted this histologic finding by demonstrating tumor masses limited to areas of lymphedema. Treatment with intravenous and local injections of recombinant interleukin 2 (rIL 2) followed by electron beam irradiation were initially effective with tumor remission for 2 months. However, the recurrent tumor did not respond to a second course of one‐shot injection of rIL 2 through the abdominal aorta and the patient succumbed to her angiosarcoma 19 months after diagnosis.</p><p><hi rend="bold">Conclusions: </hi> Radiation‐induced lymphedema may be a factor in angiosarcoma associated with radiotherapy.</p></abstract><textClass><classCode scheme="tocHeading1">Original Article</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/FE23CDAEE0CE994E13A8F280FE46A15FAEDD542E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Science, Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0560</doi><issn type="print">0303-6987</issn><issn type="electronic">1600-0560</issn><idGroup><id type="product" value="CUP"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF CUTANEOUS PATHOLOGY">Journal of Cutaneous Pathology</title></titleGroup></publicationMeta><publicationMeta level="part" position="02002"><doi origin="wiley">10.1111/cup.2002.29.issue-2</doi><numberingGroup><numbering type="journalVolume" number="29">29</numbering><numbering type="journalIssue" number="2">2</numbering></numberingGroup><coverDate startDate="2002-02">February 2002</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0009600" status="forIssue"><doi origin="wiley">10.1034/j.1600-0560.2002.290206.x</doi><idGroup><id type="supplier" value="cup1o009"></id><id type="unit" value="CUP290206"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Original Article</title></titleGroup><eventGroup><event type="firstOnline" date="2002-03-27"></event><event type="publishedOnlineFinalForm" date="2002-03-27"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.15 mode:FullText source:FullText result:FullText" date="2010-07-19"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-16"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="96">96</numbering><numbering type="pageLast" number="100">100</numbering></numberingGroup><correspondenceTo>Takabiro Kiyohara MD, Department of Dermatology, Fukui Medical University, 23–3 Shimoaizuki, Matsuoka‐cho, Yoshida‐gun, Fukui 910–1193, Japan
Tel: +81 776 61 3111
Fax: +81 776 61 8112
E‐mail: <email normalForm="kiyo@fmsrsa.fukui-med.ac.jp">kiyo@fmsrsa.fukui‐med.ac.jp</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:CUP.CUP290206.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted July 5, 2001</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="0"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="25"></count><count type="wordTotal" number="2688"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Spindle cell angiosarcoma following irradiation therapy for cervical carcinoma</title><title type="shortAuthors"><b>Kiyohara et al.</b></title><title type="short"><b>Radiation‐associated angiosarcoma</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Takahiro</givenNames><familyName>Kiyohara</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Masanobu</givenNames><familyName>Kumakiri</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>Hitoshi</givenNames><familyName>Kobayashi</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>Kei</givenNames><familyName>Itoh</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Li‐Min</givenNames><familyName>Lao</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2"><personName><givenNames>Akira</givenNames><familyName>Ohkawara</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a2"><personName><givenNames>Hideki</givenNames><familyName>Nakamura</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="JP"><unparsedAffiliation>Department of Dermatology, Fukui Medical University, Fukui, Japan,</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="JP"><unparsedAffiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background: </b> Angiosarcomas arise in the scalp and face in the elderly, in association with chronic lymphedema (Stewart–Treves syndrome), and in irradiated areas. Rarely in these settings, angiosarcomas exhibit pure spindle cell phenotype.</p><p><b>Methods: </b> Herein, the clinicopathologic features of a 72‐year‐old‐woman with spindle cell angiosarcoma are described.</p><p><b>Results: </b> A 72‐year‐old woman presented with numerous nodules and diffuse induration from the lower abdomen to the right buttock, corresponding to the area exposed to <sup>60</sup>Co‐irradiation during treatment for cervical carcinoma 10 years earlier. Histopathological examination revealed inflitrative, atypical, spindle cells that labeled with antibodies to CD31, CD34, and factor VIII‐related antigen. Ultrastructurally, these malignant spindle cells contained Weibel–Palade bodies. No features suggesting radiation dermatitis (sclerosis or bizarre, large fibroblasts) were identified, but lymphangiectases and widely spaced collagen bundles(lymphedema) were prominent in the skin surrounding the angiosarcoma. Computed tomographic scan of the abdomen highlighted this histologic finding by demonstrating tumor masses limited to areas of lymphedema. Treatment with intravenous and local injections of recombinant interleukin 2 (rIL 2) followed by electron beam irradiation were initially effective with tumor remission for 2 months. However, the recurrent tumor did not respond to a second course of one‐shot injection of rIL 2 through the abdominal aorta and the patient succumbed to her angiosarcoma 19 months after diagnosis.</p><p><b>Conclusions: </b> Radiation‐induced lymphedema may be a factor in angiosarcoma associated with radiotherapy.</p><!--
Kiyohara T, Kumakiri M, Kobayashi H, Itoh K, Lao L-M, Ohkawara A, Nakamura H. Spindle cell angiosarcoma following irradiation therapy for cervical carcinoma.
J Cutan Pathol 2002; 29: 96–100. © Blackwell Munksgaard 2002.
--></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Spindle cell angiosarcoma following irradiation therapy for cervical carcinoma</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Radiation‐associated angiosarcoma</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Spindle cell angiosarcoma following irradiation therapy for cervical carcinoma</title></titleInfo><name type="personal"><namePart type="given">Takahiro</namePart><namePart type="family">Kiyohara</namePart><affiliation>Department of Dermatology, Fukui Medical University, Fukui, Japan,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Masanobu</namePart><namePart type="family">Kumakiri</namePart><affiliation>Department of Dermatology, Fukui Medical University, Fukui, Japan,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hitoshi</namePart><namePart type="family">Kobayashi</namePart><affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kei</namePart><namePart type="family">Itoh</namePart><affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Li‐Min</namePart><namePart type="family">Lao</namePart><affiliation>Department of Dermatology, Fukui Medical University, Fukui, Japan,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Akira</namePart><namePart type="family">Ohkawara</namePart><affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hideki</namePart><namePart type="family">Nakamura</namePart><affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Science, Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2002-02</dateIssued><edition>Accepted July 5, 2001</edition><copyrightDate encoding="w3cdtf">2002</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">25</extent><extent unit="words">2688</extent></physicalDescription><abstract>Background: Angiosarcomas arise in the scalp and face in the elderly, in association with chronic lymphedema (Stewart–Treves syndrome), and in irradiated areas. Rarely in these settings, angiosarcomas exhibit pure spindle cell phenotype.</abstract><abstract>Methods: Herein, the clinicopathologic features of a 72‐year‐old‐woman with spindle cell angiosarcoma are described.</abstract><abstract>Results: A 72‐year‐old woman presented with numerous nodules and diffuse induration from the lower abdomen to the right buttock, corresponding to the area exposed to 60Co‐irradiation during treatment for cervical carcinoma 10 years earlier. Histopathological examination revealed inflitrative, atypical, spindle cells that labeled with antibodies to CD31, CD34, and factor VIII‐related antigen. Ultrastructurally, these malignant spindle cells contained Weibel–Palade bodies. No features suggesting radiation dermatitis (sclerosis or bizarre, large fibroblasts) were identified, but lymphangiectases and widely spaced collagen bundles(lymphedema) were prominent in the skin surrounding the angiosarcoma. Computed tomographic scan of the abdomen highlighted this histologic finding by demonstrating tumor masses limited to areas of lymphedema. Treatment with intravenous and local injections of recombinant interleukin 2 (rIL 2) followed by electron beam irradiation were initially effective with tumor remission for 2 months. However, the recurrent tumor did not respond to a second course of one‐shot injection of rIL 2 through the abdominal aorta and the patient succumbed to her angiosarcoma 19 months after diagnosis.</abstract><abstract>Conclusions: Radiation‐induced lymphedema may be a factor in angiosarcoma associated with radiotherapy.</abstract><relatedItem type="host"><titleInfo><title>Journal of Cutaneous Pathology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0303-6987</identifier><identifier type="eISSN">1600-0560</identifier><identifier type="DOI">10.1111/(ISSN)1600-0560</identifier><identifier type="PublisherID">CUP</identifier><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>96</start><end>100</end><total>5</total></extent></part></relatedItem><identifier type="istex">FE23CDAEE0CE994E13A8F280FE46A15FAEDD542E</identifier><identifier type="DOI">10.1034/j.1600-0560.2002.290206.x</identifier><identifier type="ArticleID">cup1o009</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Science, Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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