Spindle cell angiosarcoma following irradiation therapy for cervical carcinoma
Identifieur interne : 007744 ( Istex/Corpus ); précédent : 007743; suivant : 007745Spindle cell angiosarcoma following irradiation therapy for cervical carcinoma
Auteurs : Takahiro Kiyohara ; Masanobu Kumakiri ; Hitoshi Kobayashi ; Kei Itoh ; Li-Min Lao ; Akira Ohkawara ; Hideki NakamuraSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2002-02.
Abstract
Background: Angiosarcomas arise in the scalp and face in the elderly, in association with chronic lymphedema (Stewart–Treves syndrome), and in irradiated areas. Rarely in these settings, angiosarcomas exhibit pure spindle cell phenotype.
Url:
DOI: 10.1034/j.1600-0560.2002.290206.x
Links to Exploration step
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<front><div type="abstract">Background: Angiosarcomas arise in the scalp and face in the elderly, in association with chronic lymphedema (Stewart–Treves syndrome), and in irradiated areas. Rarely in these settings, angiosarcomas exhibit pure spindle cell phenotype.</div>
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<profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">Background: </hi>
Angiosarcomas arise in the scalp and face in the elderly, in association with chronic lymphedema (Stewart–Treves syndrome), and in irradiated areas. Rarely in these settings, angiosarcomas exhibit pure spindle cell phenotype.</p>
<p><hi rend="bold">Methods: </hi>
Herein, the clinicopathologic features of a 72‐year‐old‐woman with spindle cell angiosarcoma are described.</p>
<p><hi rend="bold">Results: </hi>
A 72‐year‐old woman presented with numerous nodules and diffuse induration from the lower abdomen to the right buttock, corresponding to the area exposed to <hi rend="superscript">60</hi>
Co‐irradiation during treatment for cervical carcinoma 10 years earlier. Histopathological examination revealed inflitrative, atypical, spindle cells that labeled with antibodies to CD31, CD34, and factor VIII‐related antigen. Ultrastructurally, these malignant spindle cells contained Weibel–Palade bodies. No features suggesting radiation dermatitis (sclerosis or bizarre, large fibroblasts) were identified, but lymphangiectases and widely spaced collagen bundles(lymphedema) were prominent in the skin surrounding the angiosarcoma. Computed tomographic scan of the abdomen highlighted this histologic finding by demonstrating tumor masses limited to areas of lymphedema. Treatment with intravenous and local injections of recombinant interleukin 2 (rIL 2) followed by electron beam irradiation were initially effective with tumor remission for 2 months. However, the recurrent tumor did not respond to a second course of one‐shot injection of rIL 2 through the abdominal aorta and the patient succumbed to her angiosarcoma 19 months after diagnosis.</p>
<p><hi rend="bold">Conclusions: </hi>
Radiation‐induced lymphedema may be a factor in angiosarcoma associated with radiotherapy.</p>
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<correspondenceTo>Takabiro Kiyohara MD, Department of Dermatology, Fukui Medical University, 23–3 Shimoaizuki, Matsuoka‐cho, Yoshida‐gun, Fukui 910–1193, Japan
Tel: +81 776 61 3111
Fax: +81 776 61 8112
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<creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Takahiro</givenNames>
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</personName>
</creator>
<creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Masanobu</givenNames>
<familyName>Kumakiri</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>Hitoshi</givenNames>
<familyName>Kobayashi</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>Kei</givenNames>
<familyName>Itoh</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Li‐Min</givenNames>
<familyName>Lao</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cr6" affiliationRef="#a2"><personName><givenNames>Akira</givenNames>
<familyName>Ohkawara</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cr7" affiliationRef="#a2"><personName><givenNames>Hideki</givenNames>
<familyName>Nakamura</familyName>
</personName>
</creator>
</creators>
<affiliationGroup><affiliation xml:id="a1" countryCode="JP"><unparsedAffiliation>Department of Dermatology, Fukui Medical University, Fukui, Japan,</unparsedAffiliation>
</affiliation>
<affiliation xml:id="a2" countryCode="JP"><unparsedAffiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</unparsedAffiliation>
</affiliation>
</affiliationGroup>
<abstractGroup><abstract type="main" xml:lang="en"><p><b>Background: </b>
Angiosarcomas arise in the scalp and face in the elderly, in association with chronic lymphedema (Stewart–Treves syndrome), and in irradiated areas. Rarely in these settings, angiosarcomas exhibit pure spindle cell phenotype.</p>
<p><b>Methods: </b>
Herein, the clinicopathologic features of a 72‐year‐old‐woman with spindle cell angiosarcoma are described.</p>
<p><b>Results: </b>
A 72‐year‐old woman presented with numerous nodules and diffuse induration from the lower abdomen to the right buttock, corresponding to the area exposed to <sup>60</sup>
Co‐irradiation during treatment for cervical carcinoma 10 years earlier. Histopathological examination revealed inflitrative, atypical, spindle cells that labeled with antibodies to CD31, CD34, and factor VIII‐related antigen. Ultrastructurally, these malignant spindle cells contained Weibel–Palade bodies. No features suggesting radiation dermatitis (sclerosis or bizarre, large fibroblasts) were identified, but lymphangiectases and widely spaced collagen bundles(lymphedema) were prominent in the skin surrounding the angiosarcoma. Computed tomographic scan of the abdomen highlighted this histologic finding by demonstrating tumor masses limited to areas of lymphedema. Treatment with intravenous and local injections of recombinant interleukin 2 (rIL 2) followed by electron beam irradiation were initially effective with tumor remission for 2 months. However, the recurrent tumor did not respond to a second course of one‐shot injection of rIL 2 through the abdominal aorta and the patient succumbed to her angiosarcoma 19 months after diagnosis.</p>
<p><b>Conclusions: </b>
Radiation‐induced lymphedema may be a factor in angiosarcoma associated with radiotherapy.</p>
<!--
Kiyohara T, Kumakiri M, Kobayashi H, Itoh K, Lao L-M, Ohkawara A, Nakamura H. Spindle cell angiosarcoma following irradiation therapy for cervical carcinoma.
J Cutan Pathol 2002; 29: 96–100. © Blackwell Munksgaard 2002.
--></abstract>
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<mods version="3.6"><titleInfo lang="en"><title>Spindle cell angiosarcoma following irradiation therapy for cervical carcinoma</title>
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<titleInfo type="abbreviated" lang="en"><title>Radiation‐associated angiosarcoma</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Spindle cell angiosarcoma following irradiation therapy for cervical carcinoma</title>
</titleInfo>
<name type="personal"><namePart type="given">Takahiro</namePart>
<namePart type="family">Kiyohara</namePart>
<affiliation>Department of Dermatology, Fukui Medical University, Fukui, Japan,</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Masanobu</namePart>
<namePart type="family">Kumakiri</namePart>
<affiliation>Department of Dermatology, Fukui Medical University, Fukui, Japan,</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Hitoshi</namePart>
<namePart type="family">Kobayashi</namePart>
<affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Kei</namePart>
<namePart type="family">Itoh</namePart>
<affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Li‐Min</namePart>
<namePart type="family">Lao</namePart>
<affiliation>Department of Dermatology, Fukui Medical University, Fukui, Japan,</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Akira</namePart>
<namePart type="family">Ohkawara</namePart>
<affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Hideki</namePart>
<namePart type="family">Nakamura</namePart>
<affiliation>Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan</affiliation>
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<place><placeTerm type="text">Oxford, UK</placeTerm>
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<dateIssued encoding="w3cdtf">2002-02</dateIssued>
<edition>Accepted July 5, 2001</edition>
<copyrightDate encoding="w3cdtf">2002</copyrightDate>
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<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
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<abstract>Background: Angiosarcomas arise in the scalp and face in the elderly, in association with chronic lymphedema (Stewart–Treves syndrome), and in irradiated areas. Rarely in these settings, angiosarcomas exhibit pure spindle cell phenotype.</abstract>
<abstract>Methods: Herein, the clinicopathologic features of a 72‐year‐old‐woman with spindle cell angiosarcoma are described.</abstract>
<abstract>Results: A 72‐year‐old woman presented with numerous nodules and diffuse induration from the lower abdomen to the right buttock, corresponding to the area exposed to 60Co‐irradiation during treatment for cervical carcinoma 10 years earlier. Histopathological examination revealed inflitrative, atypical, spindle cells that labeled with antibodies to CD31, CD34, and factor VIII‐related antigen. Ultrastructurally, these malignant spindle cells contained Weibel–Palade bodies. No features suggesting radiation dermatitis (sclerosis or bizarre, large fibroblasts) were identified, but lymphangiectases and widely spaced collagen bundles(lymphedema) were prominent in the skin surrounding the angiosarcoma. Computed tomographic scan of the abdomen highlighted this histologic finding by demonstrating tumor masses limited to areas of lymphedema. Treatment with intravenous and local injections of recombinant interleukin 2 (rIL 2) followed by electron beam irradiation were initially effective with tumor remission for 2 months. However, the recurrent tumor did not respond to a second course of one‐shot injection of rIL 2 through the abdominal aorta and the patient succumbed to her angiosarcoma 19 months after diagnosis.</abstract>
<abstract>Conclusions: Radiation‐induced lymphedema may be a factor in angiosarcoma associated with radiotherapy.</abstract>
<relatedItem type="host"><titleInfo><title>Journal of Cutaneous Pathology</title>
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<genre type="journal">journal</genre>
<identifier type="ISSN">0303-6987</identifier>
<identifier type="eISSN">1600-0560</identifier>
<identifier type="DOI">10.1111/(ISSN)1600-0560</identifier>
<identifier type="PublisherID">CUP</identifier>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>29</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>96</start>
<end>100</end>
<total>5</total>
</extent>
</part>
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<identifier type="ArticleID">cup1o009</identifier>
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<recordOrigin>Blackwell Science, Ltd</recordOrigin>
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