Activation of SRC Tyrosine Kinases Within the Spectrum of Keratinocytic Neoplasia.
Identifieur interne : 000F82 ( Istex/Corpus ); précédent : 000F81; suivant : 000F83Activation of SRC Tyrosine Kinases Within the Spectrum of Keratinocytic Neoplasia.
Auteurs : Tamu T. Brown ; Rosalie Elenitsas ; John T. SeykoraSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
The Src‐family tyrosine kinases are modulators of growth‐regulatory signals within keratinocytes. The relationship between Src kinases and epidermal neoplasia is unexplored in human biopsies. Keratinocytes express 3 Src kinases: Src, Fyn, Yes. Activation of these kinases corresponds to tyrosine phosphorylation near the active site, tyrosine 416 of human Src. This study compared the levels of total Src‐kinase protein and activated Src kinases within a spectrum of lesions ranging from actinic keratoses (AKs) to squamous cell carcinoma (SCC). An antibody that recognizes an epitope in Src, Fyn, and Yes revealed the total level of Src kinase protein; an antibody specific for the phosphoryated active site tyrosine determined the level of Src kinase activation. The level of Src‐kinase expression and activated Src kinases was evaluated in paraffin imbedded sections of AKs, SCC in‐situ (SCIS), and SCC containing adjacent unremarkable epidermis. The total level of Src kinase protein in lesions was similar to unremarkable epidermis. The level of Src kinase activation was elevated within approximately one‐third of AKs and SCIS, but was increased in over 80% of SCCs. These results demonstrate Src kinases are activated in epidermal neoplasia, and that increased Src kinase activity is associated with the transition from SCIS to SCC.
Url:
DOI: 10.1111/j.0303-6987.2005.320ad.x
Links to Exploration step
ISTEX:22086F567F5E6667A7460B291FB717B4E2DE7258Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Activation of SRC Tyrosine Kinases Within the Spectrum of Keratinocytic Neoplasia.</title>
<author><name sortKey="Brown, Tamu T" sort="Brown, Tamu T" uniqKey="Brown T" first="Tamu T." last="Brown">Tamu T. Brown</name>
<affiliation><mods:affiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Elenitsas, Rosalie" sort="Elenitsas, Rosalie" uniqKey="Elenitsas R" first="Rosalie" last="Elenitsas">Rosalie Elenitsas</name>
<affiliation><mods:affiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Seykora, John T" sort="Seykora, John T" uniqKey="Seykora J" first="John T." last="Seykora">John T. Seykora</name>
<affiliation><mods:affiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</mods:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:22086F567F5E6667A7460B291FB717B4E2DE7258</idno>
<date when="2005" year="2005">2005</date>
<idno type="doi">10.1111/j.0303-6987.2005.320ad.x</idno>
<idno type="url">https://api.istex.fr/document/22086F567F5E6667A7460B291FB717B4E2DE7258/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000F82</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000F82</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Activation of SRC Tyrosine Kinases Within the Spectrum of Keratinocytic Neoplasia.</title>
<author><name sortKey="Brown, Tamu T" sort="Brown, Tamu T" uniqKey="Brown T" first="Tamu T." last="Brown">Tamu T. Brown</name>
<affiliation><mods:affiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Elenitsas, Rosalie" sort="Elenitsas, Rosalie" uniqKey="Elenitsas R" first="Rosalie" last="Elenitsas">Rosalie Elenitsas</name>
<affiliation><mods:affiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Seykora, John T" sort="Seykora, John T" uniqKey="Seykora J" first="John T." last="Seykora">John T. Seykora</name>
<affiliation><mods:affiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Journal of Cutaneous Pathology</title>
<title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title>
<idno type="ISSN">0303-6987</idno>
<idno type="eISSN">1600-0560</idno>
<imprint><biblScope unit="vol">32</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="78">78</biblScope>
<biblScope unit="page" to="78">78</biblScope>
<biblScope unit="page-count">1</biblScope>
<publisher>Blackwell Publishing Ltd/Inc.</publisher>
<pubPlace>Oxford, UK; Malden, USA</pubPlace>
<date type="published" when="2005-01">2005-01</date>
</imprint>
<idno type="ISSN">0303-6987</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0303-6987</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The Src‐family tyrosine kinases are modulators of growth‐regulatory signals within keratinocytes. The relationship between Src kinases and epidermal neoplasia is unexplored in human biopsies. Keratinocytes express 3 Src kinases: Src, Fyn, Yes. Activation of these kinases corresponds to tyrosine phosphorylation near the active site, tyrosine 416 of human Src. This study compared the levels of total Src‐kinase protein and activated Src kinases within a spectrum of lesions ranging from actinic keratoses (AKs) to squamous cell carcinoma (SCC). An antibody that recognizes an epitope in Src, Fyn, and Yes revealed the total level of Src kinase protein; an antibody specific for the phosphoryated active site tyrosine determined the level of Src kinase activation. The level of Src‐kinase expression and activated Src kinases was evaluated in paraffin imbedded sections of AKs, SCC in‐situ (SCIS), and SCC containing adjacent unremarkable epidermis. The total level of Src kinase protein in lesions was similar to unremarkable epidermis. The level of Src kinase activation was elevated within approximately one‐third of AKs and SCIS, but was increased in over 80% of SCCs. These results demonstrate Src kinases are activated in epidermal neoplasia, and that increased Src kinase activity is associated with the transition from SCIS to SCC.</div>
</front>
</TEI>
<istex><corpusName>wiley</corpusName>
<keywords><teeft><json:string>cutaneous</json:string>
<json:string>dermatology</json:string>
<json:string>melanoma</json:string>
<json:string>nevus</json:string>
<json:string>nodule</json:string>
<json:string>neoplasm</json:string>
<json:string>melanocytic</json:string>
<json:string>histologic</json:string>
<json:string>dermis</json:string>
<json:string>malignant</json:string>
<json:string>carcinoma</json:string>
<json:string>node</json:string>
<json:string>immunohistochemical</json:string>
<json:string>metastatic</json:string>
<json:string>dermal</json:string>
<json:string>epidermal</json:string>
<json:string>lesion</json:string>
<json:string>metastasis</json:string>
<json:string>biopsy</json:string>
<json:string>dermatopathology</json:string>
<json:string>eccrine</json:string>
<json:string>lymphocyte</json:string>
<json:string>papule</json:string>
<json:string>subcutaneous</json:string>
<json:string>cyst</json:string>
<json:string>histological</json:string>
<json:string>vasculitis</json:string>
<json:string>squamous</json:string>
<json:string>lymphoma</json:string>
<json:string>basal</json:string>
<json:string>histologically</json:string>
<json:string>sarcoma</json:string>
<json:string>granulomatous</json:string>
<json:string>granuloma</json:string>
<json:string>atypia</json:string>
<json:string>kinase</json:string>
<json:string>histopathologic</json:string>
<json:string>perivascular</json:string>
<json:string>atypical</json:string>
<json:string>differential diagnosis</json:string>
<json:string>dermatitis</json:string>
<json:string>epithelial</json:string>
<json:string>immunohistochemistry</json:string>
<json:string>erythematous</json:string>
<json:string>excision</json:string>
<json:string>benign</json:string>
<json:string>dysplastic</json:string>
<json:string>positivity</json:string>
<json:string>mitotic</json:string>
<json:string>sebaceous</json:string>
<json:string>erythema</json:string>
<json:string>receptor</json:string>
<json:string>keratoses</json:string>
<json:string>eosinophil</json:string>
<json:string>stroma</json:string>
<json:string>histiocyte</json:string>
<json:string>tumor cells</json:string>
<json:string>adnexal</json:string>
<json:string>squamous cell carcinoma</json:string>
<json:string>neoplastic</json:string>
<json:string>keratinocytes</json:string>
<json:string>mucin</json:string>
<json:string>mutation</json:string>
<json:string>spitz</json:string>
<json:string>mycosis</json:string>
<json:string>adenocarcinoma</json:string>
<json:string>fibrosing</json:string>
<json:string>epithelioid</json:string>
<json:string>fungoides</json:string>
<json:string>basal cell carcinoma</json:string>
<json:string>lichen</json:string>
<json:string>actin</json:string>
<json:string>lymphadenopathy</json:string>
<json:string>epithelium</json:string>
<json:string>cell lymphoma</json:string>
<json:string>malignant melanoma</json:string>
<json:string>skin biopsy</json:string>
<json:string>skin lesions</json:string>
<json:string>follicular</json:string>
<json:string>cutis</json:string>
<json:string>mycosis fungoides</json:string>
<json:string>neurofibroma</json:string>
<json:string>medical center</json:string>
<json:string>panniculitis</json:string>
<json:string>infiltrates</json:string>
<json:string>dermatomyositis</json:string>
<json:string>vimentin</json:string>
<json:string>invasive</json:string>
<json:string>basaloid</json:string>
<json:string>etiology</json:string>
<json:string>pleomorphic</json:string>
<json:string>cytokeratin</json:string>
<json:string>anaplastic</json:string>
<json:string>asymptomatic</json:string>
<json:string>braf</json:string>
<json:string>actinic</json:string>
<json:string>melanocyte</json:string>
<json:string>lupus</json:string>
<json:string>tumour</json:string>
<json:string>junctional</json:string>
<json:string>punch biopsy</json:string>
<json:string>melanin</json:string>
<json:string>follicle</json:string>
<json:string>myoepithelial</json:string>
<json:string>alopecia</json:string>
<json:string>melanocytic lesions</json:string>
<json:string>malignancy</json:string>
<json:string>inflammation</json:string>
<json:string>gvhd</json:string>
<json:string>subcutis</json:string>
<json:string>mucinous</json:string>
<json:string>neutrophil</json:string>
<json:string>histopathological</json:string>
<json:string>hypha</json:string>
<json:string>neutrophilic</json:string>
<json:string>lymphoid</json:string>
<json:string>chemotherapy</json:string>
<json:string>nephrogenic</json:string>
<json:string>cytologic</json:string>
<json:string>dermopathy</json:string>
<json:string>rearrangement</json:string>
<json:string>intraepidermal</json:string>
<json:string>immunoreactivity</json:string>
<json:string>nephrogenic fibrosing dermopathy</json:string>
<json:string>verrucous</json:string>
<json:string>case report</json:string>
<json:string>spitz nevi</json:string>
<json:string>pathway</json:string>
<json:string>apocrine</json:string>
<json:string>desmin</json:string>
<json:string>nucleolus</json:string>
<json:string>elastosis</json:string>
<json:string>mitoses</json:string>
<json:string>exam</json:string>
<json:string>syndrome</json:string>
<json:string>lymph</json:string>
<json:string>nodular</json:string>
<json:string>histopathology</json:string>
<json:string>hyperkeratosis</json:string>
<json:string>lower extremities</json:string>
<json:string>dysplastic nevi</json:string>
<json:string>granule</json:string>
<json:string>skin biopsies</json:string>
<json:string>desmoplastic</json:string>
<json:string>hemangioma</json:string>
<json:string>palisading</json:string>
<json:string>bullous</json:string>
<json:string>srcasm</json:string>
<json:string>physical examination</json:string>
<json:string>planus</json:string>
<json:string>multinucleated</json:string>
<json:string>erythematosus</json:string>
<json:string>inflammatory</json:string>
<json:string>epidermis</json:string>
<json:string>plaque</json:string>
<json:string>factor xiiia</json:string>
<json:string>saitama</json:string>
<json:string>cockerell</json:string>
<json:string>pathology1</json:string>
<json:string>clinical impression</json:string>
<json:string>myxoid</json:string>
<json:string>xiiia</json:string>
<json:string>hyperpigmentation</json:string>
<json:string>lymphoproliferative</json:string>
<json:string>cystic</json:string>
<json:string>spindle cells</json:string>
<json:string>histology</json:string>
<json:string>necrotizing</json:string>
<json:string>zygomycosis</json:string>
<json:string>neurofibromatosis</json:string>
<json:string>atab</json:string>
<json:string>monoclonal</json:string>
<json:string>histologic findings</json:string>
<json:string>primary melanomas</json:string>
<json:string>lymphatic</json:string>
<json:string>lesional</json:string>
<json:string>folliculitis</json:string>
<json:string>clinical presentation</json:string>
<json:string>hidradenoma</json:string>
<json:string>subungal</json:string>
<json:string>keratosis</json:string>
<json:string>androgen</json:string>
<json:string>fibroma</json:string>
<json:string>cytoplasmic</json:string>
<json:string>year history</json:string>
<json:string>immune</json:string>
<json:string>sptcl</json:string>
<json:string>hamartoma</json:string>
<json:string>voriconazole</json:string>
<json:string>intradermal</json:string>
<json:string>herpes</json:string>
<json:string>eruption</json:string>
<json:string>hyperplasia</json:string>
<json:string>chromogranin</json:string>
<json:string>perifollicular</json:string>
<json:string>cytologic atypia</json:string>
<json:string>neuroendocrine</json:string>
<json:string>seborrheic</json:string>
<json:string>merkel</json:string>
<json:string>ulceration</json:string>
<json:string>histiocytic</json:string>
<json:string>eosinophilia</json:string>
<json:string>dermatosis</json:string>
<json:string>laboratory medicine</json:string>
<json:string>subset</json:string>
<json:string>intravascular</json:string>
<json:string>neoplastic cells</json:string>
<json:string>larva</json:string>
<json:string>plasmacytoid</json:string>
<json:string>cell carcinoma</json:string>
<json:string>primary cutaneous</json:string>
<json:string>reticular</json:string>
<json:string>parakeratosis</json:string>
<json:string>immunocompromised</json:string>
<json:string>fibromatosis</json:string>
<json:string>junb</json:string>
<json:string>dendritic</json:string>
<json:string>dfsp</json:string>
<json:string>plasma cells</json:string>
<json:string>phat</json:string>
<json:string>vellus</json:string>
<json:string>cytometry</json:string>
<json:string>keratin</json:string>
<json:string>shimizu</json:string>
<json:string>mediastinal</json:string>
<json:string>lipedematous</json:string>
<json:string>lymph nodes</json:string>
<json:string>common melanocytic nevi</json:string>
<json:string>calponin</json:string>
<json:string>mitotic activity</json:string>
<json:string>leukaemia</json:string>
<json:string>melanocytic nevi</json:string>
<json:string>scleromyxedema</json:string>
<json:string>keratinocyte</json:string>
<json:string>durham</json:string>
<json:string>eosinophilic</json:string>
<json:string>recurrence</json:string>
<json:string>lipomembranous</json:string>
<json:string>actinic keratoses</json:string>
<json:string>reactive</json:string>
<json:string>trichoepithelioma</json:string>
<json:string>mesenchymal</json:string>
<json:string>compound nevi</json:string>
<json:string>leukemia cutis</json:string>
<json:string>lichenoid</json:string>
<json:string>chordoma</json:string>
<json:string>immunoperoxidase</json:string>
<json:string>hematologic</json:string>
<json:string>dermatopathologists</json:string>
<json:string>vacuolar</json:string>
<json:string>dyskeratosis</json:string>
<json:string>hybridization</json:string>
<json:string>cyclin</json:string>
<json:string>leiomyosarcoma</json:string>
<json:string>apoptosis</json:string>
<json:string>clinical history</json:string>
<json:string>chondroid</json:string>
<json:string>immunohistochemical staining</json:string>
<json:string>histopathologic findings</json:string>
<json:string>positive staining</json:string>
<json:string>extramammary</json:string>
<json:string>immunohistochemical stains</json:string>
<json:string>histologic features</json:string>
<json:string>clinicopathological</json:string>
<json:string>herpetic</json:string>
<json:string>annulare</json:string>
<json:string>metaplasia</json:string>
<json:string>violaceous</json:string>
<json:string>nuclear staining</json:string>
<json:string>immunohistochemically</json:string>
<json:string>glomus</json:string>
<json:string>histiocytoma</json:string>
<json:string>pleomorphism</json:string>
<json:string>breast carcinoma</json:string>
<json:string>langerhans</json:string>
<json:string>special stains</json:string>
<json:string>clark level</json:string>
<json:string>meningothelial</json:string>
<json:string>metastatic melanoma</json:string>
<json:string>globule</json:string>
<json:string>macule</json:string>
<json:string>myofibroblastic</json:string>
<json:string>pruritic</json:string>
<json:string>polyclonal</json:string>
<json:string>smooth muscle actin</json:string>
<json:string>overlying</json:string>
<json:string>congenital</json:string>
<json:string>fungal</json:string>
<json:string>tumor</json:string>
<json:string>proliferation</json:string>
<json:string>residual</json:string>
<json:string>rash</json:string>
<json:string>lichen planus</json:string>
<json:string>tumor thickness</json:string>
<json:string>actinic keratosis</json:string>
<json:string>electron microscopy</json:string>
<json:string>merkel cell carcinoma</json:string>
<json:string>paget cells</json:string>
<json:string>prominent nucleoli</json:string>
<json:string>erythema vasculitis</json:string>
<json:string>physical exam</json:string>
<json:string>shadow cells</json:string>
<json:string>epithelioid cells</json:string>
<json:string>family history</json:string>
<json:string>desmoplastic melanoma</json:string>
<json:string>duke university</json:string>
<json:string>androgen receptor expression</json:string>
<json:string>benign neoplasm</json:string>
<json:string>unusual case</json:string>
<json:string>atypical lymphocytes</json:string>
<json:string>histological features</json:string>
<json:string>stain</json:string>
<json:string>diagnosis</json:string>
<json:string>eyelid</json:string>
<json:string>trauma</json:string>
<json:string>papillary</json:string>
<json:string>histologic examination</json:string>
<json:string>mayo clinic</json:string>
<json:string>dermal mucin</json:string>
<json:string>epidermal effacement</json:string>
<json:string>basal cell carcinomas</json:string>
<json:string>seborrheic keratoses</json:string>
<json:string>medical sciences</json:string>
<json:string>histological examination</json:string>
<json:string>epidermal nevus</json:string>
<json:string>deep dermis</json:string>
<json:string>intravascular lymphoma</json:string>
<json:string>indiana university school</json:string>
<json:string>medical history</json:string>
<json:string>focal areas</json:string>
<json:string>eccrine poroma</json:string>
<json:string>flow cytometry</json:string>
<json:string>topical steroids</json:string>
<json:string>clinical appearance</json:string>
<json:string>sebaceous carcinoma</json:string>
<json:string>elderly patients</json:string>
<json:string>cockerell department</json:string>
<json:string>tissue cultures</json:string>
<json:string>bone marrow</json:string>
<json:string>extramammary disease</json:string>
<json:string>tumor lymphangiogenesis</json:string>
<json:string>elastic fibers</json:string>
<json:string>cutaneous disease</json:string>
<json:string>endothelial cells</json:string>
<json:string>blue nevi</json:string>
<json:string>metastatic melanomas</json:string>
<json:string>systemic involvement</json:string>
<json:string>incontinentia pigmenti</json:string>
<json:string>lipedematous alopecia</json:string>
<json:string>squamous islands</json:string>
<json:string>correct diagnosis</json:string>
<json:string>clinical diagnosis</json:string>
<json:string>vesicular nuclei</json:string>
<json:string>marker</json:string>
<json:string>extremity</json:string>
<json:string>ulcerated</json:string>
<json:string>endothelial</json:string>
<json:string>surgical</json:string>
<json:string>necrosis</json:string>
<json:string>interstitial</json:string>
<json:string>steroid</json:string>
<json:string>stanford</json:string>
<json:string>paget</json:string>
<json:string>matrix</json:string>
<json:string>mayo</json:string>
<json:string>variant</json:string>
<json:string>immunohistochemical analysis</json:string>
<json:string>cutaneous lesions</json:string>
<json:string>chronic gvhd</json:string>
<json:string>first case</json:string>
<json:string>biopsy specimens</json:string>
<json:string>epithelial membrane antigen</json:string>
<json:string>immunohistochemical study</json:string>
<json:string>multinucleated giant cells</json:string>
<json:string>stanford university</json:string>
<json:string>cutaneous sparganosis</json:string>
<json:string>lymph node</json:string>
<json:string>chapel hill</json:string>
<json:string>reticular dermis</json:string>
<json:string>local recurrence</json:string>
<json:string>melanocytic neoplasms</json:string>
<json:string>similar lesions</json:string>
<json:string>precocious puberty</json:string>
<json:string>lichen sclerosus</json:string>
<json:string>columbia university college</json:string>
<json:string>polymerase chain reaction</json:string>
<json:string>braf mutations</json:string>
<json:string>monoclonal antibody</json:string>
<json:string>lobular panniculitis</json:string>
<json:string>hair follicles</json:string>
<json:string>large cell transformation</json:string>
<json:string>glomus coccygeum</json:string>
<json:string>mast cell disorders</json:string>
<json:string>boston university</json:string>
<json:string>hair matrix differentiation</json:string>
<json:string>cleveland clinic foundation</json:string>
<json:string>invasive melanoma</json:string>
<json:string>pustular drug eruption</json:string>
<json:string>rheumatoid arthritis</json:string>
<json:string>medical university</json:string>
<json:string>normal skin</json:string>
<json:string>ohio state university</json:string>
<json:string>cutaneous manifestations</json:string>
<json:string>clinical features</json:string>
<json:string>intradermal nevi</json:string>
<json:string>constitutional symptoms</json:string>
<json:string>lymph node metastasis</json:string>
<json:string>medical college</json:string>
<json:string>histologic sections</json:string>
<json:string>discoid lupus erythematosus</json:string>
<json:string>subcutaneous tissue</json:string>
<json:string>lupus erythematosus</json:string>
<json:string>genetic identity analysis</json:string>
<json:string>oklahoma health sciences center</json:string>
<json:string>eosinophilic cytoplasm</json:string>
<json:string>granuloma annulare</json:string>
<json:string>cutaneous leiomyosarcoma</json:string>
<json:string>diagnostic challenge</json:string>
<json:string>histologic criteria</json:string>
<json:string>drug eruption</json:string>
<json:string>multicentric reticulohistiocytosis</json:string>
<json:string>weight loss</json:string>
<json:string>billings departments</json:string>
<json:string>shimizu departments</json:string>
<json:string>overlying epidermis</json:string>
<json:string>previous studies</json:string>
<json:string>clear cell hidradenoma</json:string>
<json:string>cutaneous larva migrans</json:string>
<json:string>histological findings</json:string>
<json:string>recurrent nevi</json:string>
<json:string>sentinel lymph nodes</json:string>
<json:string>atypical neurofibroma</json:string>
<json:string>papillary dermis</json:string>
<json:string>matrical differentiation</json:string>
<json:string>quest diagnostics</json:string>
<json:string>male patient</json:string>
<json:string>control group</json:string>
<json:string>metastatic disease</json:string>
<json:string>cocaine</json:string>
<json:string>vesicular</json:string>
<json:string>pathogenesis</json:string>
<json:string>simplex</json:string>
<json:string>disorder</json:string>
<json:string>systemic</json:string>
<json:string>cell</json:string>
<json:string>progression</json:string>
<json:string>collagen</json:string>
<json:string>transplant</json:string>
<json:string>nra</json:string>
<json:string>unremarkable</json:string>
<json:string>dysplasia</json:string>
<json:string>caucasian</json:string>
<json:string>circumscribed</json:string>
<json:string>renal</json:string>
<json:string>necrotic</json:string>
<json:string>differentiation</json:string>
<json:string>cytoplasm</json:string>
<json:string>leukemia</json:string>
<json:string>sentinel</json:string>
<json:string>little rock</json:string>
<json:string>basement membrane</json:string>
<json:string>nodular vasculitis</json:string>
<json:string>peripheral lymphoma</json:string>
<json:string>interface dermatitis</json:string>
<json:string>leukocytoclastic vasculitis</json:string>
<json:string>skeletal muscle</json:string>
<json:string>subcutaneous nodule</json:string>
<json:string>complete digeorge syndrome</json:string>
<json:string>extensive involvement</json:string>
<json:string>surgical excision</json:string>
<json:string>hematologic malignancies</json:string>
<json:string>african american woman</json:string>
<json:string>tattoo pigment</json:string>
<json:string>histopathologic diagnosis</json:string>
<json:string>pacinian corpuscles</json:string>
<json:string>progressive mucinous histiocytosis</json:string>
<json:string>texas health science center</json:string>
<json:string>transplant patient</json:string>
<json:string>rare tumor</json:string>
<json:string>intraepidermal variant</json:string>
<json:string>lower legs</json:string>
<json:string>eccrine poromas</json:string>
<json:string>elastosis perforans serpiginosa</json:string>
<json:string>several years</json:string>
<json:string>melanin pigment uptake</json:string>
<json:string>eosinophilic panniculitis</json:string>
<json:string>primary mucinous adenocarcinoma</json:string>
<json:string>ileostomy site</json:string>
<json:string>factor viii</json:string>
<json:string>herpetic folliculitis</json:string>
<json:string>pagets disease</json:string>
<json:string>case reports</json:string>
<json:string>adnexal structures</json:string>
<json:string>follicular mucinosis</json:string>
<json:string>multiple lesions</json:string>
<json:string>skin biopsy specimen</json:string>
<json:string>collagen bundles</json:string>
<json:string>entire dermis</json:string>
<json:string>spitzoid melanomas</json:string>
<json:string>granulomatous inflammation</json:string>
<json:string>spitz nevus</json:string>
<json:string>clinical course</json:string>
<json:string>follicular eruption</json:string>
<json:string>significant difference</json:string>
<json:string>syringocystadenocarcinoma papilliferum</json:string>
<json:string>melanoma progression</json:string>
<json:string>university hospital</json:string>
<json:string>dermatofibrosarcoma protuberans</json:string>
<json:string>sentinel lymph node biopsy</json:string>
<json:string>borderline melanocytic proliferations</json:string>
<json:string>radiation therapy</json:string>
<json:string>diagnostic criteria</json:string>
<json:string>myoepithelial cells</json:string>
<json:string>metcalf department</json:string>
<json:string>louisiana state university health sciences center</json:string>
<json:string>blood cultures</json:string>
<json:string>infectious etiology</json:string>
<json:string>joseph mercy hospital</json:string>
<json:string>acute gvhd</json:string>
<json:string>wayne state university</json:string>
<json:string>rare entity</json:string>
<json:string>nonablative hsct</json:string>
<json:string>clinical practice</json:string>
<json:string>histopathologic examination</json:string>
<json:string>dermoid cyst</json:string>
<json:string>dermal edema</json:string>
<json:string>vellus hairs</json:string>
<json:string>cladophialophora bantiana</json:string>
<json:string>crowson departments</json:string>
<json:string>dermatology university</json:string>
<json:string>tissue eosinophilia</json:string>
<json:string>medical laboratories</json:string>
<json:string>dermal tumor</json:string>
<json:string>baylor college</json:string>
<json:string>anderson cancer center</json:string>
<json:string>histological patterns</json:string>
<json:string>rare mitotic figures</json:string>
<json:string>lichen simplex chronicus</json:string>
<json:string>upper dermis</json:string>
<json:string>immunohistochemical profile</json:string>
<json:string>benign trichoblastic neoplasms</json:string>
<json:string>cutaneous melanoma</json:string>
<json:string>lesional cells</json:string>
<json:string>results show</json:string>
<json:string>granular layer</json:string>
<json:string>mammary disease</json:string>
<json:string>primary cutaneous melanoma</json:string>
<json:string>skin tumors</json:string>
<json:string>basaloid neoplasm</json:string>
<json:string>keratinocyte differentiation</json:string>
<json:string>ductal differentiation</json:string>
<json:string>malignant lesions</json:string>
<json:string>nodular hidradenoma</json:string>
<json:string>lymphoid cells</json:string>
<json:string>pediatric population</json:string>
<json:string>initial biopsies</json:string>
<json:string>binder department</json:string>
<json:string>male infant</json:string>
<json:string>rare case</json:string>
<json:string>nerve sheath tumor</json:string>
<json:string>negative staining</json:string>
<json:string>interstitial granulomatous dermatitis</json:string>
<json:string>first report</json:string>
<json:string>wide excision</json:string>
<json:string>blood vessels</json:string>
<json:string>mast cells</json:string>
<json:string>definitive diagnosis</json:string>
<json:string>high index</json:string>
<json:string>month history</json:string>
<json:string>poor prognosis</json:string>
<json:string>systemic symptoms</json:string>
<json:string>such lesions</json:string>
<json:string>subcutaneous lymphoma</json:string>
<json:string>systemic plasmacytosis</json:string>
<json:string>peripheral blood</json:string>
<json:string>internal medicine</json:string>
<json:string>cutaneous lymphoma</json:string>
<json:string>complete resolution</json:string>
<json:string>mayo foundation</json:string>
<json:string>atypical fibroxanthoma</json:string>
<json:string>cellular atypia</json:string>
<json:string>primary cutaneous anaplastic</json:string>
<json:string>malignant lymphoma</json:string>
<json:string>osteoid metaplasia</json:string>
<json:string>literature review</json:string>
<json:string>nail unit</json:string>
<json:string>follicular differentiation</json:string>
<json:string>lymphatic endothelium</json:string>
<json:string>muscle weakness</json:string>
<json:string>barrett department</json:string>
<json:string>johns hopkins</json:string>
<json:string>ring finger</json:string>
<json:string>meningothelial elements</json:string>
<json:string>thrombogenic vasculopathy</json:string>
<json:string>dermoid cysts</json:string>
<json:string>growth pattern</json:string>
<json:string>incisional biopsy</json:string>
<json:string>granulomatous lymphangiitis</json:string>
<json:string>giant cells</json:string>
<json:string>karyorrhectic debris</json:string>
<json:string>further studies</json:string>
<json:string>rosalie elenitsas</json:string>
<json:string>cutaneous manifestation</json:string>
<json:string>sacral area</json:string>
<json:string>basaloid cells</json:string>
<json:string>erythema nodosum</json:string>
<json:string>klinefelter syndrome</json:string>
<json:string>peripheral palisading</json:string>
<json:string>mucin deposition</json:string>
<json:string>cutaneous mast cell disorders</json:string>
<json:string>chordoma cutis</json:string>
<json:string>rete ridges</json:string>
<json:string>recent studies</json:string>
<json:string>magro1 department</json:string>
<json:string>internal medicine2</json:string>
<json:string>fibrosing vasculitis</json:string>
<json:string>prognosis</json:string>
<json:string>clinic</json:string>
<json:string>diffuse</json:string>
<json:string>scalp</json:string>
<json:string>interface</json:string>
<json:string>cellular</json:string>
<json:string>edema</json:string>
<json:string>infection</json:string>
<json:string>deposition</json:string>
<json:string>recurrent</json:string>
<json:string>skin</json:string>
</teeft>
</keywords>
<author><json:item><name>Tamu T. Brown</name>
<affiliations><json:string>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</json:string>
</affiliations>
</json:item>
<json:item><name>Rosalie Elenitsas</name>
<affiliations><json:string>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</json:string>
</affiliations>
</json:item>
<json:item><name>John T. Seykora</name>
<affiliations><json:string>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</json:string>
</affiliations>
</json:item>
</author>
<articleId><json:string>CUP320AD</json:string>
</articleId>
<language><json:string>eng</json:string>
</language>
<originalGenre><json:string>abstract</json:string>
</originalGenre>
<abstract>The Src‐family tyrosine kinases are modulators of growth‐regulatory signals within keratinocytes. The relationship between Src kinases and epidermal neoplasia is unexplored in human biopsies. Keratinocytes express 3 Src kinases: Src, Fyn, Yes. Activation of these kinases corresponds to tyrosine phosphorylation near the active site, tyrosine 416 of human Src. This study compared the levels of total Src‐kinase protein and activated Src kinases within a spectrum of lesions ranging from actinic keratoses (AKs) to squamous cell carcinoma (SCC). An antibody that recognizes an epitope in Src, Fyn, and Yes revealed the total level of Src kinase protein; an antibody specific for the phosphoryated active site tyrosine determined the level of Src kinase activation. The level of Src‐kinase expression and activated Src kinases was evaluated in paraffin imbedded sections of AKs, SCC in‐situ (SCIS), and SCC containing adjacent unremarkable epidermis. The total level of Src kinase protein in lesions was similar to unremarkable epidermis. The level of Src kinase activation was elevated within approximately one‐third of AKs and SCIS, but was increased in over 80% of SCCs. These results demonstrate Src kinases are activated in epidermal neoplasia, and that increased Src kinase activity is associated with the transition from SCIS to SCC.</abstract>
<qualityIndicators><score>7.4</score>
<pdfVersion>1.3</pdfVersion>
<pdfPageSize>595 x 782 pts</pdfPageSize>
<refBibsNative>false</refBibsNative>
<abstractCharCount>1340</abstractCharCount>
<pdfWordCount>46669</pdfWordCount>
<pdfCharCount>312307</pdfCharCount>
<pdfPageCount>53</pdfPageCount>
<abstractWordCount>200</abstractWordCount>
</qualityIndicators>
<title>Activation of SRC Tyrosine Kinases Within the Spectrum of Keratinocytic Neoplasia.</title>
<genre><json:string>abstract</json:string>
</genre>
<host><title>Journal of Cutaneous Pathology</title>
<language><json:string>unknown</json:string>
</language>
<doi><json:string>10.1111/(ISSN)1600-0560</json:string>
</doi>
<issn><json:string>0303-6987</json:string>
</issn>
<eissn><json:string>1600-0560</json:string>
</eissn>
<publisherId><json:string>CUP</json:string>
</publisherId>
<volume>32</volume>
<issue>1</issue>
<pages><first>78</first>
<last>78</last>
<total>1</total>
</pages>
<genre><json:string>journal</json:string>
</genre>
</host>
<categories><wos><json:string>science</json:string>
<json:string>pathology</json:string>
<json:string>dermatology</json:string>
</wos>
<scienceMetrix><json:string>health sciences</json:string>
<json:string>clinical medicine</json:string>
<json:string>dermatology & venereal diseases</json:string>
</scienceMetrix>
<inist><json:string>sciences appliquees, technologies et medecines</json:string>
<json:string>sciences biologiques et medicales</json:string>
<json:string>sciences medicales</json:string>
<json:string>dermatologie</json:string>
</inist>
</categories>
<publicationDate>2005</publicationDate>
<copyrightDate>2005</copyrightDate>
<doi><json:string>10.1111/j.0303-6987.2005.320ad.x</json:string>
</doi>
<id>22086F567F5E6667A7460B291FB717B4E2DE7258</id>
<score>1</score>
<fulltext><json:item><extension>pdf</extension>
<original>true</original>
<mimetype>application/pdf</mimetype>
<uri>https://api.istex.fr/document/22086F567F5E6667A7460B291FB717B4E2DE7258/fulltext/pdf</uri>
</json:item>
<json:item><extension>zip</extension>
<original>false</original>
<mimetype>application/zip</mimetype>
<uri>https://api.istex.fr/document/22086F567F5E6667A7460B291FB717B4E2DE7258/fulltext/zip</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/document/22086F567F5E6667A7460B291FB717B4E2DE7258/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Activation of SRC Tyrosine Kinases Within the Spectrum of Keratinocytic Neoplasia.</title>
</titleStmt>
<publicationStmt><publisher>Blackwell Publishing Ltd/Inc.</publisher>
<pubPlace>Oxford, UK; Malden, USA</pubPlace>
<date type="published" when="2005-01"></date>
</publicationStmt>
<notesStmt><note type="content-type" subtype="abstract" source="abstract" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-HPN7T1Q2-R">abstract</note>
<note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note>
</notesStmt>
<sourceDesc><biblStruct type="abstract"><analytic><title level="a" type="main">Activation of SRC Tyrosine Kinases Within the Spectrum of Keratinocytic Neoplasia.</title>
<title level="a" type="short">Abstracts</title>
<author xml:id="author-0000"><persName><forename type="first">Tamu T.</forename>
<surname>Brown</surname>
</persName>
<affiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA<address><country key="US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0001"><persName><forename type="first">Rosalie</forename>
<surname>Elenitsas</surname>
</persName>
<affiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA<address><country key="US"></country>
</address>
</affiliation>
</author>
<author xml:id="author-0002"><persName><forename type="first">John T.</forename>
<surname>Seykora</surname>
</persName>
<affiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA<address><country key="US"></country>
</address>
</affiliation>
</author>
<idno type="istex">22086F567F5E6667A7460B291FB717B4E2DE7258</idno>
<idno type="DOI">10.1111/j.0303-6987.2005.320ad.x</idno>
<idno type="unit">CUP320AD</idno>
<idno type="toTypesetVersion">file:CUP.CUP320ad.pdf</idno>
</analytic>
<monogr><title level="j" type="main">Journal of Cutaneous Pathology</title>
<title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title>
<idno type="pISSN">0303-6987</idno>
<idno type="eISSN">1600-0560</idno>
<idno type="book-DOI">10.1111/(ISSN)1600-0560</idno>
<idno type="book-part-DOI">10.1111/cup.2005.32.issue-1</idno>
<idno type="product">CUP</idno>
<idno type="publisherDivision">ST</idno>
<imprint><biblScope unit="vol">32</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="78">78</biblScope>
<biblScope unit="page" to="78">78</biblScope>
<biblScope unit="page-count">1</biblScope>
<publisher>Blackwell Publishing Ltd/Inc.</publisher>
<pubPlace>Oxford, UK; Malden, USA</pubPlace>
<date type="published" when="2005-01"></date>
</imprint>
</monogr>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><abstract xml:lang="en" style="main"><p>The Src‐family tyrosine kinases are modulators of growth‐regulatory signals within keratinocytes. The relationship between Src kinases and epidermal neoplasia is unexplored in human biopsies. Keratinocytes express 3 Src kinases: Src, Fyn, Yes. Activation of these kinases corresponds to tyrosine phosphorylation near the active site, tyrosine 416 of human Src. This study compared the levels of total Src‐kinase protein and activated Src kinases within a spectrum of lesions ranging from actinic keratoses (AKs) to squamous cell carcinoma (SCC). An antibody that recognizes an epitope in Src, Fyn, and Yes revealed the total level of Src kinase protein; an antibody specific for the phosphoryated active site tyrosine determined the level of Src kinase activation. The level of Src‐kinase expression and activated Src kinases was evaluated in paraffin imbedded sections of AKs, SCC in‐situ (SCIS), and SCC containing adjacent unremarkable epidermis. The total level of Src kinase protein in lesions was similar to unremarkable epidermis. The level of Src kinase activation was elevated within approximately one‐third of AKs and SCIS, but was increased in over 80% of SCCs. These results demonstrate Src kinases are activated in epidermal neoplasia, and that increased Src kinase activity is associated with the transition from SCIS to SCC.</p>
</abstract>
<textClass><classCode scheme="tocHeading1">ASOD 41st meeting Abstracts</classCode>
</textClass>
<langUsage><language ident="EN"></language>
</langUsage>
</profileDesc>
</teiHeader>
</istex:fulltextTEI>
<json:item><extension>txt</extension>
<original>false</original>
<mimetype>text/plain</mimetype>
<uri>https://api.istex.fr/document/22086F567F5E6667A7460B291FB717B4E2DE7258/fulltext/txt</uri>
</json:item>
</fulltext>
<metadata><istex:metadataXml wicri:clean="Wiley component found"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration>
<istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd/Inc.</publisherName>
<publisherLoc>Oxford, UK; Malden, USA</publisherLoc>
</publisherInfo>
<doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0560</doi>
<issn type="print">0303-6987</issn>
<issn type="electronic">1600-0560</issn>
<idGroup><id type="product" value="CUP"></id>
<id type="publisherDivision" value="ST"></id>
</idGroup>
<titleGroup><title type="main" sort="JOURNAL OF CUTANEOUS PATHOLOGY">Journal of Cutaneous Pathology</title>
</titleGroup>
</publicationMeta>
<publicationMeta level="part" position="01001"><doi origin="wiley">10.1111/cup.2005.32.issue-1</doi>
<numberingGroup><numbering type="journalVolume" number="32">32</numbering>
<numbering type="journalIssue" number="1">1</numbering>
</numberingGroup>
<coverDate startDate="2005-01">January 2005</coverDate>
</publicationMeta>
<publicationMeta level="unit" type="abstract" position="0007800" status="forIssue"><doi origin="wiley">10.1111/j.0303-6987.2005.320ad.x</doi>
<idGroup><id type="unit" value="CUP320AD"></id>
</idGroup>
<countGroup><count type="pageTotal" number="1"></count>
</countGroup>
<titleGroup><title type="tocHeading1">ASOD 41st meeting Abstracts</title>
</titleGroup>
<eventGroup><event type="firstOnline" date="2008-06-28"></event>
<event type="publishedOnlineFinalForm" date="2008-06-28"></event>
<event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.15 mode:FullText source:Header result:Header" date="2010-07-19"></event>
<event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-16"></event>
<event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event>
</eventGroup>
<numberingGroup><numbering type="pageFirst" number="78">78</numbering>
<numbering type="pageLast" number="78">78</numbering>
</numberingGroup>
<linkGroup><link type="toTypesetVersion" href="file:CUP.CUP320ad.pdf"></link>
</linkGroup>
</publicationMeta>
<contentMeta><countGroup><count type="figureTotal" number="0"></count>
<count type="tableTotal" number="0"></count>
<count type="formulaTotal" number="0"></count>
<count type="referenceTotal" number="0"></count>
<count type="wordTotal" number="0"></count>
<count type="linksPubMed" number="0"></count>
<count type="linksCrossRef" number="0"></count>
</countGroup>
<titleGroup><title type="main">Activation of SRC Tyrosine Kinases Within the Spectrum of Keratinocytic Neoplasia.</title>
<title type="shortAuthors"><b>Abstracts</b>
</title>
<title type="short"><b>Abstracts</b>
</title>
</titleGroup>
<creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Tamu T.</givenNames>
<familyName>Brown</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Rosalie</givenNames>
<familyName>Elenitsas</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>John T.</givenNames>
<familyName>Seykora</familyName>
</personName>
</creator>
</creators>
<affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</unparsedAffiliation>
</affiliation>
</affiliationGroup>
<abstractGroup><abstract type="main" xml:lang="en"><p>The Src‐family tyrosine kinases are modulators of growth‐regulatory signals within keratinocytes. The relationship between Src kinases and epidermal neoplasia is unexplored in human biopsies. Keratinocytes express 3 Src kinases: Src, Fyn, Yes. Activation of these kinases corresponds to tyrosine phosphorylation near the active site, tyrosine 416 of human Src. This study compared the levels of total Src‐kinase protein and activated Src kinases within a spectrum of lesions ranging from actinic keratoses (AKs) to squamous cell carcinoma (SCC). An antibody that recognizes an epitope in Src, Fyn, and Yes revealed the total level of Src kinase protein; an antibody specific for the phosphoryated active site tyrosine determined the level of Src kinase activation. The level of Src‐kinase expression and activated Src kinases was evaluated in paraffin imbedded sections of AKs, SCC in‐situ (SCIS), and SCC containing adjacent unremarkable epidermis. The total level of Src kinase protein in lesions was similar to unremarkable epidermis. The level of Src kinase activation was elevated within approximately one‐third of AKs and SCIS, but was increased in over 80% of SCCs. These results demonstrate Src kinases are activated in epidermal neoplasia, and that increased Src kinase activity is associated with the transition from SCIS to SCC.</p>
</abstract>
</abstractGroup>
</contentMeta>
</header>
</component>
</istex:document>
</istex:metadataXml>
<mods version="3.6"><titleInfo lang="en"><title>Activation of SRC Tyrosine Kinases Within the Spectrum of Keratinocytic Neoplasia.</title>
</titleInfo>
<titleInfo type="abbreviated" lang="en"><title>Abstracts</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Activation of SRC Tyrosine Kinases Within the Spectrum of Keratinocytic Neoplasia.</title>
</titleInfo>
<name type="personal"><namePart type="given">Tamu T.</namePart>
<namePart type="family">Brown</namePart>
<affiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Rosalie</namePart>
<namePart type="family">Elenitsas</namePart>
<affiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">John T.</namePart>
<namePart type="family">Seykora</namePart>
<affiliation>University of Pennsylvania Medical School, Department of Dermatology, Philadelphia, PA</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="abstract" displayLabel="abstract"></genre>
<originInfo><publisher>Blackwell Publishing Ltd/Inc.</publisher>
<place><placeTerm type="text">Oxford, UK; Malden, USA</placeTerm>
</place>
<dateIssued encoding="w3cdtf">2005-01</dateIssued>
<copyrightDate encoding="w3cdtf">2005</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<physicalDescription><internetMediaType>text/html</internetMediaType>
</physicalDescription>
<abstract lang="en">The Src‐family tyrosine kinases are modulators of growth‐regulatory signals within keratinocytes. The relationship between Src kinases and epidermal neoplasia is unexplored in human biopsies. Keratinocytes express 3 Src kinases: Src, Fyn, Yes. Activation of these kinases corresponds to tyrosine phosphorylation near the active site, tyrosine 416 of human Src. This study compared the levels of total Src‐kinase protein and activated Src kinases within a spectrum of lesions ranging from actinic keratoses (AKs) to squamous cell carcinoma (SCC). An antibody that recognizes an epitope in Src, Fyn, and Yes revealed the total level of Src kinase protein; an antibody specific for the phosphoryated active site tyrosine determined the level of Src kinase activation. The level of Src‐kinase expression and activated Src kinases was evaluated in paraffin imbedded sections of AKs, SCC in‐situ (SCIS), and SCC containing adjacent unremarkable epidermis. The total level of Src kinase protein in lesions was similar to unremarkable epidermis. The level of Src kinase activation was elevated within approximately one‐third of AKs and SCIS, but was increased in over 80% of SCCs. These results demonstrate Src kinases are activated in epidermal neoplasia, and that increased Src kinase activity is associated with the transition from SCIS to SCC.</abstract>
<relatedItem type="host"><titleInfo><title>Journal of Cutaneous Pathology</title>
</titleInfo>
<genre type="journal">journal</genre>
<identifier type="ISSN">0303-6987</identifier>
<identifier type="eISSN">1600-0560</identifier>
<identifier type="DOI">10.1111/(ISSN)1600-0560</identifier>
<identifier type="PublisherID">CUP</identifier>
<part><date>2005</date>
<detail type="volume"><caption>vol.</caption>
<number>32</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>1</number>
</detail>
<extent unit="pages"><start>78</start>
<end>78</end>
<total>1</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">22086F567F5E6667A7460B291FB717B4E2DE7258</identifier>
<identifier type="DOI">10.1111/j.0303-6987.2005.320ad.x</identifier>
<identifier type="ArticleID">CUP320AD</identifier>
<recordInfo><recordContentSource>WILEY</recordContentSource>
<recordOrigin>Blackwell Publishing Ltd/Inc.</recordOrigin>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F82 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000F82 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Istex |étape= Corpus |type= RBID |clé= ISTEX:22086F567F5E6667A7460B291FB717B4E2DE7258 |texte= Activation of SRC Tyrosine Kinases Within the Spectrum of Keratinocytic Neoplasia. }}
![]() | This area was generated with Dilib version V0.6.31. | ![]() |