Epithelioid sarcoma mimicking angiosarcoma: The value of immunohistochemistry in the differential diagnosis
Identifieur interne : 003167 ( Istex/Corpus ); précédent : 003166; suivant : 003168Epithelioid sarcoma mimicking angiosarcoma: The value of immunohistochemistry in the differential diagnosis
Auteurs : A. R. Von Hochstetter ; V. E. Meyer ; J. W. Grant ; H. P. Honegger ; A. SchreiberSource :
- Virchows Archiv A [ 0174-7398 ] ; 1991-05-01.
Abstract
Summary: Epithelioid sarcoma (ES) is a rare malignant tumour of young adults, usually presenting as a skin ulcer or subcutaneous nodule in the distal portion of the upper limb. Multiple recurrences and late metastases are typical, leading to fatality in a third to one-half of all cases. The slow evolution of the tumour is one reason for its delayed recognition. The other is its frequent histological misinterpretation, in particular, as a peculiar granulomatous reaction. In our case, the primary tumour presented a variant morphological pattern so closely mimicking a cavernous angiosarcoma as to mislead several reputable opinions. Later recurrences and metastases were typical of ES, while a focal angiomatoid pattern was maintained. The morphology and immunoreactivity to a wide spectrum of tumour markers is compared with that of six file cases of classical ES. Retrospectively, all neoplastic lesions in our patient were ES. In young adults, lesions of the upper extremity, even when angiomatoid or haemorrhagic, should raise a suspicion of ES. Once epithelioid sarcoma is suspected, the differential diagnosis can be elucidated on immunohistochemical grounds. Early diagnosis provides the best opportunity for radical surgery at a stage when the tumour has not spread locally or disseminated systemically.
Url:
DOI: 10.1007/BF01606067
Links to Exploration step
ISTEX:6A52D9E43C5FAFE72A43A2F32CACB2CA2EF35415Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Epithelioid sarcoma mimicking angiosarcoma: The value of immunohistochemistry in the differential diagnosis</title><author><name sortKey="Von Hochstetter, A R" sort="Von Hochstetter, A R" uniqKey="Von Hochstetter A" first="A. R." last="Von Hochstetter">A. R. Von Hochstetter</name><affiliation><mods:affiliation>Department of Pathology, University Hospital, Zurich, Switzerland</mods:affiliation></affiliation><affiliation><mods:affiliation>Orthopaedic University Clinic Balgrist, Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Meyer, V E" sort="Meyer, V E" uniqKey="Meyer V" first="V. E." last="Meyer">V. E. Meyer</name><affiliation><mods:affiliation>Department of Reconstructive Surgery, University Hospital, Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Grant, J W" sort="Grant, J W" uniqKey="Grant J" first="J. W." last="Grant">J. W. Grant</name><affiliation><mods:affiliation>Department of Pathology, Addenbrooke's Hospital, Cambridge, UK</mods:affiliation></affiliation></author><author><name sortKey="Honegger, H P" sort="Honegger, H P" uniqKey="Honegger H" first="H. P." last="Honegger">H. P. Honegger</name><affiliation><mods:affiliation>Oncology Service, Stadtspital Triemli, Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Schreiber, A" sort="Schreiber, A" uniqKey="Schreiber A" first="A." last="Schreiber">A. Schreiber</name><affiliation><mods:affiliation>Orthopaedic University Clinic Balgrist, Zurich, Switzerland</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6A52D9E43C5FAFE72A43A2F32CACB2CA2EF35415</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1007/BF01606067</idno><idno type="url">https://api.istex.fr/document/6A52D9E43C5FAFE72A43A2F32CACB2CA2EF35415/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003167</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003167</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Epithelioid sarcoma mimicking angiosarcoma: The value of immunohistochemistry in the differential diagnosis</title><author><name sortKey="Von Hochstetter, A R" sort="Von Hochstetter, A R" uniqKey="Von Hochstetter A" first="A. R." last="Von Hochstetter">A. R. Von Hochstetter</name><affiliation><mods:affiliation>Department of Pathology, University Hospital, Zurich, Switzerland</mods:affiliation></affiliation><affiliation><mods:affiliation>Orthopaedic University Clinic Balgrist, Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Meyer, V E" sort="Meyer, V E" uniqKey="Meyer V" first="V. E." last="Meyer">V. E. Meyer</name><affiliation><mods:affiliation>Department of Reconstructive Surgery, University Hospital, Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Grant, J W" sort="Grant, J W" uniqKey="Grant J" first="J. W." last="Grant">J. W. Grant</name><affiliation><mods:affiliation>Department of Pathology, Addenbrooke's Hospital, Cambridge, UK</mods:affiliation></affiliation></author><author><name sortKey="Honegger, H P" sort="Honegger, H P" uniqKey="Honegger H" first="H. P." last="Honegger">H. P. Honegger</name><affiliation><mods:affiliation>Oncology Service, Stadtspital Triemli, Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Schreiber, A" sort="Schreiber, A" uniqKey="Schreiber A" first="A." last="Schreiber">A. Schreiber</name><affiliation><mods:affiliation>Orthopaedic University Clinic Balgrist, Zurich, Switzerland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Virchows Archiv A</title><title level="j" type="sub">Pathological Anatomy and Histopathology</title><title level="j" type="abbrev">Vichows Archiv A Pathol Anat</title><idno type="ISSN">0174-7398</idno><idno type="eISSN">1432-2307</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1991-05-01">1991-05-01</date><biblScope unit="volume">418</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="271">271</biblScope><biblScope unit="page" to="278">278</biblScope></imprint><idno type="ISSN">0174-7398</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0174-7398</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Epithelioid sarcoma (ES) is a rare malignant tumour of young adults, usually presenting as a skin ulcer or subcutaneous nodule in the distal portion of the upper limb. Multiple recurrences and late metastases are typical, leading to fatality in a third to one-half of all cases. The slow evolution of the tumour is one reason for its delayed recognition. The other is its frequent histological misinterpretation, in particular, as a peculiar granulomatous reaction. In our case, the primary tumour presented a variant morphological pattern so closely mimicking a cavernous angiosarcoma as to mislead several reputable opinions. Later recurrences and metastases were typical of ES, while a focal angiomatoid pattern was maintained. The morphology and immunoreactivity to a wide spectrum of tumour markers is compared with that of six file cases of classical ES. Retrospectively, all neoplastic lesions in our patient were ES. In young adults, lesions of the upper extremity, even when angiomatoid or haemorrhagic, should raise a suspicion of ES. Once epithelioid sarcoma is suspected, the differential diagnosis can be elucidated on immunohistochemical grounds. Early diagnosis provides the best opportunity for radical surgery at a stage when the tumour has not spread locally or disseminated systemically.</div></front></TEI><istex><corpusName>springer</corpusName><keywords><teeft><json:string>epithelioid</json:string><json:string>sarcoma</json:string><json:string>epithelioid sarcoma</json:string><json:string>tumour</json:string><json:string>enzinger</json:string><json:string>metastasis</json:string><json:string>immunohistochemical</json:string><json:string>epithelial</json:string><json:string>angiomatoid</json:string><json:string>pathol</json:string><json:string>excision</json:string><json:string>angiosarcoma</json:string><json:string>amputation</json:string><json:string>dakopatts</json:string><json:string>nodule</json:string><json:string>recurrence</json:string><json:string>neoplastic cells</json:string><json:string>young adults</json:string><json:string>angiomatoid pattern</json:string><json:string>lesion</json:string><json:string>differential diagnosis</json:string><json:string>correct diagnosis</json:string><json:string>epithelioid haemangioendothelioma</json:string><json:string>copenhagen dakopatts</json:string><json:string>primary lesion</json:string><json:string>synovial sarcoma</json:string><json:string>cavernous type</json:string><json:string>immunohistochemical screening</json:string><json:string>early recognition</json:string><json:string>vascular invasion</json:string><json:string>morphological features</json:string><json:string>upper extremity</json:string><json:string>epithelial membrane antigen</json:string><json:string>immunohistochemical study</json:string><json:string>years forearm</json:string><json:string>primary tumour</json:string><json:string>metastatic carcinoma</json:string><json:string>subcutaneous nodule</json:string><json:string>cavernous lesion</json:string><json:string>soft tissue reconstruction</json:string><json:string>serpiginous bands</json:string><json:string>amputation specimen</json:string><json:string>stadtspital triemli</json:string><json:string>epithelial markers</json:string><json:string>tumour cells</json:string><json:string>monoclonal antibodies</json:string><json:string>virchows arch</json:string><json:string>biopsy</json:string></teeft></keywords><author><json:item><name>A. R. von Hochstetter</name><affiliations><json:string>Department of Pathology, University Hospital, Zurich, Switzerland</json:string><json:string>Orthopaedic University Clinic Balgrist, Zurich, Switzerland</json:string></affiliations></json:item><json:item><name>V. E. Meyer</name><affiliations><json:string>Department of Reconstructive Surgery, University Hospital, Zurich, Switzerland</json:string></affiliations></json:item><json:item><name>J. W. Grant</name><affiliations><json:string>Department of Pathology, Addenbrooke's Hospital, Cambridge, UK</json:string></affiliations></json:item><json:item><name>H. P. Honegger</name><affiliations><json:string>Oncology Service, Stadtspital Triemli, Zurich, Switzerland</json:string></affiliations></json:item><json:item><name>A. Schreiber</name><affiliations><json:string>Orthopaedic University Clinic Balgrist, Zurich, Switzerland</json:string></affiliations></json:item></author><articleId><json:string>BF01606067</json:string><json:string>Art13</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Summary: Epithelioid sarcoma (ES) is a rare malignant tumour of young adults, usually presenting as a skin ulcer or subcutaneous nodule in the distal portion of the upper limb. Multiple recurrences and late metastases are typical, leading to fatality in a third to one-half of all cases. The slow evolution of the tumour is one reason for its delayed recognition. The other is its frequent histological misinterpretation, in particular, as a peculiar granulomatous reaction. In our case, the primary tumour presented a variant morphological pattern so closely mimicking a cavernous angiosarcoma as to mislead several reputable opinions. Later recurrences and metastases were typical of ES, while a focal angiomatoid pattern was maintained. The morphology and immunoreactivity to a wide spectrum of tumour markers is compared with that of six file cases of classical ES. Retrospectively, all neoplastic lesions in our patient were ES. In young adults, lesions of the upper extremity, even when angiomatoid or haemorrhagic, should raise a suspicion of ES. Once epithelioid sarcoma is suspected, the differential diagnosis can be elucidated on immunohistochemical grounds. Early diagnosis provides the best opportunity for radical surgery at a stage when the tumour has not spread locally or disseminated systemically.</abstract><qualityIndicators><score>5.104</score><pdfWordCount>2728</pdfWordCount><pdfCharCount>17467</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>583.28 x 785 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>198</abstractWordCount><abstractCharCount>1315</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Epithelioid sarcoma mimicking angiosarcoma: The value of immunohistochemistry in the differential diagnosis</title><genre><json:string>research-article</json:string></genre><host><title>Virchows Archiv A</title><language><json:string>unknown</json:string></language><publicationDate>1991</publicationDate><copyrightDate>1991</copyrightDate><issn><json:string>0174-7398</json:string></issn><eissn><json:string>1432-2307</json:string></eissn><journalId><json:string>428</json:string></journalId><volume>418</volume><issue>3</issue><pages><first>271</first><last>278</last></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Pathology</value></json:item></subject></host><categories><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>1991</publicationDate><copyrightDate>1991</copyrightDate><doi><json:string>10.1007/BF01606067</json:string></doi><id>6A52D9E43C5FAFE72A43A2F32CACB2CA2EF35415</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/6A52D9E43C5FAFE72A43A2F32CACB2CA2EF35415/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/6A52D9E43C5FAFE72A43A2F32CACB2CA2EF35415/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/6A52D9E43C5FAFE72A43A2F32CACB2CA2EF35415/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Epithelioid sarcoma mimicking angiosarcoma: The value of immunohistochemistry in the differential diagnosis</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><p>Springer-Verlag, 1991</p></availability><date>1990-07-12</date></publicationStmt><notesStmt><note>Case Report</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Epithelioid sarcoma mimicking angiosarcoma: The value of immunohistochemistry in the differential diagnosis</title><author xml:id="author-0000" corresp="yes"><persName><forename type="first">A.</forename><surname>von Hochstetter</surname></persName><affiliation>Department of Pathology, University Hospital, Zurich, Switzerland</affiliation><affiliation>Orthopaedic University Clinic Balgrist, Zurich, Switzerland</affiliation></author><author xml:id="author-0001"><persName><forename type="first">V.</forename><surname>Meyer</surname></persName><affiliation>Department of Reconstructive Surgery, University Hospital, Zurich, Switzerland</affiliation></author><author xml:id="author-0002"><persName><forename type="first">J.</forename><surname>Grant</surname></persName><affiliation>Department of Pathology, Addenbrooke's Hospital, Cambridge, UK</affiliation></author><author xml:id="author-0003"><persName><forename type="first">H.</forename><surname>Honegger</surname></persName><affiliation>Oncology Service, Stadtspital Triemli, Zurich, Switzerland</affiliation></author><author xml:id="author-0004"><persName><forename type="first">A.</forename><surname>Schreiber</surname></persName><affiliation>Orthopaedic University Clinic Balgrist, Zurich, Switzerland</affiliation></author><idno type="istex">6A52D9E43C5FAFE72A43A2F32CACB2CA2EF35415</idno><idno type="DOI">10.1007/BF01606067</idno><idno type="ArticleID">BF01606067</idno><idno type="ArticleID">Art13</idno></analytic><monogr><title level="j">Virchows Archiv A</title><title level="j" type="sub">Pathological Anatomy and Histopathology</title><title level="j" type="abbrev">Vichows Archiv A Pathol Anat</title><idno type="pISSN">0174-7398</idno><idno type="eISSN">1432-2307</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">14</idno><idno type="volume-issue-count">6</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1991-05-01"></date><biblScope unit="volume">418</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="271">271</biblScope><biblScope unit="page" to="278">278</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990-07-12</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: Epithelioid sarcoma (ES) is a rare malignant tumour of young adults, usually presenting as a skin ulcer or subcutaneous nodule in the distal portion of the upper limb. Multiple recurrences and late metastases are typical, leading to fatality in a third to one-half of all cases. The slow evolution of the tumour is one reason for its delayed recognition. The other is its frequent histological misinterpretation, in particular, as a peculiar granulomatous reaction. In our case, the primary tumour presented a variant morphological pattern so closely mimicking a cavernous angiosarcoma as to mislead several reputable opinions. Later recurrences and metastases were typical of ES, while a focal angiomatoid pattern was maintained. The morphology and immunoreactivity to a wide spectrum of tumour markers is compared with that of six file cases of classical ES. Retrospectively, all neoplastic lesions in our patient were ES. In young adults, lesions of the upper extremity, even when angiomatoid or haemorrhagic, should raise a suspicion of ES. Once epithelioid sarcoma is suspected, the differential diagnosis can be elucidated on immunohistochemical grounds. Early diagnosis provides the best opportunity for radical surgery at a stage when the tumour has not spread locally or disseminated systemically.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Pathology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1990-07-12">Created</change><change when="1991-05-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/6A52D9E43C5FAFE72A43A2F32CACB2CA2EF35415/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>428</JournalID><JournalPrintISSN>0174-7398</JournalPrintISSN><JournalElectronicISSN>1432-2307</JournalElectronicISSN><JournalTitle>Virchows Archiv A</JournalTitle><JournalSubTitle>Pathological Anatomy and Histopathology</JournalSubTitle><JournalAbbreviatedTitle>Vichows Archiv A Pathol Anat</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Type="Secondary">Pathology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>418</VolumeIDStart><VolumeIDEnd>418</VolumeIDEnd><VolumeIssueCount>6</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>3</IssueIDStart><IssueIDEnd>3</IssueIDEnd><IssueArticleCount>14</IssueArticleCount><IssueHistory><CoverDate><DateString>1991</DateString><Year>1991</Year><Month>5</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1991</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art13"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF01606067</ArticleID><ArticleDOI>10.1007/BF01606067</ArticleDOI><ArticleSequenceNumber>13</ArticleSequenceNumber><ArticleTitle Language="En">Epithelioid sarcoma mimicking angiosarcoma: The value of immunohistochemistry in the differential diagnosis</ArticleTitle><ArticleCategory>Case Report</ArticleCategory><ArticleFirstPage>271</ArticleFirstPage><ArticleLastPage>278</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>4</Month><Day>17</Day></RegistrationDate><Received><Year>1990</Year><Month>7</Month><Day>12</Day></Received><Revised><Year>1990</Year><Month>10</Month><Day>20</Day></Revised><Accepted><Year>1990</Year><Month>10</Month><Day>27</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1991</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>428</JournalID><VolumeIDStart>418</VolumeIDStart><VolumeIDEnd>418</VolumeIDEnd><IssueIDStart>3</IssueIDStart><IssueIDEnd>3</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1 Aff2" CorrespondingAffiliationID="Aff3"><AuthorName DisplayOrder="Western"><GivenName>A.</GivenName><GivenName>R.</GivenName><Particle>von</Particle><FamilyName>Hochstetter</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff4"><AuthorName DisplayOrder="Western"><GivenName>V.</GivenName><GivenName>E.</GivenName><FamilyName>Meyer</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff5"><AuthorName DisplayOrder="Western"><GivenName>J.</GivenName><GivenName>W.</GivenName><FamilyName>Grant</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff6"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><GivenName>P.</GivenName><FamilyName>Honegger</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>A.</GivenName><FamilyName>Schreiber</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Pathology</OrgDivision><OrgName>University Hospital</OrgName><OrgAddress><City>Zurich</City><Country>Switzerland</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgDivision>Department of Reconstructive Surgery</OrgDivision><OrgName>University Hospital</OrgName><OrgAddress><City>Zurich</City><Country>Switzerland</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgName>Orthopaedic University Clinic Balgrist</OrgName><OrgAddress><City>Zurich</City><Country>Switzerland</Country></OrgAddress></Affiliation><Affiliation ID="Aff6"><OrgDivision>Oncology Service</OrgDivision><OrgName>Stadtspital Triemli</OrgName><OrgAddress><City>Zurich</City><Country>Switzerland</Country></OrgAddress></Affiliation><Affiliation ID="Aff5"><OrgDivision>Department of Pathology</OrgDivision><OrgName>Addenbrooke's Hospital</OrgName><OrgAddress><City>Cambridge</City><Country>UK</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgName>Institut für Pathologie der Universität</OrgName><OrgAddress><Street>Schmelzbergstrasse 12</Street><Postcode>CH-8091</Postcode><City>Zürich</City><Country>Switzerland</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>Epithelioid sarcoma (ES) is a rare malignant tumour of young adults, usually presenting as a skin ulcer or subcutaneous nodule in the distal portion of the upper limb. Multiple recurrences and late metastases are typical, leading to fatality in a third to one-half of all cases. The slow evolution of the tumour is one reason for its delayed recognition. The other is its frequent histological misinterpretation, in particular, as a peculiar granulomatous reaction. In our case, the primary tumour presented a variant morphological pattern so closely mimicking a cavernous angiosarcoma as to mislead several reputable opinions. Later recurrences and metastases were typical of ES, while a focal angiomatoid pattern was maintained. The morphology and immunoreactivity to a wide spectrum of tumour markers is compared with that of six file cases of classical ES. Retrospectively, all neoplastic lesions in our patient were ES. In young adults, lesions of the upper extremity, even when angiomatoid or haemorrhagic, should raise a suspicion of ES. Once epithelioid sarcoma is suspected, the differential diagnosis can be elucidated on immunohistochemical grounds. Early diagnosis provides the best opportunity for radical surgery at a stage when the tumour has not spread locally or disseminated systemically.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Epithelioid sarcoma</Keyword><Keyword>Soft tissue sarcoma</Keyword><Keyword>Immunohistochemistry</Keyword><Keyword>Marker co-expression</Keyword></KeywordGroup><ArticleNote Type="PresentedAt"><SimplePara>Presented at the combined meeting of the European Musculoskeletal Oncology Society (EMSOS) and the North American Musculoskeletal Tumor Society (MSTS), Bologna, 13 September 1989</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Epithelioid sarcoma mimicking angiosarcoma: The value of immunohistochemistry in the differential diagnosis</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Epithelioid sarcoma mimicking angiosarcoma: The value of immunohistochemistry in the differential diagnosis</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">A.</namePart><namePart type="given">R.</namePart><namePart type="family">von Hochstetter</namePart><affiliation>Department of Pathology, University Hospital, Zurich, Switzerland</affiliation><affiliation>Orthopaedic University Clinic Balgrist, Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="given">E.</namePart><namePart type="family">Meyer</namePart><affiliation>Department of Reconstructive Surgery, University Hospital, Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="given">W.</namePart><namePart type="family">Grant</namePart><affiliation>Department of Pathology, Addenbrooke's Hospital, Cambridge, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="given">P.</namePart><namePart type="family">Honegger</namePart><affiliation>Oncology Service, Stadtspital Triemli, Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Schreiber</namePart><affiliation>Orthopaedic University Clinic Balgrist, Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1990-07-12</dateCreated><dateIssued encoding="w3cdtf">1991-05-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: Epithelioid sarcoma (ES) is a rare malignant tumour of young adults, usually presenting as a skin ulcer or subcutaneous nodule in the distal portion of the upper limb. Multiple recurrences and late metastases are typical, leading to fatality in a third to one-half of all cases. The slow evolution of the tumour is one reason for its delayed recognition. The other is its frequent histological misinterpretation, in particular, as a peculiar granulomatous reaction. In our case, the primary tumour presented a variant morphological pattern so closely mimicking a cavernous angiosarcoma as to mislead several reputable opinions. Later recurrences and metastases were typical of ES, while a focal angiomatoid pattern was maintained. The morphology and immunoreactivity to a wide spectrum of tumour markers is compared with that of six file cases of classical ES. Retrospectively, all neoplastic lesions in our patient were ES. In young adults, lesions of the upper extremity, even when angiomatoid or haemorrhagic, should raise a suspicion of ES. Once epithelioid sarcoma is suspected, the differential diagnosis can be elucidated on immunohistochemical grounds. Early diagnosis provides the best opportunity for radical surgery at a stage when the tumour has not spread locally or disseminated systemically.</abstract><note>Case Report</note><relatedItem type="host"><titleInfo><title>Virchows Archiv A</title><subTitle>Pathological Anatomy and Histopathology</subTitle></titleInfo><titleInfo type="abbreviated"><title>Vichows Archiv A Pathol Anat</title></titleInfo><genre type="journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1991-05-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Pathology</topic></subject><identifier type="ISSN">0174-7398</identifier><identifier type="eISSN">1432-2307</identifier><identifier type="JournalID">428</identifier><identifier type="IssueArticleCount">14</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>1991</date><detail type="volume"><number>418</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="pages"><start>271</start><end>278</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1991</recordOrigin></recordInfo></relatedItem><identifier type="istex">6A52D9E43C5FAFE72A43A2F32CACB2CA2EF35415</identifier><identifier type="DOI">10.1007/BF01606067</identifier><identifier type="ArticleID">BF01606067</identifier><identifier type="ArticleID">Art13</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1991</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1991</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003167 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 003167 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:6A52D9E43C5FAFE72A43A2F32CACB2CA2EF35415
|texte= Epithelioid sarcoma mimicking angiosarcoma: The value of immunohistochemistry in the differential diagnosis
}}
| This area was generated with Dilib version V0.6.31. |  |