Serveur d'exploration autour de Joseph Jankovic

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Symptomatic efficacy of rasagiline monotherapy in early Parkinson's disease: post-hoc analyses from the ADAGIO trial.

Identifieur interne : 000024 ( PubMed/Checkpoint ); précédent : 000023; suivant : 000025

Symptomatic efficacy of rasagiline monotherapy in early Parkinson's disease: post-hoc analyses from the ADAGIO trial.

Auteurs : Joseph Jankovic [États-Unis] ; Elijahu Berkovich [Israël] ; Eli Eyal [Israël] ; Eduardo Tolosa [Espagne]

Source :

RBID : pubmed:24637126

English descriptors

Abstract

The ADAGIO study included a large cohort of patients with early PD (baseline total-UPDRS = 20) who were initially randomized to rasagiline and placebo, thereby allowing analyses of symptomatic efficacy.

DOI: 10.1016/j.parkreldis.2014.02.024
PubMed: 24637126


Affiliations:


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pubmed:24637126

Le document en format XML

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<title xml:lang="en">Symptomatic efficacy of rasagiline monotherapy in early Parkinson's disease: post-hoc analyses from the ADAGIO trial.</title>
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<div type="abstract" xml:lang="en">The ADAGIO study included a large cohort of patients with early PD (baseline total-UPDRS = 20) who were initially randomized to rasagiline and placebo, thereby allowing analyses of symptomatic efficacy.</div>
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<Month>05</Month>
<Day>19</Day>
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<Month>01</Month>
<Day>14</Day>
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<Title>Parkinsonism & related disorders</Title>
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<ArticleTitle>Symptomatic efficacy of rasagiline monotherapy in early Parkinson's disease: post-hoc analyses from the ADAGIO trial.</ArticleTitle>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The ADAGIO study included a large cohort of patients with early PD (baseline total-UPDRS = 20) who were initially randomized to rasagiline and placebo, thereby allowing analyses of symptomatic efficacy.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Post-hoc analyses comparing the efficacy of rasagiline 1 mg/day (n = 288) versus placebo (n = 588) on key symptoms at 36 weeks, and on total-UPDRS scores over 72 weeks (completer population: rasagiline 1 mg/day n = 221, placebo n = 392) were performed.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Treatment with rasagiline resulted in significantly better tremor, bradykinesia, rigidity and postural-instability-gait-difficulty scores at week 36 versus placebo. Whereas the placebo group experienced progressive deterioration from baseline (2.6 UPDRS points at week 36), patients in the rasagiline group were maintained at baseline values at week 60 (UPDRS-change of 0.3 points). At week 72, patients who had received continuous monotherapy with rasagiline experienced a worsening of only 1.6 points.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Treatment with rasagiline maintained motor function to baseline values for at least a year with significant benefits observed in all key PD motor symptoms.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation>
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