Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century
Identifieur interne : 006266 ( Istex/Corpus ); précédent : 006265; suivant : 006267Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century
Auteurs : Pieter Goeminne ; Lieven DupontSource :
- Postgraduate Medical Journal [ 0032-5473 ] ; 2010-08.
Abstract
Bronchiectasis is permanently dilated airways caused by chronic bronchial inflammation secondary to inappropriate clearance of various micro-organisms and recurrent infections in the airways. At diagnosis, one should search for the underlying disease process, most of the time excluding cystic fibrosis (CF). However, in a substantial number of patients no cause is found. Next, patients need individualised therapy and follow-up by monitoring of their symptoms. Useful tools are the Leicester Cough Questionnaire and the Sputum Colour Chart. Screening patients for bacterial colonisation on a regular basis seems to be equally important, as many patients become colonised by pathogenic micro-organisms. Treatment for non-cystic fibrosis bronchiectasis differs in certain aspects from cystic fibrosis bronchiectasis and often lacks evidence. Overall, bronchiectasis is an underestimated disease, not only in prevalence and incidence, but also in its ability to cause morbidity and mortality. Further research into the underlying pathophysiological mechanisms and trials evaluating new treatments are an absolute necessity.
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DOI: 10.1136/pgmj.2009.091041
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For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</p></availability><date>2010</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century</title><author xml:id="author-1"><persName><forename type="first">Pieter</forename><surname>Goeminne</surname></persName><affiliation>Laboratory of Pneumology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium</affiliation></author><author xml:id="author-2" corresp="yes"><persName><forename type="first">Lieven</forename><surname>Dupont</surname></persName><email>lieven.dupont@uz.kuleuven.be</email><affiliation>Laboratory of Pneumology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium</affiliation></author></analytic><monogr><title level="j">Postgraduate Medical Journal</title><title level="j" type="abbrev">Postgrad Med J</title><idno type="pISSN">0032-5473</idno><idno type="eISSN">1469-0756</idno><imprint><publisher>The Fellowship of Postgraduate Medicine</publisher><date type="published" when="2010-08"></date><biblScope unit="volume">86</biblScope><biblScope unit="issue">1018</biblScope><biblScope unit="page" from="493">493</biblScope></imprint></monogr><idno type="istex">D21F41CB13410251286E07EF076FA3ECC31048CE</idno><idno type="DOI">10.1136/pgmj.2009.091041</idno><idno type="href">postgradmedj-86-493.pdf</idno><idno type="ArticleID">postgradmedj91041</idno><idno type="local">postgradmedj;86/1018/493</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Bronchiectasis is permanently dilated airways caused by chronic bronchial inflammation secondary to inappropriate clearance of various micro-organisms and recurrent infections in the airways. At diagnosis, one should search for the underlying disease process, most of the time excluding cystic fibrosis (CF). However, in a substantial number of patients no cause is found. Next, patients need individualised therapy and follow-up by monitoring of their symptoms. Useful tools are the Leicester Cough Questionnaire and the Sputum Colour Chart. Screening patients for bacterial colonisation on a regular basis seems to be equally important, as many patients become colonised by pathogenic micro-organisms. Treatment for non-cystic fibrosis bronchiectasis differs in certain aspects from cystic fibrosis bronchiectasis and often lacks evidence. Overall, bronchiectasis is an underestimated disease, not only in prevalence and incidence, but also in its ability to cause morbidity and mortality. Further research into the underlying pathophysiological mechanisms and trials evaluating new treatments are an absolute necessity.</p></abstract><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>Bronchiectasis</term></item><item><term>non-cystic fibrosis</term></item><item><term>management</term></item><item><term>diagnosis</term></item><item><term>internal medicine</term></item><item><term>thoracic medicine</term></item><item><term>chronic airways disease</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/D21F41CB13410251286E07EF076FA3ECC31048CE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="review-article"><front><journal-meta><journal-id journal-id-type="hwp">postgradmedj</journal-id><journal-id journal-id-type="nlm-ta">Postgrad Med J</journal-id><journal-id journal-id-type="publisher-id">pmj</journal-id><journal-title>Postgraduate Medical Journal</journal-title><abbrev-journal-title abbrev-type="publisher">Postgrad Med J</abbrev-journal-title><abbrev-journal-title>Postgrad Med J</abbrev-journal-title><issn pub-type="ppub">0032-5473</issn><issn pub-type="epub">1469-0756</issn><publisher><publisher-name>The Fellowship of Postgraduate Medicine</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">postgradmedj91041</article-id><article-id pub-id-type="doi">10.1136/pgmj.2009.091041</article-id><article-id pub-id-type="other">postgradmedj;86/1018/493</article-id><article-id pub-id-type="other">493</article-id><article-id pub-id-type="other">pgmj.2009.091041</article-id><article-categories><subj-group subj-group-type="heading"><subject content-type="original">Review</subject></subj-group></article-categories><title-group><article-title>Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Goeminne</surname><given-names>Pieter</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Dupont</surname><given-names>Lieven</given-names></name></contrib></contrib-group><aff>Laboratory of Pneumology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium</aff><author-notes><corresp><label>Correspondence to</label> Professor L Dupont, University Hospital Gasthuisberg, Respiratory Medicine, Herestraat 49, B-3000 Leuven, Belgium; <email>lieven.dupont@uz.kuleuven.be</email></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2010</year></pub-date><volume>86</volume><volume-id pub-id-type="other">86</volume-id><volume-id pub-id-type="other">86</volume-id><issue>1018</issue><issue-id pub-id-type="other">postgradmedj;86/1018</issue-id><issue-id pub-id-type="other">1018</issue-id><issue-id pub-id-type="other">86/1018</issue-id><fpage>493</fpage><history><date date-type="received"><day>11</day><month>9</month><year>2009</year></date><date date-type="accepted"><day>31</day><month>5</month><year>2010</year></date></history><permissions><copyright-statement>© 2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</copyright-statement><copyright-year>2010</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="postgradmedj-86-493.pdf"></self-uri><abstract><p>Bronchiectasis is permanently dilated airways caused by chronic bronchial inflammation secondary to inappropriate clearance of various micro-organisms and recurrent infections in the airways. At diagnosis, one should search for the underlying disease process, most of the time excluding cystic fibrosis (CF). However, in a substantial number of patients no cause is found. Next, patients need individualised therapy and follow-up by monitoring of their symptoms. Useful tools are the Leicester Cough Questionnaire and the Sputum Colour Chart. Screening patients for bacterial colonisation on a regular basis seems to be equally important, as many patients become colonised by pathogenic micro-organisms. Treatment for non-cystic fibrosis bronchiectasis differs in certain aspects from cystic fibrosis bronchiectasis and often lacks evidence. Overall, bronchiectasis is an underestimated disease, not only in prevalence and incidence, but also in its ability to cause morbidity and mortality. Further research into the underlying pathophysiological mechanisms and trials evaluating new treatments are an absolute necessity.</p></abstract><kwd-group><kwd>Bronchiectasis</kwd><kwd>non-cystic fibrosis</kwd><kwd>management</kwd><kwd>diagnosis</kwd><kwd>internal medicine</kwd><kwd>thoracic medicine</kwd><kwd>chronic airways disease</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century</title></titleInfo><name type="personal"><namePart type="given">Pieter</namePart><namePart type="family">Goeminne</namePart><affiliation>Laboratory of Pneumology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Lieven</namePart><namePart type="family">Dupont</namePart><affiliation>Laboratory of Pneumology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium</affiliation><affiliation>E-mail: lieven.dupont@uz.kuleuven.be</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="review-article"></genre><originInfo><publisher>The Fellowship of Postgraduate Medicine</publisher><dateIssued encoding="w3cdtf">2010-08</dateIssued><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Bronchiectasis is permanently dilated airways caused by chronic bronchial inflammation secondary to inappropriate clearance of various micro-organisms and recurrent infections in the airways. At diagnosis, one should search for the underlying disease process, most of the time excluding cystic fibrosis (CF). However, in a substantial number of patients no cause is found. Next, patients need individualised therapy and follow-up by monitoring of their symptoms. Useful tools are the Leicester Cough Questionnaire and the Sputum Colour Chart. Screening patients for bacterial colonisation on a regular basis seems to be equally important, as many patients become colonised by pathogenic micro-organisms. Treatment for non-cystic fibrosis bronchiectasis differs in certain aspects from cystic fibrosis bronchiectasis and often lacks evidence. Overall, bronchiectasis is an underestimated disease, not only in prevalence and incidence, but also in its ability to cause morbidity and mortality. Further research into the underlying pathophysiological mechanisms and trials evaluating new treatments are an absolute necessity.</abstract><subject><genre>keywords</genre><topic>Bronchiectasis</topic><topic>non-cystic fibrosis</topic><topic>management</topic><topic>diagnosis</topic><topic>internal medicine</topic><topic>thoracic medicine</topic><topic>chronic airways disease</topic></subject><relatedItem type="host"><titleInfo><title>Postgraduate Medical Journal</title></titleInfo><titleInfo type="abbreviated"><title>Postgrad Med J</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0032-5473</identifier><identifier type="eISSN">1469-0756</identifier><identifier type="PublisherID">pmj</identifier><identifier type="PublisherID-hwp">postgradmedj</identifier><identifier type="PublisherID-nlm-ta">Postgrad Med J</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>86</number></detail><detail type="issue"><caption>no.</caption><number>1018</number></detail><extent unit="pages"><start>493</start></extent></part></relatedItem><identifier type="istex">D21F41CB13410251286E07EF076FA3ECC31048CE</identifier><identifier type="DOI">10.1136/pgmj.2009.091041</identifier><identifier type="href">postgradmedj-86-493.pdf</identifier><identifier type="ArticleID">postgradmedj91041</identifier><identifier type="local">postgradmedj;86/1018/493</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</accessCondition><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><annexes><json:item><extension>jpeg</extension><original>true</original><mimetype>image/jpeg</mimetype><uri>https://api.istex.fr/document/D21F41CB13410251286E07EF076FA3ECC31048CE/annexes/jpeg</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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