The Pathogenesis of Filarial Lymphedema
Identifieur interne : 003166 ( Istex/Corpus ); précédent : 003165; suivant : 003167The Pathogenesis of Filarial Lymphedema
Auteurs : Patrick J. Lammie ; Karen T. Cuenco ; George A. PunkosdySource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2002-12.
Abstract
Abstract: Our understanding of the pathogenesis of filarial lymphedema, although evolving, is still limited. Recurrent bacterial infections play a major role in the progression of lymphedema to elephantiasis, but the host and parasite factors that trigger disease development are not known. Field studies in Haiti show that lymphedema and host responses to parasite antigens cluster in families, consistent with the hypothesis that host genes influence lymphedema susceptibility. The recent recognition that filarial parasites harbor the endosymbiotic bacteria, Wolbachia, also raises questions about the potential contribution of the inflammatory response to Wolbachia antigens to lymphedema development. In this review, we discuss potential risk factors for lymphedema and try to integrate these in a model of pathogenesis.
Url:
DOI: 10.1111/j.1749-6632.2002.tb04874.x
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Lammie, Ph.D., Division of Parasitic Diseases/F13, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341. Voice: 770‐488‐4054; fax: 770‐488‐4108; PJL1@cdc.gov.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">KAREN T.</forename><surname>CUENCO</surname></persName><affiliation>Department of Human Genetics, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">GEORGE A.</forename><surname>PUNKOSDY</surname></persName><affiliation>Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA<address><country key="US"></country></address></affiliation><affiliation>Department of Cell Biology, University of Georgia, Athens, Georgia, USA<address><country key="US"></country></address></affiliation></author><idno type="istex">6A4EAA733479784BFC8C69A8DEA1176DA2DC19E0</idno><idno type="DOI">10.1111/j.1749-6632.2002.tb04874.x</idno><idno type="unit">NYAS131</idno><idno type="toTypesetVersion">file:NYAS.NYAS131.pdf</idno></analytic><monogr><title level="j" type="main">Annals of the New York Academy of Sciences</title><title level="j" type="alt">ANNALS OF NEW YORK ACADEMY SCIENCES</title><idno type="pISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><idno type="book-DOI">10.1111/(ISSN)1749-6632</idno><idno type="book-part-DOI">10.1111/nyas.2002.979.issue-1</idno><idno type="product">NYAS</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">979</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="131">131</biblScope><biblScope unit="page" to="142">142</biblScope><biblScope unit="page-count">12</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2002-12"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">A<hi rend="smallCaps">bstract</hi>: </hi> Our understanding of the pathogenesis of filarial lymphedema, although evolving, is still limited. Recurrent bacterial infections play a major role in the progression of lymphedema to elephantiasis, but the host and parasite factors that trigger disease development are not known. Field studies in Haiti show that lymphedema and host responses to parasite antigens cluster in families, consistent with the hypothesis that host genes influence lymphedema susceptibility. The recent recognition that filarial parasites harbor the endosymbiotic bacteria, <hi rend="italic">Wolbachia,</hi> also raises questions about the potential contribution of the inflammatory response to <hi rend="italic">Wolbachia</hi> antigens to lymphedema development. In this review, we discuss potential risk factors for lymphedema and try to integrate these in a model of pathogenesis.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">Lymphatic filariasis</term><term xml:id="k2">Wuchereria bancrofti</term><term xml:id="k3">lymphedema</term></keywords><classCode scheme="tocHeading1">The Lymphatic Continuum: Lymphatic Biology and Disease: Part 4. 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Voice: 770‐488‐4054; fax: 770‐488‐4108; <email>PJL1@cdc.gov</email>.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NYAS.NYAS131.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="0"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="46"></count><count type="linksCrossRef" number="44"></count></countGroup><titleGroup><title type="main">The Pathogenesis of Filarial Lymphedema</title><title type="subtitle">Is it the Worm or Is It the Host?</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>PATRICK J.</givenNames><familyName>LAMMIE</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>KAREN T.</givenNames><familyName>CUENCO</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1 #a3"><personName><givenNames>GEORGE A.</givenNames><familyName>PUNKOSDY</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="US"><unparsedAffiliation>Department of Human Genetics, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="US"><unparsedAffiliation>Department of Cell Biology, University of Georgia, Athens, Georgia, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Lymphatic filariasis</keyword><keyword xml:id="k2">Wuchereria bancrofti</keyword><keyword xml:id="k3">lymphedema</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>A<sc>bstract</sc>: </b> Our understanding of the pathogenesis of filarial lymphedema, although evolving, is still limited. 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Recurrent bacterial infections play a major role in the progression of lymphedema to elephantiasis, but the host and parasite factors that trigger disease development are not known. Field studies in Haiti show that lymphedema and host responses to parasite antigens cluster in families, consistent with the hypothesis that host genes influence lymphedema susceptibility. The recent recognition that filarial parasites harbor the endosymbiotic bacteria, Wolbachia, also raises questions about the potential contribution of the inflammatory response to Wolbachia antigens to lymphedema development. In this review, we discuss potential risk factors for lymphedema and try to integrate these in a model of pathogenesis.</abstract><subject lang="en"><genre>keywords</genre><topic>Lymphatic filariasis</topic><topic>Wuchereria bancrofti</topic><topic>lymphedema</topic></subject><relatedItem type="host"><titleInfo><title>Annals of the New York Academy of Sciences</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0077-8923</identifier><identifier type="eISSN">1749-6632</identifier><identifier type="DOI">10.1111/(ISSN)1749-6632</identifier><identifier type="PublisherID">NYAS</identifier><part><date>2002</date><detail type="title"><title>THE LYMPHATIC CONTINUUM: Lymphatic Biology and Disease</title></detail><detail type="volume"><caption>vol.</caption><number>979</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>131</start><end>142</end><total>12</total></extent></part></relatedItem><identifier type="istex">6A4EAA733479784BFC8C69A8DEA1176DA2DC19E0</identifier><identifier type="DOI">10.1111/j.1749-6632.2002.tb04874.x</identifier><identifier type="ArticleID">NYAS131</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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